selected publications academic article Naz, S., Mazhar, M. U., Yadav, U., Ali, H. A., Khasawneh, F., Ihsan-Ul-Haq, .., Tipu, M. K., & Zhu, L. (2024). Anti-inflammatory and anti-arthritic potential of Coagulansin-A: in vitro and in vivo studies. Inflammopharmacology. Gomes-da-Silva, N. C., Soares, M., Ricci-Junior, E., Amorim, M., Alencar, L., Bhattarai, P., ... Santos-Oliveira, R. (2023). Nanomicelles of taurine inhibit the fibrillation and toxicity of amyloid & beta;1-42 peptide. 86, 104721-104721. Liu, Y., Zhang, J., Tu, Y., & Zhu, L. (2022). Potential-Independent Intracellular Drug Delivery and Mitochondrial Targeting. ACS Nano. 16(1), 1409-1420. Mendes Felix, D., Rebelo Alencar, L. M., de Menezes, F. D., do Valle Pereira Midlej, V., Aguiar, L., Piperni, S. G., ... Santos-Oliveira, R. (2021). Graphene quantum dots decorated with imatinib for leukemia treatment. 61, 102117-102117. Magne, T. M., Helal-Neto, E., Correa, L. B., Rebelo Alencar, L. M., Gemini Piperni, S., Iram, S. H., ... Santos-Oliveira, R. (2021). Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results. Colloids and Surfaces B: Biointerfaces. 206, 111952-111952. Zhang, J., Goel, A., & Zhu, L. (2021). Identification of Novel Alternative Splicing Events Associated With Tumorigenesis, Protein Modification, and Immune Microenvironment in Early-Onset Gastric Cancer. Frontiers in Oncology. 11, 640272. Liu, Y., Wang, J., Zhang, J., Marbach, S., Xu, W., & Zhu, L. (2020). Targeting Tumor-Associated Macrophages by MMP2-Sensitive Apoptotic Body-Mimicking Nanoparticles. ACS Applied Materials & Interfaces. 12(47), 52402-52414. Yao, Q., Liu, Y., Kou, L., Tu, Y., Tang, X., & Zhu, L. (2019). Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles. Nanomedicine: Nanotechnology, Biology and Medicine. 19, 71-80. Yao, Q., Kou, L., Tu, Y., & Zhu, L. (2018). MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting. Trends in Pharmacological Sciences. 39(8), 766-781. Wang, J., Lee, J. S., Kim, D., & Zhu, L. (2017). Exploration of Zinc Oxide Nanoparticles as a Multitarget and Multifunctional Anticancer Nanomedicine. ACS Applied Materials & Interfaces. 9(46), 39971-39984. Yao, Q., Choi, J. H., Dai, Z., Wang, J., Kim, D., Tang, X., & Zhu, L. (2017). Improving Tumor Specificity and Anticancer Activity of Dasatinib by Dual-Targeted Polymeric Micelles. ACS Applied Materials & Interfaces. 9(42), 36642-36654. Yao, Q., Dai, Z., Hoon Choi, J., Kim, D., & Zhu, L. (2017). Building Stable MMP2-Responsive Multifunctional Polymeric Micelles by an All-in-One Polymer-Lipid Conjugate for Tumor-Targeted Intracellular Drug Delivery. ACS Applied Materials & Interfaces. 9(38), 32520-32533. Yao, Q., Gutierrez, D. C., Hoang, N. H., Kim, D., Wang, R., Hobbs, C., & Zhu, L. (2017). Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Molecular Pharmaceutics. 14(7), 2378-2389. Zhou, Q., Hou, Y., Zhang, L. i., Wang, J., Qiao, Y., Guo, S., ... Wu, H. (2017). Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity. Theranostics. 7(7), 1806-1819. Yang, T., Li, W., Duan, X., Zhu, L., Fan, L. i., Qiao, Y., & Wu, H. (2016). Preparation of Two Types of Polymeric Micelles Based on Poly(-L-Malic Acid) for Antitumor Drug Delivery. PLoS ONE. 11(9), e0162607-e0162607. Dai, Z., Tu, Y., & Zhu, L. (2016). Multifunctional Micellar Nanocarriers for Tumor-Targeted Delivery of Hydrophobic Drugs. Journal of Biomedical Nanotechnology. 12(6), 1199-1210. Dai, Z., Yao, Q., & Zhu, L. (2016). MMP2-Sensitive PEG-Lipid Copolymers: A New Type of Tumor-Targeted P-Glycoprotein Inhibitor. ACS Applied Materials & Interfaces. 8(20), 12661-12673. Zhou, Q., Yang, T., Qiao, Y., Guo, S., Zhu, L., & Wu, H. (2015). Preparation of poly(-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery. 10(1), 1941-1952. Tu, Y., & Zhu, L. (2015). Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate. Journal of Controlled Release. 212, 94-102. Perche, F., Biswas, S., Wang, T., Zhu, L., & Torchilin, V. P. (2014). Hypoxia-targeted siRNA delivery. Angewandte Chemie International Edition. 53(13), 3362-3366. Sawant, R. R., Jhaveri, A. M., Koshkaryev, A., Zhu, L., Qureshi, F., & Torchilin, V. P. (2014). Targeted transferrin-modified polymeric micelles: enhanced efficacy in vitro and in vivo in ovarian carcinoma. Molecular Pharmaceutics. 