HR job title
- Professor
- Contact Info
- 1 979 845 5885
Westhusin, Mark Professor
Positions
My laboratory is interested in developing transgenic animal models of disease and novel platforms for the production of biopharmaceuticals. We are currently exploring methods to produce vaccines in the milk of transgenic animals.
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Overview
Publications
selected publications
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academic article
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Williams, D. K., Pinzn, C., Huggins, S., Pryor, J. H., Falck, A., Herman, F., ... Gaddy, D.
(2018).
Genetic engineering a large animal model of human hypophosphatasia in sheep. Scientific Reports.
8(1), 16945.
-
Skiles, W. M., Kester, A., Pryor, J. H., Westhusin, M. E., Golding, M. C., & Long, C. R.
(2018).
Oxygen-induced alterations in the expression of chromatin modifying enzymes and the transcriptional regulation of imprinted genes. Gene Expression Patterns.
28, 1-11.
-
Golding, M. C., Snyder, M., Williamson, G. L., Veazey, K. J., Peoples, M., Pryor, J. H., Westhusin, M. E., & Long, C. R.
(2015).
Histone-lysine N-methyltransferase SETDB1 is required for development of the bovine blastocyst. THERIOGENOLOGY.
84(8), 1411-1422.
-
Long, C. R., Westhusin, M. E., & Golding, M. C.
(2014).
Reshaping the transcriptional frontier: epigenetics and somatic cell nuclear transfer. Molecular Reproduction and Development.
81(2), 183-193.
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Cornetta, K., Tessanne, K., Long, C., Yao, J., Satterfield, C., & Westhusin, M.
(2013).
Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring. TRANSGENIC RESEARCH.
22(4), 737-745.
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Tessanne, K., Golding, M. C., Long, C. R., Peoples, M. D., Hannon, G., & Westhusin, M. E.
(2012).
Production of transgenic calves expressing an shRNA targeting myostatin. Molecular Reproduction and Development.
79(3), 176-185.
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Romano, J. E., Thompson, J. A., Kraemer, D. C., Westhusin, M. E., Tomaszweski, M. A., & Forrest, D. W.
(2011).
Effects of early pregnancy diagnosis by palpation per rectum on pregnancy loss in dairy cattle. Journal of the American Veterinary Medical Association.
239(5), 668-673.
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Golding, M. C., Williamson, G. L., Stroud, T. K., Westhusin, M. E., & Long, C. R.
(2011).
Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development. Molecular Reproduction and Development.
78(5), 306-317.
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Porada, C. D., Sanada, C., Long, C. R., Wood, J. A., Desai, J., Frederick, N., ... Almeida-Porada, G.
(2010).
Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A. Journal of Thrombosis and Haemostasis.
8(2), 276-285.
-
Liu, J., Westhusin, M., Long, C., Johnson, G., Burghardt, R., & Kraemer, D.
(2010).
Embryo production and possible species preservation by nuclear transfer of somatic cells isolated from bovine semen. THERIOGENOLOGY.
74(9), 1629-1635.
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Liu, J., Westhusin, M., Johnson, G., Raudsepp, T., Chowdhary, B., Burghardt, R., Long, C., & Kraemer, D.
(2009).
Evaluation of culture systems for attachment and proliferation of epithelial cells cultured from ovine semen. Animal Reproduction Science.
115(1-4), 49-57.
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Hanna, C., Long, C., Hinrichs, K., Westhusin, M., & Kraemer, D.
(2008).
Assessment of canine oocyte viability after transportation and storage under different conditions. Animal Reproduction Science.
105(3-4), 451-456.
-
Liu, J., Westhusin, M. E., & Kraemer, D. C.
(2008).
Production of cloned blastocysts using epithelial cells cultured from bovine semen. REPRODUCTION FERTILITY AND DEVELOPMENT.
20(1), 102-102.
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Otoi, T., Shin, T., Kraemer, D. C., & Westhusin, M. E.
(2007).
Role of cumulus cells on in vitro maturation of canine oocytes. Reproduction in Domestic Animals: physiology, pathology, biotechnology.
42(2), 184-189.
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Willingham-Rocky, L. A., Golding, M. C., Wright, J. M., Kraemer, D. C., Westhusin, M. E., & Burghardt, R. C.
