HR job title
- Professor
- Contact Info
- 1 979 845 7261
Stallone, John Professor
Positions
Research in my lab focuses on male-female differences in normal cardiovascular function, and in the development of various diseases, including hypertension, coronary artery disease, and stroke, and the roles of the sex hormones in these male-female differences in cardiovascular disease. A major topic of study in my lab is the so-called "estrogen paradox" which reveals protective effects of this female sex hormone in younger women and animals, but deleterious effects in older females.
- Overview
- Publications
- Teaching
- Works By Students
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academic article
-
Stallone, J. N., & Oloyo, A. K.
(2023).
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?. 208, 115347-115347.
-
Yu, X., Nguyen, P., Burns, N. C., Heaps, C. L., Stallone, J. N., Sohrabji, F., & Han, G.
(2022).
Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats. Steroids.
183, 108997-108997.
-
Brusenhan, R. E., Oloyo, A. O., & Stallone, J. N.
(2022).
Hypogonadal Hypertension In Male SpragueDawley Rats Is Reversed By Testosterone and its Genomically Inactive Metabolite 5Dihydrotestosterone. The FASEB Journal.
36(S1),
-
Chakraborty, S., Venkatasamy, L., & Stallone, J.
(2020).
Sex Differences in Sepsis Survival Involve Effects of Gonadal Steroid Hormones. The FASEB Journal.
34(S1), 1-1.
-
Hanson, A. E., Perusquia, M., & Stallone, J. N.
(2020).
Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens. Biology of Sex Differences.
11(1), 48.
-
Hanson, A. E., Garcia, N. W., McKenna, J. M., Perusquia, M., & Stallone, J. N.
(2019).
Hypogonadal Hypertension in Male SpragueDawley Rats Is Reversed by Testosterone Replacement Therapy, which Suppresses ReninAngiotensin System Expression. The FASEB Journal.
33(S1), 577.5-577.5.
-
Hanson, A. E., Garcia, N. W., McKenna, J. M., Perusquia, M., & Stallone, J. N.
(2018).
HypotestosteronemiaInduced Hypertension in Male SpragueDawley Rats is Reversed by Testosterone Replacement Therapy, Which is a NonGenomic, EstrogenIndependent Effect. The FASEB Journal.
32(S1), 584.9-584.9.
-
Perusqua, M., Hanson, A. E., Meza, C. M., Kubli, C., Herrera, N., & Stallone, J. N.
(2018).
Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia. The Journal of Steroid Biochemistry and Molecular Biology.
178, 65-72.
-
Yu, X., Stallone, J. N., Heaps, C. L., & Han, G.
(2018).
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries. PLoS ONE.
13(1), e0191418-e0191418.
-
Yu, X., Zhang, Q., Zhao, Y., Schwarz, B. J., Stallone, J. N., Heaps, C. L., & Han, G.
(2017).
Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA. PLoS ONE.
12(3), e0173085-e0173085.
-
Perusqua, M., Herrera, N., Ferrer, M., & Stallone, J. N.
(2017).
Antihypertensive effects of androgens in conscious, spontaneously hypertensive rats. The Journal of Steroid Biochemistry and Molecular Biology.
167, 106-114.
-
Deer, R. R., & Stallone, J. N.
(2016).
Effects of estrogen on cerebrovascular function: age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat. American Journal of Physiology. Heart and Circulatory Physiology.
310(10), H1285-H1294.
-
Stallone, J. N.
(2015).
Corticosteroid Therapy in Sepsis: When Is a Good Thing Too Much of a Good Thing?. Critical Care Medicine.
43(11), 2519-2520.
-
Stallone, J. N.
(2015).
Hypothalamo-pituitary-adrenal axis dynamics: do apples and oranges increase our understanding of the hypothalamo-pituitary-adrenal axis in illness?. Critical Care Medicine.
43(4), 914-916.
-
Perusqua, M., Greenway, C. D., Perkins, L. M., & Stallone, J. N.
(2015).
Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
309(2), R189-R195.
-
Deer, R., Perkins, L., & Stallone, J.
(2014).
Age and estrogendependent effects on cerebrovascular reactivity: shifting from beneficial to detrimental (1069.6). The FASEB Journal.
28(S1),
-
Deer, R. R., & Stallone, J. N.
(2014).
Effects of age and sex on cerebrovascular function in the rat middle cerebral artery. Biology of Sex Differences.
5(1), 12.
-
Yu, X., Li, F., Klussmann, E., Stallone, J. N., & Han, G.
(2014).
G protein-coupled estrogen receptor 1 mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP. American Journal of Physiology: Endocrinology and Metabolism.
307(4), E398-E407.
-
Yu, X., Stallone, J., & Han, G.
(2014).
G proteincoupled estrogen receptor mediates relaxation of coronary arteries via cAMP/PKAdependent activation of MLCP (1065.14). The FASEB Journal.
28(S1),
-
Li, F., Yu, X., Szynkarski, C. K., Meng, C., Zhou, B., Barhoumi, R., ... Han, G.
(2013).
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS ONE.
8(6), e64771-e64771.
-
Li, F., Yu, X., Szynkarski, C. K., Meng, C., Zhou, B., Barhoumi, R., ... Han, G.
(2013).
Correction: Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS ONE.
