HR job title
- Professor
- Contact Info
- 1 979 436-0799
- ORCiD
- 0000-0001-8799-7250
Amrein, Hubert Professor
Positions
- Senior Associate Dean of Research, Texas A&M University Naresh K. Vashisht College of Medicine, Health Science Center
- Professor, Nutrition, College of Agriculture and Life Sciences
- Professor, Cell Biology and Genetics, Texas A&M University Naresh K. Vashisht College of Medicine
My broad research interests are concerned with the sensory perception of the external chemical world. The central questions investigated in our laboratory are concerned with how animals detect and discriminate among the thousands of different chemical signals that "flood" the olfactory and taste organs. Our laboratory uses Drosophila as a model to study these problems because the Drosophilachemosensory systems are structurally and functionally very similar to those of mammals, yet they are smaller and somewhat less complex, which makes them excellent models to investigate the molecular and neural basis of olfaction and taste.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
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academic article
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Miyamoto, T., Hedjazi, S., Miyamoto, C., & Amrein, H.
(2024).
Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling. Proceedings of the National Academy of Sciences of the United States of America.
121(30), e2319958121.
-
Ahn, J., & Amrein, H.
(2023).
Opposing chemosensory functions of closely related gustatory receptors. eLife.
12, rp89795.
-
Fujii, S., Ahn, J., Jagge, C., Shetty, V., Janes, C., Mohanty, A., ... Amrein, H.
(2023).
RNA Taste Is Conserved in Dipteran Insects. Journal of Nutrition.
153(5), 1636-1645.
-
Amrein, H., & Keene, A. C.
(2022).
Sensory biology: Thirsty glia motivate water consumption. Current Biology.
32(18), R949-R952.
-
Miyamoto, T., & Amrein, H.
(2019).
Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster. Current Biology.
29(8), 1263-1272.e5.
-
Mishra, D., Thorne, N., Miyamoto, C., Jagge, C., & Amrein, H.
(2018).
The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins. PLOS Biology.
16(8), e2005570-e2005570.
-
Ahn, J. E., Chen, Y., & Amrein, H.
(2017).
Abstract. eLife.
6.
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Ahn, J., Chen, Y., & Amrein, H.
(2017).
Molecular basis of fatty acid taste in Drosophila. eLife.
6, e30115.
-
Chen, Y., & Amrein, H.
(2017).
Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons. Current Biology.
27(18), 2741-2750.e4.
-
Fujii, S., Emery, P., & Amrein, H.
(2017).
SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons. Proceedings of the National Academy of Sciences of the United States of America.
114(32), E6669-E6677.
-
Miyamoto, T., & Amrein, H.
(2017).
Gluconeogenesis: An ancient biochemical pathway with a new twist. Fly.
11(3), 218-223.
-
Amrein, H., & Rattner, B.
(2017).
From the editors. Fly.
11(1), 1-2.
-
Fujii, S., Yavuz, A., Slone, J., Jagge, C., Song, X., & Amrein, H.
(2015).
Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing. Current Biology.
25(5), 621-627.
-
Amrein, H.
(2015).
An expression system for Gustatory receptorsAnd why it failed. 8(4), 232-233.
-
Yavuz, A., Jagge, C., Slone, J., & Amrein, H.
(2014).
A genetic tool kit for cellular and behavioral analyses of insect sugar receptors. Fly.
8(4), 189-196.
-
Chen, Y., & Amrein, H.
(2014).
Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses. Current Biology.
24(17), 1969-1977.
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Chen, Y., & Amrein, H.
(2014).
Enhancing Perception of Contaminated Food through Acid-Mediated Modulation of Taste Neuron Responses (vol 24, pg 1969, 2014). Current Biology.
24(17), 2071-2071.
-
Miyamoto, T., & Amrein, H.
(2014).
Diverse roles for the Drosophila fructose sensor Gr43a. Fly.
8(1), 19-25.
-
Mishra, D., Miyamoto, T., Rezenom, Y. H., Broussard, A., Yavuz, A., Slone, J., Russell, D. H., & Amrein, H.
(2013).
The molecular basis of sugar sensing in Drosophila larvae. Current Biology.
