HR job title
- Associate Professor
- Contact Info
- 1 979 458 9248
- Websites
- ORCiD
- 0000-0002-8129-2871
Alge, Daniel Associate Professor
Positions
- Associate Professor, Biomedical Engineering, College of Engineering
- Faculty Affiliate, Institute for Engineering Education and Innovation, Texas A&M Engineering Experiment Station (TEES)
My research is in biomaterials, with an emphasis on biocompatibility and applications in tissue engineering and regenerative medicine.
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Deo, K. A., Murali, A., Tronolone, J. J., Mandrona, C., Lee, H. P., Rajput, S., ... Gaharwar, A. K.
(2024).
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Advanced healthcare materials.
e2303810.
-
Isaac, A. H., Recalde Phillips, S. Y., Ruben, E., Estes, M., Rajavel, V., Baig, T., ... Alge, D. L.
(2024).
Impact of PEG sensitization on the efficacy of PEG hydrogel-mediated tissue engineering. Nature Communications.
15(1), 3283.
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Tigner, T. J., Dampf, G., Tucker, A., Huang, Y., Jagrit, V., Clevenger, A. J., ... Alge, D. L.
(2024).
Clickable Granular Hydrogel Scaffolds for Delivery of Neural Progenitor Cells to Sites of Spinal Cord Injury. Advanced healthcare materials.
e2303912.
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Williams, T. J., Daboin, C., Kim, P., Guo, F., de Figueiredo, P., & Alge, D. L.
(2024).
Enzyme-functionalized alginate microparticles enable anaerobic culture under ambient oxygen. 121(1), 219-227.
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Tigner, T. J., Scull, G., Brown, A. C., & Alge, D. L.
(2023).
Microparticle Hydrogel Material Properties Emerge from Mixing-Induced Homogenization in a Poly(ethylene glycol) and Dextran Aqueous Two-Phase System. MACROMOLECULES.
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Lee, H., Davis, R., Wang, T., Deo, K. A., Cai, K. X., Alge, D. L., Lele, T. P., & Gaharwar, A. K.
(2023).
Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery. ACS Applied Bio Materials.
6(9), 3683-3695.
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Srivatsa Palakurthi, S., Bharat Charbe, N., Recalde Phillips, S. Y., Alge, D. L., Lu, D., & Palakurthi, S.
(2023).
Development of optimal in vitro release and permeation testing method for rectal suppositories. 640, 123042-123042.
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Williams, T. J., Jeevarathinam, A. S., Jivan, F., Baldock, V., Kim, P., McShane, M. J., & Alge, D. L.
(2023).
Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains. Journal of Materials Chemistry B.
11(8), 1749-1759.
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Jungmann, M. A., Recalde Phillips, S., Touchet, T. J., Brinson, B., Parish, K., Petersen, C., ... Alge, D. L.
(2023).
Swellable and Thermally Responsive Hydrogel/Shape Memory Polymer Foam Composites for Sealing Lung Biopsy Tracts. 9(2), 642-650.
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Patrick, C. W., Machek, J., Avazmohammadi, R., Alge, D. L., Peak, C. W., & McShane, M.
(2022).
Process for Faculty-Driven, Data-Informed Curriculum Continuity Review in Biomedical Engineering. 2(2), 265-280.
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Rajput, S., Deo, K. A., Mathur, T., Lokhande, G., Singh, K. A., Sun, Y., ... Gaharwar, A. K.
(2022).
2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath. Bioprinting.
25, e00187-e00187.
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Gregory, C. A., Lee, R. H., Liu, F., & Alge, D.
(2022).
Editorial: Approaches That Foster a Pro-Regenerative Environment. Frontiers in Bioengineering and Biotechnology.
10, 873375.
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Xin, S., Deo, K. A., Dai, J., Pandian, N., Chimene, D., Moebius, R. M., ... Alge, D. L.
(2021).
Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting. Science Advances.
7(42), eabk3087.
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Holt, S. E., Arroyo, J., Poux, E., Fricks, A., Agurcia, I., Heintschel, M., Rakoski, A., & Alge, D. L.
(2021).
Supramolecular Click Product Interactions Induce Dynamic Stiffening of Extracellular Matrix-Mimetic Hydrogels. Biomacromolecules.
