HR job title
- Retired Associate Professor
- Contact Info
- 1 254 742 7033
Zhang, Shenyuan Associate Professor
Positions
- Associate Professor, Medical Physiology, College of Medicine
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Li, J., Yan, B., Si, H., Peng, X. u., Zhang, S. L., & Hu, J.
(2017).
Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth. Scientific Reports.
7(1), 43490.
-
Li, J., Liu, Y., Jin, Y., Wang, R., Wang, J., Lu, S., ... Peng, X. u.
(2017).
Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development. Developmental Biology.
421(2), 271-283.
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Alluri, H., Grimsley, M., Anasooya Shaji, C., Varghese, K. P., Zhang, S. L., Peddaboina, C., ... Tharakan, B.
(2016).
Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. 291(53), 26958-26969.
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Wei, M., Zhou, Y., Sun, A., Ma, G., He, L., Zhou, L., ... Wang, Y.
(2016).
Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate. Pfluegers Archiv: European journal of physiology.
468(11-12), 2061-2074.
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Jing, J. i., He, L., Sun, A., Quintana, A., Ding, Y., Ma, G., ... Zhou, Y.
(2015).
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca influx. Nature Cell Biology.
17(10), 1339-1347.
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Jafarnejad, M., Cromer, W. E., Kaunas, R. R., Zhang, S. L., Zawieja, D. C., & Moore, J. E.
(2015).
Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology.
308(7), H697-H706.
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Ma, G., Wei, M., He, L., Liu, C., Wu, B. o., Zhang, S. L., ... Zhou, Y.
(2015).
Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. Nature Communications.
6(1), 7826.
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Zhou, M., Zheng, H., Si, H., Jin, Y., Peng, J. M., He, L., ... Zhang, S. L.
(2014).
Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. Journal of Biological Chemistry.
289(42), 29446-29456.
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Jin, Y., Liu, Y., Lin, Q., Li, J., Druso, J. E., Antonyak, M. A., ... Peng, X. u.
(2013).
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Molecular and Cellular Biology.
33(21), 4181-4197.
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Zheng, H., Zhou, M., Hu, C., Kuo, E., Peng, X. u., Hu, J., Kuo, L., & Zhang, S. L.
(2013).
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation. Journal of Biological Chemistry.
288(16), 11263-11272.
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Greenberg, M. L., Yu, Y., Leverrier, S., Zhang, S. L., Parker, I., & Cahalan, M. D.
(2013).
Orai1 function is essential for T cell homing to lymph nodes. Journal of Immunology.
190(7), 3197-3206.
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Estrada, I. A., Donthamsetty, R., Debski, P., Zhou, M., Zhang, S. L., Yuan, J., Han, W., & Makino, A.
(2012).
STIM1 restores coronary endothelial function in type 1 diabetic mice. 111(9), 1166-1175.
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Zhang, S., & Zheng, H.
(2012).
The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways. Methods in molecular biology (Clifton, N.J.).
843, 217-227.
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Zhang, S. L., Yeromin, A. V., Hu, J., Amcheslavsky, A., Zheng, H., & Cahalan, M. D.
(2011).
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proceedings of the National Academy of Sciences of the United States of America.
108(43), 17838-17843.
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Flach, H., Rosenbaum, M., Duchniewicz, M., Kim, S., Zhang, S. L., Cahalan, M. D., Mittler, G., & Grosschedl, R.
(2010).
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity.
33(5), 723-735.
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Yu, Y., Keller, S. H., Remillard, C. V., Safrina, O., Nicholson, A., Zhang, S. L., ... Yuan, J.
(2009).
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation.
119(17), 2313-2322.
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Zhang, S. L., Kozak, J. A., Jiang, W., Yeromin, A. V., Chen, J., Yu, Y., ... Cahalan, M. D.
(2008).
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. 283(25), 17662-17671.