23(15), 1466-1471.
-
Miyamoto, T., Wright, G., & Amrein, H.
(2013).
Nutrient sensors. Current Biology.
23(9), R369-R373.
-
Miyamoto, T., Chen, Y., Slone, J., & Amrein, H.
(2013).
Identification of a Drosophila glucose receptor using Ca2+ imaging of single chemosensory neurons. PLoS ONE.
8(2), e56304-e56304.
-
Miyamoto, T., Slone, J., Song, X., & Amrein, H.
(2012).
A fructose receptor functions as a nutrient sensor in the Drosophila brain. Cell.
151(5), 1113-1125.
-
Wang, L., Han, X., Mehren, J., Hiroi, M., Billeter, J., Miyamoto, T., ... Anderson, D. J.
(2011).
Hierarchical chemosensory regulation of male-male social interactions in Drosophila. Nature Neuroscience.
14(6), 757-762.
-
Fujii, S., & Amrein, H.
(2010).
Ventral lateral and DN1 clock neurons mediate distinct properties of male sex drive rhythm in Drosophila. Proceedings of the National Academy of Sciences of the United States of America.
107(23), 10590-10595.
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Fujii, S., Toyama, A., & Amrein, H.
(2008).
A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster. Genetics.
180(1), 179-190.
-
Miyamoto, T., & Amrein, H.
(2008).
Suppression of male courtship by a Drosophila pheromone receptor. Nature Neuroscience.
11(8), 874-876.
-
Thorne, N., & Amrein, H.
(2008).
Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons. Journal of Comparative Neurology.
506(4), 548-568.
-
Slone, J., Daniels, J., & Amrein, H.
(2007).
Sugar receptors in Drosophila. Current Biology.
17(20), 1809-1816.
-
Ebbs, M. L., & Amrein, H.
(2007).
Taste and pheromone perception in the fruit fly Drosophila melanogaster. Pflugers Archiv European Journal of Physiology.
454(5), 735-747.
-
Fujii, S., Krishnan, P., Hardin, P., & Amrein, H.
(2007).
Nocturnal male sex drive in Drosophila. Current Biology.
17(3), 244-251.
-
Wolf, M. J., Amrein, H., Izatt, J. A., Choma, M. A., Reedy, M. C., & Rockman, H. A.
(2006).
Drosophila as a model for the identification of genes causing adult human heart disease. Proceedings of the National Academy of Sciences of the United States of America.
103(5), 1394-1399.
-
Amrein, H., & Thorne, N.
(2005).
Gustatory perception and behavior in Drosophila melanogaster. Current Biology.
15(17), R673-R684.
-
Thorne, N., Bray, S., & Amrein, H.
(2005).
Function and expression of the Drosophila gr genes in the perception of sweet, bitter and pheromone compounds. CHEMICAL SENSES.
30 Suppl 1(suppl_1), i270-i272.
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Larsson, M. C., Domingos, A. I., Jones, W. D., Chiappe, M. E., Amrein, H., & Vosshall, L. B.
(2004).
Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron.
43(5), 703-714.
-
Amrein, H.
(2004).
Pheromone perception and behavior in Drosophila. Current Opinion in Neurobiology.
14(4), 435-442.
-
Thorne, N., Chromey, C., Bray, S., & Amrein, H.
(2004).
Taste perception and coding in Drosophila. Current Biology.
14(12), 1065-1079.
-
Matsunami, H., & Amrein, H.
(2004).
Taste perception: how to make a gourmet mouse. Current Biology.
14(3), R118-R120.
-
Bray, S., & Amrein, H.
(2003).
A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship. Neuron.
39(6), 1019-1029.
-
Matsunami, H., & Amrein, H.
(2003).
Taste and pheromone perception in mammals and flies. 4(7), 220-220.
-
Thorne, N., & Amrein, H.
(2003).
Vomeronasal organ: pheromone recognition with a twist. Current Biology.
13(6), R220-R222.
-
Amrein, H., & Bray, S.
(2003).
Bitter-sweet solution in taste transduction. Cell.
112(3), 283-284.
-
Fujii, S., & Amrein, H.
