HR job title
- Professor
- Contact Info
- 1 979 845 0733
Porter, Weston Professor
Positions
y laboratory is interested in determining the role of factors in normal development and how disruption of these pathways results in associated pathologies.
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academic article
-
Sanchez, L., Epps, J., Wall, S., McQueen, C., Pearson, S. J., Scribner, K., ... Porter, W. W.
(2023).
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death and Differentiation.
30(6), 1472-1487.
-
Wall, S. W., Sanchez, L., Tuttle, K. S., Pearson, S. J., Soma, S., Wyatt, G. L., ... Porter, W. W.
(2023).
Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer. Experimental & Molecular Medicine.
55(5), 1046-1063.
-
Elswood, J., Pearson, S. J., Payne, H. R., Barhoumi, R., Rijnkels, M., & W Porter, W.
(2021).
Autophagy regulates functional differentiation of mammary epithelial cells. Autophagy.
17(2), 420-438.
-
Pearson, S. J., Roy Sarkar, T., McQueen, C. M., Elswood, J., Schmitt, E. E., Wall, S. W., ... Porter, W. W.
(2019).
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene.
38(14), 2611-2626.
-
Wyatt, G. L., Crump, L. S., Young, C. M., Wessells, V. M., McQueen, C. M., Wall, S. W., ... Lyons, T. R.
(2019).
Cross-talk between SIM2s and NFB regulates cyclooxygenase 2 expression in breast cancer. Breast Cancer Research.
21(1), 131.
-
Pearson, S. J., Elswood, J., Barhoumi, R., Ming-Whitfield, B., Rijnkels, M., & Porter, W. W.
(2019).
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress. Breast Cancer Research.
21(1), 125.
-
McQueen, C. M., Schmitt, E. E., Sarkar, T. R., Elswood, J., Metz, R. P., Earnest, D., Rijnkels, M., & Porter, W. W.
(2018).
PER2 regulation of mammary gland development. Development.
145(6), dev157966.
-
Morris, D. C., Popp, J. L., Tang, L. K., Gibbs, H. C., Schmitt, E., Chaki, S. P., ... Rivera, G. M.
(2017).
Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis. Molecular Biology of the Cell.
28(24), 3500-3516.
-
Schmitt, E. E., Barhoumi, R., Metz, R. P., & Porter, W. W.
(2017).
Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland. Molecular Pharmacology.
91(3), 178-188.
-
Schmitt, E. E., Vellers, H. L., Porter, W. W., & Lightfoot, J. T.
(2016).
Environmental Endocrine Disruptor Affects Voluntary Physical Activity in Mice. Medicine & Science in Sports & Exercise.
48(7), 1251-1258.
-
Dahanayaka, S., Rezaei, R., Porter, W. W., Johnson, G. A., Burghardt, R. C., Bazer, F. W., ... Wu, G.
(2015).
Technical note: Isolation and characterization of porcine mammary epithelial cells. Journal of Animal Science.
93(11), 5186-5193.
-
Sarkar, T. R., Battula, V. L., Werden, S. J., Vijay, G. V., Ramirez-Pea, E. Q., Taube, J. H., ... Mani, S. A.
(2015).
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene.
34(23), 2958-2967.
-
Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L.
(2014).
Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
25(7), 796-800.
-
Vizzotto, M., Porter, W., Byrne, D., & Cisneros-Zevallos, L.
(2014).
Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells. JOURNAL OF MICRONUTRIENT ANALYSIS.
164, 363-370.
-
Scribner, K. C., Behbod, F., & Porter, W. W.
(2013).
Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s). Oncogene.
32(21), 2631-2639.
-
Romoser, A. A., Figueroa, D. E., Sooresh, A., Scribner, K., Chen, P. L., Porter, W., Criscitiello, M. F., & Sayes, C. M.
(2012).
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts. Toxicology Letters.
210(3), 293-301.
-
Scribner, K. C., Wellberg, E. A., Metz, R. P., & Porter, W. W.
(2011).
Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFB. Molecular Endocrinology.
25(4), 635-644.
-
Scribner, K. C., & Porter, W. W.
(2010).
Singleminded-2s (Sim2s) Promotes Breast Tumor Cell Differentiation and Inhibits Metastasis in MCF10DCIS.COM Cells. Cancer Research.