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Lioudyno, M. I., Kozak, J. A., Penna, A., Safrina, O., Zhang, S. L., Sen, D., ... Cahalan, M. D.
(2008).
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proceedings of the National Academy of Sciences of the United States of America.
105(6), 2011-2016.
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Penna, A., Demuro, A., Yeromin, A. V., Zhang, S. L., Safrina, O., Parker, I., & Cahalan, M. D.
(2008).
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature.
456(7218), 116-120.
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Zhang, S., & Cahalan, M. D.
(2007).
Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit. Journal of Visualized Experiments.
247.
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Cahalan, M. D., Zhang, S. L., Yeromin, A. V., Ohlsen, K., Roos, J., & Stauderman, K. A.
(2007).
Molecular basis of the CRAC channel. Cell Calcium.
42(2), 133-144.
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Zhang, S. L., Yeromin, A. V., Zhang, X., Yu, Y., Safrina, O., Penna, A., ... Cahalan, M. D.
(2006).
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proceedings of the National Academy of Sciences of the United States of America.
103(24), 9357-9362.
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Yeromin, A. V., Zhang, S. L., Jiang, W., Yu, Y., Safrina, O., & Cahalan, M. D.
(2006).
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature.
443(7108), 226-229.
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Roos, J., DiGregorio, P. J., Yeromin, A. V., Ohlsen, K., Lioudyno, M., Zhang, S., ... Stauderman, K. A.
(2005).
STIM1, an essential and conserved component of store-operated Ca2+ channel function. Journal of Cell Biology.
169(3), 435-445.
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Zhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D.
(2005).
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature.
437(7060), 902-905.
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Zhang, S., Sokolchik, I., Blanco, G., & Sze, J. Y.
(2004).
Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons. Development.
131(7), 1629-1638.
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Sze, J. Y., Zhang, S., Li, J., & Ruvkun, G.
(2002).
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development.
129(16), 3901-3911.
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Liu, Y., Jin, Y., Li, J., Seto, E., Kuo, E., Yu, W., ... Peng, X. u.
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects. Developmental Biology.
383(2), 239-252.
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Li, J., Yan, B., Si, H., Peng, X. u., Zhang, S. L., & Hu, J.
(2017).
Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth. Scientific Reports.
7(1), 43490.
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chapter
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Penna, A., Zhang, S. L., Yeromin, A. V., & Cahalan, M. D.
(2010).
Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai. Handbook of Cell Signaling.
(pp. 209-216).
Elsevier.
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Penna, A., Zhang, S. L., Yeromin, A. V., & Cahalan, M. D.
(2010).
Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai. Handbook of Cell Signaling.
(pp. 209-216).
Elsevier.
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conference paper
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Zhang, S., Price, D., Qian, X., Gupta, A., Wong, M., Ellisman, M. H., & Martone, M. E.
(2003).
A Cell Centered Database (CCDB) for multi-scale microscopy data management. Microscopy and Microanalysis.
1502-1503.
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Zhang, S., Price, D., Qian, X., Gupta, A., Wong, M., Ellisman, M. H., & Martone, M. E.
(2003).
A Cell Centered Database (CCDB) for multi-scale microscopy data management. Microscopy and Microanalysis.
1502-1503.
Research
co-principal investigator on
Teaching
teaching activities
- MEID605 Foundations Of Medicine I Instructor
- MPHY601 Exper Tech In Cell & Mole Bio Instructor
- MPHY633 Adv Tech In Card Research Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Physiology and Biophysics, University of California, Irvine - (Irvine, California, United States) 2005
- B.S. in Physiology and Biophysics, Fudan University - (Shanghai, Shanghai, China) 2000
- University of California, Irvine - (Irvine, California, United States) , Postdoctoral Training 2009
Contact
first name
- Shenyuan
has last name
- Zhang
mailing address
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Texas A&M Health Science Center
Medical Physiology
1114 TAMUS
Temple, TX 76504
USA
Other
- shenyuan.zhang@tamu.edu