(2007).
Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle. Gene Expression Patterns.
7(1-2), 66-71.
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Romano, J. E., Thompson, J. A., Kraemer, D. C., Westhusin, M. E., Forrest, D. W., & Tomaszweski, M. A.
(2007).
Early pregnancy diagnosis by palpation per rectum: influence on embryo/fetal viability in dairy cattle. THERIOGENOLOGY.
67(3), 486-493.
-
Romano, J. E., Thompson, J. A., Forrest, D. W., Westhusin, M. E., Tomaszweski, M. A., & Kraemer, D. C.
(2007).
Early pregnancy diagnosis by transrectal ultrasonography in dairy cattle (vol 66, pg 1034, 2006). THERIOGENOLOGY.
67(7), 1306-1306.
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Romano, J. E., Thompson, J. A., Kraemer, D. C., Westhusin, M. E., Forrest, D. W., & Tomaszweski, M. A.
(2007).
Response to comments on "Early pregnancy diagnosis by palpation per rectum: Influence on embryo/fetal viability in dairy cattle" by Juan E. Romano, et al. [Theriogenology 67 (2007) 486-493]. THERIOGENOLOGY.
68(6), 945-946.
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Westhusin, M. E., Shin, T., Templeton, J. W., Burghardt, R. C., & Adams, L. G.
(2007).
Rescuing valuable genomes by animal cloning: a case for natural disease resistance in cattle. Journal of Animal Science.
85(1), 138-142.
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Golding, M. C., Long, C. R., Carmell, M. A., Hannon, G. J., & Westhusin, M. E.
(2006).
Suppression of prion protein in livestock by RNA interference. Proceedings of the National Academy of Sciences of the United States of America.
103(14), 5285-5290.
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Williams, J. B., Shin, T., Liu, L., Flores-Foxworth, G., Romano, J., Blue-McClendon, A., Kraemer, D., & Westhusin, M. E.
(2006).
Cloning of exotic/endangered species: desert bighorn sheep. Methods in molecular biology (Clifton, N.J.).
348, 169-182.
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Romano, J. E., Thompson, J. A., Forrest, D. W., Westhusin, M. E., Tomaszweski, M. A., & Kraemer, D. C.
(2006).
Early pregnancy diagnosis by transrectal ultrasonography in dairy cattle. THERIOGENOLOGY.
66(4), 1034-1041.
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Otoi, T., Shin, T., Kraemer, D. C., & Westhusin, M. E.
(2004).
Influence of maturation culture period on the development of canine oocytes after in vitro maturation and fertilization. 44(6), 631-637.
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Choi, Y., Love, L. B., Westhusin, M. E., & Hinrichs, K.
(2004).
Activation of equine nuclear transfer oocytes: methods and timing of treatment in relation to nuclear remodeling. Biology of Reproduction.
70(1), 46-53.
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Golding, M. C., & Westhusin, M. E.
(2003).
Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues. Gene Expression Patterns.
3(5), 551-558.
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Willingham-Rocky, L. A., Hinrichs, K., Westhusin, M. E., & Kraemer, D. C.
(2003).
Effects of stage of oestrous cycle and progesterone supplementation during culture on maturation of canine oocytes in vitro. REPRODUCTION.
126(4), 501-508.
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Choi, Y. H., Chung, Y. G., Walker, S. C., Westhusin, M. E., & Hinrichs, K.
(2003).
In vitro development of equine nuclear transfer embryos: effects of oocyte maturation media and amino acid composition during embryo culture. Zygote: the biology of gametes and early embryos.
11(1), 77-86.
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Westhusin, M., Hinrichs, K., Choi, Y., Shin, T., Liu, L., & Kraemer, D.
(2003).
Cloning companion animals (horses, cats, and dogs). Cellular Reprogramming.
5(4), 301-317.
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Long, C. R., Walker, S. C., Tang, R. T., & Westhusin, M. E.
(2003).
New commercial opportunities for advanced reproductive technologies in horses, wildlife, and companion animals. THERIOGENOLOGY.
59(1), 139-149.
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Otoi, T., Willingham, L., Shin, T., Kraemer, D. C., & Westhusin, M.