22(7), 3040-3048.
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Jhan, Y., Palou Zuniga, G., Singh, K. A., Gaharwar, A. K., Alge, D. L., & Bishop, C. J.
(2021).
Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells. ACS Applied Bio Materials.
4(2), 1294-1306.
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Jeevarathinam, A. S., Guo, F., Williams, T., Smolen, J. A., Hyde, J. A., McShane, M. J., de Figueiredo, P., & Alge, D. L.
(2021).
Enzyme functionalized microgels enable precise regulation of dissolved oxygen and anaerobe culture. Mater Today Bio.
9, 100092-100092.
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Holt, S. E., Rakoski, A., Jivan, F., Prez, L. M., & Alge, D. L.
(2020).
Hydrogel Synthesis and Stabilization via Tetrazine Click-Induced Secondary Interactions. Macromolecular Rapid Communications.
41(14), e2000287-2000287.
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Deo, K. A., Singh, K. A., Peak, C. W., Alge, D. L., & Gaharwar, A. K.
(2020).
Bioprinting 101: Design, Fabrication, and Evaluation of Cell-Laden 3D Bioprinted Scaffolds. Tissue Engineering Part A.
26(5-6), 318-338.
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Xin, S., Dai, J., Gregory, C. A., Han, A., & Alge, D. L.
(2020).
Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method. Advanced Functional Materials.
30(6), 1907102-1907102.
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Tigner, T. J., Rajput, S., Gaharwar, A. K., & Alge, D. L.
(2020).
Comparison of Photo Cross Linkable Gelatin Derivatives and Initiators for Three-Dimensional Extrusion Bioprinting. Biomacromolecules.
21(2), 454-463.
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Jivan, F., & Alge, D. L.
(2020).
Bio-Orthogonal, Site-Selective Conjugation of Recombinant Proteins to Microporous Annealed Particle Hydrogels for Tissue Engineering. Advanced Therapeutics.
3(1),
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Xin, S., Gregory, C. A., & Alge, D. L.
(2020).
Interplay between degradability and integrin signaling on mesenchymal stem cell function within poly(ethylene glycol) based microporous annealed particle hydrogels. Acta Biomaterialia.
101, 227-236.
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Isaac, A., Jivan, F., Xin, S., Hardin, J., Luan, X., Pandya, M., Diekwisch, T., & Alge, D. L.
(2019).
Microporous Bio-orthogonally Annealed Particle Hydrogels for Tissue Engineering and Regenerative Medicine. ACS Biomaterial Science and Engineering.
5(12), 6395-6404.
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Xin, S., Chimene, D., Garza, J. E., Gaharwar, A. K., & Alge, D. L.
(2019).
Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting. BIOMATERIALS SCIENCE.
7(3), 1179-1187.
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Jivan, F., Fabela, N., Davis, Z., & Alge, D. L.
(2018).
Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors. 6(30), 4929-4936.
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Xin, S., Wyman, O. M., & Alge, D. L.
(2018).
Assembly of PEG Microgels into Porous Cell-Instructive 3D Scaffolds via Thiol-Ene Click Chemistry. Advanced healthcare materials.
7(11), e1800160-1800160.
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Holt, S. E., Ward, E. S., Ober, R. J., & Alge, D. L.
(2017).
Shooting for the moon: using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics. MRS Communications.
7(3), 427-441.
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Jivan, F., Yegappan, R., Pearce, H., Carrow, J. K., McShane, M., Gaharwar, A. K., & Alge, D. L.
(2016).
Sequential Thiol-Ene and Tetrazine Click Reactions for the Polymerization and Functionalization of Hydrogel Microparticles. Biomacromolecules.
17(11), 3516-3523.
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Magin, C. M., Alge, D. L., & Anseth, K. S.
(2016).
Bio-inspired 3D microenvironments: a new dimension in tissue engineering. Biomedical Materials.
11(2), 022001-022001.
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Chimene, D., Alge, D. L., & Gaharwar, A. K.
(2016).
ChemInform Abstract: TwoDimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects. ChemInform.
47(3), no-no.
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Jaiswal, M. K., Xavier, J. R., Carrow, J. K., Desai, P., Alge, D., & Gaharwar, A. K.
