HR job title
- Associate Professor
- Contact Info
- 3612210757
- Websites
- ORCiD
- 0000-0002-4047-1726
Zhu, Lin Associate Professor
Positions
- Associate Professor, Irma Lerma Rangel School of Pharmacy, Health Science Center
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
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academic article
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Naz, S., Mazhar, M. U., Yadav, U., Ali, H. A., Khasawneh, F., Ihsan-Ul-Haq, .., Tipu, M. K., & Zhu, L.
(2024).
Anti-inflammatory and anti-arthritic potential of Coagulansin-A: in vitro and in vivo studies. Inflammopharmacology.
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Gomes-da-Silva, N. C., Soares, M., Ricci-Junior, E., Amorim, M., Alencar, L., Bhattarai, P., ... Santos-Oliveira, R.
(2023).
Nanomicelles of taurine inhibit the fibrillation and toxicity of amyloid & beta;1-42 peptide. 86, 104721-104721.
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Liu, Y., Zhang, J., Tu, Y., & Zhu, L.
(2022).
Potential-Independent Intracellular Drug Delivery and Mitochondrial Targeting. ACS Nano.
16(1), 1409-1420.
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Mendes Felix, D., Rebelo Alencar, L. M., de Menezes, F. D., do Valle Pereira Midlej, V., Aguiar, L., Piperni, S. G., ... Santos-Oliveira, R.
(2021).
Graphene quantum dots decorated with imatinib for leukemia treatment. 61, 102117-102117.
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Magne, T. M., Helal-Neto, E., Correa, L. B., Rebelo Alencar, L. M., Gemini Piperni, S., Iram, S. H., ... Santos-Oliveira, R.
(2021).
Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results. Colloids and Surfaces B: Biointerfaces.
206, 111952-111952.
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Zhang, J., Goel, A., & Zhu, L.
(2021).
Identification of Novel Alternative Splicing Events Associated With Tumorigenesis, Protein Modification, and Immune Microenvironment in Early-Onset Gastric Cancer. Frontiers in Oncology.
11, 640272.
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Liu, Y., Wang, J., Zhang, J., Marbach, S., Xu, W., & Zhu, L.
(2020).
Targeting Tumor-Associated Macrophages by MMP2-Sensitive Apoptotic Body-Mimicking Nanoparticles. ACS Applied Materials & Interfaces.
12(47), 52402-52414.
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Yao, Q., Liu, Y., Kou, L., Tu, Y., Tang, X., & Zhu, L.
(2019).
Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles. Nanomedicine: Nanotechnology, Biology and Medicine.
19, 71-80.
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Yao, Q., Kou, L., Tu, Y., & Zhu, L.
(2018).
MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting. Trends in Pharmacological Sciences.
39(8), 766-781.
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Wang, J., Lee, J. S., Kim, D., & Zhu, L.
(2017).
Exploration of Zinc Oxide Nanoparticles as a Multitarget and Multifunctional Anticancer Nanomedicine. ACS Applied Materials & Interfaces.
9(46), 39971-39984.
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Yao, Q., Choi, J. H., Dai, Z., Wang, J., Kim, D., Tang, X., & Zhu, L.
(2017).
Improving Tumor Specificity and Anticancer Activity of Dasatinib by Dual-Targeted Polymeric Micelles. ACS Applied Materials & Interfaces.
9(42), 36642-36654.
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Yao, Q., Dai, Z., Hoon Choi, J., Kim, D., & Zhu, L.
(2017).
Building Stable MMP2-Responsive Multifunctional Polymeric Micelles by an All-in-One Polymer-Lipid Conjugate for Tumor-Targeted Intracellular Drug Delivery. ACS Applied Materials & Interfaces.
9(38), 32520-32533.
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Yao, Q., Gutierrez, D. C., Hoang, N. H., Kim, D., Wang, R., Hobbs, C., & Zhu, L.
(2017).
Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Molecular Pharmaceutics.
14(7), 2378-2389.
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Zhou, Q., Hou, Y., Zhang, L. i., Wang, J., Qiao, Y., Guo, S., ... Wu, H.
(2017).
Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity. Theranostics.
7(7), 1806-1819.
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Yang, T., Li, W., Duan, X., Zhu, L., Fan, L. i., Qiao, Y., & Wu, H.
(2016).
Preparation of Two Types of Polymeric Micelles Based on Poly(-L-Malic Acid) for Antitumor Drug Delivery. PLoS ONE.
11(9), e0162607-e0162607.
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Dai, Z., Tu, Y., & Zhu, L.
(2016).
Multifunctional Micellar Nanocarriers for Tumor-Targeted Delivery of Hydrophobic Drugs. Journal of Biomedical Nanotechnology.
12(6), 1199-1210.
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Dai, Z., Yao, Q., & Zhu, L.
(2016).
MMP2-Sensitive PEG-Lipid Copolymers: A New Type of Tumor-Targeted P-Glycoprotein Inhibitor. ACS Applied Materials & Interfaces.
8(20), 12661-12673.
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Zhou, Q., Yang, T., Qiao, Y., Guo, S., Zhu, L., & Wu, H.
(2015).
Preparation of poly(-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery. 10(1), 1941-1952.
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Tu, Y., & Zhu, L.
(2015).
Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate. Journal of Controlled Release.
212, 94-102.
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Perche, F., Biswas, S., Wang, T., Zhu, L., & Torchilin, V. P.
(2014).
Hypoxia-targeted siRNA delivery. Angewandte Chemie International Edition.
