PHENOLICS IN PEACHES AND PLUMS PREFERENTIALLY SUPPRESS THE GROWTH OF ESTROGEN-INDEPENDENT MDA-MB-435 BREAST CANCER CELLS
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Commercial varieties of peaches and plums have been reported to contain a mixture of phenolics that may exert anticancer activity. Our objective was to evaluate the cancer suppression activity of extracts from a commercial variety of peach 'Rich Lady' (RL) and of a plum 'Black Splendor' (BS) and identify the phenolic fractions with potential as chemopreventive natural compounds. The peach RL extract effectively inhibited the proliferation of the estrogen independent MDA-MB-435 breast cancer cell line. The IC50 was ∼ 42 mg/L for this cell line compared to a IC50 of ∼130 mg/L and ∼ 515 mg/L for the non cancerous breast line MCF-10A and the estrogen dependent breast cancer line MCF-7 respectively. Similarly, BS extracts showed greater effects on MDA-MB-435 cells compared to the other breast cancer or the normal breast cell lines. In general, BS extracts was less effective than RL extracts. Within all RL and BS fractions, Fraction 3 (flavonoids) and Fraction 4 (procyanidins) were the most potent against the three cell lines. However, phenolic acids present in F1 of RL have potential as chemopreventive dietary compounds because of the relatively high growth inhibition exerted on the MDA-MB-435 cancer cells and low toxicity to the normal cells.
author list (cited authors)
Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L.