(2002).
Effects of oocyte culture density on meiotic competence of canine oocytes. REPRODUCTION.
124(6), 775-781.
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Choi, Y. H., Love, C. C., Chung, Y. G., Varner, D. D., Westhusin, M. E., Burghardt, R. C., & Hinrichs, K.
(2002).
Production of nuclear transfer horse embryos by Piezo-driven injection of somatic cell nuclei and activation with stallion sperm cytosolic extract. Biology of Reproduction.
67(2), 561-567.
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Shin, T., Kraemer, D., Pryor, J., Liu, L., Rugila, J., Howe, L., ... Westhusin, M.
(2002).
A cat cloned by nuclear transplantation. Nature.
415(6874), 859-859.
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Choi, Y., Shin, T., Love, C. C., Johnson, C., Varner, D. D., Westhusin, M. E., & Hinrichs, K.
(2002).
Effect of co-culture with theca interna on nuclear maturation of horse oocytes with low meiotic competence, and subsequent fusion and activation rates after nuclear transfer. THERIOGENOLOGY.
57(3), 1005-1011.
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Choi, Y. H., Love, C. C., Chung, Y. G., Varner, D. D., Westhusin, M. E., Burghardt, R. C., & Hinrichs, K.
(2002).
Use of Piezo-driven direct nuclear injection and activation with stallion sperm extract to produce horse nuclear transfer embryos. THERIOGENOLOGY.
58(2-4), 771-774.
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Natale, D. R., De Sousa, P. A., Westhusin, M. E., & Watson, A. J.
(2001).
Sensitivity of bovine blastocyst gene expression patterns to culture environments assessed by differential display RT-PCR. REPRODUCTION.
122(5), 687-693.
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Jones, K. L., Hill, J., Shin, T. Y., Lui, L., & Westhusin, M.
(2001).
DNA hypomethylation of karyoplasts for bovine nuclear transplantation. Molecular Reproduction and Development.
60(2), 208-213.
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Calder, M. D., Caveney, A. N., Westhusin, M. E., & Watson, A. J.
(2001).
Cyclooxygenase-2 and prostaglandin E(2)(PGE(2)) receptor messenger RNAs are affected by bovine oocyte maturation time and cumulus-oocyte complex quality, and PGE(2) induces moderate expansion of the bovine cumulus in vitro. Biology of Reproduction.
65(1), 135-140.
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Watson, P. H., Westhusin, M. E., & Watson, A. J.
(2001).
Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation. 203(3), 175-184.
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Elhassan, Y. M., Wu, G., Leanez, A. C., Tasca, R. J., Watson, A. J., & Westhusin, M. E.
(2001).
Amino acid concentrations in fluids from the bovine oviduct and uterus and in KSOM-based culture media. THERIOGENOLOGY.
55(9), 1907-1918.
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Hill, J. R., Winger, Q. A., Burghardt, R. C., & Westhusin, M. E.
(2001).
Bovine nuclear transfer embryo development using cells derived from a cloned fetus. Animal Reproduction Science.
67(1-2), 17-26.
-
Westhusin, M. E., Long, C. R., Shin, T., Hill, J. R., Looney, C. R., Pryor, J. H., & Piedrahita, J. A.
(2001).
Cloning to reproduce desired genotypes. THERIOGENOLOGY.
55(1), 35-49.
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Liu, L., Shin, T., Pryor, J. H., Kraemer, D., & Westhusin, M.
(2001).
Regenerated bovine fetal fibroblasts support high blastocyst development following nuclear transfer. Cloning.
3(2), 51-58.
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Betts, D., Bordignon, V., Hill, J., Winger, Q., Westhusin, M., Smith, L., & King, W.
(2001).
Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proceedings of the National Academy of Sciences of the United States of America.
98(3), 1077-1082.
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Westhusin, M. E., Burghardt, R. C., Ruglia, J. N., Willingham, L. A., Liu, L., Shin, T., Howe, L. M., & Kraemer, D. C.
(2001).
Potential for cloning dogs. Journal of reproduction and fertility. Supplement.
57(57), 287-293.
-
Betts, D. H., Bordignon, V., Hill, J. R., Winger, Q., Westhusin, M. E., Smith, L. C., & Allan King, W.
