HR job title
- Associate Professor
- Contact Info
- 1 713 677 7416
Reiner, David Associate Professor
Positions
- Associate Professor, Institute of Biosciences and Technology, School of Medicine
he Reiner lab research is divided into two general areas: mechanisms of cell signaling and harnessing model genetic organisms for drug discovery and translational biology.
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Fakieh, R., Duong, T., Wu, Y., Rasmussen, N., & Reiner, D.
(2022).
A simple strategy for addition of degron tags to endogenous genes harboring prior insertions of fluorescent protein. 2022, 10.17912/micropub.biology.000622.
-
Zhang, Q. i., Hrach, H., Mangone, M., & Reiner, D. J.
(2022).
Identifying the Caenorhabditis elegans vulval transcriptome. G3: Genes, Genomes, Genetics.
12(6), jkac091-.
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Pedone, K. H., Gonzlez-Prez, V., Leopold, L. E., Rasmussen, N. R., Der, C. J., Cox, A. D., Ahmed, S., & Reiner, D. J.
(2021).
Engineering threshold-based selection systems. G3: Genes, Genomes, Genetics.
11(9), jkab234.
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Rasmussen, N. R., & Reiner, D. J.
(2021).
Nuclear translocation of the tagged endogenous MAPK MPK-1 denotes a subset of activation events in C. elegans development. Journal of Cell Science.
134(17), jcs258456.
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Mardick, J. I., Rasmussen, N. R., Wightman, B., & Reiner, D. J.
(2021).
Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C.elegans nervous system. Developmental Biology.
477, 37-48.
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Rasmussen, N. R., Smith, H. E., & Reiner, D. J.
(2021).
The MLK-1/SCD-4 Mixed Lineage Kinase/MAP3K functions to promote dauer formation upstream of DAF-2/InsR. 2021, 10.17912/micropub.biology.000405.
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Wu, Y., & Reiner, D. J.
(2021).
A signalling cascade for Ral. Small GTPases.
1-8.
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Ashley, G. E., Duong, T., Levenson, M. T., Martinez, M., Johnson, L. C., Hibshman, J. D., ... Ward, J. D.
(2021).
An expanded auxin-inducible degron toolkit for Caenorhabditis elegans. 217(3), iyab006.
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Duong, T., Rasmussen, N. R., & Reiner, D. J.
(2020).
Insulated Switches: Dual-Function Protein RalGEFRGL-1 Promotes Developmental Fidelity. International Journal of Molecular Sciences.
21(20), 7610-7610.
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Duong, T., Rasmussen, N. R., Ballato, E., Mote, F. S., & Reiner, D. J.
(2020).
The Rheb-TORC1 signaling axis functions as a developmental checkpoint. Development (Cambridge).
147(5), dev181727.
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Duong, T., Rasmussen, N. R., Ballato, E., Mote, F. S., & Reiner, D. J.
(2020).
The Rheb-TORC1 signaling axis functions as a developmental checkpoint. Development (Cambridge).
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Shin, H., Braendle, C., Monahan, K. B., Kaplan, R., Zand, T. P., Mote, F. S., Peters, E. C., & Reiner, D. J.
(2019).
Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals. PLOS Genetics.
15(5), e1008056-e1008056.
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Rasmussen, N. R., Dickinson, D. J., & Reiner, D. J.
(2018).
Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditis elegans. 210(4), 1339-1354.
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Shin, H., & Reiner, D. J.
(2018).
The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning. Journal of Developmental Biology.
6(4), 30-30.
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Shin, H., Kaplan, R., Duong, T., Fakieh, R., & Reiner, D. J.
(2018).
Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C.elegans Cell Fate Patterning. Cell Reports.
24(10), 2669-2681.e5.
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Reiner, D. J., & Lundquist, E. A.
(2018).
Small GTPases. WormBook.
2018, 1-65.
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Walck-Shannon, E., Lucas, B., Chin-Sang, I., Reiner, D., Kumfer, K., Cochran, H., Bothfeld, W., & Hardin, J.
(2016).
CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis. PLOS Genetics.
12(11), e1006415-e1006415.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., ... Bagniewska-Zadworna, A.
(2016).
Erratum. Autophagy.
12(2), 443-443.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., ... Zughaier, S. M.
(2016).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy.
12(1), 1-222.
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Walck-Shannon, E., Reiner, D., & Hardin, J.
(2015).
Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans. Journal of Cell Science.
