The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways. Academic Article

abstract

• Cardiovascular development is a precisely coordinated process at multilevels. It involves cross-talking among numerous signaling transduction pathways to ensure proper cell polarity, migration, proliferation, differentiation, and programmed death. Here, genome-wide RNA interference screens in Drosophila cells are introduced as novel approaches to discover potential regulators, with special emphases on (1) cell growth and viability, and (2) receptor tyrosine kinase and extracellular-signal-regulated kinase signaling pathway.

authors

• Zhang, Shenyuan

published proceedings

• Methods Mol Biol

author list (cited authors)

• Zhang, S., & Zheng, H.

citation count

• 0

complete list of authors

• Zhang, Shenyuan||Zheng, Hongying

publication date

• February 2012

publisher

• Springer Nature  Publisher

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Animals
• Cell Line
• Cell Proliferation
• Cell Survival
• Drosophila Melanogaster
• Extracellular Signal-Regulated MAP Kinases
• Genomics
• RNA Interference
• RNA, Double-Stranded
• Reference Standards
• Signal Transduction

PubMed Central ID

• 22222536

Digital Object Identifier (DOI)

• 10.1007/978-1-61779-523-7_21

start page

• 217

end page

• 227

volume

• 843

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2F978-1-61779-523-7_21