(2002).
Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. 21(20), 5353-5363.
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Dunipace, L., Meister, S., McNealy, C., & Amrein, H.
(2001).
Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Current Biology.
11(11), 822-835.
-
Warr, C. G., Vosshall, L. B., Amrein, H. O., Carlson, J. R., Gao, Q., & Smith, D. P.
(2000).
A unified nomenclature system for the Drosophila odorant receptors. Drosophila Odorant Receptor Nomenclature Committee. Cell.
102(2), 145-146.
-
Amrein, H.
(2000).
Multiple RNA-protein interactions in Drosophila dosage compensation. 1(6), XV-XVI.
-
Amrein, H.
(2000).
Multiple RNA-protein interactions in Drosophila dosage compensation. 1(6), REVIEWS1030-reviews1030.1.
-
Vosshall, L. B., Amrein, H., Morozov, P. S., Rzhetsky, A., & Axel, R.
(1999).
A spatial map of olfactory receptor expression in the Drosophila antenna. Cell.
96(5), 725-736.
-
Amrein, H., & Axel, R.
(1997).
Genes expressed in neurons of adult male Drosophila. Cell.
88(4), 459-469.
-
Hedley, M. L., Amrein, H., & Maniatis, T.
(1995).
An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proceedings of the National Academy of Sciences of the United States of America.
92(25), 11524-11528.
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Hilfiker, A., Amrein, H., Dbendorfer, A., Schneiter, R., & Nthiger, R.
(1995).
The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila. Development.
121(12), 4017-4026.
-
Amrein, H., Hedley, M. L., & Maniatis, T.
(1994).
The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell.
76(4), 735-746.
-
Amrein, H., Maniatis, T., & Nthiger, R.
(1990).
Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. 9(11), 3619-3629.
-
Steinmann-Zwicky, M., Amrein, H., & Nthiger, R.
(1990).
Genetic control of sex determination in Drosophila. Advances in genetics.
27(C), 189-237.
-
Amrein, H., Gorman, M., & Nthiger, R.
(1988).
The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell.
55(6), 1025-1035.
-
Ahn, J., & Amrein, H.
Opposing chemosensory functions of closely related gustatory receptors. eLife.
12.
-
Miyamoto, T., Hedjazi, S., Miyamoto, C., & Amrein, H.
(2024).
Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling. Proceedings of the National Academy of Sciences of the United States of America.
121(30), e2319958121.
-
chapter
-
Amrein, H.
(2016).
Mechanism of Taste Perception in Drosophila. Chemosensory Transduction.
(pp. 245-269).
Elsevier.
-
Amrein, H.
(2016).
Chapter 14 Mechanism of Taste Perception in Drosophila. Chemosensory Transduction.
(pp. 245-269).
Elsevier.
-
Amrein, H.
(2016).
Mechanism of Taste Perception in Drosophila. Chemosensory Transduction.
(pp. 245-269).
Elsevier.
-
conference paper
-
Simcock, N. K., Miriyala, A., Wright, G. A., & Amrein, H.
(2019).
The sugar taste of honeybees. CHEMICAL SENSES.
E15-E15.
-
Ahn, J., Mishra, D., Jagge, C., Miyamoto, C., & Amrein, H.
(2019).
The taste of RNA in insects. CHEMICAL SENSES.
E119-E120.
-
Amrein, H., Mishra, D., Thorne, N., Miyamoto, C., & Jagge, C.
(2019).
The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins. CHEMICAL SENSES.
E8-E9.
-
Amrein, H., & Miyamoto, T.
(2018).
Neuronal gluconeogenesis regulates systemic glucose homeostasis. CHEMICAL SENSES.
E6-E6.
-
Chen, Y., & Amrein, H.
(2018).
Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Sensory Neurons. CHEMICAL SENSES.
E37-E38.
-
Amrein, H., Chen, Y., & Ahn, J.
(2016).
Distinct molecular receptors mediate sweet and fatty acid taste through overlapping sets of taste neurons. CHEMICAL SENSES.
391-391.
-
Amrein, H., Chen, Y., & Ahn, J.
(2016).
