HR job title
- Professor and Department Head
- Contact Info
Keene, Alex Professor and Department Head
Positions
- Professor and Department Head, Biology, College of Arts and Sciences
- Overview
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- Teaching
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Overview
Publications
selected publications
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academic article
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Kozol, R. A., Canavan, A., Tolentino, B., Keene, A. C., Kowalko, J. E., & Dubou, E. R.
(2024).
Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish, Astyanax mexicanus
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Brown, E. B., Lloyd, E., Martin-Pea, A., McFarlane, S., Dahanukar, A., & Keene, A. C.
(2024).
Aging is associated with a modality-specific decline in taste
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Brown, E. B., Zhang, J., Lloyd, E., Lanzon, E., Botero, V., Tomchik, S., & Keene, A. C.
(2023).
Neurofibromin 1 mediates sleep depth in Drosophila. PLOS Genetics.
19(12), e1011049-e1011049.
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Lloyd, E., Rastogi, A., Holtz, N., Aaronson, B., Craig Albertson, R., & Keene, A. C.
(2023).
Ontogeny and social context regulate the circadian activity patterns of Lake Malawi cichlids. Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology.
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Lloyd, E., Privat, M., Sumbre, G., Dubou, E. R., & Keene, A. C.
(2023).
A protocol for whole-brain Ca2+ imaging in Astyanax mexicanus, a model of comparative evolution. STAR Protocols.
4(4), 102517-102517.
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Brown, E., Worden, K., Li, Y., Masek, P., & Keene, A. C.
(2023).
Innate and Conditioned Taste Processing in Drosophila. Cold Spring Harbor protocols.
2023(6), Pdb.top107864-pdb.top107864.
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Brown, E., Worden, K., Li, Y., Masek, P., & Keene, A. C.
(2023).
Measurement of Reflexive Feeding Response in Drosophila. Cold Spring Harbor protocols.
2023(6), Pdb.prot108092-pdb.prot108092.
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Brown, E., Worden, K., Li, Y., Masek, P., & Keene, A. C.
(2023).
Measurement of Taste Memory in Drosophila. Cold Spring Harbor protocols.
2023(6), Pdb.prot108093-pdb.prot108093.
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Hess, R. A., Erickson, O. A., Cole, R. B., Isaacs, J. M., Alvarez-Clare, S., Arnold, J., ... Dolan, E. L.
(2023).
Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences. CBE : Life Sciences Education.
22(2), ar25.
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Brown, E. B., & Keene, A. C.
(2023).
Sleep regulation: The gut sets the threshold. Current Biology.
33(10), R420-R423.
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Moran, R. L., Richards, E. J., Ornelas-Garca, C. P., Gross, J. B., Donny, A., Wiese, J., ... McGaugh, S. E.
(2023).
Selection-driven trait loss in independently evolved cavefish populations. Nature Communications.
14(1), 2557.
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Kozol, R. A., Yuiska, A., Han, J. H., Tolentino, B., Lopatto, A., Lewis, P., ... Dubou, E. R.
(2023).
Novel Husbandry Practices Result in Rapid Rates of Growth and Sexual Maturation Without Impacting Adult Behavior in the Blind Mexican Cavefish. Zebrafish.
20(2), 86-94.
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Palermo, J., Chesi, A., Zimmerman, A., Sonti, S., Pahl, M. C., Lasconi, C., ... Keene, A. C.
(2023).
Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Science Advances.
9(1), eabq0844.
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Zimmerman, A., Palermo, J., Chesi, A., Sonti, S., Lasconi, C., Brown, E., ... Keene, A.
(2022).
Cross-species validation of insomnia-associated loci identified through variant-to-gene mapping implicates PIGQ as a conserved regulator of sleep duration. 100, s114-S114.
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Rodriguez-Morales, R., Gonzalez-Lerma, P., Yuiska, A., Han, J. H., Guerra, Y., Crisostomo, L., ... Kowalko, J. E.
(2022).
Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus. BMC Ecology.
22(1), 116.
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Amrein, H., & Keene, A. C.
(2022).
Sensory biology: Thirsty glia motivate water consumption. Current Biology.
32(18), R949-R952.
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Lloyd, E., McDole, B., Privat, M., Jaggard, J. B., Dubou, E. R., Sumbre, G., & Keene, A. C.
(2022).
Blind cavefish retain functional connectivity in the tectum despite loss of retinal input. Current Biology.
32(17), 3720-3730.e3.
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Oliva, C., Hinz, N. K., Robinson, W., Barrett Thompson, A. M., Booth, J., Crisostomo, L. M., ... Keene, A. C.
(2022).
Characterizing the genetic basis of trait evolution in the Mexican cavefish. Evolution and Development.
24(5), 131-144.
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Duboue, E. R., Kowalko, J. E., & Keene, A. C.
(2022).
Course-based undergraduate research experiences (CURES) as a pathway to diversify science. Evolution and Development.
24(5), 127-130.
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Perry, A., McGaugh, S. E., Keene, A. C., & Blackmon, H.
