HR job title
- Professor
- Contact Info
- 1 979 845 4106
- ORCiD
- 0000-0002-7575-2368
Chiu, Weihsueh Professor
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Overview
Publications
selected publications
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academic article
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Camargo, K., Vogelbein, M. A., Horney, J. A., Dellapenna, T. M., Knap, A. H., Sericano, J. L., ... Unger, M. A.
(2022).
Biosensor applications in contaminated estuaries: Implications for disaster research response. Environmental Research.
204(Pt A), 111893-111893.
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Hsieh, N., Bois, F. Y., Tsakalozou, E., Ni, Z., Yoon, M., Sun, W., ... Chiu, W. A.
(2021).
A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms. Journal of Pharmacokinetics and Pharmacodynamics.
48(6), 893-908.
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Chen, Z., Jang, S., Kaihatu, J. M., Zhou, Y., Wright, F. A., Chiu, W. A., & Rusyn, I.
(2021).
Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions. Int J Environ Res Public Health.
18(24), 13378-13378.
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Erber, L., Goodman, S., Wright, F. A., Chiu, W. A., Tretyakova, N. Y., & Rusyn, I.
(2021).
Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene. CHEMICAL RESEARCH IN TOXICOLOGY.
34(11), 2375-2383.
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Sakolish, C., Luo, Y., Valdiviezo, A., Vernetti, L. A., Rusyn, I., & Chiu, W. A.
(2021).
Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Toxicology.
463, 152954-152954.
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Camargo, K. M., Foster, M., Buckingham, B., McDonald, T. J., & Chiu, W. A.
(2021).
Characterizing baseline legacy chemical contamination in urban estuaries for disaster-research through systematic evidence mapping: A case study. Chemosphere.
281, 130925-130925.
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Burnett, S. D., Blanchette, A. D., Chiu, W. A., & Rusyn, I.
(2021).
Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors. CHEMICAL RESEARCH IN TOXICOLOGY.
34(9), 2110-2124.
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Lind, L., Araujo, J. A., Barchowsky, A., Belcher, S., Berridge, B. R., Chiamvimonvat, N., ... Smith, M. T.
(2021).
Key Characteristics of Cardiovascular Toxicants. Environ Health Perspect.
129(9), 095001-095001.
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Chiu, W. A., & Ndeffo-Mbah, M. L.
(2021).
Using test positivity and reported case rates to estimate state-level COVID-19 prevalence and seroprevalence in the United States. PLoS Computational Biology.
17(9), e1009374-e1009374.
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Camargo, K., Sericano, J. L., Bhandari, S., Hoelscher, C., McDonald, T. J., Chiu, W. A., ... Knap, A. H.
(2021).
Corrigendum to "Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: Considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region" [Mar. Pollut. Bull. 162, (January 2021), 111872]. MARINE POLLUTION BULLETIN.
168, 112235-112235.
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Roman-Hubers, A. T., Cordova, A. C., Aly, N. A., McDonald, T. J., Lloyd, D. T., Wright, F. A., ... Rusyn, I.
(2021).
Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry–Mass Spectrometry. ENERGY & FUELS.
35(13), 10529-10539.
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Valdiviezo, A., Luo, Y., Chen, Z., Chiu, W. A., & Rusyn, I.
(2021).
Quantitative in Vitro-to-in Vivo Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides. TOXICOLOGICAL SCIENCES.
183(1), 60-69.
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Jang, S., McDonald, T. J., Bhandari, S., Rusyn, I., & Chiu, W. A.
(2021).
Spatial and temporal distribution of surface water contaminants in the Houston Ship Channel after the Intercontinental Terminal Company Fire. Journal of Exposure Science and Environmental Epidemiology.
31(5), 887-899.
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Fantke, P., Chiu, W. A., Aylward, L., Judson, R., Huang, L., Jang, S., ... Jolliet, O.
(2021).
Exposure and Toxicity Characterization of Chemical Emissions and Chemicals in Products: Global Recommendations and Implementation in USEtox. International Journal of Life Cycle Assessment.
26(5), 899-915.
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Dalaijamts, C., Cichocki, J. A., Luo, Y., Rusyn, I., & Chiu, W. A.
(2021).
Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice. TOXICOLOGICAL SCIENCES.
182(2), 168-182.
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Roman-Hubers, A. T., McDonald, T. J., Baker, E. S., Chiu, W. A., & Rusyn, I.
(2021).
A Comparative Analysis of Analytical Techniques for Rapid Oil Spill Identification. Environmental Toxicology and Chemistry.
40(4), 1034-1049.
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Aly, N. A., Casillas, G., Luo, Y., McDonald, T. J., Wade, T. L., Zhu, R., ... Rusyn, I.
(2021).
Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks. Journal of Exposure Science and Environmental Epidemiology.
31(5), 810-822.
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Chiu, W. A., & Paoli, G. M.
(2021).
