Genes expressed in neurons of adult male Drosophila. Academic Article

abstract

• We have identified two genes, roX1 and roX2, whose expression in the adult fly is restricted to neurons of males. The two genes reside on the X chromosome, and each encodes an RNA with no apparent open reading frame. Both genes are physically linked to female-specific genes that encode proteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin family. The male-specific transcripts are positively regulated by the dosage compensation pathway in an all-or-none fashion. Our data suggest that the multimeric complex of dosage compensation proteins may operate in different ways on different sets of X-linked genes.

authors

• Amrein, Hubert

published proceedings

• Cell

altmetric score

• 9

author list (cited authors)

• Amrein, H., & Axel, R.

citation count

• 192

complete list of authors

• Amrein, H||Axel, R

publication date

• February 1997

publisher

• Elsevier  Publisher

published in

• Cell  Journal

keywords

• Age Factors
• Animals
• Brain
• DNA, Complementary
• Drosophila Melanogaster
• Drosophila Proteins
• Female
• Ganglia, Invertebrate
• Gene Dosage
• Gene Expression
• Gene Expression Regulation, Developmental
• Gene Library
• Genes, Insect
• Genetic Linkage
• Insect Hormones
• Male
• Molecular Sequence Data
• Neurons
• Nuclear Proteins
• Peripheral Nervous System
• RNA, Messenger
• RNA-Binding Proteins
• Sequence Homology, Amino Acid
• Sex Determination Analysis
• Transcription, Genetic
• X Chromosome
• Y Chromosome

PubMed Central ID

• 9038337

Digital Object Identifier (DOI)

• 10.1016/s0092-8674(00)81886-3

start page

• 459

end page

• 469

volume

• 88

issue

• 4

URL

• http://dx.doi.org/10.1016/s0092-8674(00)81886-3