(2022).
CaveCrawler: an interactive analysis suite for cavefish bioinformatics. G3: Genes, Genomes, Genetics.
12(8), jkac132.
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Chin, J., Phan, T., Albert, L. T., Keene, A. C., & Dubou, E. R.
(2022).
Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish. Scientific Reports.
12(1), 12826.
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Palermo, J., Keene, A. C., & DiAngelo, J. R.
(2022).
Expression of a constitutively active insulin receptor in Drosulfakinin (Dsk) neurons regulates metabolism and sleep in Drosophila. Biochemistry and Biophysics Reports.
30, 101280-101280.
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Brown, E. B., Klok, J., & Keene, A. C.
(2022).
Measuring metabolic rate in single flies during sleep and waking states via indirect calorimetry. Journal of Neuroscience Methods.
376, 109606-109606.
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Lunsford, E. T., Paz, A., Keene, A. C., & Liao, J. C.
(2022).
Evolutionary convergence of a neural mechanism in the cavefish lateral line system. eLife.
11, e77387.
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Zimmerman, A., Palermo, J., Chesi, A., Sonti, S., Lasconi, C., Brown, E., ... Grant, S.
(2022).
0029 Developing a pipeline for translating genome-wide association signals to behavioral correlates of sleep dysfunction. 45(Supplement_1), a13-a13.
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Erickson, O. A., Cole, R. B., Isaacs, J. M., Alvarez-Clare, S., Arnold, J., Augustus-Wallace, A., ... Dolan, E. L.
(2022).
"How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19. CBE : Life Sciences Education.
21(1), ar1.
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Moran, R. L., Jaggard, J. B., Roback, E. Y., Kenzior, A., Rohner, N., Kowalko, J. E., ... Keene, A. C.
(2022).
Hybridization underlies localized trait evolution in cavefish. iScience.
25(2), 103778-103778.
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Patch, A., Paz, A., Holt, K. J., Dubou, E. R., Keene, A. C., Kowalko, J. E., & Fily, Y.
(2022).
Kinematic analysis of social interactions deconstructs the evolved loss of schooling behavior in cavefish. PLoS ONE.
17(4), e0265894-e0265894.
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Li, W., & Keene, A. C.
(2021).
Flies sense the world while sleeping. Nature.
598(7881), 423-424.
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Gehrman, P., Palermo, J., Sonti, S., Lasconi, C., Chesi, A., Mazzotti, D., Grant, S., & Keene, A.
(2021).
63. LEVERAGING GWAS FOR INSOMNIA TO IDENTIFY NOVEL REGULATORS OF SLEEP. European Neuropsychopharmacology.
51, e75-e75.
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O'Gorman, M., Thakur, S., Imrie, G., Moran, R. L., Choy, S., Sifuentes-Romero, I., ... Kowalko, J. E.
(2021).
Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish. Current Biology.
31(16), 3694-3701.e4.
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Murakami, K., Palermo, J., Stanhope, B. A., Gibbs, A. G., & Keene, A. C.
(2021).
A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79. G3: Genes, Genomes, Genetics.
11(8), jkab199.
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Botero, V., Stanhope, B. A., Brown, E. B., Grenci, E. C., Boto, T., Park, S. J., ... Tomchik, S. M.
(2021).
Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila. Nature Communications.
12(1), 4285.
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Mack, K. L., Jaggard, J. B., Persons, J. L., Roback, E. Y., Passow, C. N., Stanhope, B. A., ... McGaugh, S. E.
(2021).
Repeated evolution of circadian clock dysregulation in cavefish populations. 17(7), e1009642-e1009642.
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Brown, E. B., Shah, K. D., Palermo, J., Dey, M., Dahanukar, A., & Keene, A. C.
(2021).
Ir56d-dependent fatty acid responses in Drosophila uncover taste discrimination between different classes of fatty acids. eLife.
10, e67878.
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Lloyd, E., Chhouk, B., Conith, A. J., Keene, A. C., & Albertson, R. C.
(2021).
Diversity in rest-activity patterns among Lake Malawi cichlid fishes suggests a novel axis of habitat partitioning. Journal of Experimental Biology.
224(7), jeb.242186.
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Warren, W. C., Boggs, T. E., Borowsky, R., Carlson, B. M., Ferrufino, E., Gross, J. B., ... Rohner, N.
(2021).
A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution. Nature Communications.
12(1), 1447.
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Shafer, O. T., & Keene, A. C.
(2021).
The Regulation of Drosophila Sleep. Current Biology.
31(1), R38-R49.
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Collie, J., Granela, O., Brown, E. B., & Keene, A. C.
(2020).
Aggression Is Induced by Resource Limitation in the Monarch Caterpillar. iScience.
23(12), 101791-101791.
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McGaugh, S. E., Passow, C. N., Jaggard, J. B., Stahl, B. A., & Keene, A. C.
(2020).
Unique transcriptional signatures of sleep loss across independently evolved cavefish populations. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
334(7-8), 497-510.