53(13), 3362-3366.
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Sawant, R. R., Jhaveri, A. M., Koshkaryev, A., Zhu, L., Qureshi, F., & Torchilin, V. P.
(2014).
Targeted transferrin-modified polymeric micelles: enhanced efficacy in vitro and in vivo in ovarian carcinoma. Molecular Pharmaceutics.
11(2), 375-381.
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Tu, Y., & Zhu, L.
(2014).
Lipids and their derivatives: by-products used as essential building blocks for modern drug delivery systems. Current Drug Targets.
15(5), 502-517.
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Zhu, L., Perche, F., Wang, T., & Torchilin, V. P.
(2014).
Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials.
35(13), 4213-4222.
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Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P.
(2013).
Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America.
110(42), 17047-17052.
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Wu, H., Zhu, L., & Torchilin, V. P.
(2013).
pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery. Biomaterials.
34(4), 1213-1222.
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Zhu, L., & Torchilin, V. P.
(2013).
Stimulus-responsive nanopreparations for tumor targeting. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences.
5(1), 96-107.
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Zhu, L., Kate, P., & Torchilin, V. P.
(2012).
Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano.
6(4), 3491-3498.
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Zhu, L., & Mahato, R. I.
(2010).
Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjugate Chemistry.
21(11), 2119-2127.
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Zhu, L., & Mahato, R. I.
(2010).
Lipid and polymeric carrier-mediated nucleic acid delivery. Expert Opinion on Drug Delivery.
7(10), 1209-1226.
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Zhu, L., Huo, Z., Wang, L., Tong, X., Xiao, Y., & Ni, K.
(2009).
Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes. International Journal of Pharmaceutics.
370(1-2), 136-143.
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Cheng, G., Zhu, L., & Mahato, R. I.
(2008).
Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. 5(6), 1093-1102.
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Zhu, L., Lu, Y., Miller, D. D., & Mahato, R. I.
(2008).
Structural and formulation factors influencing pyridinium lipid-based gene transfer. Bioconjugate Chemistry.
19(12), 2499-2512.
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Tu, Y., Zhu, L., Wang, G., Zhao, L., & Xiang, B.
(2008).
Development and validation of a LC-ESI-MS assay for determination of icariin in rat plasma after administration of Herba Epimedii. Chromatographia.
67(7-8), 591-597.
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Zhu, L., Ye, Z., Cheng, K., Miller, D. D., & Mahato, R. I.
(2008).
Site-specific delivery of oligonucleotides to hepatocytes after systemic administration. Bioconjugate Chemistry.
19(1), 290-298.
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Tu, Y., Zhao, L., Zhu, L., Wang, G., & Xiang, B.
(2006).
Simultaneous determination of Acteoside, Astragaloside IV and Icariside-I in the traditional Chinese medicinal preparation Shenbao by HPLC-MS. Chromatographia.
64(7-8), 453-458.
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Wang, L. L., Zhu, L., Ni, K. Y., Tu, Y., Xiao, Y., & Peng, G. G.
(2006).
Study on tissue distribution of methotrexate magnetoliposomes in mice by HPLC. Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989).
41(20), 1572-1575.
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Zhu, L., Wang, L. L., Ni, K. Y., Tong, X., Dai, L., & Tu, J.
(2006).
Preparation of stable magnetoliposomes with high encapsulation efficiency of methotrexate. Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989).
41(17), 1324-1327.
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Ying, T. u., Luhua, Z., Lin, Z., Guangji, W., & Binren, X.
(2004).
Separation and identification of 20 chemical constituents in the traditional Chinese medicinal preparation Shenbao tablet by LC-ESI-MS3. Journal of Chromatographic Science.
42(4), 177-183.
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Liu, Y., Dai, Z., Wang, J., Tu, Y., & Zhu, L.
Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment. Chemical Communications.
55(29), 4254-4257.
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Naz, S., Mazhar, M. U., Yadav, U., Ali, H. A., Khasawneh, F., Ihsan-Ul-Haq, .., Tipu, M. K., & Zhu, L.
(2024).
Anti-inflammatory and anti-arthritic potential of Coagulansin-A: in vitro and in vivo studies. Inflammopharmacology.
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conference paper
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Zhu, L.
(2019).
MMP2-sensitive tumor-targeted drug delivery and sensitization. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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Zhu, L.
(2019).
MMP2-sensitive tumor-targeted drug delivery and sensitization. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
Research
Teaching
teaching activities
- PHAR642 Pharmaceutics I Instructor
- PHAR741 Pharmaceutics Ii Instructor
- PHAR742 Basic Pharmacokinetics Instructor
- PHSC681 Seminar Instructor
- PHSC685 Directed Studies Instructor
- PHSC689 Sptp: Nanomedicine Instructor
- PHSC691 Research Instructor
- PHSC752 Nanotech For Biomed Appls Instructor
Background
education and training
- Ph.D. in Pharmaceutics, University of Tennessee Health Science Center - (Memphis, Tennessee, United States) 2010
- M.S. in Pharmaceutics, China Pharmaceutical University - (Nanjing, China) 2003
- B.E. in Pharmaceutics, China Pharmaceutical University - (Nanjing, China) 1997
- Northeastern University - (Shenyang, China) , Postdoctoral Training 2013
Contact
first name
- Lin
has last name
- Zhu
mailing address
-
1010 West Ave. B
MSC131
Kingsville, Texas 78363
USA
Other
- lzhu@tamhsc.edu