Preparation of stable magnetoliposomes with high encapsulation efficiency of methotrexate Academic Article

abstract

• OBJECTIVE: To get an optimized formulation of the stable magnetoliposomes with high encapsulation efficiency of methotrexate. METHODS: The methotrexate magnetoliposomes were prepared by reverse evaporating method. The formulation was optimized by orthogonal design. The encapsulation efficiency, the particle size and the content of encapsulated Fe 2 O 3 were determined. RESULTS: The encapsulation efficiency of the methotrexate reached 60%, and the particle size of the liposome was 627.8 nm with the polydispersity index of 0.131. The concentration of the encapsulated Fe 2 O 3 was 116.1 g. CONCLUSION: The results suggest that this method can be used to prepare a stable magnetoliposomes with high encapsulation efficiency of methotrexate.

authors

• Zhu, Lin

published proceedings

• Chinese Pharmaceutical Journal

author list (cited authors)

• Zhu, L., Wang, L. L., Ni, K. Y., Tong, X., Dai, L., & Tu, J.

complete list of authors

• Zhu, L||Wang, LL||Ni, KY||Tong, X||Dai, L||Tu, J

publication date

• September 2006

published in

• Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989)  Journal

start page

• 1324

end page

• 1327

volume

• 41

issue

• 17