MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting. Academic Article

abstract

• Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and therapeutic targets. Recently, MMPs have been investigated as robust tumor microenvironmental stimuli for 'smart' MMP-responsive drug delivery and tumor targeting and have shown great potential in cancer diagnosis and therapy. In this article, we review the newly emerging MMP-responsive strategies and major MMP-responsive nanomaterials and nanocarriers used for tumor-targeted delivery of drugs and imaging agents at the tissue, cellular, and intracellular levels. We also discuss the challenges and critical considerations in their development and clinical translation.

authors

• Zhu, Lin

published proceedings

• Trends Pharmacol Sci

altmetric score

• 18

author list (cited authors)

• Yao, Q., Kou, L., Tu, Y., & Zhu, L.

citation count

• 141

complete list of authors

• Yao, Qing||Kou, Longfa||Tu, Ying||Zhu, Lin

publication date

• January 2018

publisher

• Elsevier  Publisher

published in

• Trends in Pharmacological Sciences  Journal

keywords

• Drug Delivery
• Drug Delivery Systems
• Humans
• Matrix Metalloproteinase
• Matrix Metalloproteinases
• Molecular Targeted Therapy
• Nanocarriers
• Nanoparticles
• Neoplasms
• Stimuli-responsive
• Tumor Microenvironment
• Tumor Targeting

Digital Object Identifier (DOI)

• 10.1016/j.tips.2018.06.003

start page

• 766

end page

• 781

volume

• 39

issue

• 8

URL

• http://dx.doi.org/10.1016/j.tips.2018.06.003