(2000).
Assessment of telomerase activity and telomere length in cloned bovine embryos, fetuses and offspring derived by somatic cell nuclear transfer. Cloning.
2(3), 145.
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Hill, J. R., Burghardt, R. C., Jones, K., Long, C. R., Looney, C. R., Shin, T., ... Westhusin, M. E.
(2000).
Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biology of Reproduction.
63(6), 1787-1794.
-
Westhusin, M., & Piedrahita, J.
(2000).
Three little pigs worth the huff and puff?. Nature Biotechnology.
18(11), 1144-1145.
-
Winger, Q. A., Hill, J. R., Shin, T., Watson, A. J., Kraemer, D. C., & Westhusin, M. E.
(2000).
Genetic reprogramming of lactate dehydrogenase, citrate synthase, and phosphofructokinase mRNA in bovine nuclear transfer embryos produced using bovine fibroblast cell nuclei. 56(4), 458-464.
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Winger, Q. A., Hill, J. R., Shin, T., Watson, A. J., Kraemer, D. C., & Westhusin, M. E.
(2000).
Genetic reprogramming of lactate dehydrogenase, citrate synthase, and phosphofructokinase mRNA in bovine nuclear transfer embryos produced using bovine fibroblast cell nuclei. Molecular Reproduction and Development.
56(4), 458-464.
-
Hill, J. R., Winger, Q. A., Long, C. R., Looney, C. R., Thompson, J. A., & Westhusin, M. E.
(2000).
Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells. Biology of Reproduction.
62(5), 1135-1140.
-
Lee, C. K., Moore, K., Scales, N., Westhusin, M., Newton, G., Im, K. S., & Piedrahita, J. A.
(2000).
Isolation and Genetic Transformation of Primordial Germ Cell (PGC)- Derived Cells from Cattle, Goats, Rabbits and Rats. Animal Bioscience.
13(5), 587-594.
-
Natale, D. R., Kidder, G. M., Westhusin, M. E., & Watson, A. J.
(2000).
Assessment by differential display-RT-PCR of mRNA transcript transitions and alpha-amanitin sensitivity during bovine preattachment development. 55(2), 152-163.
-
Watson, A. J., De Sousa, P., Caveney, A., Barcroft, L. C., Natale, D., Urquhart, J., & Westhusin, M. E.
(2000).
Impact of bovine oocyte maturation media on oocyte transcript levels, blastocyst development, cell number, and apoptosis. Biology of Reproduction.
62(2), 355-364.
-
Natale, D. R., Kidder, G. M., Westhusin, M. E., & Watson, A. J.
(2000).
Assessment by differential display-RT-PCR of mRNA transcript transitions and -amanitin sensitivity during bovine preattachment development. Molecular Reproduction and Development.
55(2), 152-163.
-
Winger, Q. A., Hill, J. R., Watson, A. J., & Westhusin, M. E.
(2000).
Characterization of a bovine cDNA encoding citrate synthase, and presence of citrate synthase mRNA during bovine pre-attachment development. Molecular Reproduction and Development.
55(1), 14-19.
-
Winger, Q. A., Hill, J. R., Watson, A. J., & Westhusin, M. E.
(2000).
Characterization of a bovine cDNA encoding citrate synthase, and presence of citrate synthase mRNA during bovine pre-attachment development. 55(1), 14-19.
-
Latham, K. E., & Westhusin, M. E.
(2000).
Nuclear transplantation and cloning in mammals. Methods in molecular biology (Clifton, N.J.).
136, 405-425.
-
Hill, J. R., Roussel, A. J., Cibelli, J. B., Edwards, J. F., Hooper, N. L., Miller, M. W., ... Stice, S. L.
(1999).
Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies). THERIOGENOLOGY.
51(8), 1451-1465.
-
De Sousa, P. A., Winger, Q., Hill, J. R., Jones, K., Watson, A. J., & Westhusin, M. E.
(1999).
Reprogramming of fibroblast nuclei after transfer into bovine oocytes. Cloning.
1(1), 63-69.
-
Elhassan, Y. M., Kraemer, D. C., & Westhusin, M. E.
