HR job title
- Associate Professor
- Contact Info
- 979-436-9642
- ORCiD
- 0000-0002-7398-2274
Liu, Fei Associate Professor
Positions
- Associate Professor, Cell Biology and Genetics, School of Medicine
Our laboratory conducts research in:
1. The characterization and application of standardized mesenchymal stem cells (MSCs) derived from iPS cells and their extracellular vesicles (EVs). Current application focuses on treating diseases caused by over-activation of immune system, such as Sjogren's syndrome, an autoimmune disease causing dry eyes and dry mouth, and cytokine storm caused by infections.
2. Roles of tissue-resident macrophages in the development, homeostasis, and regeneration of salivary glands damaged by radiation therapy for cancer.
1. The characterization and application of standardized mesenchymal stem cells (MSCs) derived from iPS cells and their extracellular vesicles (EVs). Current application focuses on treating diseases caused by over-activation of immune system, such as Sjogren's syndrome, an autoimmune disease causing dry eyes and dry mouth, and cytokine storm caused by infections.
2. Roles of tissue-resident macrophages in the development, homeostasis, and regeneration of salivary glands damaged by radiation therapy for cancer.
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Zhao, Q., Pan, S., Zhang, L., Zhang, Y., Shahsavari, A., Lotey, P., ... Liu, F.
(2023).
A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses. Journal of Dental Research.
102(5), 536-545.
-
Zhao, Q., Bae, E., Zhang, Y. u., Shahsavari, A., Lotey, P., Lee, R. H., & Liu, F.
(2023).
Inhibitory Effects of Extracellular Vesicles from iPS-Cell-Derived Mesenchymal Stem Cells on the Onset of Sialadenitis in Sjgren's Syndrome Are Mediated by Immunomodulatory Splenocytes and Improved by Inhibiting miR-125b. International Journal of Molecular Sciences.
24(6), 5258-5258.
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Yang, T., Zhao, Q., Hu, M., Pan, S., Zhang, L., Zhu, R., ... Shan, Z.
(2022).
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages. Antioxidants.
11(10), 2050-2050.
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Gregory, C. A., Lee, R. H., Liu, F., & Alge, D.
(2022).
Editorial: Approaches That Foster a Pro-Regenerative Environment. Frontiers in Bioengineering and Biotechnology.
10, 873375.
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Hu, L., Du, C., Yang, Z. i., Yang, Y., Zhu, Z., Shan, Z., ... Liu, F.
(2021).
Transient Activation of Hedgehog Signaling Inhibits Cellular Senescence and Inflammation in Radiated Swine Salivary Glands through Preserving Resident Macrophages. International Journal of Molecular Sciences.
22(24), 13493-13493.
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Kim, H., Zhao, Q., Barreda, H., Kaur, G., Hai, B. o., Choi, J. M., ... Lee, R. H.
(2021).
Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjogren's Syndrome. Aging and Disease.
12(6), 1409-1422.
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Rogers, R. E., Haskell, A., White, B. P., Dalal, S., Lopez, M., Tahan, D., ... Kaunas, R.
(2021).
A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers. Stem Cells Translational Medicine.
10(12), 1650-1665.
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Zhao, Q., Hai, B. o., Kelly, J., Wu, S., & Liu, F.
(2021).
Extracellular vesicle mimics made from iPS cell-derived mesenchymal stem cells improve the treatment of metastatic prostate cancer. Stem Cell Research and Therapy.
12(1), 29.
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Zhao, Q., Zhang, L., Hai, B. o., Wang, J., Baetge, C. L., Deveau, M. A., ... Liu, F.
(2020).
Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages. Cancer Research.
80(24), 5531-5542.
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Zhao, Q., Hai, B. o., Zhang, X., Xu, J., Koehler, B., & Liu, F.
(2020).
Biomimetic nanovesicles made from iPS cell-derived mesenchymal stem cells for targeted therapy of triple-negative breast cancer. Nanomedicine: Nanotechnology, Biology and Medicine.
24, 102146-102146.
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McNeill, E. P., Zeitouni, S., Pan, S., Haskell, A., Cesarek, M., Tahan, D., ... Gregory, C. A.
(2020).
Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities. Nature Communications.
11(1), 3025.
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Hai, B. o., Zhao, Q., Deveau, M. A., & Liu, F.
(2018).
Delivery of Sonic Hedgehog Gene Repressed Irradiation-induced Cellular Senescence in Salivary Glands by Promoting DNA Repair and Reducing Oxidative Stress. Theranostics.
8(4), 1159-1167.
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Hai, B. o., Shigemoto-Kuroda, T., Zhao, Q., Lee, R. H., & Liu, F.
(2018).
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjgren's Syndrome. Stem Cells International.
2018, 2092315-10.
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Hu, L., Zhu, Z., Hai, B. o., Chang, S., Ma, L., Xu, Y., ... Wang, S.
(2018).
Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model. Theranostics.
8(16), 4321-4331.