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Paz, A., McDole, B., Kowalko, J. E., Duboue, E. R., & Keene, A. C.
(2020).
Evolution of the acoustic startle response of Mexican cavefish. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
334(7-8), 474-485.
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McGaugh, S. E., Kowalko, J. E., Dubou, E., Lewis, P., Franz-Odendaal, T. A., Rohner, N., Gross, J. B., & Keene, A. C.
(2020).
Dark world rises: The emergence of cavefish as a model for the study of evolution, development, behavior, and disease. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
334(7-8), 397-404.
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Chin, J., Loomis, C. L., Albert, L. T., Medina-Trenche, S., Kowalko, J., Keene, A. C., & Dubou, E. R.
(2020).
Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
334(7-8), 486-496.
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Sifuentes-Romero, I., Ferrufino, E., Thakur, S., Laboissonniere, L. A., Solomon, M., Smith, C. L., ... Kowalko, J. E.
(2020).
Repeated evolution of eye loss in Mexican cavefish: Evidence of similar developmental mechanisms in independently evolved populations. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
334(7-8), 423-437.
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Jaggard, J. B., Lloyd, E., Yuiska, A., Patch, A., Fily, Y., Kowalko, J. E., ... Keene, A. C.
(2020).
Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations. Science Advances.
6(38), eaba3126.
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Pamboro, E., Brown, E. B., & Keene, A. C.
(2020).
Dietary fatty acids promote sleep through a taste-independent mechanism. Genes, Brain and Behavior.
19(4), e12629.
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Stanhope, B. A., Jaggard, J. B., Gratton, M., Brown, E. B., & Keene, A. C.
(2020).
Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury. Current Biology.
30(6), 1092-1101.e3.
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Brown, E. B., Shah, K. D., Faville, R., Kottler, B., & Keene, A. C.
(2020).
Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity. 16(3), e1008270-e1008270.
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Stahl, B. A., Peu, R., McDole, B., Kenzior, A., Jaggard, J. B., Gaudenz, K., ... Rohner, N.
(2019).
Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system. Developmental Dynamics.
248(8), 679-687.
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Paz, A., & Keene, A. C.
(2019).
What Can a Blind Fish Teach Us About Sleep?. 7, 103.
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Chin, J., Albert, L. T., Loomis, C. L., Keene, A. C., & Dubou, E. R.
(2019).
Behavioral Approaches to Studying Innate Stress in Zebrafish. Journal of Visualized Experiments.
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Chin, J., Albert, L. T., Loomis, C. L., Keene, A. C., & Dubou, E. R.
(2019).
Behavioral Approaches to Studying Innate Stress in Zebrafish. Journal of Visualized Experiments.
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Stahl, B. A., Jaggard, J. B., Chin, J., Kowalko, J. E., Keene, A. C., & Dubou, E. R.
(2019).
Manipulation of Gene Function in Mexican Cavefish. Journal of Visualized Experiments.
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Stahl, B. A., Jaggard, J. B., Chin, J., Kowalko, J. E., Keene, A. C., & Dubou, E. R.
(2019).
Manipulation of Gene Function in Mexican Cavefish. Journal of Visualized Experiments.
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Jaggard, J. B., Lloyd, E., Lopatto, A., Duboue, E. R., & Keene, A. C.
(2019).
Automated Measurements of Sleep and Locomotor Activity in Mexican Cavefish. Journal of Visualized Experiments.
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Jaggard, J. B., Lloyd, E., Lopatto, A., Duboue, E. R., & Keene, A. C.
(2019).
Automated Measurements of Sleep and Locomotor Activity in Mexican Cavefish. Journal of Visualized Experiments.
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Passow, C. N., Kono, T., Stahl, B. A., Jaggard, J. B., Keene, A. C., & McGaugh, S. E.
(2019).
Nonrandom RNAseq gene expression associated with RNAlater and flash freezing storage methods. Molecular Ecology Resources.
19(2), 456-464.
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Yurgel, M. E., Kakad, P., Zandawala, M., Nssel, D. R., Godenschwege, T. A., & Keene, A. C.
(2019).
A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions. PLOS Biology.
17(2), e2006409-e2006409.
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Brown, E. B., Slocumb, M. E., Szuperak, M., Kerbs, A., Gibbs, A. G., Kayser, M. S., & Keene, A. C.
(2019).
Starvation resistance is associated with developmentally specified changes in sleep, feeding and metabolic rate. Journal of Experimental Biology.
222(Pt 3), jeb191049.
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Loomis, C., Peu, R., Jaggard, J. B., Wang, Y., McKinney, S. A., Raftopoulos, S. C., ... Duboue, E. R.
(2019).
An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish. Frontiers in Neuroanatomy.
13, 88.
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Zandawala, M., Yurgel, M. E., Texada, M. J., Liao, S., Rewitz, K. F., Keene, A. C., & Nssel, D. R.
(2018).
Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin. PLOS Genetics.
14(11), e1007767-e1007767.