(1999).
A simple salt solution medium supplemented with yolk plasma and lactate (YPLM) supports development of preimplantation bovine embryos in vitro. Animal Reproduction Science.
57(3-4), 153-166.
-
Watson, A. J., Westhusin, M. E., De Sousa, P. A., Betts, D. H., & Barcroft, L. C.
(1999).
Gene expression regulating blastocyst formation. THERIOGENOLOGY.
51(1), 117-133.
-
Hill, J., Winger, Q., Jones, K., Keller, D., King, W. A., & Westhusin, M.
(1999).
The effect of donor cell serum starvation and oocyte activation compounds on the development of somatic cell cloned embryos. Cloning.
1(4), 201-208.
-
Watson, A. J., Westhusin, M. E., & Winger, Q. A.
(1999).
IGF paracrine and autocrine interactions between conceptus and oviduct. Journal of reproduction and fertility. Supplement.
54, 303-315.
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Chapman, S. A., Keller, D. L., Westhusin, M. E., Drew, M. L., & Kraemer, D. C.
(1999).
In vitro production of axis deer (axis axis) embryos, a preliminary study. THERIOGENOLOGY.
51(1), 280-280.
-
Elhassan, Y. M., Tasca, R. J., & Westhusin, M. E.
(1999).
Levels of amino acids in bovine oviductal and uterine fluids in comparison to levels available in a culture medium supplemented with commercial stocks. THERIOGENOLOGY.
51(1), 237-237.
-
Hill, J. R., Winger, Q. A., Jones, K. L., Thompson, J. A., Burghardt, R. C., & Westhusin, M. E.
(1999).
Serum starvation of bovine fetal fibroblasts prior to nuclear transfer increases in vitro development rates. THERIOGENOLOGY.
51(1), 204-204.
-
Hill, J., Westhusin, M., & Varner, D. D.
(1998).
Advances in large-animal reproduction: In vitro production of embryos. VETERINARY MEDICINE.
93(6), 575-+.
-
Hill, J., Westhusin, M., & Varner, D. D.
(1998).
Advances in large-animal reproduction: The expanding role of ultrasonography. VETERINARY MEDICINE.
93(5), 480-484.
-
Hill, J., Westhusin, M., & Varner, D. D.
(1998).
Advances in large-animal reproduction: Updated techniques for artificial insemination and embryo transfer. VETERINARY MEDICINE.
93(5), 485-490.
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Robison, C. D., Davis, D. S., Templeton, J. W., Westhusin, M., Foxworth, W. B., Gilsdorf, M. J., & Adams, L. G.
(1998).
Conservation of germ plasm from bison infected with Brucella abortus. Journal of Wildlife Diseases.
34(3), 582-589.
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De Sousa, P. A., Westhusin, M. E., & Watson, A. J.
(1998).
Analysis of variation in relative mRNA abundance for specific gene transcripts in single bovine oocytes and early embryos. Molecular Reproduction and Development.
49(2), 119-130.
-
De Sousa, P. A., Westhusin, M. E., & Watson, A. J.
(1998).
Analysis of variation in relative mRNA abundance for specific gene transcripts in single bovine oocytes and early embryos. 49(2), 119-130.
-
Azambuja, R. M., Kraemer, D. C., & Westhusin, M. E.
(1998).
Effect of low temperatures on in-vitro matured bovine oocytes. THERIOGENOLOGY.
49(6), 1155-1164.
-
De Sousa, P. A., Caveney, A., Westhusin, M. E., & Watson, A. J.
(1998).
Temporal patterns of embryonic gene expression and their dependence on oogenetic factors. THERIOGENOLOGY.
49(1), 115-128.
-
Natale, D. R., Westhusin, M. E., & Watson, A. J.
(1998).
Characterization of differentially expressed mRNAs in bovine pre-attachment embryos cultured in defined and serum-supplemented/co-culture systems. THERIOGENOLOGY.
49(1), 188-188.
-
Azambuja, R. M., Kraemer, D. C., & Westhusin, M. E.
(1997).
Effects of low temperatures on in vitro produced bovine zygotes. Molecular Reproduction and Development.
47(4), 435-439.
-
Azambuja, R. M., Kraemer, D. C., & Westhusin, M. E.
