Protective Effect of Nardostachys jatamansi on Radiation Induced Anxiety and Oxidative Stress
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Background: Nardostachys jatamansi (family Valerianaceae), an indigenous medicinal plant induces in organism a state of resistance against stress. It helps to promote physical and mental health augment resistance of the body against disease and has shown potent antioxidant activity. Objectives: To study the anxiolytic and protective effect of 100mg of ethanolic extract of Nardostachys jatamansi was studied on the mice exposed to 6Gy Electron beam radiation (ERR). Methods: The animals were treated with 100mg of Nardostachys jatamansi extract (NJE) for 15 days before radiation exposure. The anxiety status of animals observed once for every 3 days during experiment period. The level of lipid peroxidation and glutathione (GSH) was estimated 15 days after irradiation. Results: The irradiation of animals resulted in an elevation in anxiety, lipid peroxidation and reduction in GSH. Treatment of mice with NJE before irradiation caused a significant depletion in anxiety, lipid peroxidation followed by significant elevation in GSH. Conclusion: Our results indicate that the protective activity of NJE on radiation induced anxiety and oxidative stress may be due to free radical scavenging and increased antioxidant level in mice.
