Protective Effect of Nardostachys jatamansi on Radiation Induced Anxiety and Oxidative Stress Academic Article uri icon

abstract

  • Background: Nardostachys jatamansi (family Valerianaceae), an indigenous medicinal plant induces in organism a state of resistance against stress. It helps to promote physical and mental health augment resistance of the body against disease and has shown potent antioxidant activity. Objectives: To study the anxiolytic and protective effect of 100mg of ethanolic extract of Nardostachys jatamansi was studied on the mice exposed to 6Gy Electron beam radiation (ERR). Methods: The animals were treated with 100mg of Nardostachys jatamansi extract (NJE) for 15 days before radiation exposure. The anxiety status of animals observed once for every 3 days during experiment period. The level of lipid peroxidation and glutathione (GSH) was estimated 15 days after irradiation. Results: The irradiation of animals resulted in an elevation in anxiety, lipid peroxidation and reduction in GSH. Treatment of mice with NJE before irradiation caused a significant depletion in anxiety, lipid peroxidation followed by significant elevation in GSH. Conclusion: Our results indicate that the protective activity of NJE on radiation induced anxiety and oxidative stress may be due to free radical scavenging and increased antioxidant level in mice.

published proceedings

  • Biomedicine

author list (cited authors)

  • Suchetha Kumari, N., & Madhu, L. N.

complete list of authors

  • Suchetha Kumari, N||Madhu, LN

publication date

  • July 2012