(2016).
Mechanically Stiff Nanocomposite Hydrogels at Ultralow Nanoparticle Content. ACS Nano.
10(1), 246-256.
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Chimene, D., Alge, D. L., & Gaharwar, A. K.
(2015).
Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects. ADVANCED MATERIALS.
27(45), 7261-7284.
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Gandavarapu, N. R., Alge, D. L., & Anseth, K. S.
(2014).
Back matter. BIOMATERIALS SCIENCE.
2(9), 1305-1305.
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Kirschner, C. M., Alge, D. L., Gould, S. T., & Anseth, K. S.
(2014).
Clickable, photodegradable hydrogels to dynamically modulate valvular interstitial cell phenotype. Advanced healthcare materials.
3(5), 649-657.
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Gandavarapu, N. R., Alge, D. L., & Anseth, K. S.
(2014).
Osteogenic differentiation of human mesenchymal stem cells on 5 integrin binding peptide hydrogels is dependent on substrate elasticity. 2(3), 352-361.
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Alge, D. L., Donohue, D. F., & Anseth, K. S.
(2014).
ChemInform Abstract: Facile and Efficient Lewis Acid Catalyzed Synthesis of an Asymmetric Tetrazine Useful for BioOrthogonal Click Chemistry Applications. 45(5), no-no.
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Azagarsamy, M. A., McKinnon, D. D., Alge, D. L., & Anseth, K. S.
(2014).
Coumarin-Based Photodegradable Hydrogel: Design, Synthesis, Gelation, and Degradation Kinetics. ACS Macro Letters.
3(6), 515-519.
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Gandavarapu, N. R., Alge, D. L., & Anseth, K. S.
(2014).
Osteogenic differentiation of human mesenchymal stem cells on 5 integrin binding peptide hydrogels is dependent on substrate elasticity (vol 2, pg 352, 2014). 2(9), 1305-1305.
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Bethel, M., Levenda, J., Hogg, P., Alge, D., Chu, T., & Mullis, B.
(2013).
Compressive loading causes unique mechanism of failure in second generation sliding hip screw. 5(4), 311-311.
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Koehler, K. C., Alge, D. L., Anseth, K. S., & Bowman, C. N.
(2013).
Development of a Maleimide Amino Acid for Use as a Tool for Peptide Conjugation and Modification. 19(3), 265-274.
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Alge, D. L., Azagarsamy, M. A., Donohue, D. F., & Anseth, K. S.
(2013).
Synthetically tractable click hydrogels for three-dimensional cell culture formed using tetrazine-norbornene chemistry. Biomacromolecules.
14(4), 949-953.
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Alge, D. L., Goebel, W. S., & Chu, T.
(2013).
Effects of DCPD cement chemistry on degradation properties and cytocompatibility: comparison of MCPM/-TCP and MCPM/HA formulations. Biomedical Materials.
8(2), 025010-025010.
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Koehler, K. C., Alge, D. L., Anseth, K. S., & Bowman, C. N.
(2013).
A Diels-Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells. Biomaterials.
34(16), 4150-4158.
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Alge, D. L., & Anseth, K. S.
(2013).
Bioactive hydrogels: Lighting the way. Nature Materials.
12(11), 950-952.
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Leight, J. L., Alge, D. L., Maier, A. J., & Anseth, K. S.
(2013).
Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate. 34(30), 7344-7352.
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Alge, D. L., Donohue, D. F., & Anseth, K. S.
(2013).
Facile and efficient Lewis acid catalyzed synthesis of an asymmetric tetrazine useful for bio-orthogonal click chemistry applications. Tetrahedron Letters.
54(41), 5639-5641.
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Azagarsamy, M. A., Alge, D. L., Radhakrishnan, S. J., Tibbitt, M. W., & Anseth, K. S.
(2012).
Photocontrolled nanoparticles for on-demand release of proteins. Biomacromolecules.
13(8), 2219-2224.
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Alge, D. L., Bennett, J., Treasure, T., Voytik-Harbin, S., Goebel, W. S., & Chu, T.
(2012).
Poly(propylene fumarate) reinforced dicalcium phosphate dihydrate cement composites for bone tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
100(7), 1792-1802.
