HR job title
- Associate Professor
- Contact Info
- 214 370 7229
- Websites
Wang, Xiaofang Associate Professor
Positions
- Associate Professor, Biomedical Sciences, School of Dentistry
My research interests are focused on the signaling regulation of bone and tooth development. Currently, my lab is focused on two kinases on the secretory pathway that are critical for bone and tooth development, Fam20B and Fam20C. I am also interested in mapping the pathogenic genes for bone and tooth diseases in mutant mice/humans. We characterize the gene function using multidisciplinary methods, including genetically engineered animal models, tissue/organ culture/transplantation, Single Cell RNA-Seq, ISH, IHC, and proteomic approaches.
Key words: bone, cartilage, tooth, dentin, enamel, chondrocytes, transgenic, genetics, signaling, FAM20C, FAM20B, kinase, mineralization, FGF23
Key words: bone, cartilage, tooth, dentin, enamel, chondrocytes, transgenic, genetics, signaling, FAM20C, FAM20B, kinase, mineralization, FGF23
- Overview
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Overview
Publications
selected publications
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academic article
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Fujikawa, K., Nonaka, N., Wang, X., & Shibata, S.
(2022).
An in situ hybridization study of syndecan family during the late stages of developing mouse molar tooth germ. 97(4), 358-368.
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Dong, C., Lamichhane, B., Yamazaki, H., Vasquez, B., Wang, J., Zhang, Y., ... Wang, X.
(2022).
The phosphorylation of serine55 in enamelin is essential for murine amelogenesis. Matrix Biology.
111, 245-263.
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Dong, C., Lamichhane, B., Zhang, Y., & Wang, X.
(2022).
Detection and Quantitation of Label-Retaining Cells in Mouse Incisors using a 3D Reconstruction Approach after Tissue Clearing. Journal of Visualized Experiments.
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Fang, X., Ni, N., Wang, X., Tian, Y., Ivanov, I., Rijnkels, M., ... Li, Q.
(2022).
EZH2 and Endometrial Cancer Development: Insights from a Mouse Model. 11(5), 909-909.
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Chen, J., Sun, T., You, Y., Wu, B., Wang, X., & Wu, J.
(2021).
Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration. Frontiers in Cell and Developmental Biology.
9, 760532.
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Wu, J., Tian, Y. e., Han, L. u., Liu, C., Sun, T., Li, L., ... Wang, X.
(2020).
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biology.
18(1), 87.
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Wu, J., Li, H., Han, L. u., Sun, T., Tian, Y. e., & Wang, X.
(2020).
The spatiotemporal expression pattern of Syndecans in murine embryonic teeth. Gene Expression Patterns.
36, 119109-119109.
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Xie, X., Wang, J., Wang, K., Li, C., Zhang, S., Jing, D., ... Feng, J. Q.
(2019).
Axin2+-Mesenchymal PDL Cells, Instead of K14+ Epithelial Cells, Play a Key Role in Rapid Cementum Growth. Journal of Dental Research.
98(11), 1262-1270.
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Wu, J., Feng, J. Q., & Wang, X.
(2019).
In Situ Hybridization on Mouse Paraffin Sections Using DIG-Labeled RNA Probes. Methods in molecular biology (Clifton, N.J.).
1922, 163-171.
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Wu, J., & Wang, X.
(2019).
Isolation of SIBLING Proteins from Bone and Dentin Matrices. 1922, 211-218.
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Wu, J., & Wang, X.
(2019).
Whole-Mount In Situ Hybridization of Mouse Embryos Using DIG-Labeled RNA Probes. Methods in molecular biology (Clifton, N.J.).
1922, 151-159.
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Liu, X., Li, N., Zhang, H., Liu, J., Zhou, N., Ran, C., ... Liu, C.
(2018).
Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. European Journal Of Oral Sciences.
126(5), 433-436.
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Wei, C., Wu, M., Wang, C., Liu, R., Zhao, H., Yang, L. i., ... Du, L.
(2018).
Long Noncoding RNA Lnc-SEMT Modulates IGF2 Expression by Sponging miR-125b to Promote Sheep Muscle Development and Growth. Cellular Physiology and Biochemistry.
49(2), 447-462.
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Wang, X., Park, S., Zeng, L., Jain, A., & Ha, T.
(2018).
Toward Single-Cell Single-Molecule Pull-Down. Biophysical Journal.
115(2), 283-288.
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Li, C., Jing, Y., Wang, K., Ren, Y., Liu, X., Wang, X., ... Feng, J. Q.
(2018).
Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process. International Journal of Biological Sciences.
14(7), 693-704.
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Liu, C., Zhang, H., Jani, P., Wang, X., Lu, Y., Li, N., Xiao, J., & Qin, C.