128(21), e1.1-e1.1.
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Walck-Shannon, E., Reiner, D., & Hardin, J.
(2015).
Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans. Development (Cambridge).
142(20), 3549-3560.
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Kidd, A. R., Muiz-Medina, V., Der, C. J., Cox, A. D., & Reiner, D. J.
(2015).
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity. PLoS One.
10(7), e0133226-e0133226.
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Gentry, L. R., Martin, T. D., Reiner, D. J., & Der, C. J.
(2014).
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1843(12), 2976-2988.
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Martin, T. D., Chen, X., Kaplan, R., Saltiel, A. R., Walker, C. L., Reiner, D. J., & Der, C. J.
(2014).
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Molecular Cell.
53(2), 209-220.
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Dickinson, D. J., Ward, J. D., Reiner, D. J., & Goldstein, B.
(2013).
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nature Methods.
10(10), 1028-1034.
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Peters, E. C., Gossett, A. J., Goldstein, B., Der, C. J., & Reiner, D. J.
(2013).
Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations. G3: Genes, Genomes, Genetics.
3(2), 181-195.
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Reiner, D. J.
(2011).
Ras effector switching as a developmental strategy. Small GTPases.
2(2), 109-112.
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Neel, N. F., Martin, T. D., Stratford, J. K., Zand, T. P., Reiner, D. J., & Der, C. J.
(2011).
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes and Cancer.
2(3), 275-287.
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Zand, T. P., Reiner, D. J., & Der, C. J.
(2011).
Ras effector switching promotes divergent cell fates in C. elegans vulval patterning. Developmental Cell.
20(1), 84-96.
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Gonzlez-Prez, V., Reiner, D. J., Alan, J. K., Mitchell, C., Edwards, L. J., Khazak, V., Der, C. J., & Cox, A. D.
(2010).
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. Journal of Molecular Signaling.
5(0), 2-2.
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Reiner, D. J., Ailion, M., Thomas, J. H., & Meyer, B. J.
(2008).
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling. Current Biology.
18(15), 1101-1109.
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Reiner, D. J., Gonzlez-Prez, V., Der, C. J., & Cox, A. D.
(2008).
Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo. METHODS IN ENZYMOLOGY.
439, 425-449.
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Cox, A. D., Gonzalez-Perez, V., Reiner, D. J., Der, C. J., & Khazak, V.
(2006).
582 POSTER Analysis of small molecule Ras/Raf interaction inhibitors in C. elegans identifies both on-target and off-target activities. 4(12), 176-176.
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Reiner, D. J., Weinshenker, D., Tian, H., Thomas, J. H., Nishiwaki, K., Miwa, J., ... Garcia, L. R.
(2006).
Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Journal of Neurogenetics.
41-66.
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Petersen, C. I., McFarland, T. R., Stepanovic, S. Z., Yang, P., Reiner, D. J., Hayashi, K., ... Balser, J. R.
(2004).
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. 101(32), 11773-11778.
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Reiner, D. J., Newton, E. M., Tian, H., & Thomas, J. H.
(1999).
Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II. Nature.
402(6758), 199-203.
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Fuchs, A. F., Reiner, D., & Pong, M.
(1996).
Transfer of gain changes from targeting to other types of saccade in the monkey: constraints on possible sites of saccadic gain adaptation. Journal of Neurophysiology.
76(4), 2522-2535.
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Reiner, D. J., Weinshenker, D., & Thomas, J. H.
(1995).
Analysis of dominant mutations affecting muscle excitation in Caenorhabditis elegans. 141(3), 961-976.
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Reiner, D. J., & Thomas, J. H.
(1995).
Reversal of a muscle response to GABA during C. elegans male development. The Journal of Neuroscience.
15(9), 6094-6102.
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Fakieh, R., Duong, T., Wu, Y., Rasmussen, N., & Reiner, D.
(2022).
A simple strategy for addition of degron tags to endogenous genes harboring prior insertions of fluorescent protein. 2022, 10.17912/micropub.biology.000622.
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chapter
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Hardin, J., Serre, J., King, R., Walck-Shannon, E., & Reiner, D.
(2022).
Imaging Epidermal Cell Rearrangement in the C. elegans Embryo. Methods in Molecular Biology.
Methods in Molecular Biology.
(pp. 345-376).
Springer US.
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Rasmussen, N. R., & Reiner, D. J.
(2021).
Ras, Ral, and Rap1 in C. elegans. Methods in Molecular Biology.