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Xu, M., Horrell, J., Snitow, M., Cui, J., Gochnauer, H., Syrett, C. M., ... Millar, S. E.
(2017).
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature Communications.
8(1), 15397.
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Ullah, M., Kuroda, Y., Bartosh, T. J., Liu, F., Zhao, Q., Gregory, C., ... Prockop, D. J.
(2017).
Erratum: iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discovery.
3(1), 17029.
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Ullah, M., Kuroda, Y., Bartosh, T. J., Liu, F., Zhao, Q., Gregory, C., ... Prockop, D. J.
(2017).
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discovery.
3(1), 16064.
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Hai, B. o., Zhao, Q., Qin, L., Rangaraj, D., Gutti, V. R., & Liu, F.
(2016).
Rescue Effects and Underlying Mechanisms of Intragland Shh Gene Delivery on Irradiation-Induced Hyposalivation. HUMAN GENE THERAPY.
27(5), 390-399.
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Gaillard, D., Xu, M., Liu, F., Millar, S. E., & Barlow, L. A.
(2015).
-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates. PLOS Genetics.
11(5), e1005208-e1005208.
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Zhao, Q., Gregory, C. A., Lee, R. H., Reger, R. L., Qin, L., Hai, B. o., ... Liu, F.
(2015).
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs. Proceedings of the National Academy of Sciences of USA.
112(2), 530-535.
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Zhao, Q., & Liu, F.
(2014).
Mesenchymal stem cells in progression and treatment of cancers. Frontiers in Biology.
9(3), 186-194.
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Liu, F., & Wang, S.
(2014).
Molecular cues for development and regeneration of salivary glands. Histology and Histopathology: cellular and molecular biology.
29(3), 305-312.
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Hai, B. o., Qin, L., Yang, Z., Zhao, Q., Shangguan, L., Ti, X., ... Liu, F.
(2014).
Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation. 20(1), 140-150.
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Yang, Z., Hai, B. o., Qin, L., Ti, X., Shangguan, L., Zhao, Y., ... Liu, F.
(2013).
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a -catenin-dependent manner. Molecular and Cellular Biology.
33(23), 4732-4744.
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Chang, J., Wang, C., Liu, J., Huang, Y., Jin, C., Yang, C., ... Wang, F.
(2013).
Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells. Journal of Biological Chemistry.
288(40), 28952-28961.
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Janssens, S., Van Den Broek, O., Davenport, I. R., Akkers, R. C., Liu, F., Veenstra, G., ... Destre, O.
(2013).
The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation. The International Journal of Developmental Biology.
57(1), 49-54.
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Shangguan, L., Ti, X., Krause, U., Hai, B. o., Zhao, Y., Yang, Z., & Liu, F.
(2012).
Inhibition of TGF-/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects. Stem Cells.
30(12), 2810-2819.
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Hai, B. o., Yang, Z., Shangguan, L., Zhao, Y., Boyer, A., & Liu, F.
(2012).
Concurrent transient activation of Wnt/-catenin pathway prevents radiation damage to salivary glands. International Journal of Radiation: Oncology - Biology - Physics.
83(1), e109-e116.
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Yang, Z., & Liu, F.
(2012).
Wnt/-catenin signaling for dental regeneration. Stem Cells in Oral Medicine.
1, 3-8.
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Liu, F., Dangaria, S., Andl, T., Zhang, Y., Wright, A. C., Damek-Poprawa, M., ... Millar, S. E.
(2010).
-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors. Journal of Dental Research.
89(9), 909-914.
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Hai, B. o., Yang, Z., Millar, S. E., Choi, Y. S., Taketo, M. M., Nagy, A., & Liu, F.
(2010).
Wnt/-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells and Development.
19(11), 1793-1801.
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Liu, F., & Millar, S. E.
(2010).
Wnt/beta-catenin signaling in oral tissue development and disease. Journal of Dental Research.
89(4), 318-330.
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Afouda, B. A., Martin, J., Liu, F., Ciau-Uitz, A., Patient, R., & Hoppler, S.
(2008).
GATA transcription factors integrate Wnt signalling during heart development. Development (Cambridge).
135(19), 3185-3190.
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Zhang, Y., Andl, T., Liu, F., Yang, S. H., Taketo, M. M., Dlugosz, A. A., & Millar, S. E.
(2008).
Constitutive activation of -catenin signaling in embryonic surface epithelium results in global acquisition of hair follicle fate. Developmental Biology.
319(2), 537-537.
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Liu, F., Andl, T., Zhang, Y., & Millar, S.
(2008).
WNT/-Catenin signaling maintains regenerating adult oral appendage organs and promotes stem cell expansion and de novo organ development. Developmental Biology.
319(2), 555-555.
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Zhang, Y., Andl, T., Yang, S. H., Teta, M., Liu, F., Seykora, J. T., ... Millar, S. E.
(2008).
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (Cambridge).
135(12), 2161-2172.
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Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., ... Millar, S. E.
(2008).
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Developmental Biology.
313(1), 210-224.
