HR job title
- Assistant Professor
- Contact Info
- ORCiD
- 0000-0001-8022-6760
Roy Sarkar, Tapasree Research Assistant Professor
Positions
- Research Assistant Professor, Biology, College of Arts and Sciences
Aberrant activation of the biological process, termed epithelial-mesenchymal transition (EMT) plays an important role
in the acquisition of malignant phenotypes as well as cancer stem (CSC) properties by epithelial cancer cells. EMT facilitates the metastatic dissemination which is the major cause of cancer related mortality. The main focus of my work is to identify the molecular mechanisms that induce EMT and to develop novel therapeutic strategies for preventing and treating metastasis.
in the acquisition of malignant phenotypes as well as cancer stem (CSC) properties by epithelial cancer cells. EMT facilitates the metastatic dissemination which is the major cause of cancer related mortality. The main focus of my work is to identify the molecular mechanisms that induce EMT and to develop novel therapeutic strategies for preventing and treating metastasis.
Research Areas
- Overview
- Publications
- Teaching
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Overview
Publications
selected publications
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academic article
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Nguyen, T., Maniyar, A., Sarkar, M., Sarkar, T. R., & Neelgund, G. M.
(2023).
The Cytotoxicity of Carbon Nanotubes and Hydroxyapatite, and Graphene and Hydroxyapatite Nanocomposites against Breast Cancer Cells. Nanomaterials.
13(3), 556-556.
-
Sarkar, M., Nguyen, T., Gundre, E., Ogunlusi, O., El-Sobky, M., Giri, B., & Sarkar, T. R.
(2023).
Cancer-associated fibroblasts: The chief architect in the tumor microenvironment. Frontiers in Cell and Developmental Biology.
11, 1089068.
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Rajput, S., Deo, K. A., Mathur, T., Lokhande, G., Singh, K. A., Sun, Y., ... Gaharwar, A. K.
(2022).
2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath. Bioprinting.
25, e00187-e00187.
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Dey, S., Murmu, N., Mondal, T., Saha, I., Chatterjee, S., Manna, R., ... Giri, B.
(2022).
Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection. Biomedicine and Pharmacotherapy.
156, 113801-113801.
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Sphyris, N., King, C., Hoar, J., Werden, S. J., Vijay, G. V., Miura, N., Gaharwar, A., & Sarkar, T. R.
(2021).
Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth. Oncotarget.
12(8), 823-844.
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Maity, A. K., Lee, S. C., Hu, L., Bell-Pedersen, D., Mallick, B. K., & Sarkar, T. R.
(2021).
Circadian Gene Selection for Time-to-event Phenotype by Integrating CNV and RNAseq Data. Chemometrics and Intelligent Laboratory Systems.
212, 104276-104276.
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Maity, A. K., Lee, S. C., Mallick, B. K., & Sarkar, T. R.
(2020).
Bayesian structural equation modeling in multiple omics data with application to circadian genes. Bioinformatics.
36(13), 3951-3958.
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Carrow, J. K., Singh, K. A., Jaiswal, M. K., Ramirez, A., Lokhande, G., Yeh, A. T., ... Gaharwar, A. K.
(2020).
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials. Proceedings of the National Academy of Sciences of USA.
117(24), 13329-13338.
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Pearson, S. J., Roy Sarkar, T., McQueen, C. M., Elswood, J., Schmitt, E. E., Wall, S. W., ... Porter, W. W.
(2019).
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene.
38(14), 2611-2626.
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Vijay, G. V., Zhao, N. a., Den Hollander, P., Toneff, M. J., Joseph, R., Pietila, M., ... Mani, S. A.
(2019).
GSK3 regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Research.
21(1), 37.
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Roy Sarkar, T., Maity, A. K., Niu, Y., & Mallick, B. K.
(2019).
Multiple Omics Data Integration to Identify Long Noncoding RNA Responsible for Breast Cancer-Related Mortality. Cancer Informatics.
