HR job title
- Assistant Professor
- Contact Info
- 1 979 436 0870
- Websites
- ORCiD
- 0000-0003-2884-6895
West, A. Phillip Assistant Professor
Positions
- Assistant Professor, Microbial Pathogenesis and Immunology, School of Medicine
Mitochondria are complex and dynamic organelles integral to many processes including energy generation, programmed cell death, signal transduction, and immunity. Research in my laboratory centers on understanding how mitochondria regulate innate immunity and inflammatory processes to influence human health and disease.
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Hu, L., De Hoyos, D., Lei, Y., West, A. P., & Walsh, A. J.
(2024).
3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data. APL Bioengineering.
8(1), 016112.
-
Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Li, Y., Fails, D., ... West, A. P.
(2023).
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity. Cell.
186(14), 3013-3032.e22.
-
Scott, K. S., Chelette, B., Chidomere, C., Phillip West, A., & Dantzer, R.
(2023).
Cisplatin decreases voluntary wheel-running activity but does not impair food-motivated behavior in mice. 111, 169-176.
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Farris, L. C., Torres-Odio, S., Adams, L. G., West, A. P., & Hyde, J. A.
(2023).
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway. Journal of Immunology.
210(11), 1761-1770.
-
Warren, E. B., Gordon-Lipkin, E. M., Cheung, F., Chen, J., Mukherjee, A., Apps, R., ... McGuire, P. J.
(2023).
Inflammatory and interferon gene expression signatures in patients with mitochondrial disease. JOURNAL OF TRANSLATIONAL MEDICINE.
21(1), 331.
-
Al Khatib, I., Deng, J., Lei, Y., Torres-Odio, S., Rojas, G. R., Newman, L. E., ... Shutt, T. E.
(2023).
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT. Human Molecular Genetics.
ddad062.
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Scott, K., Boukelmoune, N., Taniguchi, C., West, A. P., Heijnen, C. J., & Dantzer, R.
(2023).
Resolution of cisplatin-induced fatigue does not require endogenous interleukin-10 in male mice. Behavioural Brain Research.
444, 114381-114381.
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Keeney, J. N., Winters, A. D., Sitcheran, R., & West, A. P.
(2023).
NF-B-Inducing Kinase Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells. 210(8), 1123-1133.
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Key, J., Gispert, S., Koornneef, L., Sleddens-Linkels, E., Kohli, A., Torres-Odio, S., ... Auburger, G.
(2022).
CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2. Cells.
12(1), 52-52.
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Weindel, C. G., Zhao, X., Martinez, E., Bell, S. L., Vail, K. J., Coleman, A. K., ... Watson, R. O.
(2022).
Gasdermin D promotes hyperinfLammation by triggering necroptosis in the presence of mitochondrial stress. Journal of Immunology.
208(1), 52.06-52.06.
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Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S., ... West, A. P.
(2022).
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNAcGASSTING Signaling Axis. Journal of Immunology.
208(1_Supplement), 50.05-50.05.
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Bryant, J. D., Lei, Y., VanPortfliet, J. J., Winters, A. D., & West, A. P.
(2022).
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells. 2(2), e372.
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Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., ... Watson, R. O.
(2022).
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell.
185(17), 3214-3231.e23.
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Scott, K., Phan, T. T., West, A. P., Taniguchi, C. M., & Dantzer, R.
(2022).
Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma. Behavioural Brain Research.
417, 113607-113607.
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Key, J., Torres-Odio, S., Bach, N. C., Gispert, S., Koepf, G., Reichlmeir, M., ... Auburger, G.
(2021).
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA. Cells.
10(12), 3354-3354.
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Vichaya, E. G., Ford, B. G., Moltenkine, J. M., Taniguchi, C. M., Phillip West, A., & Dantzer, R.
(2021).
Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy. Brain, Behavior, and Immunity.
98, 161-172.
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Maletzko, A., Key, J., Wittig, I., Gispert, S., Koepf, G., Canet-Pons, J., ... Auburger, G.
(2021).
Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse. Neurogenetics.
22(4), 297-312.
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Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Phan, T. T., ... West, A. P.
(2021).
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness. Brain, Behavior, and Immunity.
97, 204-218.
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Sutherland, T. C., Sefiani, A., Horvat, D., Huntington, T. E., Lei, Y., West, A. P., & Geoffroy, C. G.
(2021).
Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons. 10(7), 1625-1625.
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Lei, Y., Guerra Martinez, C., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., ... West, A. P.
(2021).
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Science Advances.
7(22), eabe7548.
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Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S. S., ... West, A. P.
(2021).
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis. Journal of Immunology.
206(8), 1890-1900.
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Key, J., Maletzko, A., Kohli, A., Gispert, S., Torres-Odio, S., Wittig, I., ... Auburger, G.
(2020).
Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics.
21(3), 187-203.
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Hoffpauir, C. T., Bell, S. L., West, K. O., Jing, T., Wagner, A. R., Torres-Odio, S., ... Watson, R. O.
(2020).
TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. 205(1), 153-167.
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Zhao, B., Xu, P., Rowlett, C. M., Jing, T., Shinde, O., Lei, Y., ... Li, P.
(2020).
The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature.
587(7835), 673-677.
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Stoker, M. L., Newport, E., Hulit, J. C., West, A. P., & Morten, K. J.
(2019).
Impact of pharmacological agents on mitochondrial function: a growing opportunity?. Biochemical Society Transactions.
47(6), 1757-1772.
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Yambire, K. F., Rostosky, C., Watanabe, T., Pacheu-Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., ... Raimundo, N.
(2019).
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. eLife.
8, e51031.
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Wu, Z., Oeck, S., West, A. P., Mangalhara, K. C., Sainz, A. G., Newman, L. E., ... Shadel, G. S.
(2019).
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Nature Metabolism.
1(12), 1209-1218.
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Zhao, B., Du, F., Xu, P., Shu, C., Sankaran, B., Bell, S. L., ... Li, P.
(2019).
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature.
569(7758), 718-722.
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West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O.
(2019).
The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. Cell Reports.
29(6), 1594-1609.e5.
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Mlih, M., Khericha, M., Birdwell, C., West, A. P., & Karpac, J.
(2018).
A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis. PLoS Biology.
16(7), e2005796-e2005796.
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West, A. P.
(2018).
Editorial. Mitochondrion.
41, 1-1.
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Weindel, C. G., Bell, S. L., Vail, K., West, A. P., Patrick, K. L., & Watson, R. O.
(2018).
LRRK2 is required for macrophage homeostasis and the control of type I IFN. 200(1_Supplement), 169.16-169.16.
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Araujo, L. F., Siena, A., Plaa, J. R., Brotto, D. B., Barros, I. I., Muys, B. R., ... Silva, W. A.
(2018).
Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. Scientific Reports.
8(1), 14190.
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Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., ... Ambati, J.
(2018).
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration (vol 24, pg 50, 2017). Nature Medicine.
24(1),
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Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., ... Ambati, J.
(2018).
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature Medicine.
24(1), 50-61.
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West, A. P.
(2017).
Mitochondrial dysfunction as a trigger of innate immune responses and inflammation. Toxicology.
391, 54-63.
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West, A. P., & Shadel, G. S.
(2017).
Mitochondrial DNA in innate immune responses and inflammatory pathology. Nature Reviews Immunology.
17(6), 363-375.
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Kang, M., Yoon, C. M., Kim, B. H., Lee, C., Zhou, Y., Sauler, M., ... Elias, J. A.
(2015).
Suppression of NLRX1 in chronic obstructive pulmonary disease. 125(6), 2458-2462.
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West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., ... Shadel, G. S.
(2015).
Mitochondrial DNA stress primes the antiviral innate immune response. Nature.
520(7548), 553-557.
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Thakar, J., Mohanty, S., West, A. P., Joshi, S. R., Ueda, I., Wilson, J., ... Shaw, A. C.
(2015).
Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging.