Recent Advances in Probabilistic Dose-Response Assessment to Inform Risk-Based Decision Making. Risk Anal.
41(4), 596-609.
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Burnett, S. D., Blanchette, A. D., Chiu, W. A., & Rusyn, I.
(2021).
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk characterization. Expert Opin Drug Metab Toxicol.
17(8), 1-16.
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Luo, Y., Chen, Z., Blanchette, A. D., Zhou, Y., Wright, F. A., Baker, E. S., Chiu, W. A., & Rusyn, I.
(2021).
Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes. Food Chem Toxicol.
149, 111979-111979.
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Sakolish, C., Reese, C. E., Luo, Y., Valdiviezo, A., Schurdak, M. E., Gough, A., ... Rusyn, I.
(2021).
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Toxicology.
448, 152651-152651.
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Brozek, J. L., Canelo-Aybar, C., Akl, E. A., Bowen, J. M., Bucher, J., Chiu, W. A., ... GRADE Working Group.
(2021).
GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence-An overview in the context of health decision-making. Journal of Clinical Epidemiology.
129, 138-150.
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Camargo, K., Sericano, J. L., Bhandari, S., Hoelscher, C., McDonald, T. J., Chiu, W. A., ... Knap, A. H.
(2021).
Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: Considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region. MARINE POLLUTION BULLETIN.
162, 111872-111872.
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Hsieh, N., Chen, Z., Rusyn, I., & Chiu, W. A.
(2021).
Risk Characterization and Probabilistic Concentration-Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays. Environ Health Perspect.
129(1), 17004-017004.
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Chen, Z., Lloyd, D., Zhou, Y., Chiu, W. A., Wright, F. A., & Rusyn, I.
(2021).
Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data. TOXICOLOGICAL SCIENCES.
179(1), 108-120.
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Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y., Wright, F. A., ... Reif, D. M.
(2021).
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. Environ Health Perspect.
129(1), 17701-017701.
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Blanchette, A. D., Burnett, S. D., Grimm, F. A., Rusyn, I., & Chiu, W. A.
(2020).
A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model. TOXICOLOGICAL SCIENCES.
178(2), 391-403.
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Luo, Y., Aly, N. A., McCord, J., Strynar, M. J., Chiu, W. A., Dodds, J. N., Baker, E. S., & Rusyn, I.
(2020).
Rapid Characterization of Emerging Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foams Using Ion Mobility Spectrometry-Mass Spectrometry. ENVIRONMENTAL SCIENCE & TECHNOLOGY.
54(23), 15024-15034.
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Chiu, W. A., & Ndeffo-Mbah, M. L.
(2020).
Using Test Positivity and Reported Case Rates to Estimate State-Level COVID-19 Prevalence and Seroprevalence in the United States. 2020.10.07.20208504.
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Bois, F. Y., Hsieh, N., Gao, W., Chiu, W. A., & Reisfeld, B.
(2020).
Well-tempered MCMC simulations for population pharmacokinetic models. Journal of Pharmacokinetics and Pharmacodynamics.
47(6), 543-559.
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Blessinger, T., Davis, A., Chiu, W. A., Stanek, J., Woodall, G. M., Gift, J., Thayer, K. A., & Bussard, D.
(2020).
Application of a unified probabilistic framework to the dose-response assessment of acrolein. Environ Int.
143, 105953-105953.
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Rusyn, I., Chiu, W. A., & Wright, F. A.
(2020).
Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics. TOXICOLOGICAL SCIENCES.
177(2), 521-522.
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Chiu, W. A., Fischer, R., & Ndeffo-Mbah, M. L.
(2020).
State-level needs for social distancing and contact tracing to contain COVID-19 in the United States. Nat Hum Behav.
4(10), 1080-1090.
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Aly, N. A., Luo, Y., Liu, Y., Casillas, G., McDonald, T. J., Kaihatu, J. M., ... Rusyn, I.
(2020).
Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident. Environmental Pollution.
265(Pt B), 115009-115009.
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Smith, M. T., Guyton, K. Z., Kleinstreuer, N., Borrel, A., Cardenas, A., Chiu, W. A., ... Fielden, M.
(2020).
The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiology, Biomarkers and Prevention.
29(10), 1887-1903.
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Dalaijamts, C., Cichocki, J. A., Luo, Y., Rusyn, I., & Chiu, W. A.
(2020).
PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. TOXICOLOGY AND APPLIED PHARMACOLOGY.
400, 115069-115069.
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Grimm, F. A., Klaren, W. D., Li, X., Lehmler, H., Karmakar, M., Robertson, L. W., Chiu, W. A., & Rusyn, I.
(2020).
Cardiovascular Effects of Polychlorinated Biphenyls and Their Major Metabolites. Environ Health Perspect.
128(7), 77008-077008.
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Hsieh, N., Reisfeld, B., & Chiu, W. A.
(2020).
pksensi: An R package to apply global sensitivity analysis in physiologically based kinetic modeling. SoftwareX.
