Molecular basis of the CRAC channel. Academic Article

abstract

• Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitting Ca(2+) entry and sustained [Ca(2+)](i) signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade that is initiated by T cell receptor engagement and leads to altered expression of genes that results ultimately in the production of cytokines and cell proliferation. In the past three years, RNA interference screens together with over-expression and site-directed mutagenesis have identified the triggering molecule (Stim) that links store depletion to CRAC channel-mediated Ca(2+) influx and the pore subunit (Orai) of the CRAC channel that allows highly selective entry of Ca(2+) ions into cells.

authors

• Zhang, Shenyuan

published proceedings

• Cell Calcium

author list (cited authors)

• Cahalan, M. D., Zhang, S. L., Yeromin, A. V., Ohlsen, K., Roos, J., & Stauderman, K. A.

citation count

• 133

complete list of authors

• Cahalan, Michael D||Zhang, Shenyuan L||Yeromin, Andriy V||Ohlsen, Kari||Roos, Jack||Stauderman, Kenneth A

publication date

• January 2007

publisher

• Elsevier  Publisher

published in

• Cell Calcium  Journal

keywords

• Amino Acid Sequence
• Animals
• Calcium Channels
• Drosophila Proteins
• Humans
• Membrane Proteins
• Molecular Sequence Data
• ORAI1 Protein
• RNA Interference
• Stromal Interaction Molecule 1
• T-Lymphocytes

Digital Object Identifier (DOI)

• 10.1016/j.ceca.2007.03.002

start page

• 133

end page

• 144

volume

• 42

issue

• 2

URL

• http://dx.doi.org/10.1016/j.ceca.2007.03.002