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Stahl, B. A., Peco, E., Davla, S., Murakami, K., Caicedo Moreno, N. A., van Meyel, D. J., & Keene, A. C.
(2018).
The Taurine Transporter Eaat2 Functions in Ensheathing Glia to Modulate Sleep and Metabolic Rate. Current Biology.
28(22), 3700-3708.e4.
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Herman, A., Brandvain, Y., Weagley, J., Jeffery, W. R., Keene, A. C., Kono, T., ... McGaugh, S. E.
(2018).
The role of gene flow in rapid and repeated evolution of cave-related traits in Mexican tetra, Astyanax mexicanus. Molecular Ecology.
27(22), 4397-4416.
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Yurgel, M. E., Shah, K. D., Brown, E. B., Burns, C., Bennick, R. A., DiAngelo, J. R., & Keene, A. C.
(2018).
Ade2 Functions in the Drosophila Fat Body To Promote Sleep. G3: Genes, Genomes, Genetics.
8(11), 3385-3395.
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Chin, J., Gassant, C. E., Amaral, P. M., Lloyd, E., Stahl, B. A., Jaggard, J. B., Keene, A. C., & Duboue, E. R.
(2018).
Convergence on reduced stress behavior in the Mexican blind cavefish. Developmental Biology.
441(2), 319-327.
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Lloyd, E., Olive, C., Stahl, B. A., Jaggard, J. B., Amaral, P., Dubou, E. R., & Keene, A. C.
(2018).
Evolutionary shift towards lateral line dependent prey capture behavior in the blind Mexican cavefish. Developmental Biology.
441(2), 328-337.
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Keene, A. C., & Duboue, E. R.
(2018).
The origins and evolution of sleep. Journal of Experimental Biology.
221(Pt 11), jeb159533.
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Brown, E. B., Torres, J., Bennick, R. A., Rozzo, V., Kerbs, A., DiAngelo, J. R., & Keene, A. C.
(2018).
Variation in sleep and metabolic function is associated with latitude and average temperature in Drosophila melanogaster. Ecology and Evolution.
8(8), 4084-4097.
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Yurgel, M. E., & Keene, A. C.
(2018).
Sleep: Helicon Cells Charge the Circuit. Current Biology.
28(7), R317-R319.
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Jaggard, J. B., Stahl, B. A., Lloyd, E., Prober, D. A., Duboue, E. R., & Keene, A. C.
(2018).
Hypocretin underlies the evolution of sleep loss in the Mexican cavefish. eLife.
7, e32637.
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Tauber, J. M., Brown, E. B., Li, Y., Yurgel, M. E., Masek, P., & Keene, A. C.
(2017).
A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste. PLOS Genetics.
13(11), e1007059-e1007059.
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Stahl, B. A., & Keene, A. C.
(2017).
To rebound or not to rebound. eLife.
6, e31646.
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Stahl, B. A., Slocumb, M. E., Chaitin, H., DiAngelo, J. R., & Keene, A. C.
(2017).
Sleep-Dependent Modulation of Metabolic Rate in Drosophila. 40(8),
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Jaggard, J., Robinson, B. G., Stahl, B. A., Oh, I., Masek, P., Yoshizawa, M., & Keene, A. C.
(2017).
The lateral line confers evolutionarily derived sleep loss in the Mexican cavefish. Journal of Experimental Biology.
220(Pt 2), 284-293.
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Murphy, K. R., Deshpande, S. A., Yurgel, M. E., Quinn, J. P., Weissbach, J. L., Keene, A. C., ... Ja, W. W.
(2016).
Postprandial sleep mechanics in Drosophila. 5, e19334.
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Masek, P., & Keene, A. C.
(2016).
Gustatory processing and taste memory in Drosophila. Journal of Neurogenetics.
30(2), 112-121.
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Murakami, K., Yurgel, M. E., Stahl, B. A., Masek, P., Mehta, A., Heidker, R., ... Keene, A. C.
(2016).
translin Is Required for Metabolic Regulation of Sleep. Current Biology.
26(7), 972-980.
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Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., ... Wright, K. P.
(2015).
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. 38(12), 1849-1860.
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Seidner, G., Robinson, J. E., Wu, M., Worden, K., Masek, P., Roberts, S. W., Keene, A. C., & Joiner, W. J.
(2015).
Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster. Current Biology.
25(22), 2928-2938.
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Garbe, D. S., Bollinger, W. L., Vigderman, A., Masek, P., Gertowski, J., Sehgal, A., & Keene, A. C.
(2015).
Context-specific comparison of sleep acquisition systems in Drosophila. Biology Open.
4(11), 1558-1568.
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Yurgel, M. E., Masek, P., DiAngelo, J., & Keene, A. C.
(2015).
Genetic dissection of sleep-metabolism interactions in the fruit fly. Journal of Comparative Physiology A: sensory, neural, and behavioral physiology.
201(9), 869-877.
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Masek, P., Worden, K., Aso, Y., Rubin, G. M., & Keene, A. C.
(2015).