(2018).
FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. Journal of Cellular Physiology.
233(4), 3476-3486.
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Liu, C., Zhou, N., Wang, Y. u., Zhang, H., Jani, P., Wang, X., ... Qin, C.
(2018).
Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Experimental Cell Research.
363(2), 188-195.
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Yan, W., Ma, P., Tian, Y. e., Wang, J., Qin, C., Feng, J. Q., & Wang, X.
(2017).
The importance of a potential phosphorylation site in enamelin on enamel formation. International Journal of Oral Science.
9(11), e4-6.
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Ma, P., Yan, W., Tian, Y., He, J., Brookes, S. J., & Wang, X.
(2016).
The Importance of Serine Phosphorylation of Ameloblastin on Enamel Formation. Journal of Dental Research.
95(12), 1408-1414.
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Ma, P., Yan, W., Tian, Y. e., Wang, J., Feng, J. Q., Qin, C., Cheng, Y., & Wang, X.
(2016).
Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects. Scientific Reports.
6(1), 29814.
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Xie, X., Liu, C., Zhang, H., Jani, P. H., Lu, Y., Wang, X., Zhang, B., & Qin, C.
(2016).
Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Scientific Reports.
6(1), 25364.
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Jani, P. H., Gibson, M. P., Liu, C., Zhang, H., Wang, X., Lu, Y., & Qin, C.
(2016).
Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biology.
52-54, 95-112.
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Yang, X., Yan, W., Tian, Y. e., Ma, P., Opperman, L. A., & Wang, X.
(2016).
Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone. The FASEB Journal.
30(1), 121-128.
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Meng, T., Huang, Y., Wang, S., Zhang, H., Dechow, P. C., Wang, X., ... Lu, Y.
(2015).
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. Journal of Biological Chemistry.
290(49), 29593-29602.
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Tian, Y. e., Ma, P., Liu, C., Yang, X., Crawford, D. M., Yan, W., ... Wang, X.
(2015).
Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors. European Journal Of Oral Sciences.
123(6), 396-402.
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Liu, C., Wang, X., Zhang, H., Xie, X., Liu, P., Liu, Y., ... Qin, C.
(2015).
Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics. Journal of Cellular Physiology.
230(11), 2581-2587.
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Du, E., Wang, X., Yang, W., Kaback, D., Yee, S., Qin, C., George, A., & Hao, J.
(2015).
Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. International Journal of Oral Science.
7(2), 89-94.
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Wang, X., Wang, J., Liu, Y., Yuan, B., Ruest, L. B., Feng, J. Q., & Qin, C.
(2015).
The specific role of FAM20C in dentinogenesis. Journal of Dental Research.
94(2), 330-336.
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Liu, P., Zhang, H., Liu, C., Wang, X., Chen, L. i., & Qin, C.
(2014).
Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice. PLoS ONE.
9(12), e114396-e114396.
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Gibson, M. P., Jani, P., Wang, X., Lu, Y., & Qin, C.
(2014).
Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of Oral Biosciences.
56(4), 143-148.
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Wang, X., Wang, J., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C.
(2014).
Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connective Tissue Research.
55(4), 299-303.
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Gibson, M. P., Jani, P., Liu, Y., Wang, X., Lu, Y., Feng, J. Q., & Qin, C.
(2013).
Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice. European Journal Of Oral Sciences.
121(6), 545-550.
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Wang, X., Jung, J., Liu, Y., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C.
(2013).
The specific role of FAM20C in amelogenesis. Journal of Dental Research.
92(11), 995-999.
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Li, C., Xie, X., Wang, X., Sun, Y., Liu, P., Chen, L. i., & Qin, C.
(2013).
Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands. Journal of Molecular Histology.
44(2), 231-239.
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Gibson, M. P., Liu, Q., Zhu, Q., Lu, Y., Jani, P., Wang, X., ... Qin, C.
(2013).
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. European Journal Of Oral Sciences.
121(2), 76-85.
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Gibson, M. P., Zhu, Q., Wang, S., Liu, Q., Liu, Y., Wang, X., ... Lu, Y.
(2013).
The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Journal of Biological Chemistry.
288(10), 7204-7214.
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Wang, X., Wang, S., Lu, Y., Gibson, M. P., Liu, Y., Yuan, B., Feng, J. Q., & Qin, C.
(2012).
FAM20C plays an essential role in the formation of murine teeth. Journal of Biological Chemistry.
287(43), 35934-35942.
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Zhu, Q., Gibson, M. P., Liu, Q., Liu, Y., Lu, Y., Wang, X., Feng, J. Q., & Qin, C.
(2012).
Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. Journal of Biological Chemistry.
287(36), 30426-30435.