Ionotropic Receptors mediate sour and fatty acid taste in Drosophila. CHEMICAL SENSES.
E121-E121.
-
Miyamoto, T., & Amrein, H.
(2009).
Axons of Gustatory Receptor 32a Expressing Neurons Extend Their Terminal Throughout Adult Lifetime. CHEMICAL SENSES.
A3-A4.
-
Wolf, M. J., Amrein, H., Izatt, J. A., Reedy, M., & Rockman, H. A.
(2005).
Genome-wide screen in adult drosophila to identify novel cardiomyopathy genes. Circulation.
U47-U47.
-
Wolf, M. J., Amrein, H., Izatt, J. A., Reedy, M., & Rockman, H. A.
(2005).
Genome-wide screen in adult drosophila to identify novel cardiomyopathy genes. Circulation.
U26-U26.
-
Simcock, N. K., Miriyala, A., Wright, G. A., & Amrein, H.
(2019).
The sugar taste of honeybees. CHEMICAL SENSES.
E15-E15.
-
institutional repository document
-
Miyamoto, T., Hedjazi, S., Miyamoto, C., & Amrein, H.
(2023).
Drosophila Neuronal Glucose 6 Phosphatase is a modulator of Neuropeptide Release that regulates muscle glycogen stores via FMRFamide signaling
-
Ahn, J., & Amrein, H.
(2023).
Opposing chemosensory functions of closely related gustatory receptors
-
Miyamoto, T., & Amrein, H.
(2018).
Neuronal Gluconeogenesis Regulate Systemic Glucose Homeostasis
-
Miyamoto, T., Hedjazi, S., Miyamoto, C., & Amrein, H.
(2023).
Drosophila Neuronal Glucose 6 Phosphatase is a modulator of Neuropeptide Release that regulates muscle glycogen stores via FMRFamide signaling
Research
principal investigator on
- The taste of ribonucleosides: The molecular and cellular basis underlying chemosensory detection of previously unknown macronutrients awarded by National Institute on Deafness and Other Communication Disorders - (Bethesda, Maryland, United States) 2020 - 2025
- Modulation of peptidergic neurons by the gluconeogenic enzyme Glucose-6-Phosphatase awarded by National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States) 2020 - 2022
- Taste Receptor Coding awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2020
- Convergence of Cellular and Molecular Pathways in Appetitive Taste awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2020
- Gustatory Receptors sense RNA and ribonuclcic acid metabolites as nutrients and signaling molecules during rapid growth awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2019
- Regulation of Feeding Behavior by Brain-based Nutrient Sensors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2019
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS491 Hnr-research Instructor
- GENE491 Hnr-research Instructor
- GENE608 Crit Analysis Gene Lit Director
- GENE677 Genes And Diseases Instructor
- GENE691 Research Instructor
- MCMD677 Genes And Diseases Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NFSC691 Research Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NUTR691 Research Instructor
Works By Students
chaired theses and dissertations
-
Yavuz, Ahmet E (2017-12). Molecular Basis of Sugar Sensing in Drosophila.
Background
education and training
- Ph.D. in Molecular Genetics, University of Zurich - (Zurich, Switzerland) 1989
- B.S. in Genetics and Molecular Biology, University of Zurich - (Zurich, Switzerland) 1983
- Columbia University - (New York, New York, United States) , Postdoctoral Training 1998
- Harvard University - (Cambridge, Massachusetts, United States) , Postdoctoral Training 1991
awards and honors
- College of Medicine, Research Excellence Award, Senior Division, conferred by Texas A&M University - (College Station, Texas, United States), 2014
- Senior Fellow Award, Swiss National Science Foundation Laboratory of Dr. R. Axel, conferred by Columbia University - (New York, New York, United States), 1991
- Long Term Fellow Award, European Molecular Biology Organization Laboratory of Dr. T. Maniatis, conferred by Harvard University - (Cambridge, Massachusetts, United States), 1989
Contact
first name
- Hubert
has last name
- Amrein
mailing address
-
Cell Biology and Genetics
School of Medicine
4350 MREB 2
Bryan, TX 77807
USA
Other
- amrein@tamu.edu