selected publications academic article Li, J., Yan, B., Si, H., Peng, X. u., Zhang, S. L., & Hu, J (2017). Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth. Scientific Reports. 7(1), 43490. Alluri, H., Grimsley, M., Anasooya Shaji, C., Varghese, K. P., Zhang, S. L., Peddaboina, C., ... Tharakan, B (2016). Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. Journal of Biological Chemistry. 291(53), 26958-26969. Wei, M., Zhou, Y., Sun, A., Ma, G., He, L., Zhou, L., ... Wang, Y (2016). Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate. Pfluegers Archiv: European journal of physiology. 468(11-12), 2061-2074. Ma, G., Wei, M., He, L., Liu, C., Wu, B. o., Zhang, S. L., ... Zhou, Y (2015). Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. NATURE COMMUNICATIONS. 6(1), 7826. Jing, J. i., He, L., Sun, A., Quintana, A., Ding, Y., Ma, G., ... Zhou, Y. (2015). Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca influx. Nature Cell Biology. Zhou, M., Zheng, H., Si, H., Jin, Y., Peng, J. M., He, L., ... Zhang, S. L (2014). Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. Journal of Biological Chemistry. 289(42), 29446-29456. Jin, Y., Liu, Y., Lin, Q., Li, J., Druso, J. E., Antonyak, M. A., ... Peng, X. u (2013). Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol. 33(21), 4181-4197. Liu, Y., Jin, Y., Li, J., Seto, E., Kuo, E., Yu, W., ... Peng, X. u (2013). Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects. Dev Biol. 383(2), 239-252. Zheng, H., Zhou, M., Hu, C., Kuo, E., Peng, X. u., Hu, J., Kuo, L., & Zhang, S. L (2013). Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation. Journal of Biological Chemistry. 288(16), 11263-11272. Zhang, S., & Zheng, H (2012). The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways. Methods Mol Biol. 843, 217-227. Estrada, I. A., Donthamsetty, R., Debski, P., Zhou, M., Zhang, S. L., Yuan, J., Han, W., & Makino, A (2012). STIM1 restores coronary endothelial function in type 1 diabetic mice. CIRCULATION RESEARCH. 111(9), 1166-1175. Yu, Y., Keller, S. H., Remillard, C. V., Safrina, O., Nicholson, A., Zhang, S. L., ... Yuan, J (2009). A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 119(17), 2313-2322. Zhang, S. L., Kozak, J. A., Jiang, W., Yeromin, A. V., Chen, J., Yu, Y., ... Cahalan, M. D (2008). Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. Journal of Biological Chemistry. 283(25), 17662-17671. Lioudyno, M. I., Kozak, J. A., Penna, A., Safrina, O., Zhang, S. L., Sen, D., ... Cahalan, M. D (2008). Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proceedings of the National Academy of Sciences of USA. 105(6), 2011-2016. Cahalan, M. D., Zhang, S. L., Yeromin, A. V., Ohlsen, K., Roos, J., & Stauderman, K. A (2007). Molecular basis of the CRAC channel. Cell Calcium. 42(2), 133-144. Zhang, S., & Cahalan, M. D (2007). Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit. Journal of Visualized Experiments. 247. Yeromin, A. V., Zhang, S. L., Jiang, W., Yu, Y., Safrina, O., & Cahalan, M. D (2006). Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature. 443(7108), 226-229. Zhang, S. L., Yeromin, A. V., Zhang, X., Yu, Y., Safrina, O., Penna, A., ... Cahalan, M. D (2006). Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proceedings of the National Academy of Sciences of USA. 103(24), 9357-9362. Zhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D (2005). STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 437(7060), 902-905. Roos, J., DiGregorio, P. J., Yeromin, A. V., Ohlsen, K., Lioudyno, M., Zhang, S., ... Stauderman, K. A (2005). STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 169(3), 435-445. Zhang, S., Sokolchik, I., Blanco, G., & Sze, J. Y (2004). Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons. Development (Cambridge). 131(7), 1629-1638. Sze, J. Y., Zhang, S., Li, J., & Ruvkun, G (2002). The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (Cambridge). 129(16), 3901-3911. chapter Penna, A., Zhang, S. L., Yeromin, A. V., & Cahalan, M. D. (2010). Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai. Handbook of Cell Signaling. (pp. 209-216). Elsevier. conference paper Zhang, S., Price, D., Qian, X., Gupta, A., Wong, M., Ellisman, M. H., & Martone, M. E (2003). A Cell Centered Database (CCDB) for multi-scale microscopy data management. MICROSCOPY AND MICROANALYSIS. 1502-1503.
co-principal investigator on Molecular Control of Calcium Influx at the ER-Plasma Membrane Junctions awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2023
teaching activities MPHY601 Exper Tech In Cell & Mole Bio Instructor MPHY633 Adv Tech In Card Research Instructor MSCI685 Directed Studies Instructor MSCI691 Research Credit: Medical Sci Instructor
education and training Ph.D. in Physiology and Biophysics, University of California, Irvine - (Irvine, California, United States) 2005 B.S. in Physiology and Biophysics, Fudan University - (Shanghai, Shanghai, China) 2000 University of California, Irvine - (Irvine, California, United States) , Postdoctoral Training 2009