HR job title
- Research Scientist
- Contact Info
LN, Madhu Research Scientist
Positions
- Research Scientist, College of Medicine, Health Science Center
- Associate Research Scientist, Cell Biology and Genetics, College of Medicine
- Overview
- Publications
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Kodali, M., Madhu, L. N., Reger, R. L., Milutinovic, B., Upadhya, R., Gonzalez, J. J., ... Shetty, A. K.
(2023).
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction. 108, 118-134.
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Attaluri, S., Arora, M., Madhu, L. N., Kodali, M., Shuai, B., Melissari, L., ... Shetty, A. K.
(2022).
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and Disease.
13(2), 583-613.
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Madhu, L. N., Somayaji, Y., & Shetty, A. K.
(2022).
Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease. Ageing Research Reviews.
78, 101637-101637.
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Madhu, L. N., Kodali, M., & Shetty, A. K.
(2022).
Promise of metformin for preventing age-related cognitive dysfunction. NEURAL REGENERATION RESEARCH.
17(3), 503-507.
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Attaluri, S., Upadhya, R., Kodali, M., Madhu, L. N., Upadhya, D., Shuai, B., & Shetty, A. K.
(2022).
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. Frontiers in Immunology.
13, 853000.
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Upadhya, R., Madhu, L. N., Rao, S., & Shetty, A. K.
(2022).
Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p. Frontiers in Molecular Neuroscience.
15, 845542.
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Dickey, B., Madhu, L. N., & Shetty, A. K.
(2021).
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies. Pharmacology and Therapeutics.
220, 107716-107716.
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Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., Melissari, L., Rao, X., & Shetty, A. K.
(2021).
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox Biology.
43, 101973-101973.
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Kodali, M., Attaluri, S., Madhu, L. N., Shuai, B., Upadhya, R., Gonzalez, J. J., Rao, X., & Shetty, A. K.
(2021).
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus. Aging Cell.
20(2), e13277.
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Madhu, L. N., Telkar, S., Kamath, D., D Souza, M. E., Rao, S., Nayak, P. S., & Sarojini, B. K.
(2020).
Inhibition of Ehrlich ascites cancer, hypoxia-inducible factor-1 alpha, and the kinase insert domain-containing receptor/fms-like tyrosine kinase-binding domains of vascular endothelial growth factor by Thiazole Acetamide Derivatives. 16(Supplement), S74-S81.
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Gita, D., Dos Santos, Y., Upadhya, R., Kodali, M., Madhu, L. N., & Shetty, A. K.
(2020).
Extracellular Vesicles in the Forebrain Display Reduced miR-346 and miR-331-3p in a Rat Model of Chronic Temporal Lobe Epilepsy. Molecular Neurobiology.
57(3), 1674-1687.
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Upadhya, R., Madhu, L. N., Attaluri, S., Gita, D., Pinson, M. R., Kodali, M., ... Shetty, A. K.
(2020).
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. Journal of Extracellular Vesicles.
9(1), 1809064-1809064.
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Shetty, A. K., Attaluri, S., Kodali, M., Shuai, B., Shetty, G. A., Upadhya, D., ... Rao, X.
(2020).
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness. Redox Biology.
28, 101389-101389.
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Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M.
(2019).
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease. Aging and Disease.
10(2), 470-482.
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Kodali, M., Castro, O. W., Kim, D., Thomas, A., Shuai, B., Attaluri, S., ... Shetty, A. K.
(2019).
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain. International Journal of Molecular Sciences.
21(1), 181-181.
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Madhu, L. N., Attaluri, S., Kodali, M., Shuai, B., Upadhya, R., Gitai, D., & Shetty, A. K.
(2019).
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. Brain, Behavior, and Immunity.
81, 430-443.
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Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N.
(2018).
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging and Disease.
9(6), 1165-1184.
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Rao, B. L., Gowda, M., Asha, S., Byrappa, K., Narayana, B., Somashekar, R., ... Sangappa, Y.
(2017).
Rapid synthesis of gold nanoparticles using silk fibroin: characterization, antibacterial activity, and anticancer properties. 50(4), 289-297.
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Salian, V. V., Narayana, B., Sarojini, B. K., Sindhupriya, E. S., Madhu, L. N., & Rao, S.
(2017).
Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4-Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one. Letters in Drug Design and Discovery.
14(2), 216-227.
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Madhu, L. N., Rao, S., & Sarojini, B. K.
(2016).
No impact on P-gp level in radioresistant MCF-7 cells. Journal of Radiation and Cancer Research.
7(1), 2-56.
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Narayana, M. L., Rao, S., & Kunhanna, S. B.