7(1), 38-52.
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Rongvaux, A., Jackson, R., Harman, C., Li, T., West, A. P., de Zoete, M. R., ... Flavell, R. A.
(2014).
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell.
159(7), 1563-1577.
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Mannam, P., Shinn, A. S., Srivastava, A., Neamu, R. F., Walker, W. E., Bohanon, M., ... Lee, P. J.
(2014).
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal of Physiology: Lung Cellular and Molecular Physiology.
306(7), L604-L619.
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West, A. P., Shadel, G. S., & Ghosh, S.
(2011).
Mitochondria in innate immune responses. Nature Reviews Immunology.
11(6), 389-402.
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West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., ... Ghosh, S.
(2011).
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature.
472(7344), 476-480.
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Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., ... Ghosh, S.
(2010).
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature.
466(7310), 1115-1119.
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Sengupta, D., Koblansky, A., Gaines, J., Brown, T., West, A. P., Zhang, D., ... Ghosh, S.
(2010).
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. Journal of Immunology.
184(2), 956-964.
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Hayden, M. S., West, A. P., & Ghosh, S.
(2006).
SnapShot: NF-kappaB signaling pathways. Cell.
127(6), 1286-1287.
-
Hayden, M. S., West, A. P., & Ghosh, S.
(2006).
NF-kappaB and the immune response. Oncogene.
25(51), 6758-6780.
-
West, A. P., Dancho, B. A., & Mizel, S. B.
(2005).
Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5. 280(10), 9482-9488.
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Mizel, S. B., West, A. P., & Hantgan, R. R.
(2003).
Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. 278(26), 23624-23629.
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Mizel, S. B., Honko, A. N., Moors, M. A., Smith, P. S., & West, A. P.
(2003).
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. Journal of Immunology.
170(12), 6217-6223.
-
Hu, L., De Hoyos, D., Lei, Y., West, A. P., & Walsh, A. J.
(2024).
3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data. APL Bioengineering.
8(1), 016112.
-
book
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West, A. P., Koblansky, A. A., & Ghosh, S.
(2006).
Recognition and signaling by toll-like receptors. Ed. 22.
Annual Reviews.
-
West, A. P., Koblansky, A. A., & Ghosh, S.
(2006).
Recognition and signaling by toll-like receptors. Ed. 22.
Annual Reviews.
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conference paper
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Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S., ... West, A. P.
(2022).
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis. Journal of Immunology.
-
Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S., ... West, A. P.
(2022).
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis. Journal of Immunology.
-
institutional repository document
-
Warren, E., Gordon-Lipkin, E. M., Cheung, F., Chen, J., Mukherjee, A., Apps, R., ... McGuire, P. J.
(2023).
Inflammatory and interferon gene expression signatures in patients with mitochondrial disease
-
Hu, L., Wang, N., Bryant, J. D., Liu, L., Xie, L., West, A. P., & Walsh, A. J.
(2022).
Machine learning prediction of cancer cell metabolism from autofluorescence lifetime images
-
Keeney, J. N., Winters, A., Sitcheran, R., & West, A. P.
(2022).
NF-B-Inducing Kinase (NIK) Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells
-
Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Li, Y., Fails, D., ... West, A. P.
(2022).
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
-
Farris, L. C., Torres-Odio, S., Adams, L. G., West, A. P., & Hyde, J. A.
(2022).
Borrelia burgdorferi engages mammalian type I interferon responses via the cGAS-STING pathway
-
Gispert, S., Key, J., Kohli, A., Torres-Odio, S., Koepf, G., Amr, S., ... Auburger, G.
(2022).
Clpp-Deletion Causes Azoospermia, with Meiosis-I Delay and Insufficient Biosynthesis of Spermatid Factors, Due to Mitochondrial Dysfunction with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2
-
Gispert, S., Key, J., Kohli, A., Torres-Odio, S., Koepf, G., Amr, S., ... Auburger, G.
(2022).