(1997).
Effects of low temperatures on in vitro produced bovine zygotes. Molecular Reproduction and Development.
47(4), 435-439.
-
Westhusin, M.
(1997).
From mighty mice to mighty cows. Nature Genetics.
17(1), 4-5.
-
Byrd, S. R., Flores-Foxworth, G., Applewhite, A. A., & Westhusin, M. E.
(1997).
In vitro maturation of ovine oocytes in a portable incubator. THERIOGENOLOGY.
47(4), 857-864.
-
Coonrod, S. A., Herr, J. C., & Westhusin, M. E.
(1996).
Inhibition of bovine fertilization in vitro by antibodies to SP-10. Reproduction.
107(2), 287-297.
-
Westhusin, M. E., & De Azambuja, R. M.
(1996).
Development of in vitro derived bovine embryos following pronuclear transplantation and in vitro culture. Animal Reproduction Science.
45(1-2), 29-35.
-
Westhusin, M. E., Collas, P., Marek, D., Sullivan, E., Stepp, P., Pryor, J., & Barnes, F.
(1996).
Reducing the amount of cytoplasm available for early embryonic development decreases the quality but not quantity of embryos produced by in vitro fertilization and nuclear transplantation. THERIOGENOLOGY.
46(2), 243-252.
-
WILSON, J. M., WILLIAMS, J. D., BONDIOLI, K. R., LOONEY, C. R., WESTHUSIN, M. E., & MCCALLA, D. F.
(1995).
COMPARISON OF BIRTH-WEIGHT AND GROWTH-CHARACTERISTICS OF BOVINE CALVES PRODUCED BY NUCLEAR TRANSFER (CLONING), EMBRYO-TRANSFER AND NATURAL MATING. 38(1-2), 73-83.
-
Flores-Foxworth, G., Coonrod, S. A., Moreno, J. F., Byrd, S. R., Kraemer, D. C., & Westhusin, M.
(1995).
Interspecific transfer of IVM IVF-derived red sheep (Ovis orientalis gmelini ) embryos to domestic sheep (Ovis aries ). THERIOGENOLOGY.
44(5), 681-690.
-
Coonrod, S. A., Westhusin, M. E., & Naz, R. K.
(1994).
Monoclonal antibody to human fertilization antigen-1 (FA-1) inhibits bovine fertilization in vitro: application in immunocontraception. Biology of Reproduction.
51(1), 14-23.
-
Barnes, F. L., Collas, P., Powell, R., King, W. A., Westhusin, M., & Shepherd, D.
(1993).
Influence of recipient oocyte cell cycle stage on DNA synthesis, nuclear envelope breakdown, chromosome constitution, and development in nuclear transplant bovine embryos. Molecular Reproduction and Development.
36(1), 33-41.
-
Barnes, F., Endebrock, M., Looney, C., Powell, R., Westhusin, M., & Bondioli, K.
(1993).
Embryo cloning in cattle: the use of in vitro matured oocytes. Reproduction.
97(2), 317-320.
-
Westhusin, M. E., Levanduski, M. J., Scarborough, R., Looney, C. R., & Bondioli, K. R.
(1992).
Viable embryos and normal calves after nuclear transfer into Hoechst stained enucleated demi-oocytes of cows. Reproduction.
95(2), 475-480.
-
Westhusin, M. E., Pryor, J. H., & Bondioli, K. R.
(1991).
Nuclear transfer in the bovine embryo: a comparison of 5-day, 6-day, frozen-thawed, and nuclear transfer donor embryos. Molecular Reproduction and Development.
28(2), 119-123.
-
BONDIOLI, K. R., WESTHUSIN, M. E., & LOONEY, C. R.
(1990).
PRODUCTION OF IDENTICAL BOVINE OFFSPRING BY NUCLEAR TRANSFER. THERIOGENOLOGY.
33(1), 165-174.
-
Westhusin, M. E., Slapak, J. R., Fuller, D. T., & Kraemer, D. C.
(1989).
Culture of agar-embedded one and two cell bovine embryos and embryos produced by nuclear transfer in the sheep and rabbit oviduct. THERIOGENOLOGY.
31(1), 271-271.