(2016).
Novel strategy for the development of radioresistance breast cancer cell line. 4.
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Viveka, S., Dinesha, .., Madhu, L. N., & Nagaraja, G. K.
(2015).
Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities. 146(9), 1547-1555.
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Viveka, S., Dinesha, S., Madhu, L. N., & Nagaraja, G. K.
(2015).
ChemInform Abstract: Synthesis of New Pyrazole Derivatives via Multicomponent Reaction and Evaluation of Their Antimicrobial and Antioxidant Activities. ChemInform.
46(52), no-no.
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Vijay, R., Vishakh, R., SharmilaK, P., MadhuL, N., PushpalathaK, C., & Kumari, S.
(2015).
Effect of Sub lethal dose electron beam irradiation on Swiss albino mice lung: A pilot Study. 9, 51-60.
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Rao, S., Shetty, S., Nalilu, S., & Madhu, L.
(2015).
Radioprotective Properties of Chitosan on Cultured Human Lymphocytes against Electron Beam Radiation. Journal of Applied Pharmaceutical Science.
147-151.
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Nayak, P. S., Narayana, B., Sarojini, B. K., Fernades, J., Bharath, B. R., & Madhu, L. N.
(2015).
Synthesis, molecular docking and biological evaluation of novel bis-pyrazole derivatives for analgesic, anti-inflammatory and antimicrobial activities. MEDICINAL CHEMISTRY RESEARCH.
24(12), 4191-4206.
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Sapnakumari, M., Narayana, B., Sarojini, B. K., & Madhu, L. N.
(2014).
Synthesis of new indazole derivatives as potential antioxidant agents. 23(5), 2368-2376.
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N., S. K., & N., M. L.
(2014).
DIETARY SUPPLEMENTATION OF NATURAL AND SYNTHETIC PRODUCTS REDUCES ANXIETY IN MICE AGAINST ELECTRON BEAM RADIATION INDUCED OXIDATIVE STRESS. 04(03), 028-032.
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Kumari, S. N., & Madhu, L. N.
(2014).
DIETARY SUPPLEMENTATION OF NATURAL AND SYNTHETIC PRODUCTS REDUCES ANXIETY IN MICE AGAINST ELECTRON BEAM RADIATION INDUCED OXIDATIVE STRESS. 4(3), 28-32.
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Madhu, L. N., & Kumari, N. S.
(2014).
Radioprotective effect of sulphydryl group containing triazole derivative to modulate the radiation- induced clastogenic effects. Research in Pharmaceutical Sciences.
9(1), 23-29.
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Samshuddin, S., Narayana, B., Sarojini, B. K., & Madhu, L. N.
(2013).
A study on the reactions of alkyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate and in vitro antioxidant activity of derivatives. 22(6), 3002-3011.
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Shetty, S., Rao, S., SuchethaKumari, N., Madhu, L. N., & Vishakh, R.
(2013).
Modulatory effect of Allium sativumEthanolic Extract on Cultured Human Lymphocytes. Journal of Applied Pharmaceutical Science.
3(4), 73-77.
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Shetty, S., Suschetha Kumari, N., & Madhu, L. N.
(2013).
Oxidative stress, antioxidant status and DNA damage in Type 2 diabetes melittus. Research journal of pharmaceutical, biological and chemical sciences.
4(1), 437-443.
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Madhu, L. N., Kumari, N. S., Naveen, P., & Sanjeev, G.
(2012).
Protective Effect of Nardostachys jatamansi Against Radiation-induced Damage at Biochemical and Chromosomal Levels in Swiss Albino Mice. Indian Journal of Pharmaceutical Sciences.
74(5), 460-465.
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Suchetha Kumari, N., & Madhu, L. N.
(2012).
Protective Effect of Nardostachys jatamansi on Radiation Induced Anxiety and Oxidative Stress. Biomedicine.
32(3), 337-341.
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Madhu L N.
(2012).
Validation of DNA Damage Progression with Days after Single Exposure of Sublethal Dosage of Electron Beam Radiation. Journal of Applied Pharmaceutical Science.
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Madhu, L. N., Kumari, N. S., & Sarojini, B. K.
(2011).
In vitro and In vivo antioxidant property of sulphydryl group containing 1, 2, 4 Triazole derivative. Drug Invention Today.
3(12), 297-300.
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N, S. K., & Madhu, L. N.
(2011).
EFFECT OF ELECTRON BEAM RADIATION ON HEMATOPOIETIC CELLS OF SWISS ALBINO MICE. 01(01/03), 15-18.
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Kumari, S. N., & Madhu, L. N.