A dopamine-modulated neural circuit regulating aversive taste memory in Drosophila. Current Biology.
25(11), 1535-1541.
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Keene, A. C., & Joiner, W. J.
(2015).
Neurodegeneration: paying it off with sleep. Current Biology.
25(6), R234-R236.
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Yoshizawa, M., Robinson, B. G., Dubou, E. R., Masek, P., Jaggard, J. B., O'Quin, K. E., ... Keene, A. C.
(2015).
Distinct genetic architecture underlies the emergence of sleep loss and prey-seeking behavior in the Mexican cavefish. BMC Biology.
13(1), 15.
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Slocumb, M. E., Regalado, J. M., Yoshizawa, M., Neely, G. G., Masek, P., Gibbs, A. G., & Keene, A. C.
(2015).
Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila. 10(7), e0131275-e0131275.
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McGaugh, S. E., Gross, J. B., Aken, B., Blin, M., Borowsky, R., Chalopin, D., ... Warren, W. C.
(2014).
The cavefish genome reveals candidate genes for eye loss. 5(1), 5307.
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Masek, P., Reynolds, L. A., Bollinger, W. L., Moody, C., Mehta, A., Murakami, K., ... Keene, A. C.
(2014).
Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster. Journal of Experimental Biology.
217(Pt 17), 3122-3132.
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Murakami, K., & Keene, A. C.
(2014).
Development: better sleep on it, children. 24(12), R569-R571.
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Masek, P., & Keene, A. C.
(2013).
Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons. PLOS Genetics.
9(9), e1003710-e1003710.
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Robertson, M., & Keene, A. C.
(2013).
Molecular mechanisms of age-related sleep loss in the fruit fly - a mini-review. 59(4), 334-339.
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Masek, P., & Keene, A. C.
(2012).
Dopamine: on the threshold of sleep. 22(22), R949-R951.
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Keene, A. C., & Masek, P.
(2012).
Optogenetic induction of aversive taste memory. 222, 173-180.
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Sassu, E. D., McDermott, J. E., Keys, B. J., Esmaeili, M., Keene, A. C., Birnbaum, M. J., & DiAngelo, J. R.
(2012).
Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. 426(1), 43-48.
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Keene, A. C., & Sprecher, S. G.
(2012).
Seeing the light: photobehavior in fruit fly larvae. 35(2), 104-110.
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Dubou, E. R., Borowsky, R. L., & Keene, A. C.
(2012).
-adrenergic signaling regulates evolutionarily derived sleep loss in the Mexican cavefish. Brain, Behavior and Evolution.
80(4), 233-243.
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Dus, M., Min, S., Keene, A. C., Lee, G. Y., & Suh, G.
(2011).
Taste-independent detection of the caloric content of sugar in Drosophila. Proceedings of the National Academy of Sciences of the United States of America.
108(28), 11644-11649.
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Keene, A. C., Mazzoni, E. O., Zhen, J., Younger, M. A., Yamaguchi, S., Blau, J., Desplan, C., & Sprecher, S. G.
(2011).
Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. 31(17), 6527-6534.
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Dubou, E. R., Keene, A. C., & Borowsky, R. L.
(2011).
Evolutionary convergence on sleep loss in cavefish populations. Current Biology.
21(8), 671-676.
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Neely, G. G., Keene, A. C., Duchek, P., Chang, E. C., Wang, Q., Aksoy, Y. A., ... Penninger, J. M.
(2011).
TrpA1 regulates thermal nociception in Drosophila. PLoS ONE.
6(8), e24343-e24343.
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Neely, G. G., Hess, A., Costigan, M., Keene, A. C., Goulas, S., Langeslag, M., ... Penninger, J. M.
(2010).
A genome-wide Drosophila screen for heat nociception identifies 23 as an evolutionarily conserved pain gene. Cell.
143(4), 628-638.
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McDonald, D. M., & Keene, A. C.
(2010).
The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila. Aging.
2(8), 519-522.
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Keene, A. C., Dubou, E. R., McDonald, D. M., Dus, M., Suh, G., Waddell, S., & Blau, J.
(2010).
Clock and cycle limit starvation-induced sleep loss in Drosophila. Current Biology.
20(13), 1209-1215.
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Neely, G. G., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., ... Penninger, J. M.
(2010).
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell.
141(1), 142-153.
-
Keene, A. C., & Waddell, S.
(2007).
Drosophila olfactory memory: single genes to complex neural circuits. Nature Reviews Neuroscience.
8(5), 341-354.
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Krashes, M. J., Keene, A. C., Leung, B., Armstrong, J. D., & Waddell, S.
(2007).
Sequential use of mushroom body neuron subsets during drosophila odor memory processing. Neuron.
53(1), 103-115.
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Keene, A. C., Krashes, M. J., Leung, B., Bernard, J. A., & Waddell, S.
(2006).
Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation. Current Biology.
16(15), 1524-1530.
-
Yu, D., Keene, A. C., Srivatsan, A., Waddell, S., & Davis, R. L.