70(24_Supplement), p4-06-06-p4-06-06.
-
Wellberg, E., Metz, R. P., Parker, C., & Porter, W. W.
(2010).
The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. Development.
137(6), 945-952.
-
Qu, X., Metz, R. P., Porter, W. W., Neuendorff, N., Earnest, B. J., & Earnest, D. J.
(2010).
The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver. Toxicology Letters.
196(1), 28-32.
-
Byrne, D. H., Noratto, G., Cisneros-Zevallos, L., Porter, W., & Vizzotto, M.
(2009).
Health Benefits of Peach, Nectarine and Plums. Acta Horticulturae.
841(841), 267-273.
-
Noratto, G., Cisneros-Zevallos, L., Byrne, D. H., Okie, W. R., & Porter, W.
(2009).
Molecular Mechanisms Involved in the Inhibition of MDA-MB-435 Breast Cancer Cells by Phenolic Acids from the Red Flesh Peach BY00P6653. Acta Horticulturae.
841(841), 67-72.
-
Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L.
(2009).
Phenolics in Peaches and Plums Preferentially Suppress the Growth of Estrogen-Independent MDA-MB-435 Breast Cancer Cells. Acta Horticulturae.
841(841), 567-570.
-
Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L.
(2009).
Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells. Journal of Agricultural and Food Chemistry.
57(12), 5219-5226.
-
Qu, X., Metz, R. P., Porter, W. W., Cassone, V. M., & Earnest, D. J.
(2009).
Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver. TOXICOLOGY AND APPLIED PHARMACOLOGY.
234(3), 370-377.
-
Gustafson, T. L., Wellberg, E., Laffin, B., Schilling, L., Metz, R. P., Zahnow, C. A., & Porter, W. W.
(2009).
Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta. Oncogene.
28(12), 1561-1568.
-
Billups, S. C., Neville, M. C., Rudolph, M., Porter, W., & Schedin, P.
(2009).
Identifying significant temporal variation in time course microarray data without replicates. BMC Bioinformatics.
10(1), 96.
-
Lewis, M. T., & Porter, W. W.
(2009).
Methods in mammary gland biology and breast cancer research: an update. Journal of Mammary Gland Biology and Neoplasia.
14(4), 365-365.
-
Boggs, R. M., Wright, Z. M., Stickney, M. J., Porter, W. W., & Murphy, K. E.
(2008).
MicroRNA expression in canine mammary cancer. MAMMALIAN GENOME.
19(7-8), 561-569.
-
Laffin, B., Wellberg, E., Kwak, H., Burghardt, R. C., Metz, R. P., Gustafson, T., Schedin, P., & Porter, W. W.
(2008).
Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Molecular and Cellular Biology.
28(6), 1936-1946.
-
Higgins, K. J., Liu, S., Abdelrahim, M., Vanderlaag, K., Liu, X., Porter, W., Metz, R., & Safe, S.
(2008).
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology.
22(2), 388-402.
-
Qu, X., Metz, R. P., Porter, W. W., Cassone, V. M., & Earnest, D. J.
(2007).
Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland. Molecular Pharmacology.
72(5), 1349-1358.
-
Kwak, H., Gustafson, T., Metz, R. P., Laffin, B., Schedin, P., & Porter, W. W.
(2007).
Inhibition of breast cancer growth and invasion by single-minded 2s. Carcinogenesis.
28(2), 259-266.
-
Dash, B., Afriyie-Gyawu, E., Huebner, H. J., Porter, W., Wang, J. S., Jolly, P. E., & Phillips, T. D.
(2007).
Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. Journal of Toxicology and Environmental Health - Part A.
70(1), 58-66.
-
Dash, B., Metz, R., Huebner, H. J., Porter, W., & Phillips, T. D.
(2007).
Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene.
387(1-2), 93-108.
-
Kilgore, J. A., Hoose, S. A., Gustafson, T. L., Porter, W., & Kladde, M. P.
(2007).
Single-molecule and population probing of chromatin structure using DNA methyltransferases. Methods.
41(3), 320-332.
-
Higgins, K. J., Liu, S., Abdelrahim, M., Yoon, K., Vanderlaag, K., Porter, W., Metz, R. P., & Safe, S.
(2006).
Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. ENDOCRINOLOGY.
