Poly(Ethylene glycol) click hydrogels with embedded sensing microdomains for a long-term, implantable biosensor
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2019 Omnipress - All rights reserved. Statement of Purpose: Chronic diseases affect millions of Americans, decreasing quality of life. Continuously monitoring these conditions allows patients and healthcare professionals to make informed decisions regarding medication and lifestyle habits for better disease management. Our previously published work has demonstrated that a bulk ionically-cross linked alginate hydrogel containing alginate microparticles encapsulating benzoporphyrin dye and oxidoreductase enzymes can be used as an implantable system for continuous monitoring of glucose and lactate via optical interrogation.12 Alginate is a widely-used biocompatible hydrogel that can be ionically-cross linked by multivalent cations, such as calcium (Ca2+). While alginate hydrogels offer the benefit of mild gelation conditions, they tend to disintegrate over time in bodily fluids as the multivalent cations are replaced by monovalent cations.3 In this work, we investigate a more stable matrix better suited for long-term sensing using poly(elhylene glycol) (PEG), which is widely used in biomedical applications for its high biocompatibility, stability, and anti-fouling properties. Pairing PEG with thiol-vinyl sulfone click-chemistry (PEG-SH-VS) allows for rapid and controlled covalent crosslinking under mild conditions, resulting in stable bulk hydrogels.4 We hypothesized that incorporating sensing alginate microparticles into a PEG-SH-VS hydrogel would provide an improved platform for long-term, continuous monitoring.
