Wnt/beta-catenin signaling in oral tissue development and disease. Academic Article

abstract

• The Wnt/beta-catenin signaling pathway is one of several key conserved intercellular signaling pathways in animals, and plays fundamental roles in the proliferation, regeneration, differentiation, and function of many cell and tissue types. This pathway is activated in a dynamic manner during the morphogenesis of oral organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occur normally. Conversely, forced activation of Wnt/beta-catenin signaling promotes the formation of ectopic teeth and taste papillae. In this review, we discuss our current understanding of the roles of Wnt/beta-catenin signaling in oral tissue development and in related human diseases, and the potential of manipulating this pathway for therapeutic purposes.

authors

• Liu, Fei

published proceedings

• J Dent Res

altmetric score

• 3

author list (cited authors)

• Liu, F., & Millar, S. E.

citation count

• 170

complete list of authors

• Liu, F||Millar, SE

publication date

• January 2010

publisher

• SAGE Publications  Publisher

published in

• Journal of Dental Research  Journal

keywords

• Animals
• Beta Catenin
• Craniofacial Abnormalities
• Gene Expression Regulation, Developmental
• Humans
• Maxillofacial Development
• Mouth
• Mouth Neoplasms
• Odontogenesis
• Signal Transduction
• Wnt Proteins

PubMed Central ID

• 20200414

Digital Object Identifier (DOI)

• 10.1177/0022034510363373

start page

• 318

end page

• 330

volume

• 89

issue

• 4

URL

• http://dx.doi.org/10.1177/0022034510363373