147(7), 3285-3295.
-
Metz, R. P., Kwak, H., Gustafson, T., Laffin, B., & Porter, W. W.
(2006).
Differential transcriptional regulation by mouse single-minded 2s. Journal of Biological Chemistry.
281(16), 10839-10848.
-
Dash, B., Metz, R., Huebner, H. J., Porter, W., & Phillips, T. D.
(2006).
Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris. Gene.
381(1-2), 1-12.
-
Dash, B., Afriyie-Gyawu, E., Huebner, H. J., Porter, W., Wang, J. S., Jolly, P. E., & Phillips, T. D.
(2006).
Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies. Journal of Toxicology and Environmental Health - Part A.
69(13), 1203-1216.
-
McDaniel, S. M., Rumer, K. K., Biroc, S. L., Metz, R. P., Singh, M., Porter, W., & Schedin, P.
(2006).
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. American Journal of Pathology.
168(2), 608-620.
-
Metz, R. P., Qu, X., Laffin, B., Earnest, D., & Porter, W. W.
(2006).
Circadian clock and cell cycle gene expression in mouse mammary epithelial cells and in the developing mouse mammary gland. Developmental Dynamics.
235(1), 263-271.
-
Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., ... Safe, S.
(2004).
A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. MOLECULAR CANCER THERAPEUTICS.
3(3), 247-260.
-
Porter, W., Wang, F., Duan, R., Qin, C., Castro-Rivera, E., Kim, K., & Safe, S.
(2001).
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology.
26(1), 31-42.
-
Wang, Y., Porter, W. W., Suh, N., Honda, T., Gribble, G. W., Leesnitzer, L. M., ... Sporn, M. B.
(2000).
A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Molecular Endocrinology.
14(10), 1550-1556.
-
Willett, K. L., Wilson, C., Thomsen, J., & Porter, W.
(2000).
Evidence for and against the presence of polynuclear aromatic hydrocarbon and 2,3,7,8-tetrachloro-p-dioxin binding proteins in the marine mussels, Bathymodiolus and Modiolus modiolus. Aquatic Toxicology.
48(1), 51-64.
-
Duan, R., Porter, W., Samudio, I., Vyhlidal, C., Kladde, M., & Safe, S.
(1999).
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology.
13(9), 1511-1521.
-
Suh, N., Wang, Y., Honda, T., Gribble, G. W., Dmitrovsky, E., Hickey, W. F., ... Sporn, M. B.
(1999).
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Research.
59(2), 336-341.
-
Sun, G., Porter, W., & Safe, S.
(1998).
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology.
12(6), 882-890.
-
Duan, R., Porter, W., & Safe, S.
(1998).
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. ENDOCRINOLOGY.
139(4), 1981-1990.
-
Porter, W., Saville, B., Hoivik, D., & Safe, S.
(1997).
Functional synergy between the transcription factor Sp1 and the estrogen receptor. Molecular Endocrinology.
11(11), 1569-1580.
-
Wang, F., Porter, W., Xing, W., Archer, T. K., & Safe, S.
(1997).
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene. Biochemistry.
36(25), 7793-7801.
-
Gillesby, B. E., Stanostefano, M., Porter, W., Safe, S., Wu, Z. F., & Zacharewski, T. R.
(1997).
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression. Biochemistry.
36(20), 6080-6089.
-
Wang, W. L., Porter, W., Burghardt, R., & Safe, S. H.
(1997).
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis.
18(5), 925-933.
-
Porter, W., Wang, F., Wang, W., Duan, R., & Safe, S.
(1996).
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. Molecular Endocrinology.
10(11), 1371-1378.
-
Wang, W. L., Thomsen, J. S., Porter, W., Moore, M., & Safe, S.
(1996).
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells. British Journal of Cancer.
73(3), 316-322.
-
Krishnan, V., Porter, W., Santostefano, M., Wang, X., & Safe, S.
(1995).
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Molecular and Cellular Biology.
15(12), 6710-6719.
-
Wang, X., Porter, W., Krishnan, V., Narasimhan, T. R., & Safe, S.
(1993).
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Molecular and Cellular Endocrinology.
96(1-2), 159-166.
-
Sanchez, L., Epps, J., Wall, S., McQueen, C., Pearson, S. J., Scribner, K., ... Porter, W. W.