11(2), 375-381. Tu, Y., & Zhu, L. (2014). Lipids and their derivatives: by-products used as essential building blocks for modern drug delivery systems. Current Drug Targets. 15(5), 502-517. Zhu, L., Perche, F., Wang, T., & Torchilin, V. P. (2014). Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 35(13), 4213-4222. Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P. (2013). Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America. 110(42), 17047-17052. Wu, H., Zhu, L., & Torchilin, V. P. (2013). pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery. Biomaterials. 34(4), 1213-1222. Zhu, L., & Torchilin, V. P. (2013). Stimulus-responsive nanopreparations for tumor targeting. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences. 5(1), 96-107. Zhu, L., Kate, P., & Torchilin, V. P. (2012). Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano. 6(4), 3491-3498. Zhu, L., & Mahato, R. I. (2010). Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjugate Chemistry. 21(11), 2119-2127. Zhu, L., & Mahato, R. I. (2010). Lipid and polymeric carrier-mediated nucleic acid delivery. Expert Opinion on Drug Delivery. 7(10), 1209-1226. Zhu, L., Huo, Z., Wang, L., Tong, X., Xiao, Y., & Ni, K. (2009). Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes. International Journal of Pharmaceutics. 370(1-2), 136-143. Cheng, G., Zhu, L., & Mahato, R. I. (2008). Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. 5(6), 1093-1102. Zhu, L., Lu, Y., Miller, D. D., & Mahato, R. I. (2008). Structural and formulation factors influencing pyridinium lipid-based gene transfer. Bioconjugate Chemistry. 19(12), 2499-2512. Tu, Y., Zhu, L., Wang, G., Zhao, L., & Xiang, B. (2008). Development and validation of a LC-ESI-MS assay for determination of icariin in rat plasma after administration of Herba Epimedii. Chromatographia. 67(7-8), 591-597. Zhu, L., Ye, Z., Cheng, K., Miller, D. D., & Mahato, R. I. (2008). Site-specific delivery of oligonucleotides to hepatocytes after systemic administration. Bioconjugate Chemistry. 19(1), 290-298. Tu, Y., Zhao, L., Zhu, L., Wang, G., & Xiang, B. (2006). Simultaneous determination of Acteoside, Astragaloside IV and Icariside-I in the traditional Chinese medicinal preparation Shenbao by HPLC-MS. Chromatographia. 64(7-8), 453-458. Wang, L. L., Zhu, L., Ni, K. Y., Tu, Y., Xiao, Y., & Peng, G. G. (2006). Study on tissue distribution of methotrexate magnetoliposomes in mice by HPLC. Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989). 41(20), 1572-1575. Zhu, L., Wang, L. L., Ni, K. Y., Tong, X., Dai, L., & Tu, J. (2006). Preparation of stable magnetoliposomes with high encapsulation efficiency of methotrexate. Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989). 41(17), 1324-1327. Ying, T. u., Luhua, Z., Lin, Z., Guangji, W., & Binren, X. (2004). Separation and identification of 20 chemical constituents in the traditional Chinese medicinal preparation Shenbao tablet by LC-ESI-MS3. Journal of Chromatographic Science. 42(4), 177-183. Liu, Y., Dai, Z., Wang, J., Tu, Y., & Zhu, L. Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment. Chemical Communications. 55(29), 4254-4257. conference paper Zhu, L. (2019). MMP2-sensitive tumor-targeted drug delivery and sensitization. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
principal investigator on Improving tumor specificity and overcoming drug resistance of proteasome inhibitors by a dual-targeted drug delivery system awarded by National Institute of Health - (Islamabad, Pakistan)
teaching activities PHAR642 Pharmaceutics I Instructor PHAR741 Pharmaceutics Ii Instructor PHAR742 Basic Pharmacokinetics Instructor PHSC681 Seminar Instructor PHSC685 Directed Studies Instructor PHSC689 Sptp: Nanomedicine Instructor PHSC691 Research Instructor
education and training Ph.D. in Pharmaceutics, University of Tennessee Health Science Center - (Memphis, Tennessee, United States) 2010 M.S. in Pharmaceutics, China Pharmaceutical University - (Nanjing, China) 2003 B.E. in Pharmaceutics, China Pharmaceutical University - (Nanjing, China) 1997 Northeastern University - (Shenyang, China) , Postdoctoral Training 2013