HR job title
- Retired Associate Professor
- Contact Info
- 214-370-7203
- Websites
- ORCiD
- 0000-0003-1058-2772
Groppe, Jay Associate Professor
Positions
- Associate Professor, Biomedical Sciences, School of Dentistry
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Wentworth, K. L., Lalonde, R. L., Groppe, J. C., Brewer, N., Moody, T., Hansberry, S., ... Hsiao, E. C.
(2022).
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models. 37(11), 2058-2076.
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Kaplan, F. S., Groppe, J. C., Xu, M., Towler, O. W., Grunvald, E., Kalunian, K., ... Shore, E. M.
(2022).
An ACVR1R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva. American Journal of Medical Genetics, Part A.
188(3), 806-817.
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Groppe, J. C.
(2019).
Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy. Expert Opinion on Drug Discovery.
14(12), 1237-1253.
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Lu, G., Tandang-Silvas, M. R., Dawson, A. C., Dawson, T. J., & Groppe, J. C.
(2018).
Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification. BONE.
112, 71-89.
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Wang, H., Lindborg, C., Lounev, V., Kim, J., McCarrick-Walmsley, R., Xu, M., ... Pignolo, R. J.
(2016).
Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling. Journal of Bone and Mineral Research.
31(9), 1652-1665.
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Kaplan, F. S., Kobori, J. A., Orellana, C., Calvo, I., Rosello, M., Martinez, F., ... Groppe, J. C.
(2015).
Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients. American Journal of Medical Genetics, Part A.
167A(10), 2265-2271.
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Whitman, M., Rosen, V., Brivanlou, A. H., Groppe, J. C., Sebald, W., & Mueller, T.
(2013).
Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nature Medicine.
19(7), 809-810.
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Wang, X., Wang, S., Li, C., Gao, T., Liu, Y., Rangiani, A., ... Qin, C.
(2012).
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. 8(5), e1002708-e1002708.
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Zimmer, J., Doelken, S. C., Horn, D., Groppe, J. C., Shore, E. M., Kaplan, F. S., & Seemann, P.
(2012).
Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance. PLoS ONE.
7(4), e35062-e35062.
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Ishii, Y., Takizawa, T., Iwasaki, H., Fujita, Y., Murakami, M., Groppe, J. C., & Tanaka, K.
(2012).
Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds. Biochemical Genetics.
50(1-2), 12-18.
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Zuniga, J. E., Ilangovan, U., Mahlawat, P., Hinck, C. S., Huang, T., Groppe, J. C., McEwen, D. G., & Hinck, A. P.
(2011).
The TR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding. Journal of Molecular Biology.
412(4), 601-618.
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HE, G., BROWNE, K. A., GROPPE, J. C., BLASKO, A., MEI, H., & BRUICE, T. C.
(2010).
ChemInform Abstract: Microgonotropens and Their Interactions with DNA. Part 1. Synthesis of the Tripyrrole Peptides DienMicrogonotropena, b, and c and Characterization of Their Interactions with dsDNA. ChemInform.
24(49), no-no.
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Seemann, P., Brehm, A., Knig, J., Reissner, C., Stricker, S., Kuss, P., ... Mundlos, S.
(2009).
Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. PLOS Genetics.
5(11), e1000747-e1000747.
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Nickel, J., Sebald, W., Groppe, J. C., & Mueller, T. D.
(2009).
Intricacies of BMP receptor assembly. Cytokine and Growth Factor Reviews.
20(5-6), 367-377.
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Wang, Y., Groppe, J. C., Wu, J., Ogawa, T., Mues, G., D'Souza, R. N., & Kapadia, H.
(2009).
Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9. Human Molecular Genetics.
18(15), 2863-2874.
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Groppe, J. C., Shore, E. M., & Kaplan, F. S.
(2007).
Functional modeling of the ACVR1 (R206H) mutation in FOP. 462(462), 87-92.
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Ziga, J. E., Groppe, J. C., Cui, Y., Hinck, C. S., Contreras-Shannon, V., Pakhomova, O. N., ... Hinck, A. P.
(2005).
Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent. Journal of Molecular Biology.
354(5), 1052-1068.
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Ilangovan, U., Ding, W., Zhong, Y., Wilson, C. L., Groppe, J. C., Trbovich, J. T., ... Hinck, A. P.
(2005).
Structure and dynamics of the homodimeric dynein light chain km23. Journal of Molecular Biology.
352(2), 338-354.
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Perrin, M. H., Fischer, W. H., Kunitake, K. S., Craig, A. G., Koerber, S. C., Cervini, L. A., ... Vale, W. W.
(2001).
Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. 276(34), 31528-31534.
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Degnan, B. M., Groppe, J. C., & Morse, D. E.
(1995).
Chymotrypsin mRNA expression in digestive gland amoebocytes: cell specification occurs prior to metamorphosis and gut morphogenesis in the gastropod, Haliotis rufescens. Development, Genes and Evolution.
205(1-2), 97-101.
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Groppe, J. C., & Morse, D. E.
(1995).