-
Looney, C. R., Westhusin, M. E., & Bondioli, K. R.
(1989).
Effect of cooling temperatures on pre-compacted bovine embryos. THERIOGENOLOGY.
31(1), 218-218.
-
Slapak, J. R., & Westhusin, M. E.
(1989).
Effect of procedures utilized for nuclear transfer on bovine oocyte activation. THERIOGENOLOGY.
31(1), 258-258.
-
WESTHUSIN, M. E., & KRAEMER, D. C.
(1986).
FERTILIZATION OF HAMSTER OVA BY SPERM INJECTION - THE EFFECT OF SPERM PLACEMENT ON SPERM DECONDENSATION AND PRONUCLEAR FORMATION. THERIOGENOLOGY.
25(1), 215-215.
-
WESTHUSIN, M. E., ANDERSON, J. G., HARMS, P. G., & KRAEMER, D. C.
(1984).
MICROINJECTION OF SPERMATOZOA INTO BOVINE EGGS. THERIOGENOLOGY.
21(1), 274-274.
-
Williams, D. K., Pinzn, C., Huggins, S., Pryor, J. H., Falck, A., Herman, F., ... Gaddy, D.
(2018).
Genetic engineering a large animal model of human hypophosphatasia in sheep. Scientific Reports.
8(1), 16945.
-
conference paper
-
Williams, D. K., Pinzon, C. A., Huggins, S., Pryor, J. H., Georges, H. M., Hermann, F., ... Suva, L. J.
(2018).
Genetically Engineering a Sheep Model of Hypophosphatasia. The FASEB Journal.
859.10-859.10.
-
Williams, D. K., Pryor, J. H., Huggins, S., Georges, H. M., Pinzon, C. A., Hermann, F., ... Suva, L. J.
(2017).
Genetic engineering a sheep model of Hypophosphatasia. Journal of Bone and Mineral Research.
S397-S397.
-
Long, C. R., Golding, M. C., & Westhusin, M. E.
(2014).
Lentivirus mediated transgenic livestock: applications in biomedical research. TRANSGENIC RESEARCH.
192-193.
-
Romano, J. E., Thompson, J. A., Kraemer, D. C., Westhusin, M. E., Forrest, D. W., & Tomaszweski, M. A.
(2006).
Early pregnancy diagnosis by palpation per rectum on embryo/fetus viability in dairy cattle. THERIOGENOLOGY.
667-667.
-
Elhassan, Y. M., Zhang, X., Kramer, D. C., & Westhusin, M. E.
(2000).
Blastocyst development of in vitro produced morula-stage bovine embryos briefly exposed to Ultraviolet light following Hoechst staining. Biology of Reproduction.
253-253.
-
Watson, P. H., Westhusin, M. E., & Watson, A. J.
(2000).
Characterization of PTHrP and PTHr in the bovine ovary. Biology of Reproduction.
168-169.
-
Liu, L., Shin, T. Y., Kraemer, D., & Westhusin, M. E.
(2000).
High blastocyst development following nuclear transfer with fibroblast cells derived from a cloned fetus. Biology of Reproduction.
191-191.
-
Calder, M. D., Caveney, A. N., Westhusin, M. E., & Watson, A. J.
(2000).
The role of cyclooxygenase (COX-2), prostaglandin E2 (PGE2) and prostaglandin receptors 2 and 3 (EP2 and EP3) during maturation in vitro of bovine cumulus oocyte complexes (COCs). Biology of Reproduction.
271-272.
-
Winger, Q. A., Hill, J. R., Watson, A. J., & Westhusin, M. E.
(1999).
Genetic reprogramming of phosphofructokinase in nuclear transfer embryos produced using bovine fetal fibroblasts. Biology of Reproduction.
268-269.
-
Westhusin, M. E., Hill, J. R., Winger, Q. A., Jones, K. L., DeSousa, P. A., & Watson, A. J.
(1999).
Reprogramming gene expression following nuclear transfer into bovine oocytes. Biology of Reproduction.
79-79.
-
Elhassan, Y. M., Lee, C. P., Tasca, R. J., & Westhusin, M. E.
(1999).