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Alge, D. L., Goebel, W. S., & Chu, T.
(2012).
In vitro degradation and cytocompatibility of dicalcium phosphate dihydrate cements prepared using the monocalcium phosphate monohydrate/hydroxyapatite system reveals rapid conversion to HA as a key mechanism. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
100(3), 595-602.
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Mackey, A. C., Karlinsey, R. L., Chu, T., MacPherson, M., & Alge, D. L.
(2012).
Development of Niobium Oxide Coatings on Sand-Blasted Titanium Alloy Dental Implants. Materials Sciences and Applications.
2012(05), 301-305.
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Santa Cruz Chavez, G., Alge, D. L., & Chu, T.
(2011).
Additive concentration effects on dicalcium phosphate dihydrate cements prepared using monocalcium phosphate monohydrate and hydroxyapatite. Biomedical Materials.
6(6), 065007-065007.
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Chandrasekhar, K. S., Zhou, H., Zeng, P., Alge, D., Li, W., Finney, B. A., Yoder, M. C., & Li, J.
(2011).
Blood vessel wall-derived endothelial colony-forming cells enhance fracture repair and bone regeneration. Calcified Tissue International.
89(5), 347-357.
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Alge, D. L., & Chu, T.
(2010).
Calcium phosphate cement reinforcement by polymer infiltration and in situ curing: a method for 3D scaffold reinforcement. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
94(2), 547-555.
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McAteer, M. E., Niziolek, P. J., Ellis, S. N., Alge, D. L., & Robling, A. G.
(2010).
Mechanical stimulation and intermittent parathyroid hormone treatment induce disproportional osteogenic, geometric, and biomechanical effects in growing mouse bone. Calcified Tissue International.
86(5), 389-396.
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Alge, D. L., Zhou, D., Adams, L. L., Wyss, B. K., Shadday, M. D., Woods, E. J., Gabriel Chu, T. M., & Goebel, W. S.
(2010).
Donor-matched comparison of dental pulp stem cells and bone marrow-derived mesenchymal stem cells in a rat model. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE.
4(1), 73-81.
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Alge, D. L., Santa Cruz, G., Goebel, W. S., & Chu, T.
(2009).
Characterization of dicalcium phosphate dihydrate cements prepared using a novel hydroxyapatite-based formulation. Biomedical Materials.
4(2), 025016-025016.
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Recalde Phillips, S. Y., Perez-Ponce, K. D., Ruben, E., Baig, T., Poux, E., Gregory, C. A., & Alge, D. L.
Impact of Annealing Chemistry on the Properties and Performance of Microporous Annealed Particle Hydrogels. Biomacromolecules.
25(9), 5798-5808.
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Faraz, J., Ramanathan, Y., Omar, W., Hannah, P., Akhilesh, G., & Daniel, A.
Synthesis and characterization of hydrogel microsphere matrices with tunable bioactivity using click chemistry. Frontiers in Bioengineering and Biotechnology.
4.
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Deo, K. A., Murali, A., Tronolone, J. J., Mandrona, C., Lee, H. P., Rajput, S., ... Gaharwar, A. K.
(2024).
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Advanced healthcare materials.
e2303810.
-
chapter
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Alge, D. L.
(2016).
Photochemical Patterning of Cellular Microenvironments. Microscale Technologies for Cell Engineering.
(pp. 27-46).
Springer Nature.
-
Alge, D. L., & Anseth, K. S.
(2013).
CHAPTER 8. ThiolX Chemistries in Polymer and Materials Science.
(pp. 165-194).
Royal Society of Chemistry (RSC).
-
Alge, D. L., & Anseth, K. S.
(2013).
Thiol-X Reactions in Tissue Engineering. THIOL-X CHEMISTRIES IN POLYMER AND MATERIALS SCIENCE.
(pp. 165-194).
-
Alge, D. L.
(2016).
Photochemical Patterning of Cellular Microenvironments. Microscale Technologies for Cell Engineering.
(pp. 27-46).
Springer Nature.
-
conference paper
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Cheburkanov, V., Holt, S., Alge, D., & Yakovlev, V.
(2021).
Assessing hydrogel viscoelastic properties using spontaneous Brillouin scattering. Proceedings of SPIE.
