Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering Conference Paper uri icon

abstract

  • 2016 SPIE. We report a novel nanophotonic biosensor surface capable of both colorimetric detection and Raman-scattered detection of DNA infection markers at extreme sensitivities. Combining direct-write lithography, dip-pen nanolithography based DNA patterning, and molecular self-assembly, we create molecularly-active plasmonic nanostructures onto which metallic nanoparticles are located via DNA-hybridization. Arraying these structures enables optical surfaces that change state when contacted by specific DNA sequences; shifting the surface color while simultaneously generating strong Raman-scattering signals. Patterning the DNA markers onto the plasmonic surface as micro-scale symbols results in easily identifiable color shifts, making this technique applicable to multiplexed lab-on-a-chip and point-of-care diagnostic applications.

name of conference

  • Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII

published proceedings

  • NANOSCALE IMAGING, SENSING, AND ACTUATION FOR BIOMEDICAL APPLICATIONS XIII

altmetric score

  • 3

author list (cited authors)

  • Heydari, E., Mabbott, S., Thompson, D., Graham, D., Cooper, J. M., & Clark, A. W.

citation count

  • 0

complete list of authors

  • Heydari, Esmaeil||Mabbott, Samuel||Thompson, David||Graham, Duncan||Cooper, Jonathan M||Clark, Alasdair W

editor list (cited editors)

  • Cartwright, A. N., Nicolau, D. V., & Fixler, D.

publication date

  • April 2016