12, 100609-100609.
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Chen, Z., Liu, Y., Wright, F. A., Chiu, W. A., & Rusyn, I.
(2020).
Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX.
37(4), 623-638.
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Luo, Y., Ferguson, K. C., Rusyn, I., & Chiu, W. A.
(2020).
In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. TOXICOLOGICAL SCIENCES.
174(2), 168-177.
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Sakolish, C., Chen, Z., Dalaijamts, C., Mitra, K., Liu, Y., Fulton, T., ... Chiu, W. A.
(2020).
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro.
63, 104752-104752.
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Bhandari, S., Lewis, P., Craft, E., Marvel, S. W., Reif, D. M., & Chiu, W. A.
(2020).
HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston-Galveston-Brazoria Region. Int J Environ Res Public Health.
17(4), 1130-1130.
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Danforth, C., Chiu, W. A., Rusyn, I., Schultz, K., Bolden, A., Kwiatkowski, C., & Craft, E.
(2020).
An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environ Int.
134, 105280-105280.
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Samet, J. M., Chiu, W. A., Cogliano, V., Jinot, J., Kriebel, D., Lunn, R. M., ... Wild, C. P.
(2020).
The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification. Journal of the National Cancer Institute.
112(1), 30-37.
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Kvasnicka, J., Stylianou, K. S., Nguyen, V. K., Huang, L., Chiu, W. A., Burton, G. A., Semrau, J., & Jolliet, O.
(2019).
Human Health Benefits from Fish Consumption vs. Risks from Inhalation Exposures Associated with Contaminated Sediment Remediation: Dredging of the Hudson River. Environ Health Perspect.
127(12), 127004-127004.
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Johnson, N., Uwak, I., Lam, J., Xu, X., Foster, M., Moriarty, M., ... Chiu, W.
(2019).
Application of the Navigation Guide systematic review methodology and meta-analysis to evaluate the association between prenatal particulate matter air pollution exposure and birth weight. Environmental Epidemiology.
3, 448-449.
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Ferguson, K. C., Luo, Y., Rusyn, I., & Chiu, W. A.
(2019).
Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro.
60, 245-251.
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Onel, M., Beykal, B., Ferguson, K., Chiu, W. A., McDonald, T. J., Zhou, L., ... Pistikopoulos, E. N.
(2019).
Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One.
14(10), e0223517-e0223517.
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Wang, M., Orr, A. A., He, S., Dalaijamts, C., Chiu, W. A., Tamamis, P., & Phillips, T. D.
(2019).
Montmorillonites Can Tightly Bind Glyphosate and Paraquat Reducing Toxin Exposures and Toxicity. ACS Omega.
4(18), 17702-17713.
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Burnett, S. D., Blanchette, A. D., Grimm, F. A., House, J. S., Reif, D. M., Wright, F. A., Chiu, W. A., & Rusyn, I.
(2019).
Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. TOXICOLOGY AND APPLIED PHARMACOLOGY.
381, 114711-114711.
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Luo, Y., Cichocki, J. A., Hsieh, N., Lewis, L., Wright, F. A., Threadgill, D. W., Chiu, W. A., & Rusyn, I.
(2019).
Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. Environ Health Perspect.
127(6), 67011-067011.
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Stermer, A. R., Klein, D., Wilson, S. K., Dalaijamts, C., Bai, C. Y., Hall, S. J., ... Boekelheide, K.
(2019).
Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environmental Toxicology and Pharmacology.
68, 1-3.
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Lewis, L., Borowa-Mazgaj, B., de Conti, A., Chappell, G. A., Luo, Y., Bodnar, W., ... Rusyn, I.
(2019).
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse. CHEMICAL RESEARCH IN TOXICOLOGY.
32(5), 887-898.
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Blanchette, A. D., Grimm, F. A., Dalaijamts, C., Hsieh, N., Ferguson, K., Luo, Y., Rusyn, I., & Chiu, W. A.
(2019).
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships. CLINICAL PHARMACOLOGY & THERAPEUTICS.
105(5), 1175-1186.
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Englehardt, J. D., & Chiu, W. A.
(2019).
A general dose-response relationship for chronic chemical and other health stressors and mixtures based on an emergent illness severity model. PLoS One.
14(2), e0211780-e0211780.
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Cichocki, J. A., Luo, Y., Furuya, S., Venkatratnam, A., Konganti, K., Chiu, W. A., ... Rusyn, I.
(2019).
Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. TOXICOLOGICAL SCIENCES.
167(1), 126-137.
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Fantke, P., Aylward, L., Bare, J., Chiu, W. A., Dodson, R., Dwyer, R., ... McKone, T. E.
(2018).
Advancements in Life Cycle Human Exposure and Toxicity Characterization. Environ Health Perspect.
126(12), 125001-125001.
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Guyton, K. Z., Rieswijk, L., Wang, A., Chiu, W. A., & Smith, M. T.