Sequence-independent detection of gene family homologs: identification of a transcript encoding a molluscan serine protease homologous to the pancreatic enzymes of vertebrates. Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology.
110(1), 75-82.
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HE, G. X., BROWNE, K. A., GROPPE, J. C., BLASKO, A., MEI, H. Y., & BRUICE, T. C.
(1993).
MICROGONOTROPENS AND THEIR INTERACTIONS WITH DNA .1. SYNTHESIS OF THE TRIPYRROLE PEPTIDES DIEN-MICROGONOTROPEN-A, DIEN-MICROGONOTROPEN-B, AND DIEN-MICROGONOTROPEN-C AND CHARACTERIZATION OF THEIR INTERACTIONS WITH DSDNA. Journal of the American Chemical Society.
115(16), 7061-7071.
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Groppe, J. C., & Morse, D. E.
(1993).
Molluscan chymotrypsin-like protease: structure, localization, and substrate specificity. Archives of Biochemistry and Biophysics.
305(1), 159-169.
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Groppe, J. C., & Morse, D. E.
(1993).
Isolation of full-length RNA templates for reverse transcription from tissues rich in RNase and proteoglycans. Analytical Biochemistry.
210(2), 337-343.
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Reed, S. I., Ferguson, J., & Groppe, J. C.
(1982).
Preliminary characterization of the transcriptional and translational products of the Saccharomyces cerevisiae cell division cycle gene CDC28. Molecular and Cellular Biology.
2(4), 412-425.
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Ferguson, J., Groppe, J. C., & Reed, S. I.
(1981).
Construction and characterization of three yeast-Escherichia coli shuttle vectors designed for rapid subcloning of yeast genes on small DNA fragments. Gene.
16(1-3), 191-197.
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Wentworth, K. L., Lalonde, R. L., Groppe, J. C., Brewer, N., Moody, T., Hansberry, S., ... Hsiao, E. C.
(2022).
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models. 37(11), 2058-2076.
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chapter
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Kaplan, F. S., Groppe, J. C., Seemann, P., Pignolo, R. J., & Shore, E. M.
(2010).
Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene. BONE AND DEVELOPMENT.
(pp. 233-249).
Springer Nature.
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Kaplan, F. S., Groppe, J. C., Seemann, P., Pignolo, R. J., & Shore, E. M.
(2010).
Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene. BONE AND DEVELOPMENT.
(pp. 233-249).
Springer Nature.
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conference paper
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Groppe, J. C., Lu, G., Tandang-Silvas, M. R., Dawson, A., & Dawson, T.
(2018).
Hypoxia-selective allosteric destabilization and degradation of a receptor protein kinase: potential prophylaxis by H-SAAD/Ds. The FASEB Journal.
799.8-799.8.
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Groppe, J. C., Tandang-Silvas, M. R., Pathi, A., Wu, J., Lu, G., Le, V. Q., ... Kaplan, F. S.
(2016).
Activities of Dysregulated ALK2 Receptor Kinases Provide Insight Into the Protein Structural-Functional Basis of Fibrodysplasia Ossificans Progressiva. The FASEB Journal.
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Groppe, J. C., Lu, G., Dawson, A., & Dawson, T.
(2016).
Novel Allosteric Destabilizers as Therapeutics for Genetic Diseases and Trauma. The FASEB Journal.
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Groppe, J. C., Wu, J., Shore, E. M., & Kaplan, F. S.
(2011).
In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP. Cells, Tissues, Organs: in vivo, in vitro.
291-295.
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Groppe, J. C., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A. N., Kwiatkowski, W., ... Choe, S.
(2002).
Structural basis of BMP signalling inhibition by Noggin, a novel cystine knot protein. Molecular Biology of the Cell.
6A-6A.
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Groppe, J. C., Lu, G., Tandang-Silvas, M. R., Dawson, A., & Dawson, T.
(2018).
Hypoxia-selective allosteric destabilization and degradation of a receptor protein kinase: potential prophylaxis by H-SAAD/Ds. The FASEB Journal.
799.8-799.8.
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patent
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Groppe, J. C.
(2018).
Inhibitors of activin-like receptor kinases
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Groppe, J. C.
(2018).
Inhibitors of activin-like receptor kinases
Research
co-principal investigator on
Teaching
teaching activities
- OBIO601 Cellular And Molec Biology Instructor
Background
education and training
- Ph.D. in Biochemistry - Molecular Biology, University of California, Santa Barbara - (Santa Barbara, California, United States) 1991
- B.A. in Biochemistry - Molecular Biology, University of California, Santa Barbara - (Santa Barbara, California, United States) 1980
- University of Basel - (Basel, Basel-Stadt, Switzerland) , Postdoctoral Training 1999
- University of California, Santa Barbara - (Santa Barbara, California, United States) , Postdoctoral Training 1993
awards and honors
Contact
first name
- Jay
has last name
- Groppe
mailing address
-
Texas A&M University College of Dentistry
Biomedical Sciences
3302 Gaston Avenue
Dallas, TX 75246
USA
Other
- groppe@tamu.edu