High-to-Low Dose Extrapolation: Issues and Approaches Academic Article

abstract

• Both model-independent and model-dependent approaches to low-dose extrapolation are used in the USEPA's current and future risk assessments. Some of the major issues in choosing and implementing different approaches include: Knowledge of mode-of-action, biological relationships at low dose Characterization of uncertainty and variability Degree of confidence and consistency in results. The USEPA is working both to advance the science and methods in this area as well as to make use of the best science that is available for its current risk assessments.

authors

• Chiu, Weihsueh

published proceedings

• Human and Ecological Risk Assessment An International Journal

author list (cited authors)

• Chiu, W. A., Chen, C., Hogan, K., Lipscomb, J. C., Scott, C. S., & Subramaniam, R.

citation count

• 4

complete list of authors

• Chiu, Weihsueh A||Chen, Chao||Hogan, Karen||Lipscomb, John C||Scott, Cheryl Siegel||Subramaniam, Ravi

publication date

• March 2007

publisher

• Taylor & Francis  Publisher

published in

• Human and Ecological Risk Assessment  Journal

Digital Object Identifier (DOI)

• 10.1080/10807030601107544

start page

• 46

end page

• 51

volume

• 13

issue

• 1

URL

• http://dx.doi.org/10.1080/10807030601107544