(2018).
Key Characteristics Approach to Carcinogenic Hazard Identification. CHEMICAL RESEARCH IN TOXICOLOGY.
31(12), 1290-1292.
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Luo, Y., Hsieh, N., Soldatow, V. Y., Chiu, W. A., & Rusyn, I.
(2018).
Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology.
409, 33-43.
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Sakolish, C., Weber, E. J., Kelly, E. J., Himmelfarb, J., Mouneimne, R., Grimm, F. A., ... Rusyn, I.
(2018).
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Scientific Reports.
8(1), 14882.
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Dalaijamts, C., Cichocki, J. A., Luo, Y., Rusyn, I., & Chiu, W. A.
(2018).
Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. TOXICOLOGY AND APPLIED PHARMACOLOGY.
352, 142-152.
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Grimm, F. A., Blanchette, A., House, J. S., Ferguson, K., Hsieh, N., Dalaijamts, C., ... Rusyn, I.
(2018).
A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX.
35(4), 441-452.
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Guyton, K. Z., Rusyn, I., Chiu, W. A., Corpet, D. E., van den Berg, M., Ross, M. K., ... Smith, M. T.
(2018).
Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg. Carcinogenesis.
39(8), 1091-1093.
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Chiu, W. A., Guyton, K. Z., Martin, M. T., Reif, D. M., & Rusyn, I.
(2018).
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX.
35(1), 51-64.
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Hsieh, N., Reisfeld, B., Bois, F. Y., & Chiu, W. A.
(2018).
Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling. Frontiers in Pharmacology.
9(JUN), 588.
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Chiu, W. A., Axelrad, D. A., Dalaijamts, C., Dockins, C., Shao, K., Shapiro, A. J., & Paoli, G.
(2018).
Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects. Environ Health Perspect.
126(6), 067009-067009.
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Wignall, J. A., Muratov, E., Sedykh, A., Guyton, K. Z., Tropsha, A., Rusyn, I., & Chiu, W. A.
(2018).
Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals. Environ Health Perspect.
126(5), 057008-057008.
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Dorman, D. C., Chiu, W., Hales, B. F., Hauser, R., Johnson, K. J., Mantus, E., ... Waters, K. M.
(2018).
Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence. Journal of Toxicology and Environmental Health Part B.
21(4), 269-289.
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Dorman, D. C., Chiu, W., Hales, B. F., Hauser, R., Johnson, K. J., Mantus, E., ... Waters, K. M.
(2018).
Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance. Journal of Toxicology and Environmental Health Part B.
21(4), 207-226.
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Guyton, K. Z., Rusyn, I., Chiu, W. A., Corpet, D. E., van den Berg, M., Ross, M. K., ... Smith, M. T.
(2018).
Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis.
39(4), 614-622.
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Chiu, W. A., & Rusyn, I.
(2018).
Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. MAMMALIAN GENOME.
29(1-2), 182-189.
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Luo, Y., Furuya, S., Chiu, W., & Rusyn, I.
(2018).
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A.
81(1-3), 37-52.
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Venkatratnam, A., House, J. S., Konganti, K., McKenney, C., Threadgill, D. W., Chiu, W. A., ... Rusyn, I.
(2018).
Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. MAMMALIAN GENOME.
29(1-2), 168-181.
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Chiu, W. A., Wright, F. A., & Rusyn, I.
(2017).
A tiered, Bayesian approach to estimating of population variability for regulatory decision-making. ALTEX.
34(3), 377-388.
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Bokkers, B., Mengelers, M. J., Bakker, M. I., Chiu, W. A., & Slob, W.
(2017).
APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. Food Chem Toxicol.
110, 408-417.
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Zhou, Y., Cichocki, J. A., Soldatow, V. Y., Scholl, E. H., Gallins, P. J., Jima, D., ... Rusyn, I.
(2017).
Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse. TOXICOLOGICAL SCIENCES.
160(1), 95-110.
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Cichocki, J. A., Furuya, S., Luo, Y., Iwata, Y., Konganti, K., Chiu, W. A., ... Rusyn, I.
(2017).
Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. TOXICOLOGICAL SCIENCES.
159(2), 481-481.
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Cichocki, J. A., Furuya, S., Luo, Y., Iwata, Y., Konganti, K., Chiu, W. A., ... Rusyn, I.
(2017).
Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. TOXICOLOGICAL SCIENCES.
159(1), 102-113.
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Venkatratnam, A., Furuya, S., Kosyk, O., Gold, A., Bodnar, W., Konganti, K., ... Rusyn, I.
(2017).
Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism. TOXICOLOGICAL SCIENCES.
158(1), 48-62.
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Grimm, F. A., Russell, W. K., Luo, Y., Iwata, Y., Chiu, W. A., Roy, T., ... Rusyn, I.
(2017).
Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across. ENVIRONMENTAL SCIENCE & TECHNOLOGY.
