The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein.

abstract

• The gene transformer-2 (tra-2) of Drosophila is necessary not only for female sexual differentiation but also for normal spermatogenesis in males. We have cloned and characterized the tra-2 gene. Its putative protein has a domain that is homologous to RNA binding proteins. This suggests that the tra-2 protein might achieve the female-specific splicing of the transcript of dsx, a sex-determining gene whose mode of expression depends on tra-2. The protein coding region of the tra-2 transcript is identical in males and females. In both sexes, a low level of transcript is present in the soma and a high level in the germ line. This indicates that tra-2 is regulated in a way different from other sex-determining genes.

authors

• Amrein, Hubert

published proceedings

• Cell

altmetric score

• 6

author list (cited authors)

• Amrein, H., Gorman, M., & Nthiger, R.

citation count

• 230

complete list of authors

• Amrein, H||Gorman, M||Nöthiger, R

publisher

• Elsevier  Publisher

published in

• Cell  Journal

keywords

• Animals
• Base Sequence
• Carrier Proteins
• Cloning, Molecular
• Drosophila
• Female
• Gene Expression Regulation
• Male
• Molecular Sequence Data
• RNA-Binding Proteins
• Sex Differentiation
• Spermatogenesis
• Transcription, Genetic

PubMed Central ID

• 3144434

Digital Object Identifier (DOI)

• 10.1016/0092-8674(88)90247-4

start page

• 1025

end page

• 1035

volume

• 55

issue

• 6

URL

• https://doi.org/10.1016/0092-8674(88)90247-4