18, 1176935119871933-117693511987193.
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McQueen, C. M., Schmitt, E. E., Sarkar, T. R., Elswood, J., Metz, R. P., Earnest, D., Rijnkels, M., & Porter, W. W.
(2018).
PER2 regulation of mammary gland development. Development (Cambridge).
145(6), dev157966.
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Bollong, M. J., Pietil, M., Pearson, A. D., Sarkar, T. R., Ahmad, I., Soundararajan, R., ... Lairson, L. L.
(2017).
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of USA.
114(46), E9903-E9912.
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Taube, J. H., Sphyris, N., Johnson, K. S., Reisenauer, K. N., Nesbit, T. A., Joseph, R., ... Mani, S. A.
(2017).
The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget.
8(39), 65548-65565.
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Mitra, S., Federico, L., Zhao, W., Dennison, J., Sarkar, T. R., Zhang, F., ... Mills, G. B.
(2016).
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget.
7(26), 40252-40265.
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Devaiah, S. P., Owens, D. K., Sibhatu, M. B., Sarkar, T. R., Strong, C. L., Mallampalli, V., ... McIntosh, C. A.
(2016).
Identification, Recombinant Expression, and Biochemical Analysis of Putative Secondary Product Glucosyltransferases from Citrus paradisi. Journal of Agricultural and Food Chemistry.
64(9), 1957-1969.
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Werden, S. J., Sphyris, N., Sarkar, T. R., Paranjape, A. N., LaBaff, A. M., Taube, J. H., ... Mani, S. A.
(2016).
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
35(46), 5977-5988.
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Sphyris, N., Sarkar, T. R., Battula, V. L., Andreeff, M., & Mani, S. A.
(2015).
GD2 and GD3 synthase: novel drug targets for cancer therapy. Molecular & cellular oncology.
2(3), e975068-e975068.
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Sarkar, T. R., Battula, V. L., Werden, S. J., Vijay, G. V., Ramirez-Pea, E. Q., Taube, J. H., ... Mani, S. A.
(2015).
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene.
34(23), 2958-2967.
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Putluri, N., Maity, S., Kommagani, R., Creighton, C. J., Putluri, V., Chen, F., ... Sreekumar, A.
(2014).
Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia.
16(5), 390-402.
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Hollier, B. G., Tinnirello, A. A., Werden, S. J., Evans, K. W., Taube, J. H., Sarkar, T. R., ... Mani, S. A.
(2013).
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Research.
73(6), 1981-1992.
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Malouf, G. G., Taube, J. H., Lu, Y., Roysarkar, T., Panjarian, S., Estecio, M. R., ... Issa, J.
(2013).
Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. 14(12), R144-R144.
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Sarkar, T. R., Sharan, S., Wang, J., Pawar, S. A., Cantwell, C. A., Johnson, P. F., ... Sterneck, E.
(2012).
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBP expression and contributes to transformation of breast tumor cells. Molecular and Cellular Biology.
32(2), 320-332.
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Wang, J., Sarkar, T. R., Zhou, M., Sharan, S., Ritt, D. A., Veenstra, T. D., ... Sterneck, E.
(2010).
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Proceedings of the National Academy of Sciences of USA.
107(37), 16131-16136.
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Pawar, S. A., Sarkar, T. R., Balamurugan, K., Sharan, S., Wang, J., Zhang, Y., ... Sterneck, E.
(2010).
C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Proceedings of the National Academy of Sciences of USA.
107(20), 9210-9215.
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Sarkar, T. R., & Irudayaraj, J.
(2008).
Carboxyl-coated magnetic nanoparticles for mRNA isolation and extraction of supercoiled plasmid DNA. Analytical Biochemistry.
379(1), 130-132.
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Nguyen, T., Maniyar, A., Sarkar, M., Sarkar, T. R., & Neelgund, G. M.
(2023).