The effect of NaCl-associated osmolarity changes on bovine embryo development in a completely defined culture medium supplemented with amino acids at oviductal fluid levels. Biology of Reproduction.
248-248.
-
Lee, C. P., Elhassan, Y. M., & Westhusin, M. E.
(1999).
The effect of mercaptoethanol and N-acetyl cysteine on development of bovine blastocysts produced in vitro. Biology of Reproduction.
193-193.
-
Keller, D. L., Chapman, S. A., Westhusin, M. E., Drew, M. L., & Kraemer, D. C.
(1999).
Production of in-vitro derived blackbuck antelope (Antilope cervicapra) embryos using standard bovine protocols. THERIOGENOLOGY.
287-287.
-
Winger, Q. W., Elhassan, Y. M., Watson, A. J., & Westhusin, M. E.
(1998).
Expression of lactate dehydrogenase mRNAs in bovine pre-attachment embryos. Biology of Reproduction.
95-95.
-
Elhassan, Y. M., & Westhusin, M. E.
(1997).
An egg yolk fraction high in LDL supports in vitro development of bovine embryos in a cell-free basic salt solution supplemented with lactate. Biology of Reproduction.
222-222.
-
Evans, G. K., Evans, J. W., Vogelsang, M. M., & Westhusin, M. E.
(1997).
The effects of heparin exposure on equine oocytes matured in-vitro. 94-99.
-
Elhassan, Y. M., & Westhusin, M. E.
(1996).
In vitro development of bovine embryos in a BRL coculture system supplemented with EGG yolk in the presence or absence of fetal bovine serum and bovine serum albumin. Biology of Reproduction.
98-98.
-
WOLFE, B. A., WESTHUSIN, M. E., STEPP, P., & KRAEMER, D. C.
(1994).
EMBRYOS PRODUCED BY THE TRANSFER OF CAPRINE NUCLEI TO ENUCLEATED BOVINE OOCYTES ARE CAPABLE OF CLEAVAGE BUT DO NOT DEVELOP TO BLASTOCYSTS. Biology of Reproduction.
72-72.
-
Williams, D. K., Pinzon, C. A., Huggins, S., Pryor, J. H., Georges, H. M., Hermann, F., ... Suva, L. J.
(2018).
Genetically Engineering a Sheep Model of Hypophosphatasia. The FASEB Journal.
859.10-859.10.
Research
principal investigator on
- Development of New Approaches for Genetic Modification of Livestock awarded by National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States) 2014 - 2019
- Functional Anaylsis of the Embryonic Epigenome In A Non-Rodent Model awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2010 - 2016
- Functional Analysis of the Embryonic Epigenome In A Non-Rodent Model - Supplemental Account awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2011 - 2015
co-principal investigator on
Teaching
teaching activities
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- VTPP485 Directed Studies Instructor
- VTPP691 Research Instructor
Works By Students
chaired theses and dissertations
-
Campbell, Scott Robert (2016-12). Development and Evaluation of an Oral Contraceptive for Wild Pigs.
-
Golding, Michael Cameron (2005-02). Expression of the bovine DNA (cytosine 5) methyltransferase family during preimplantation development and aberrations induced by somatic cell nuclear transfer.
-
Liu, Jie (2009-05). Recovery and evaluation of somatic cells from ovine and bovine semen for use in nuclear transfer.
-
Peoples, Michael D 1978- (2010-12). Identification and Characterization of Bovine Pol III Promoters to Express a Short-Hairpin RNA.
-
Tessanne, Kimberly J. (2012-02). Development of Transgenic Livestock with Reduced Myostatin Expression Using RNA Interference.
-
Willingham-Rocky, Lauri A. (2009-05). Evaluation of oocyte competency in bovine and canine species via non-invasive assessment of oocyte quality.
Background
education and training
- Ph.D. in Veterinary Physiology, Texas A&M University - (College Station, Texas, United States) 1986
- M.S. in Veterinary Physiology, Texas A&M University - Corpus Christi - (Corpus Christi, Texas, United States) 1983
- B.S. in Animal Science, Kansas State University - (Manhattan, Kansas, United States) 1980
Contact
first name
- Mark
has last name
- Westhusin
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
In the News
- m-westhusin@tamu.edu