Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning. Academic Article

abstract

• Formation of normal olfactory memory requires the expression of the wild-type amnesiac gene in the dorsal paired medial (DPM) neurons. Imaging the activity in the processes of DPM neurons revealed that the neurons respond when the fly is stimulated with electric shock or with any odor that was tested. Pairing odor and electric-shock stimulation increases odor-evoked calcium signals and synaptic release from DPM neurons. These memory traces form in only one of the two branches of the DPM neuron process. Moreover, trace formation requires the expression of the wild-type amnesiac gene in the DPM neurons. The cellular memory traces first appear at 30 min after conditioning and persist for at least 1 hr, a time window during which DPM neuron synaptic transmission is required for normal memory. DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition.

authors

• Keene, Alex

published proceedings

• Cell

altmetric score

• 4

author list (cited authors)

• Yu, D., Keene, A. C., Srivatsan, A., Waddell, S., & Davis, R. L.

citation count

• 128

complete list of authors

• Yu, Dinghui||Keene, Alex C||Srivatsan, Anjana||Waddell, Scott||Davis, Ronald L

publication date

• December 2005

publisher

• Elsevier  Publisher

published in

• Cell  Journal

keywords

• Animals
• Calcium
• Conditioning, Classical
• Drosophila Melanogaster
• Drosophila Proteins
• Electric Stimulation
• Memory
• Neurons
• Neuropeptides
• Odorants
• Smell
• Synaptic Transmission
• Time Factors
• Transgenes

PubMed Central ID

• 16325586

Digital Object Identifier (DOI)

• 10.1016/j.cell.2005.09.037

start page

• 945

end page

• 957

volume

• 123

issue

• 5

URL

• http://dx.doi.org/10.1016/j.cell.2005.09.037