Mitochondria in innate immune responses. Academic Article

abstract

• The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.

authors

• West, A. Phillip

published proceedings

• Nat Rev Immunol

altmetric score

• 45.11

author list (cited authors)

• West, A. P., Shadel, G. S., & Ghosh, S.

citation count

• 888

complete list of authors

• West, A Phillip||Shadel, Gerald S||Ghosh, Sankar

publication date

• June 2011

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Immunology  Journal

keywords

• Animals
• Bacterial Infections
• Humans
• Immunity, Innate
• Mitochondria
• Mitochondrial Proteins
• Models, Immunological
• Reactive Oxygen Species
• Signal Transduction
• Virus Diseases

PubMed Central ID

• 21597473

Digital Object Identifier (DOI)

• 10.1038/nri2975

start page

• 389

end page

• 402

volume

• 11

issue

• 6

URL

• http://dx.doi.org/10.1038/nri2975