Neurodegeneration: paying it off with sleep.

abstract

• A new study in fruit flies suggests modulation of neural activity links sleep and Alzheimer's disease. Both sleep loss and amyloid beta increase neural excitability, which reinforces the accumulation of amyloid beta and shortens lifespan.

authors

• Keene, Alex

published proceedings

• Curr Biol

altmetric score

• 0.5

author list (cited authors)

• Keene, A. C., & Joiner, W. J.

citation count

• 5

complete list of authors

• Keene, Alex C||Joiner, William J

publication date

• March 2015

publisher

• Elsevier  Publisher

published in

• Current Biology  Journal

keywords

• Alzheimer Disease
• Amyloid Beta-Peptides
• Animals
• Animals, Genetically Modified
• Disease Models, Animal
• Drosophila Melanogaster
• Humans
• Nerve Degeneration
• Sleep
• Sleep Deprivation

PubMed Central ID

• 25784043

Digital Object Identifier (DOI)

• 10.1016/j.cub.2015.02.003

start page

• R234

end page

• R236

volume

• 25

issue

• 6

URL

• http://dx.doi.org/10.1016/j.cub.2015.02.003