51(12), 7197-7207.
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Cichocki, J. A., Furuya, S., Venkatratnam, A., McDonald, T. J., Knap, A. H., Wade, T., ... Rusyn, I.
(2017).
Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environ Health Perspect.
125(5), 057006-057006.
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Sirenko, O., Grimm, F. A., Ryan, K. R., Iwata, Y., Chiu, W. A., Parham, F., ... Tice, R. R.
(2017).
In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. TOXICOLOGY AND APPLIED PHARMACOLOGY.
322, 60-74.
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Cichocki, J. A., Furuya, S., Konganti, K., Luo, Y., McDonald, T. J., Iwata, Y., ... Rusyn, I.
(2017).
Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. J Pharmacol Exp Ther.
361(1), 17-28.
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Maclaren, T., Westphal, M., Sarwar, E., Mattison, D., Chiu, W. A., Dix, D., Kavlock, R., & Krewski, D.
(2017).
Challenges and opportunities in the risk assessment of existing substances in Canada: lessons learned from the international community. International Journal of Risk Assessment and Management.
20(1/2/3), 261-261.
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Cote, I., Andersen, M. E., Ankley, G. T., Barone, S., Birnbaum, L. S., Boekelheide, K., ... DeWoskin, R. S.
(2016).
The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions. Environ Health Perspect.
124(11), 1671-1682.
-
Cichocki, J. A., Guyton, K. Z., Guha, N., Chiu, W. A., Rusyn, I., & Lash, L. H.
(2016).
Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps. J Pharmacol Exp Ther.
359(1), 110-123.
-
Chiu, W. A., & Slob, W.
(2015).
A Unified Probabilistic Framework for Dose-Response Assessment of Human Health Effects. Environ Health Perspect.
123(12), 1241-1254.
-
Salazar, K. D., Brinkerhoff, C. J., Lee, J. S., & Chiu, W. A.
(2015).
Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol. TOXICOLOGY AND APPLIED PHARMACOLOGY.
288(3), 439-452.
-
Yoo, H. S., Cichocki, J. A., Kim, S., Venkatratnam, A., Iwata, Y., Kosyk, O., ... Rusyn, I.
(2015).
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. TOXICOLOGICAL SCIENCES.
147(2), 339-349.
-
Woo, H. D., Chiu, W. A., Jo, S., & Kim, J.
(2015).
Benchmark Dose for Urinary Cadmium based on a Marker of Renal Dysfunction: A Meta-Analysis. PLoS One.
10(5), e0126680-e0126680.
-
Abdo, N., Xia, M., Brown, C. C., Kosyk, O., Huang, R., Sakamuru, S., ... Wright, F. A.
(2015).
Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study. Environ Health Perspect.
123(5), 458-466.
-
Lash, L. H., Chiu, W. A., Guyton, K. Z., & Rusyn, I.
(2014).
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
762, 22-36.
-
Krewski, D., Westphal, M., Andersen, M. E., Paoli, G. M., Chiu, W. A., Al-Zoughool, M., ... Cote, I.
(2014).
A framework for the next generation of risk science. Environ Health Perspect.
122(8), 796-805.
-
Benbrahim-Tallaa, L., Lauby-Secretan, B., Loomis, D., Guyton, K. Z., Grosse, Y., El Ghissassi, F., ... International Agency for Research on Cancer Monograph Working Group.
(2014).
Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. Lancet Oncol.
15(9), 924-925.
-
Chiu, W. A., Campbell, J. L., Clewell, H. J., Zhou, Y., Wright, F. A., Guyton, K. Z., & Rusyn, I.
(2014).
Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environ Health Perspect.
122(5), 456-463.
-
Wignall, J. A., Shapiro, A. J., Wright, F. A., Woodruff, T. J., Chiu, W. A., Guyton, K. Z., & Rusyn, I.
(2014).
Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environ Health Perspect.
122(5), 499-505.
-
Guyton, K. Z., Hogan, K. A., Scott, C. S., Cooper, G. S., Bale, A. S., Kopylev, L., ... Chiu, W. A.
(2014).
Human health effects of tetrachloroethylene: key findings and scientific issues. Environ Health Perspect.
122(4), 325-334.
-
Rusyn, I., Chiu, W. A., Lash, L. H., Kromhout, H., Hansen, J., & Guyton, K. Z.
(2014).
Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard. Pharmacology & Therapeutics.
141(1), 55-68.
-
Kushman, M. E., Kraft, A. D., Guyton, K. Z., Chiu, W. A., Makris, S. L., & Rusyn, I.
(2013).
A systematic approach for identifying and presenting mechanistic evidence in human health assessments. Regulatory Toxicology and Pharmacology.
67(2), 266-277.
-
Euling, S. Y., Thompson, C. M., Chiu, W. A., & Benson, R.
(2013).
An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study. TOXICOLOGY AND APPLIED PHARMACOLOGY.
271(3), 324-335.