Methods in Molecular Biology.
(pp. 423-436).
Springer US.
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Hardin, J., Serre, J., King, R., Walck-Shannon, E., & Reiner, D.
(2022).
Imaging Epidermal Cell Rearrangement in the C. elegans Embryo. Methods in Molecular Biology.
Methods in Molecular Biology.
(pp. 345-376).
Springer US.
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conference paper
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Gentry, L. R., Martin, T. D., Reiner, D. J., & Der, C. J.
(2014).
Abstract A08: Mechanistic dissection of Ral GTPase signaling in driving KRAS-dependent pancreatic cancer growth. Molecular Cancer Research.
A08-A08.
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Gentry, L. R., Martin, T. D., Reiner, D. J., & Der, C. J.
(2014).
Abstract A08: Mechanistic dissection of Ral GTPase signaling in driving KRAS-dependent pancreatic cancer growth. Molecular Cancer Research.
A08-A08.
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institutional repository document
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Zhang, Q. i., Hrach, H., Mangone, M., & Reiner, D. J.
(2022).
Identifying the C. elegans vulval transcriptome
-
Pedone, K. H., Gonzlez-Prez, V., Leopold, L. E., Der, C. J., Cox, A. D., Ahmed, S., & Reiner, D. J.
(2021).
Engineering Threshold-Based Selection Systems
-
Mardick, J. I., Rasmussen, N. R., Wightman, B., & Reiner, D. J.
(2021).
Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system
-
Rasmussen, N. R., & Reiner, D. J.
(2021).
Nuclear translocation of tagged endogenous ERK/MPK-1 MAP Kinase denotes a subset of activation events in C. elegans development
-
Ashley, G., Duong, T., Levenson, M. T., Martinez, M., Hibshman, J. D., Saeger, H. N., ... Ward, J. D.
(2020).
Expanding theCaenorhabditis elegansauxin-inducible degron system toolkit with internal expression and degradation controls and improved modular constructs for CRISPR/Cas9-mediated genome editing
-
Shin, H., Braendle, C., Monahan, K. B., Kaplan, R., Zand, T. P., Mote, F. S., ... Reiner, D. J.
(2018).
Developmental fidelity imposed by the RGL-1 Balanced Switch mediating opposing signals
-
Shin, H., Kaplan, R., Duong, T., Fakieh, R., & Reiner, D. J.
(2018).
Ral signals through a MAP4 Kinase-p38 MAP kinase cascade inC. eleganscell fate patterning
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Rasmussen, N. R., Dickinson, D. J., & Reiner, D. J.
(2018).
C. elegansRAP-1 reinforces LET-60/Ras induction of cell fate
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Zhang, Q. i., Hrach, H., Mangone, M., & Reiner, D. J.
(2022).
Identifying the C. elegans vulval transcriptome
Research
principal investigator on
- Novel Signals Regulate Cell Fate Patterning awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2021
- Global Changes In the 3'UTRome Toggle Responsiveness To Growth Factors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2020
- Global Changes In the 3'UTRome Toggle Responsiveness To Growth Factors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2020
- Global Changes In the 3'UTRome Toggle Responsiveness To Growth Factors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2020
- The Ral Small GTPase In C. elegans development awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2016
Teaching
teaching activities
- BIOC523 Extracellular Matrix Instructor
- BIOC545 Adv Molecular Biol & Genetics Instructor
- GENE491 Hnr-research Instructor
- IBST689 Sptp:md Sc Jc Instructor
- IBST691 Research Credit: Medical Sci Instructor
- MSCI601 Contem Top In Adv Cell Bio I Instructor
- MSCI685 Directed Studies Instructor
- NSCI511 Sci Policy & Ethics-rice/ibt Instructor
Background
education and training
- Ph.D. in Genetics, University of Washington - (Seattle, Washington, United States) 1996
- B.A. in Biology, Carleton College - (Northfield, Minnesota, United States) 1988
- University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) , Postdoctoral Training 2004
- University of California, Berkeley - (Berkeley, California, United States) , Postdoctoral Training 2002
- University of Washington - (Seattle, Washington, United States) , Postdoctoral Training 1997
Contact
first name
- David
has last name
- Reiner
mailing address
-
Texas A&M Health Science Center
Ibt Center For Translational Cancer Research
1201 TAMUS
Houston, TX 77030-3303
USA
Other
- dreiner@tamu.edu