NF-kappaB and the immune response. Academic Article

abstract

• One of the primary physiological roles of nuclear factor-kappa B (NF-kappaB) is in the immune system. In particular, NF-kappaB family members control the transcription of cytokines and antimicrobial effectors as well as genes that regulate cellular differentiation, survival and proliferation, thereby regulating various aspects of innate and adaptive immune responses. In addition, NF-kappaB also contributes to the development and survival of the cells and tissues that carry out immune responses in mammals. This review, therefore, describes the role of the NF-kappaB pathway in the development and functioning of the immune system.

authors

• West, A. Phillip

published proceedings

• Oncogene

altmetric score

• 6.25

author list (cited authors)

• Hayden, M. S., West, A. P., & Ghosh, S.

citation count

• 935

complete list of authors

• Hayden, MS||West, AP||Ghosh, S

publication date

• October 2006

publisher

• Springer Nature  Publisher

published in

• Oncogene  Journal

keywords

• Adaptation, Physiological
• Animals
• Humans
• Immune System
• Immunity, Innate
• Lymphoid Tissue
• NF-kappa B

PubMed Central ID

• 17072327

Digital Object Identifier (DOI)

• 10.1038/sj.onc.1209943

start page

• 6758

end page

• 6780

volume

• 25

issue

• 51

URL

• http://dx.doi.org/10.1038/sj.onc.1209943