-
Chiu, W. A., Euling, S. Y., Scott, C. S., & Subramaniam, R. P.
(2013).
Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era. TOXICOLOGY AND APPLIED PHARMACOLOGY.
271(3), 309-323.
-
Wilson, V. S., Keshava, N., Hester, S., Segal, D., Chiu, W., Thompson, C. M., & Euling, S. Y.
(2013).
Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. TOXICOLOGY AND APPLIED PHARMACOLOGY.
271(3), 299-308.
-
Zeise, L., Bois, F. Y., Chiu, W. A., Hattis, D., Rusyn, I., & Guyton, K. Z.
(2013).
Towards a better consideration of the interindividual variability in chemical risk assessment. Environnement, Risques and Santé.
12(3), 211-212.
-
Chiu, W. A., Jinot, J., Scott, C. S., Makris, S. L., Cooper, G. S., Dzubow, R. C., ... Caldwell, J. C.
(2013).
Human health effects of trichloroethylene: key findings and scientific issues. Environ Health Perspect.
121(3), 303-311.
-
Zeise, L., Bois, F. Y., Chiu, W. A., Hattis, D., Rusyn, I., & Guyton, K. Z.
(2013).
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect.
121(1), 23-31.
-
Klein, M., Neerchal, N., Sinha, B., Chiu, W., & White, P.
(2012).
Statistical inferences from serially correlated methylene chloride data. Sankhya: The Indian Journal of Statistics.
74 B(PART 2), 211-237.
-
Klein, M., Neerchal, N., Sinha, B., Chiu, W., & White, P.
(2012).
Statistical inferences from serially correlated methylene chloride data. Sankhya B.
74(2), 211-237.
-
Chiu, W. A., Guyton, K. Z., Hogan, K., & Jinot, J.
(2012).
Approaches to human health risk assessment based on the signal-to-noise crossover dose. Environ Health Perspect.
120(7), a264-a264.
-
Chiu, W. A., & Crump, K. S.
(2012).
Using Copulas to Introduce Dependence in Dose-Response Modeling of Multiple Binary Endpoints. Journal of Agricultural, Biological, and Environmental Statistics.
17(1), 107-127.
-
Chiu, W. A.
(2011).
Trichloroacetic acid: updated estimates of its bioavailability and its contribution to trichloroethylene-induced mouse hepatomegaly. Toxicology.
285(3), 114-125.
-
Chiu, W. A., & Ginsberg, G. L.
(2011).
Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans. TOXICOLOGY AND APPLIED PHARMACOLOGY.
253(3), 203-234.
-
Crump, K. S., Chen, C., Chiu, W. A., Louis, T. A., Portier, C. J., Subramaniam, R. P., & White, P. D.
(2010).
What Role for Biologically Based Dose–Response Models in Estimating Low-Dose Risk?. Environ Health Perspect.
118(5), 585-588.
-
Crump, K. S., Chiu, W. A., & Subramaniam, R. P.
(2010).
Issues in using human variability distributions to estimate low-dose risk. Environ Health Perspect.
118(3), 387-393.
-
Guyton, K. Z., Chiu, W. A., Bateson, T. F., Jinot, J., Scott, C. S., Brown, R. C., & Caldwell, J. C.
(2009).
A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants. Environ Health Perspect.
117(11), 1664-1672.
-
Chiu, W. A., Okino, M. S., & Evans, M. V.
(2009).
Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach. TOXICOLOGY AND APPLIED PHARMACOLOGY.
241(1), 36-60.
-
Evans, M. V., Chiu, W. A., Okino, M. S., & Caldwell, J. C.
(2009).
Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly. TOXICOLOGY AND APPLIED PHARMACOLOGY.
236(3), 329-340.
-
Thompson, C. M., Sonawane, B., Barton, H. A., DeWoskin, R. S., Lipscomb, J. C., Schlosser, P., Chiu, W. A., & Krishnan, K.
(2008).
Approaches for applications of physiologically based pharmacokinetic models in risk assessment. Journal of Toxicology and Environmental Health Part B.
11(7), 519-547.
-
Barton, H. A., Chiu, W. A., Setzer, R. W., Andersen, M. E., Bailer, A. J., Bois, F. Y., ... Tan, Y.
(2007).
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. TOXICOLOGICAL SCIENCES.
99(2), 395-402.
-
Chiu, W. A., & Bois, F. Y.
(2007).
An Approximate Method for Population Toxicokinetic Analysis With Aggregated Data. Journal of Agricultural, Biological, and Environmental Statistics.
12(3), 346-363.
-
Chiu, W. A., Barton, H. A., DeWoskin, R. S., Schlosser, P., Thompson, C. M., Sonawane, B., Lipscomb, J. C., & Krishnan, K.
(2007).
Evaluation of physiologically based pharmacokinetic models for use in risk assessment. Journal of Applied Toxicology.
27(3), 218-237.