The Cytotoxicity of Carbon Nanotubes and Hydroxyapatite, and Graphene and Hydroxyapatite Nanocomposites against Breast Cancer Cells. Nanomaterials.
13(3), 556-556.
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chapter
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Sarkar, T. R., McNeal, C. J., Meininger, C. J., Niu, Y., Mallick, B. K., Carroll, R. J., & Wu, G.
(2021).
Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans. Advances in Experimental Medicine and Biology.
Wu, G. (Eds.),
Amino Acids in Nutrition and Health. Advances in Experimental Medicine and Biology.
(pp. 211-227).
Springer International Publishing.
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Sarkar, T. R., McNeal, C. J., Meininger, C. J., Niu, Y., Mallick, B. K., Carroll, R. J., & Wu, G.
(2021).
Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans. Advances in Experimental Medicine and Biology.
Wu, G. (Eds.),
Amino Acids in Nutrition and Health. Advances in Experimental Medicine and Biology.
(pp. 211-227).
Springer International Publishing.
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conference paper
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Sarkar, T. R., Sphyris, N., Schmitt, E., Wyatt, G., Wall, S., & Porter, W.
(2018).
The role of effective energy restriction on metastatic tumor growth. The FASEB Journal.
811.2-811.2.
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Mendoza-Villanueva, D. Y., Kim, S., Ali, H. R., Sharan, S., Sarkar, T. R., Caldas, C., Landberg, G., & Sterneck, E.
(2013).
CEBPD (C/EBP delta) acts as a tumor suppressor in hormone receptor positive breast cancer cells and may serve as biomarker to predict the need for adjuvant therapy. Cancer Research.
3464-3464.
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Balamurugan, K., Sarkar, T. R., Wang, J. M., Sharan, S., Anver, M. M., Sterneck, E., & Leighty, R.
(2011).
The tumor suppressor C/EBP delta (CEBPD) promotes metastasis of MMTV-Neu mouse mammary tumors and augments mTOR/AKT/HIF-1 activity through inhibition of FBXW7 expression. Clinical and Experimental Metastasis.
185-185.
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Sarkar, T. R., Strong, C. L., Sibhatu, M. B., Pike, L. M., & McIntosh, C. A.
(2007).
Cloning, expression and characterization of a putative flavonoid glucosyltransferase from grapefruit (citrus paradisi) leaves. 247-+.
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Sarkar, T. R., Sphyris, N., Schmitt, E., Wyatt, G., Wall, S., & Porter, W.
(2018).
The role of effective energy restriction on metastatic tumor growth. The FASEB Journal.
811.2-811.2.
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institutional repository document
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Maity, A. K., Lee, S. C., Mallick, B. K., & Sarkar, T. R.
(2021).
Bayesian Structural Equation Modeling in Multiple Omics Data Integration with Application to Circadian Genes
-
Maity, A. K., Lee, S. C., Mallick, B. K., & Sarkar, T. R.
(2021).
Bayesian Structural Equation Modeling in Multiple Omics Data Integration with Application to Circadian Genes
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIOL291 Research Instructor
- BIOL451 Bioinformatics Instructor
- BIOL489 Sptp: Cancer Bioinformatics Instructor
- BIOL489 Sptp:cancer Bioinformatics Instructor
- BIOL491 Hnr-research Instructor
- BIOL651 Bioinformatics Instructor
- BIOL689 Sptp: Cancer Bioinformatics Instructor
- BIOL689 Sptp:cancer Bioinformatics Instructor
- BIOL691 Research Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- SCEN100 First Yr Seminar Instructor
Background
education and training
- Ph.D. in Biological Engineering, Purdue University - (West Lafayette, Indiana, United States) 2008
Contact
first name
- Tapasree
has last name
- Roy Sarkar
mailing address
-
Texas A & M University
525 Lubbock St
Butler Hall, 3258
College Station, TX 77843
USA
Other
- tsarkar@bio.tamu.edu