(2005).
Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning. Cell.
123(5), 945-957.
-
Keene, A. C., & Waddell, S.
(2005).
Drosophila Memory: Dopamine Signals Punishment?. Current Biology.
15(23), 2176-2176.
-
Keene, A. C., & Waddell, S.
(2005).
Drosophila memory: dopamine signals punishment?. Current Biology.
15(22), R932-R934.
-
Keene, A. C., Stratmann, M., Keller, A., Perrat, P. N., Vosshall, L. B., & Waddell, S.
(2004).
Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. Neuron.
44(3), 521-533.
-
Ding, H., Schwarz, D. S., Keene, A., Affar, E. B., Fenton, L., Xia, X., ... Xu, Z.
(2003).
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell.
2(4), 209-217.
-
Keene, A. C., Jones, J. E., Wade, G. N., & Corp, E. S.
(2003).
Forebrain sites of NPY action on estrous behavior in Syrian hamsters. Physiology and Behavior.
78(4-5), 711-716.
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Jones, J. E., Pick, R. R., Davenport, M. D., Keene, A. C., Corp, E. S., & Wade, G. N.
(2002).
Disinhibition of female sexual behavior by a CRH receptor antagonist in Syrian hamsters. American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
283(3), R591-R597.
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Kozol, R. A., Canavan, A., Tolentino, B., Keene, A. C., Kowalko, J. E., & Dubou, E. R.
(2024).
Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish, Astyanax mexicanus
-
book
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Keene, A., Yoshizawa, M., & McGaugh, S. E.
(2015).
Biology and Evolution of the Mexican Cavefish. Academic Press.
-
Keene, A., Yoshizawa, M., & McGaugh, S. E.
(2015).
Biology and Evolution of the Mexican Cavefish. Academic Press.
-
chapter
-
Lloyd, E., Kozol, R. A., Duboue, E. R., & Keene, A. C.
(2023).
Immunohistochemistry and In Vivo Neural Imaging in A. mexicanus. Neuromethods.
Emerging Model Organisms.
(pp. 221-234).
Springer Nature.
-
Hutton, P., Lloyd, E., Dotson, M., & Keene, A. C.
(2023).
Sleep Behavior Analysis in Astyanax mexicanus. Neuromethods.
Emerging Model Organisms.
(pp. 235-247).
Springer Nature.
-
Keene, A. C., & Appelbaum, L.
(2019).
Chapter 24 Sleep in Fish Models. Handbook of Behavioral Neuroscience.
Handbook of Sleep Research.
(pp. 363-374).
Elsevier.
-
Dubou, E. R., & Keene, A. C.
(2016).
Chapter 15 Investigating the Evolution of Sleep in the Mexican Cavefish. Biology and Evolution of the Mexican Cavefish.
(pp. 291-308).
Elsevier.
-
Keene, A. C., Yoshizawa, M., & McGaugh, S. E.
(2016).
Preface. Biology and Evolution of the Mexican Cavefish.
(pp. xiii-xiv).
Elsevier.
-
Lloyd, E., Kozol, R. A., Duboue, E. R., & Keene, A. C.
(2023).
Immunohistochemistry and In Vivo Neural Imaging in A. mexicanus. Neuromethods.
Emerging Model Organisms.
(pp. 221-234).
Springer Nature.
-
conference paper
-
Zimmerman, A., Palermo, J., Chesi, A., Sonti, S., Lasconi, C., Brown, E., ... Grant, S.
(2022).
DEVELOPING A PIPELINE FOR TRANSLATING GENOME-WIDE ASSOCIATION SIGNALS TO BEHAVIORAL CORRELATES OF SLEEP DYSFUNCTION. A13-A13.
-
Zimmerman, A., Palermo, J., Chesi, A., Sonti, S., Lasconi, C., Brown, E., ... Grant, S.
(2022).
DEVELOPING A PIPELINE FOR TRANSLATING GENOME-WIDE ASSOCIATION SIGNALS TO BEHAVIORAL CORRELATES OF SLEEP DYSFUNCTION. A13-A13.
-
institutional repository document
-
Ogunlusi, O., Sarkar, M., Chakrabarti, A., Boland, D., Nguyen, T., Sampson, J., ... Sarkar, T. R.
(2024).
Circadian rhythm disruption alters mammary gland morphology and accelerates cold aggressive tumorigenesis through a LILRB4-dependent pathway
-
Paz, A., Holt, K. J., Clarke, A., Aviles, A., Abraham, B., Keene, A. C., ... Kowalko, J. E.
(2023).
Changes in local interaction rules during ontogeny underlie the evolution of collective behavior
-
Moran, R. L., Richards, E. J., Ornelas-Garca, C. P., Gross, J. B., Donny, A., Wiese, J., ... McGaugh, S. E.
(2022).
Selection-driven trait loss in independently evolved cavefish populations
-
Kozol, R. A., Yuiska, A., Han, J. H., Tolentino, B., Lopatto, A., Lewis, P., ... Dubou, E. R.