-
Chiu, W. A., Chen, C., Hogan, K., Lipscomb, J. C., Scott, C. S., & Subramaniam, R.
(2007).
High-to-Low Dose Extrapolation: Issues and Approaches. Human and Ecological Risk Assessment.
13(1), 46-51.
-
Bachmaier, J. T., Aiello, K., Bastian, R. K., Cheng, J. J., Chiu, W. A., Goodman, J., ... Wolbarst, A. B.
(2007).
Management of sewage sludge and ash containing radioactive materials. International Journal of Environment and Waste Management.
1(2-3), 113-127.
-
Keshava, N., Chiu, W. A., & Caldwell, J. C.
(2007).
PPAR and TCE: Keshava et al. Respond. Environ Health Perspect.
115(1), a15-a16.
-
Chiu, W. A., Micallef, S., Monster, A. C., & Bois, F. Y.
(2007).
Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: empirical results and comparisons with previous studies. TOXICOLOGICAL SCIENCES.
95(1), 23-36.
-
Chiu, W. A., & White, P.
(2006).
SteadyState Solutions to PBPK Models and Their Applications to Risk Assessment I: RoutetoRoute Extrapolation of Volatile ChemicalsAuthors' Response to Letter by Dr. Kenneth Bogen. Risk Anal.
26(6), 1417-1418.
-
Hack, C. E., Chiu, W. A., Jay Zhao, Q., & Clewell, H. J.
(2006).
Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. Regulatory Toxicology and Pharmacology.
46(1), 63-83.
-
Chiu, W. A., Okino, M. S., Lipscomb, J. C., & Evans, M. V.
(2006).
Issues in the pharmacokinetics of trichloroethylene and its metabolites. Environ Health Perspect.
114(9), 1450-1456.
-
Chiu, W. A., Caldwell, J. C., Keshava, N., & Scott, C. S.
(2006).
Key scientific issues in the health risk assessment of trichloroethylene. Environ Health Perspect.
114(9), 1445-1449.
-
Scott, C. S., & Chiu, W. A.
(2006).
Trichloroethylene cancer epidemiology: a consideration of select issues. Environ Health Perspect.
114(9), 1471-1478.
-
Chiu, W. A., & Bois, F. Y.
(2006).
Revisiting the population toxicokinetics of tetrachloroethylene. Arch Toxicol.
80(6), 386-386.
-
Chiu, W. A., & Bois, F. Y.
(2006).
Revisiting the population toxicokinetics of tetrachloroethylene. Arch Toxicol.
80(6), 382-385.
-
Chiu, W. A., & White, P.
(2006).
Steady-state solutions to PBPK models and their applications to risk assessment I: Route-to-route extrapolation of volatile chemicals. Risk Anal.
26(3), 769-780.
-
Caldwell, J. C., Evans, M. V., Marcus, A. H., Scott, C. S., Chiu, W. A., Okino, M. S., & Preuss, P. W.
(2006).
Comments on Article “Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene” by Clewell and Andersen. Crit Rev Toxicol.
36(3), 291-294.
-
Wolbarst, A. B., Chiu, W. A., Yu, C., Aiello, K., Bachmaier, J. T., Bastian, R. K., ... Setlow, L. W.
(2006).
Radioactive materials in biosolids: dose modeling. HEALTH PHYSICS.
90(1), 16-30.
-
Bastian, R. K., Bachmaier, J. T., Schmidt, D. W., Salomon, S. N., Jones, A., Chiu, W. A., ... Lenhart, T.
(2005).
Radioactive Materials in Biosolids. Journal of Environmental Quality.
34(3), 1152-1152.
-
Chiu, W. A., Fan, X., & Ostriker, J. P.
(2003).
CombiningWilkinson Microwave Anisotropy Probeand Sloan Digital Sky Survey Quasar Data on Reionization Constrains Cosmological Parameters and Star Formation Efficiency. Astrophysical Journal.
599(2), 759-772.
-
Chiu, W. A., Gnedin, N. Y., & Ostriker, J. P.
(2001).
The Expected Mass Function for LowMass Galaxies in a Cold Dark Matter Cosmology: Is There a Problem?. Astrophysical Journal.
563(1), 21-27.
-
Chiu, W. A., & Ostriker, J. P.
(2000).
A semianalytic model for cosmological reheating and reionization due to the gravitational collapse of structure. Astrophysical Journal.
534(2 PART 1), 507-532.
-
Chiu, W. A., Hassenzahl, D. M., & Kammen, D. M.
(1999).
A Comparison of Regulatory Implications of Traditional and Exact Two-Stage Dose-Response Models. Risk Anal.
19(1), 15-22.
-
Chiu, W. A., Ostriker, J. P., & Strauss, M. A.
(1998).
Using Cluster Abundances and Peculiar Velocities to Test the Gaussianity of the Cosmological Density Field. Astrophysical Journal.
494(2), 479-490.