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Liu, F., Thirumangalathu, S., Gallant, N. M., Yang, S. H., Stoick-Cooper, C. L., Reddy, S. T., ... Millar, S. E.
(2007).
Wnt-beta-catenin signaling initiates taste papilla development. Nature Genetics.
39(1), 106-112.
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Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., ... Millar, S. E.
(2006).
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology.
16(10), 1041-1049.
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Liu, F., van den Broek, O., Destre, O., & Hoppler, S.
(2005).
Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development. Development (Cambridge).
132(24), 5375-5385.
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Wang, X., Zhang, G., Liu, F., Han, M., Xu, D., & Zang, Y.
(2004).
Prevalence of human parvovirus B19 DNA in cardiac tissues of patients with congenital heart diseases indicated by nested PCR and in situ hybridization. Journal of Clinical Virology.
31(1), 20-24.
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Liu, X., Zhu, Y., Han, W., Li, Y., Chen, L., Jia, W., ... Jin, B.
(2003).
Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR4, DR5, DcR1, and DcR2. Hybridoma: a journal of molecular immunology and experimental and clinical immunotherapy.
22(2), 121-125.
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Xie, X., Ouyang, W., Xue, J., Zhang, X., Liu, F., Zhuang, R., & Jin, B.
(2003).
[Cloning, prokaryotic expression of LAIR and identification of their immunological reactivities]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
19(2), 118-120.
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Zhao, Y., You, H., Liu, F., An, H., Shi, Y., Yu, Q., & Fan, D.
(2002).
Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells. Cancer Letters.
185(2), 211-218.
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Liu, F., Liu, Y., Li, D., Zhu, Y., Ouyang, W., Xie, X., & Jin, B.
(2002).
The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain. MOLECULAR AND CELLULAR BIOCHEMISTRY.
232(1-2), 163-167.
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Wang, X., Li, Y., Li, H., Liu, F., & Jia, G.
(2002).
Effects of perindopril on soluble intercellular adhesion molecule-1 in patients with congestive heart failure. Heart.
88(4), 417-418.
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Liu, F., Liu, Y., Jin, B., Dong, B. Q., & Zhu, Y.
(1999).
Preparation and characterization of monoclonal antibodies against GAM protein: a novel gp130-associated molecule. Hybridoma.
18(4), 351-357.
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Zhao, Q., Pan, S., Zhang, L., Zhang, Y., Shahsavari, A., Lotey, P., ... Liu, F.
(2023).
A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses. Journal of Dental Research.
102(5), 536-545.
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chapter
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Zhao, Q., & Liu, F.
(2022).
Derivation and Characterization of Mesenchymal Stem Cells from iPS Cells. Methods in Molecular Biology.
Induced Pluripotent Stem (iPS) Cells.
(pp. 443-454).
Springer Nature.
-
Liu, F.
(2012).
Functional Restoration of Salivary Glands After Radiotherapy: Roles of Wnt and Hedgehog Pathways. Hayat, M. A. (Eds.),
Stem Cells and Cancer Stem Cells, Volume 8.
(pp. 287-295).
Springer Nature.
-
Zhao, Q., & Liu, F.
(2022).
Derivation and Characterization of Mesenchymal Stem Cells from iPS Cells. Methods in Molecular Biology.
Induced Pluripotent Stem (iPS) Cells.
(pp. 443-454).
Springer Nature.
Research
principal investigator on
- Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy (Liu, Fei) awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2021 - 2026
- Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjogren's syndrome or radiotherapy awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2022 - 2024
- Therapeutic Effects of MSC-Derived Extracellular Vesicles on Sjögren's Syndrome awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2020
- Nanoparticles Made from iPS Cell-Derived Mesenchymal Stem Cells as Standardized Natural Platforms for Targeted Treatment of Drug-Resistant Prostate Cancer awarded by United States Army - (Washington D.C., District of Columbia, United States) 2016 - 2020
- Mechanisms of Hedgehop Mediated Rescue of Radiation-Induced Hyposalivation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2016
Teaching
teaching activities
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- GENE677 Genes And Diseases Instructor
- MCMD677 Genes And Diseases Instructor
- MSCI601 Contem Top In Adv Cell Bio I Instructor And Section Director
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Immunology, Fourth Military Medical University - (Xi'an, Shaanxi, China) 2002
- M.S. in Immunology, Fourth Military Medical University - (Xi'an, Shaanxi, China) 1998
- B.M. in Clinical Medicine, Fourth Military Medical University - (Xi'an, Shaanxi, China) 1995
- University of Pennsylvania - (Philadelphia, Pennsylvania, United States) , Postdoctoral Training 2008
- University of Aberdeen - (Aberdeen, United Kingdom) , Postdoctoral Training 2005
- University of Dundee - (Dundee, United Kingdom) , Postdoctoral Training 2003
Contact
first name
- Fei
has last name
- Liu
mailing address
-
Texas A&M Health Science Center
Regenerative Medicine
1114 TAMUS
College Station, TX 77845
USA
Other
In the News
- fliu@tamu.edu