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Zhu, Q., Prasad, M., Kong, H., Lu, Y., Sun, Y., Wang, X., ... Qin, C.
(2012).
Partial Blocking of Mouse DSPP Processing by Substitution of Gly451–Asp452 Bond Suggests the Presence of Secondary Cleavage Site(s). Connective Tissue Research.
53(4), 307-312.
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Wang, X., Wang, S., Li, C., Gao, T., Liu, Y., Rangiani, A., ... Qin, C.
(2012).
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. 8(5), e1002708-e1002708.
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Zhao, J., Tian, Y. e., Xu, J., Liu, D., Wang, X., & Zhao, B.
(2011).
Endurance exercise is a leptin signaling mimetic in hypothalamus of Wistar rats. 10(1), 225.
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Prasad, M., Zhu, Q., Sun, Y., Wang, X., Kulkarni, A., Boskey, A., Feng, J. Q., & Qin, C.
(2011).
Expression of dentin sialophosphoprotein in non-mineralized tissues. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology.
59(11), 1009-1021.
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Wang, X., Hao, J., Xie, Y., Sun, Y., Hernandez, B., Yamoah, A. K., ... Qin, C.
(2010).
Expression of FAM20C in the osteogenesis and odontogenesis of mouse. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology.
58(11), 957-967.
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Sun, Y., Prasad, M., Gao, T., Wang, X., Zhu, Q., D'Souza, R., Feng, J. Q., & Qin, C.
(2010).
Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. Journal of Biological Chemistry.
285(41), 31713-31722.
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Zhu, Q., Sun, Y., Prasad, M., Wang, X., Yamoah, A. K., Li, Y., Feng, J., & Qin, C.
(2010).
Glycosaminoglycan chain of dentin sialoprotein proteoglycan. Journal of Dental Research.
89(8), 808-812.
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Sun, Y., Lu, Y., Chen, S., Prasad, M., Wang, X., Zhu, Q., ... Qin, C.
(2010).
Key proteolytic cleavage site and full-length form of DSPP. Journal of Dental Research.
89(5), 498-503.
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Sun, Y., Gandhi, V., Prasad, M., Yu, W., Wang, X., Zhu, Q., ... Qin, C.
(2010).
Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. International Journal of Oral and Maxillofacial Surgery.
39(3), 272-281.
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Wang, X., Xiao, M., Shi, J., Zhang, H., Hu, L., & Kong, X.
(2005).
[IRF6 gene mutation analysis in a van Der Woude syndrome family in Henan province]. Shanghai kou qiang yi xue = Shanghai journal of stomatology.
14(3), 234-237.
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Wang, X., Liu, J., Zhang, H., Xiao, M., Li, J., Yang, C., ... Kong, X.
(2003).
Novel mutations in the IRF6 gene for Van der Woude syndrome. Human Genetics.
113(5), 382-386.
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Wang, X., Liu, J., Xiao, M., Zhang, H., Hu, L., & Kong, X.
(2003).
A genetic analysis of Van Der Woude syndrome families. Chinese Journal of Clinical Rehabilitation.
7(14), 2068-2069.
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Liu, J., Wang, X., Shi, J., Zhang, H., Hu, L., & Kong, X.
(2003).
Mutation analysis of MEPE and IBSP genes in two DGI-II families. Chinese Journal of Clinical Rehabilitation.
7(14), 2066-2067.
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Fujikawa, K., Nonaka, N., Wang, X., & Shibata, S.
(2022).
An in situ hybridization study of syndecan family during the late stages of developing mouse molar tooth germ. 97(4), 358-368.
Research
principal investigator on
- The Role of FAM20B-Catalyzed Proteoglycans in Tooth Development awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- The Role of FAM20B-Catalyzed Proteoglycans in Tooth Development awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2022
- Role of FAM20C in the Phosphorylation of SIBLING Protein awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
Teaching
teaching activities
- OBIO641 Cel Mol Bio Of Oral Cra Tis Ii Instructor
- OBIO642 Technique In Cell Molec Bio Instructor
Background
education and training
- Ph.D. in Oral Biology, Fourth Military Medical University - (Xi'an, Shaanxi, China) 2003
- M.S. in Oral Biology, Fourth Military Medical University - (Xi'an, Shaanxi, China) 2000
- Texas A&M Health Science Center - (College Station, Texas, United States) , Postdoctoral Training 2012
- The Ohio State University - (Columbus, Ohio, United States) , Postdoctoral Training 2008
awards and honors
Contact
first name
- Xiaofang
has last name
- Wang
mailing address
-
Texas A&M University College of Dentistry
Biomedical Sciences
3302 Gaston Avenue
Dallas, TX 75246
USA
Other
- xfwang@tamu.edu