ClpP-Deletion Causes Azoospermia, with Meiosis-I Delay and Insufficient Biosynthesis of Spermatid Factors, Due to Mitochondrial Dysfunction with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2
-
Khatib, I. A., Deng, J., Lei, Y., Torres-Odio, S., Rojas, G. R., Newman, L. E., ... Shutt, T. E.
(2022).
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
-
Weindel, C. G., Zhao, X., Martinez, E., Bell, S. L., Vail, K. J., Coleman, A. K., ... Watson, R. O.
(2021).
Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection
-
Key, J., Torres-Odio, S., Bach, N. C., Gispert, S., Koepf, G., Reichlmeir, M., ... Auburger, G.
(2021).
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX With Its Interactors at the Nucleoid and RNA Granule
-
Sutherland, T. C., Sefiani, A., Horvat, D., Huntington, T. E., Lei, Y., West, A. P., & Geoffroy, C. G.
(2021).
The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria
-
Maletzko, A., Key, J., Wittig, I., Gispert, S., Koepf, G., Canet-Pons, J., ... Auburger, G.
(2021).
Prominent Increases of Nuclear DNAJA3and Cytosolic STAT1 with Nucleic Acid Sensors Underlie Innate Immunity Activation in ClpP-null Mouse
-
Lei, Y., Martinez, C. G., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., ... West, A. P.
(2020).
Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
-
Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Shetty, A. K., West, L. C., & West, A. P.
(2020).
Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness
-
Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S., ... West, A. P.
(2020).
Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis
-
Hoffpauir, C. T., Bell, S. L., West, K. O., Jing, T., Torres-Odio, S., Cox, J. S., ... Watson, R. O.
(2019).
TRIM14 is a key regulator of the type I interferon response during Mycobacterium tuberculosis infection
-
West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O.
(2019).
The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages
-
Warren, E., Gordon-Lipkin, E. M., Cheung, F., Chen, J., Mukherjee, A., Apps, R., ... McGuire, P. J.
(2023).
Inflammatory and interferon gene expression signatures in patients with mitochondrial disease
Research
principal investigator on
- Type I Interferon Responses in the Pathobiology of Anthracycline-induced Cardiotoxicity awarded by National Heart Lung and Blood Institute - (Bethesda, Maryland, United States) 2020 - 2025
- Mitochondrial Dysfunction and Aberrant Immune Activation in the Pathobiology of Gulf War Illness awarded by United States Army - (Washington D.C., District of Columbia, United States) 2017 - 2020
- Inborn Errors of Innate Immunity and Impaired Antimicrobial Defenses in Primary Mitochondrial Diseases awarded by Congressionally Directed Medical Research Programs - (Frederick, Maryland, United States) 2018 - 2019
- Innate Immune Signaling and Type I Interferon Responses as Novel Modifiers of Mitochondrial Disease Pathology awarded by United States Army - (Washington D.C., District of Columbia, United States) 2017 - 2019
- Mitochondrial DNA Instability Engages a Cancer-Related Interferon Program to Modify the Immune Microenvironment and NAD+ Metabolome and Enhance Melanoma Growth awarded by Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States) 2017
investigator on
Teaching
teaching activities
- GENE691 Research Instructor
- MPIM601 Microbial Pathogenesis Of Huma Instructor
- MSCI601 Contem Top In Adv Cell Bio I Instructor
- MSCI630 Pathogenesis Of Human Disease Instructor
- MSCI635 Mammalian Immunobiology Instructor
- MSCI685 Directed Studies Instructor
- MSCI689 Sptp: Mammalian Immunobiology Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Immunobiology, Yale University - (New Haven, Connecticut, United States) 2011
- B.S. in Biological Sciences, Science Education, North Carolina State University - (Raleigh, North Carolina, United States) 2001
- Yale University - (New Haven, Connecticut, United States) , Postdoctoral Training 2015
Contact
first name
- A. Phillip
has last name
- West
mailing address
-
Texas A&M Health Science Center
Microbial Pathogenesis And Immunology
1114 TAMUS
College Station, TX 77843-1113
USA
Other
- awest@tamu.edu