(2022).
Novel husbandry practices result in rapid rates of growth and sexual maturation without impacting adult behavior in the blind Mexican cavefish
-
Zimmerman, A. J., Doldur-Balli, F., Keenan, B. T., Shetty, Z. Y., Palermo, J., Chesi, A., ... Pack, A. I.
(2022).
Zebrafish screen of high-confidence effector genes at insomnia GWAS loci implicates conserved regulators of sleep-wake behaviors
-
Brown, E. B., Zhang, J., Lloyd, E., Lanzon, E., Botero, V., Tomchik, S., & Keene, A. C.
(2022).
Neurofibromin 1 mediates sleep depth in Drosophila
-
Rodriguez-Morales, R., Gonzalez-Lerma, P., Yuiska, A., Han, J. H., Guerra, Y., Crisostomo, L., ... Kowalko, J.
(2022).
Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus
-
Kozol, R. A., Conith, A. J., Yuiska, A., Cree-Newman, A., Tolentino, B., Banesh, K., ... Duboue, E. R.
(2022).
A brain-wide analysis maps structural evolution to distinct anatomical modules
-
Lunsford, E. T., Paz, A., Keene, A. C., & Liao, J. C.
(2022).
Evolutionary convergence of a neural mechanism in the cavefish lateral line system
-
Hess, R. A., Erickson, O. A., Cole, R. B., Isaacs, J. M., Alvarez-Clare, S., Arnold, J., ... Dolan, E. L.
(2022).
Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences
-
Palermo, J., Chesi, A., Zimmerman, A., Sonti, S., Lasconi, C., Brown, E. B., ... Keene, A. C.
(2021).
Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleep
-
Oliva, C., Hinz, N. K., Robinson, W., Thompson, A., Booth, J., Crisostomo, L. M., ... Keene, A. C.
(2021).
Characterizing the genetic basis of trait evolution in the Mexican cavefish
-
Perry, A., McGaugh, S. E., Keene, A. C., & Blackmon, H.
(2021).
CaveCrawler: An interactive analysis suite for cavefish bioinformatics
-
Brown, E. B., Klok, J., & Keene, A. C.
(2021).
Measuring metabolic rate in single flies during sleep and waking states
-
Lloyd, E., McDole, B., Privat, M., Jaggard, J. B., Dubou, E., Sumbre, G., & Keene, A.
(2021).
Blind cavefish retain functional connectivity in the tectum despite loss of retinal input
-
Chin, J., Phan, T., Albert, L. T., Keene, A. C., & Dubou, E. R.
(2021).
Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish
-
Erickson, O. A., Cole, R. B., Isaacs, J. M., Alvarez-Clare, S., Arnold, J., Augustus-Wallace, A., ... Dolan, E. L.
(2021).
How do we do this at a distance?! A descriptive study of remote undergraduate research programs during COVID-19
-
Moran, R. L., Jaggard, J. B., Roback, E. Y., Rohner, N., Kowalko, J. E., Ornelas-Garca, C. P., McGaugh, S. E., & Keene, A. C.
(2021).
Hybridization underlies localized trait evolution in cavefish
-
Murakami, K., Palermo, J., Stanhope, B. A., & Keene, A. C.
(2021).
A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79
-
OGorman, M., Thakur, S., Imrie, G., Moran, R. L., Duboue, E., Rohner, N., ... Kowalko, J. E.
(2020).
Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish
-
Collie, J., Granela, O., Brown, E., & Keene, A. C.
(2020).
Aggression is induced by resource limitation in the monarch caterpillar
-
Lloyd, E., Chhouk, B., Keene, A. C., & Albertson, R. C.
(2020).
Diversity in rest-activity patterns among Lake Malawi cichlid fishes suggests novel axis of habitat partitioning
-
Warren, W., Boggs, T., Borowsky, R., Carlson, B., Ferrufino, E., Gross, J., ... Rohner, N.
(2020).
A chromosome level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution
-
Warren, W. C., Boggs, T. E., Borowsky, R., Carlson, B. M., Ferrufino, E., Gross, J. B., ... Rohner, N.
(2020).
A chromosome level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution
-
Brown, E. B., Shah, K. D., Palermo, J., Dey, M., Dahanukar, A., & Keene, A. C.
(2020).
Ir56d-dependent fatty acid responses in Drosophila uncovers taste discrimination between different classes of fatty acids
-
Chin, J. S., Loomis, C. L., Albert, L. T., Medina-Trenche, S., Kowalko, J., Keene, A. C., & Dubou, E. R.
(2020).
Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations
-
Patch, A., Paz, A., Holt, K., Duboue, E., Kowalko, J. E., Keene, A. C., & Fily, Y.
(2020).
Kinematic analysis deconstructs the evolved loss of schooling behavior in cavefish
-
Mack, K. L., Jaggard, J. B., Persons, J. L., Passow, C. N., Stanhope, B. A., Ferrufino, E., ... McGaugh, S. E.
(2020).