(2023).
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death and Differentiation.
30(6), 1472-1487.
-
conference paper
-
Schmitt, E. E., Porter, W. W., & Lightfoot, J. T.
(2015).
Endocrine-disruption And The Regulation Of Physical Activity And Mammary Gland Development In Mice. Medicine & Science in Sports & Exercise.
76-76.
-
Rezaei, R., Dahanayaka, S., Porter, W. W., Burghardt, R. C., Johnson, G. A., Tian, Y., Bazer, F. W., & Wu, G.
(2013).
Preparation and culture of porcine mammary epithelial cells. Amino Acids.
605-605.
-
Scribner, K. C., & Porter, W. W.
(2011).
The bHLH/PAS transcription factor, Singleminded-2s (Sim2s), promotes breast tumor cell differentiation and inhibits metastasis. Clinical and Experimental Metastasis.
213-213.
-
Safe, S., Wang, F., Porter, W., Duan, R., & McDougal, A.
(1998).
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology Letters.
343-347.
-
Schmitt, E. E., Porter, W. W., & Lightfoot, J. T.
(2015).
Endocrine-disruption And The Regulation Of Physical Activity And Mammary Gland Development In Mice. Medicine & Science in Sports & Exercise.
76-76.
Research
principal investigator on
- Circadian Regulation of PAH Metabolism awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2015 - 2021
- Transcriptional Regulation of Differentiation Gene Expression awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2020
- Diet-dependent regulation of DCIS progression awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2019
- SIM2s Regulation of Senescence awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
investigator on
- Texas A&M Center for Environmental Health Research awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2019 - 2024
- Nutrition, Biostatistics and Bioinformatics Training Grant awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2021
- Fellow 2 - THAILAND - Cadmium Food Contamination awarded by United States Department of Agriculture - (Washington D.C., District of Columbia, United States) 2017 - 2019
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS491 Hnr-research Instructor
- GENE681 Seminar Instructor
- GENE682 Seminar Presentation Instructor
- GENE685 Directed Studies Instructor
- GENE691 Research Instructor
- VIBS222 Great Poisonings Of The World Instructor
- VIBS411 Tumor Cell Biol Carcinog Instructor
- VIBS485 Directed Studies Instructor
- VIBS611 Tumor Cell Biol Carcinog Instructor
- VIBS685 Directed Studies Instructor
- VIBS691 Research Instructor
- VPAT691 Research Instructor
- VTPP491 Research Instructor
Works By Students
chaired theses and dissertations
-
Kwak, Hyeong-il (2009-05). The Role of single minded 2 short in mammary gland development and breast cancer.
-
Laffin, Brian Edward (2009-05). Regulation of epithelial-mesenchymal transition and DNA damage responses by singleminded-2s.
-
Nemec, Matthew James (2016-08). Polyphenolics from Mango (Mangifera Indica L.) Suppress Breast Cancer Ductal Carcinoma In Situ Proliferation Both In Vitro And In Vivo: Potential Role of the IGFR-1-AKT-AMPK-mTOR-Signaling Axis.
-
Pfent, Catherine Marie (2015-11). Characterization and Inhibition of Canine Osteosarcoma Tumor-Initiating Cells.
-
Rychlik, Kristal Ann (2017-05). Prenatal Exposure to Particulate Air Pollution and Effects on Postnatal Immune Response.
-
Scribner, Kelly C (2013-05). Regulation of Mammary cell Differentiation and Metabolism by Singleminded-2s.
-
Wellberg, Elizabeth (2010-07). Regulation of Mammary Lactogenic Differentiation by Singleminded-2s.
Background
education and training
- Ph.D. in Toxicology, Texas A&M University - (College Station, Texas, United States) 1997
- B.S. in Genetics, Texas A&M University - (College Station, Texas, United States) 1991
- Baylor College of Medicine - (Houston, Texas, United States) , Postdoctoral Training 2001
- The University of Texas Southwestern Medical Center - (Dallas, Texas, United States) , Postdoctoral Training 1998
Contact
first name
- Weston
has last name
- Porter
mailing address
-
Texas A&M University
Veterinary Integrative Biosciences
4458 TAMU
College Station, TX 77843-7784
USA
Other
- wporter@tamu.edu