Mitochondrial DNA in innate immune responses and inflammatory pathology. Academic Article

abstract

• Mitochondrial DNA (mtDNA) - which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases - is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or circulation, mtDNA can engage multiple pattern-recognition receptors in cell-type- and context-dependent manners to trigger pro-inflammatory and type I interferon responses. Here, we review the expanding research field of mtDNA in innate immune responses to highlight new mechanistic insights and discuss the physiological and pathological relevance of this exciting area of mitochondrial biology.

authors

• West, A. Phillip

published proceedings

• Nat Rev Immunol

altmetric score

• 24.95

author list (cited authors)

• West, A. P., & Shadel, G. S.

citation count

• 503

complete list of authors

• West, A Phillip||Shadel, Gerald S

publication date

• June 2017

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Immunology  Journal

keywords

• Alarmins
• Animals
• DNA, Mitochondrial
• Humans
• Immunity, Innate
• Inflammation

PubMed Central ID

• 28393922

Digital Object Identifier (DOI)

• 10.1038/nri.2017.21

start page

• 363

end page

• 375

volume

• 17

issue

• 6

URL

• http://dx.doi.org/10.1038/nri.2017.21

user-defined tag

• 3 Good Health and Well-Being