Genetic control of sex determination in Drosophila. Academic Article uri icon


  • This chapter presents Bridges' classic model that attempted to explain how sex is determined in Drosophil. Bridges visualized this signal as the result of two sets of counteracting elements, with the X chromosomes carrying female-determining factors and the autosomes male-determining factors. This chapter concentrates on the sex determination pathway in somatic cells, but it also discusses some aspects of dosage compensation and sex determination in the germ line because the three processes are in part controlled by the same genes. Moreover, this chapter deals with the second step from Sxl to dsx. It also explains how it might implement differential activity of Sxl. The chapter addresses the question of how dsx achieves differential expression of those genes that actually produce the sexual dimorphism at the phenotypical level. 1990 Academic Press Inc.

published proceedings

  • Adv Genet

author list (cited authors)

  • Steinmann-Zwicky, M., Amrein, H., & Nthiger, R.

citation count

  • 96

complete list of authors

  • Steinmann-Zwicky, M||Amrein, H||Nöthiger, R

publication date

  • January 1990