(2011).
EFFECT OF ELECTRON BEAM RADIATION ON HEMATOPOIETIC CELLS OF SWISS ALBINO MICE. 1(1-3), 15-18.
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Kumari N, S., K.M, D. G., N., S., & L. N, M.
(2011).
EFFECT OF YOGA THERAPY ON BODY MASS INDEX AND OXIDATIVE STATUS. 01(01/03), 10-14.
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Kumari, S. N., Gowda, D., Sukesh, N., Madhu, L. N., & Kathyayani.
(2011).
EFFECT OF YOGA THERAPY ON BODY MASS INDEX AND OXIDATIVE STATUS. 1(1-3), 10-14.
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Naveen, P., Suchetha Kumari, N., Sanjeev, G., Damodara Gowda, K. M., & Madhu, L. N.
(2011).
Radioprotective effect of Nardostachys jatamansi against whole body electron beam induced oxidative stress and tissue injury in rats. Journal of Pharmacy Research.
4(7), 2197-2200.
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Siddartha, .., Rao, P., Kumari, N., Kumar, S., & Madhu, L. N.
(2010).
An epidemiology of prevalence of Type 2 Diabetes among the adult residents in Dakshina Kannada district. 1, 586-592.
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Shenoy, M., Suchetha Kumari, N., Shetty, G., Madhu, L. N., & Ramitha, K.
(2010).
Status of Lipid Perodixation And Sialic Acid in Generelised Vitiligo. 33-36.
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Li, H., Sarojini, B. K., Raj, C., Madhu, L. N., & Yathirajan, H. S.
(2008).
(E)-3-(3-Bromo-phen-yl)-1-(4-methyl-phenyl)prop-2-en-1-one. 64(Pt 11), o2238-U3069.
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Kodali, M., Madhu, L. N., Reger, R. L., Milutinovic, B., Upadhya, R., Gonzalez, J. J., ... Shetty, A. K.
(2023).
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction. 108, 118-134.
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conference paper
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Somayaji, Y., Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., & Shetty, A. K.
(2023).
Montelukast Treatment Attenuates Cognitive Dysfunction in a Model of Chronic Gulf War Illness With Modulation of Leukotriene Signaling and NLRP3-Inflammasome Activation. Cell Transplantation.
24-25.
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Kodali, M., Madhu, L. N., Reger, R., Milutinovic, B., Upadhya, R., Gonzalez, J. J., ... Shetty, A. K.
(2022).
HUMAN MSC-DERIVED EXTRACELLULAR VESICLE TREATMENT AFTER TBI CAN DIMINISH CHRONIC NEUROINFLAMMATION BY BLOCKING NLRP3 INFLAMMASOME-MEDIATED P38 MAPK SIGNALING CASCADE. JOURNAL OF NEUROTRAUMA.
A64-A65.
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Upadhya, R., Madhu, L. N., Attaluri, S., & Shetty, A. K.
(2021).
Modeling Neuroinflammation using iMicroglia Differentiated from hiPSCs: Efficacy of NSC-derived Extracellular Vesicles for Modulating Activated Microglia. Cell Transplantation.
22-22.
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Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K.
(2019).
Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. Cell Transplantation.
476-477.
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Suschetha Kumari, N., Madhu, L. N., Bhandary, S., Shetty, S., & Shetty, V.
(2012).
Evaluation of Erythrocyte antioxidant defense enzyme activity in electron beam irradiated mice. 169-173.
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Shetty, S., Suchethakumari, N., & Ln, M.
(2012).
Variations in Serum Myeloperoxidase Levels With Respect To Hyperglycemia, Duration of Diabetes, Bmi, Sex And Aging in Type 2 Diabetes Mellitus
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Suchetha Kumari, N., Madhu, L. N., & Sanjeev, G.
(2010).
Effect of Electron Beam radiation on Antioxidant status of Swiss albino mice. 413-416.
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Somayaji, Y., Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., & Shetty, A. K.
(2023).
Montelukast Treatment Attenuates Cognitive Dysfunction in a Model of Chronic Gulf War Illness With Modulation of Leukotriene Signaling and NLRP3-Inflammasome Activation. Cell Transplantation.
24-25.
Background
education and training
- Ph.D. in Biotechnology, Nitte University - (Mangalore, Karnataka, India) 2014
- M.Sc. in Biotechnology, Mangalore University - (Mangalore, Karnataka, India) 2009
- B.S. in Biochemistry, Botany, Zoology, St Aloysius College - (Mangalore, India) 2007
Contact
first name
- Madhu
has last name
- LN
Other
- lnmadhu802@tamu.edu