116741j-116741j-8.
-
Isaac, A., Winklepleck, V., & Alge, D.
(2019).
The anti-peg immune response: Fact, fiction, or a legitimate concern for biomaterials?. Annual Meeting- Society for Biomaterials in Conjunction with the International Biomaterials Symposium.
248.
-
Xin, S., Dai, J., Han, A., & Alge, D.
(2019).
A microfluidic method for creating poly(Ethylene glycol) gradient microgel scaffolds to modulate human mesenchymal stem cell behavior. Annual Meeting- Society for Biomaterials in Conjunction with the International Biomaterials Symposium.
399.
-
Xin, S., Gregory, C., & Alge, D.
(2019).
Interplay between degradability and integrin signaling on mesenchymal stem cell function within porous poly(Ethylene glycol) microgel scaffolds. Annual Meeting- Society for Biomaterials in Conjunction with the International Biomaterials Symposium.
253.
-
Marozas, I., Alge, D., & Anseth, K.
(2015).
Thiol-ene Photoclick chemistry as an approach for user directed covalent tethering of bioactive proteins to synthetic hydrogel scaffolds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Alge, D. L., Zhou, D., Adams, L. L., Wyss, B. K., Shadday, M. D., Chu, T., Woods, E. J., & Goebel, W. S.
(2008).
Rat dental pulp-derived stem cells display greater proliferative and osteogenic potential than bone marrow-derived mesenchymal stem cells from the same donor rat. Experimental Hematology.
S87-S88.
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Baldock, V., Jivan, F., Alge, D., & McShane, M.
Poly(Ethylene glycol) click hydrogels with embedded sensing microdomains for a long-term, implantable biosensor. Annual Meeting- Society for Biomaterials in Conjunction with the International Biomaterials Symposium.
831.
-
Cheburkanov, V., Holt, S., Alge, D., & Yakovlev, V.
(2021).
Assessing hydrogel viscoelastic properties using spontaneous Brillouin scattering. Proceedings of SPIE.
116741j-116741j-8.
Research
principal investigator on
- Impact of the Anti-PEG Response on the Efficacy of PEG Hydrogel-Mediated Bone Regeneration awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2021
- Osteoinductive Microgel-Based Scaffolds for hMSC Delivery awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2020
co-principal investigator on
investigator on
Teaching
teaching activities
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT685 Directed Studies Instructor
- BMEN291 Hnr-research Instructor
- BMEN344 Bio Response Med Devices Instructor
- BMEN344 Biol Interactions & Testing Instructor
- BMEN483 Polymeric Biomatrl Synth Instructor
- BMEN487 Drug Delivery Instructor
- BMEN491 Hnr-research Instructor
- BMEN635 Biomtrls Compatibility Instructor
- BMEN683 Polymeric Biomatrl Synth Instructor
- BMEN684 Professional Internship Instructor
- BMEN685 Directed Studies Instructor
- BMEN687 Drug Delivery Instructor
- BMEN689 Sptp: Immun Implant Biomat Instructor
- BMEN691 Research Instructor
- ENGR491 Hnr-research Instructor
- MSEN491 Hnr-research Instructor
- MSEN691 Research Instructor
Works By Students
chaired theses and dissertations
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Cereceres, Stacy Nicole (2018-08). Development of Hydrogel Wound Dressings for Chronic Wound Healing.
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Jivan, Faraz (2019-11). Sequential Click Reactions To Synthesize And Functionalize Hydrogel Biomaterials.
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Xin, Shangjing (2019-11). Assembly of Microgel Building Blocks into Cell-instructive Microporous Annealed Particle Hydrogels for Tissue Engineering.
Background
education and training
- Ph.D. in Biomedical Engineering, Purdue University - (West Lafayette, Indiana, United States) 2010
- B.S. in Biosystems Engineering, Clemson University - (Clemson, South Carolina, United States) 2006
- University of Colorado Boulder - (Boulder, Colorado, United States) , Postdoctoral Training 2014
awards and honors
Contact
first name
- Daniel
has last name
- Alge
mailing address
-
Texas A&M University
Biomedical Engineering
3120 TAMU
College Station, TX 77843-3120
USA
Other
In the News
- dalge@tamu.edu