Mitochondrial dysfunction as a trigger of innate immune responses and inflammation. Academic Article uri icon

abstract

  • A growing literature indicates that mitochondria are key participants in innate immune pathways, functioning as both signaling platforms and contributing to effector responses. In addition to regulating antiviral signaling and antibacterial immunity, mitochondria are also important drivers of inflammation caused by sterile injury. Much research on mitochondrial control of immunity now centers on understanding how mitochondrial constituents released during cellular damage simulate the innate immune system. When mitochondrial integrity is compromised, mitochondrial damage-associated molecular patterns engage pattern recognition receptors, trigger inflammation, and promote pathology in an expanding list of diseases. Here, I review the emerging knowledge of mitochondrial dysfunction in innate immune responses and discuss how environmental exposures may induce mitochondrial damage to potentiate inflammation and human disease.

published proceedings

  • Toxicology

altmetric score

  • 0.25

author list (cited authors)

  • West, A. P.

citation count

  • 118

complete list of authors

  • West, A Phillip

publication date

  • November 2017