Repeated evolution of circadian clock dysregulation in cavefish populations
-
Botero, V., Stahl, B. A., Grenci, E. C., Boto, T., Park, S. J., King, L. B., ... Tomchik, S. M.
(2019).
Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
-
Jaggard, J., Lloyd, E., Yuiska, A., Patch, A., Fily, Y., Kowalko, J. E., ... Keene, A. C.
(2019).
Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations
-
Paz, A., McDole, B., Kowalko, J. E., Duboue, E. R., & Keene, A. C.
(2019).
Evolution of the acoustic startle response of Mexican cavefish
-
McGaugh, S. E., Passow, C. N., Jaggard, J. B., Stahl, B. A., & Keene, A. C.
(2019).
Unique transcriptional signatures of sleep loss across independently evolved cavefish populations
-
Stahl, B. A., Jaggard, J. B., & Keene, A. C.
(2019).
Sleep regulates the glial engulfment receptor Draper to promote Wallerian degeneration
-
Pamboro, E., Brown, E. B., & Keene, A. C.
(2019).
Dietary fatty acids promote sleep through a taste-independent mechanism
-
Brown, E. B., Shah, K. D., Faville, R., Kottler, B., & Keene, A. C.
(2019).
Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity
-
Loomis, C., Peu, R., Jaggard, J., Wang, Y., McKinney, S., Raftopoulos, S., ... Duboue, E. R.
(2019).
An adult brain atlas reveals broad neuroanatomical changes in independently evolved populations of Mexican cavefish
-
Stahl, B. A., Peu, R., McDole, B., Kenzior, A., Jaggard, J. B., Gaudenz, K., ... Rohner, N.
(2019).
Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system
-
Brown, E. B., Slocumb, M. E., Szuperak, M., Kerbs, A., Gibbs, A. G., Kayser, M. S., & Keene, A. C.
(2018).
Starvation resistance is associated with developmentally specified changes in sleep, feeding, and metabolic rate
-
Passow, C. N., Kono, T., Stahl, B. A., Jaggard, J. B., Keene, A. C., & McGaugh, S. E.
(2018).
RNAlater and flash freezing storage methods nonrandomly influence observed gene expression in RNAseq experiments
-
Ly, S., Kaun, K., Lee, C., Stewart, D., Pulver, S. R., & Keene, A. C.
(2018).
Long-term impact of intensive postgraduate laboratory training at the Cold Spring Harbor Neurobiology of Drosophila summer course
-
Yurgel, M. E., Shah, K. D., Brown, E. B., Bennick, R. A., DiAngelo, J. R., & Keene, A. C.
(2018).
Ade2 functions in the Drosophila fat body to promote sleep
-
Zandawala, M., Yurgel, M. E., Liao, S., Texada, M. J., Rewitz, K. F., Keene, A. C., & Nssel, D. R.
(2018).
Orchestration of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin
-
Herman, A., Brandvain, Y., Weagley, J., Jeffery, W. R., Keene, A. C., Kono, T., ... McGaugh, S. E.
(2018).
The role of gene flow in rapid and repeated evolution of cave related traits in Mexican tetra, Astyanax mexicanus
-
Yurgel, M. E., Kakad, P., Zandawala, M., Nassel, D., Godenschwege, T. A., & Keene, A. C.
(2018).
A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions
-
Brown, E. B., Torres, J., Bennick, R. A., Rozzo, V., Kerbs, A., DiAngelo, J. R., & Keene, A. C.
(2017).
Geographic variation in sleep and metabolic function is associated with latitude and temperature
-
Tauber, J. M., Brown, E., Li, Y., Yurgel, M. E., Masek, P., & Keene, A. C.
(2017).
A subset of sweet-sensing neurons identified by IR56d are necessaryand sufficient for fatty acid taste
-
Stahl, B. A., Slocumb, M. E., Chaitin, H., DiAngelo, J. R., & Keene, A. C.
(2017).
Sleep-dependent modulation of metabolic rate in Drosophila
-
Jaggard, J. B., Stahl, B. A., Lloyd, E., Prober, D. A., Duboue, E. R., & Keene, A. C.
(2017).
Hypocretin underlies the evolution of sleep loss in the Mexican cavefish
-
Ogunlusi, O., Sarkar, M., Chakrabarti, A., Boland, D., Nguyen, T., Sampson, J., ... Sarkar, T. R.
(2024).
Circadian rhythm disruption alters mammary gland morphology and accelerates cold aggressive tumorigenesis through a LILRB4-dependent pathway
Teaching
teaching activities
- ARSC101 First Yr Seminar Instructor
- BIOL100 Horizons In Biology Instructor
- BIOL291 Research Instructor
- BIOL467 Integrat Animal Behavior Instructor
- BIOL489 Sptp: Sp Tp: Biol Thru Film Instructor
- BIOL491 Hnr-research Instructor
- BIOL685 Directed Studies Instructor
- BIOL691 Research Instructor
Contact
first name
- Alex
has last name
- Keene
Other
- keenea@tamu.edu