-
Camargo, K., Vogelbein, M. A., Horney, J. A., Dellapenna, T. M., Knap, A. H., Sericano, J. L., ... Unger, M. A.
(2022).
Biosensor applications in contaminated estuaries: Implications for disaster research response. Environmental Research.
204(Pt A), 111893-111893.
-
chapter
-
Krishnan, K., McPhail, B., Chiu, W., & White, P.
(2013).
Modeling of Sensitive Subpopulations and Interindividual Variability in Pharmacokinetics for Health Risk Assessments. Computational Toxicology.
(pp. 45-66).
Elsevier.
-
Krishnan, K., McPhail, B., Chiu, W., & White, P.
(2013).
Modeling of Sensitive Subpopulations and Interindividual Variability in Pharmacokinetics for Health Risk Assessments. Computational Toxicology.
(pp. 45-66).
Elsevier.
-
conference paper
-
Aurisano, N., Huang, L., Jang, S., Chiu, W. A., Judson, R., Jolliet, O., & Fantke, P.
(2021).
Broadening the chemical coverage to derive human toxicity dose-response factors for non-cancer endpoints. Toxicol Lett.
S241-S241.
-
Herzler, M., Chiu, W. A., & Slob, W.
(2016).
New WHO guidance on uncertainty in hazard characterization - A unified tiered approach integrating deterministic and probabilistic methods. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
S81-S81.
-
Herzler, M., Chiu, W. A., & Slob, W.
(2016).
New WHO guidance on uncertainty in hazard characterization - A unified tiered approach integrating deterministic and probabilistic methods. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
81-81.
-
Bastian, R. K., Bachmaier, J. T., Schmidt, D. W., Salomon, S. N., Jones, A., Chiu, W. A., ... Lenhart, T.
(2005).
Radioactive materials in biosolids: national survey, dose modeling, and publicly owned treatment works (POTW) guidance. Journal of Environmental Quality.
64-74.
-
Aurisano, N., Huang, L., Jang, S., Chiu, W. A., Judson, R., Jolliet, O., & Fantke, P.
(2021).
Broadening the chemical coverage to derive human toxicity dose-response factors for non-cancer endpoints. Toxicol Lett.
S241-S241.
-
institutional repository document
-
Chiu, W., Johnson, N., Lam, J., Xu, X., Taylor, B., Foster, M., ... Taiwo, S.
(2017).
Association between prenatal exposures to ambient air pollution and birthweight
-
Chiu, W., Johnson, N., Lam, J., Xu, X., Taylor, B., Foster, M., ... Taiwo, S.
(2017).
Association between prenatal exposures to ambient air pollution and birthweight
Research
co-principal investigator on
investigator on
- Texas A&M Center for Environmental Health Research awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2019 - 2024
- Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2017 - 2022
- Regulatory Science in Environmental Health and Toxicology awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2016 - 2021
- TEX-VAL: Texas A&M Tissue Chip Validation Consortium awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2020
- Cardiotoxicity Adverse Outcome Pathway Center: Organotypic Culture Model and In Vitro-to-In Vivo Extrapolation for High-Throughput Hazard, Dose-Response and Variability Assessments awarded by Environmental Protection Agency - (Washington D.C., District of Columbia, United States) 2015 - 2020
- TEX-VAL: Texas A&M Tissue Chip Validation Center awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2019
- Toxicogenetics of tetrachloroethylene awarded by Environmental Protection Agency - (Washington D.C., District of Columbia, United States) 2014 - 2017
Teaching
teaching activities
- VIBS285 Directed Studies Instructor
- VIBS485 Directed Studies Instructor
- VIBS641 Princ Human Hlth Risk Assmt Instructor
- VIBS684 Professional Internship Instructor
- VIBS684 Professional Internship Instructor
- VIBS689 Sptp:risk Assessment Principle Instructor
- VIBS691 Research Instructor
Works By Students
chaired theses and dissertations
-
Cuevas, Carolyn Elizabeth (2017-05). Causes of Death for Law Enforcement Officers in the Line of Duty: A One Health Approach to Trauma Mortality Survivability Assessment.
-
Ferguson, Kyle Charles (2018-05). Characterization of Complex Substances Used in Biological Profiling Through Determination of the Free Concentration Within In Vitro Assays.
Background
education and training
- Cert. in Science, Technology, and Environmental Policy, Princeton University - (Princeton, New Jersey, United States) 1998
- Ph.D. in Physics, Princeton University - (Princeton, New Jersey, United States) 1998
- M.A. in Physics, Princeton University - (Princeton, New Jersey, United States) 1995
- A.B. in Physics, Harvard University - (Cambridge, Massachusetts, United States) 1993
Contact
first name
- Weihsueh
has last name
- Chiu
mailing address
-
Texas A&M University
Veterinary Integrative Biosciences
4458 TAMU
College Station, TX 77843-4458
USA
Other
In the News
- wchiu@tamu.edu