8(7), 10.1371/annotation/ce509358-9f5c-4a8c-9b0d-80.
-
Bautista-Ortega, J., Stallone, J. N., & Ruiz-Feria, C. A.
(2013).
Effects of arginine and antioxidant vitamins on pulmonary artery reactivity to phenylephrine in the broiler chicken. Poultry Science.
92(4), 1062-1072.
-
Puttabyatappa, Y., Stallone, J. N., Ergul, A., El-Remessy, A. B., Kumar, S., Black, S., ... White, R. E.
(2013).
Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels. Journal of Pharmacology and Experimental Therapeutics.
345(1), 7-14.
-
Perusqua, M., Espinoza, J., Montao, L. M., & Stallone, J. N.
(2012).
Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature. 56(3-4), 176-182.
-
Pechenino, A. S., Lee, A. R., Lin, L. i., Mbai, F. N., Stallone, J. N., & Knowlton, A. A.
(2012).
Reply to "Letter to the Editor: 'Understanding the WHI gap"'. Physiological Genomics.
44(5), 330-330.
-
Deenadayalu, V., Puttabyatappa, Y., Liu, A. T., Stallone, J. N., & White, R. E.
(2012).
Testosterone-induced relaxation of coronary arteries: activation of BKCa channels via the cGMP-dependent protein kinase. American Journal of Physiology. Heart and Circulatory Physiology.
302(1), H115-H123.
-
Sellers, M., & Stallone, J.
(2011).
SEX DIFFERENCES IN CONSTRICTOR RESPONSES TO BERAPROST IN RAT MESENTERIC ARTERIOLES: ROLES OF THROMBOXANE VS. PGE2 PROSTANOID RECEPTORS. The FASEB Journal.
25(S1), 1026.35-1026.35.
-
Yu, X., Ma, H., Barman, S. A., Liu, A. T., Sellers, M., Stallone, J. N., ... Han, G.
(2011).
Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. American Journal of Physiology: Endocrinology and Metabolism.
301(5), E882-E888.
-
Pechenino, A. S., Lin, L. i., Mbai, F. N., Lee, A. R., He, X., Stallone, J. N., & Knowlton, A. A.
(2011).
Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation. Physiological Genomics.
43(18), 1065-1073.
-
LeBlanc, A. J., Reyes, R., Kang, L. S., Dailey, R. A., Stallone, J. N., Moningka, N. C., & Muller-Delp, J. M.
(2010).
Corrigendum. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
298(5), r1446-r1446.
-
Perusqua, M., & Stallone, J. N.
(2010).
Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites. American Journal of Physiology. Heart and Circulatory Physiology.
298(5), H1301-H1307.
-
Sellers, M. M., & Stallone, J. N.
(2010).
Indomethacin enhances reactivity to vasopressin in normotensive and hypertensive rats, while PGE2 receptor blockade only attenuates reactivity in normotensive rats. The FASEB Journal.
24(S1), 982.14-982.14.
-
LeBlanc, A. J., Reyes, R., Kang, L. S., Dailey, R. A., Stallone, J. N., Moningka, N. C., & Muller-Delp, J. M
(2009).
Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
297(6), R1713-R1723.
-
Li, M., Kuo, L., & Stallone, J. N.
(2008).
Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression. American Journal of Physiology. Heart and Circulatory Physiology.
294(6), H2444-H2455.
-
Sellers, M. M., & Stallone, J. N
(2008).
Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure. American Journal of Physiology. Heart and Circulatory Physiology.
294(5), H1978-H1986.
-
Sellers, M., Xu, F., & Stallone, J.
(2008).
Selective Estrogen Receptor Agonists Enhance Blood Pressure, Thromboxane and Prostacyclin in Aortic CoarctationInduced Hypertensive Female Rats. The FASEB Journal.
22(S1), 941.14-941.14.
-
Spier, S. A., Delp, M. D., Stallone, J. N., Dominguez, J. M., & Muller-Delp, J. M
(2007).
Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide. American Journal of Physiology. Heart and Circulatory Physiology.
292(6), H3119-H3127.
-
Li, M., & Stallone, J. N
(2005).
Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function. American Journal of Physiology. Heart and Circulatory Physiology.
289(4), H1542-H1550.
-
Weis, M. T., Brady, M., Moore, M., Crumley, J., & Stallone, J. N.
(2005).
Inhibiting long-chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells. Journal of Vascular Research.
42(4), 275-283.
-
Weis, M. T., Crumley, J. L., Young, L. H., & Stallone, J. N
(2004).
Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardioscience.
63(2), 338-346.
-
Stallone, J. N.
(2004).
Predicting mortality from sepsis: is protein C a true crystal ball?. Critical Care Medicine.
32(7), 1620-1621.
-
Voss, M. R., Stallone, J. N., Li, M., Cornelussen, R., Knuefermann, P., & Knowlton, A. A
(2003).
Gender differences in the expression of heat shock proteins: the effect of estrogen. American Journal of Physiology. Heart and Circulatory Physiology.
285(2), H687-H692.
-
Fulton, C. T., & Stallone, J. N
(2002).
Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids. American Journal of Physiology. Heart and Circulatory Physiology.
283(5), H2062-H2073.
-
Stallone, J. N., Salisbury, R. L., & Fulton, C. T
(2001).
Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta. Journal of applied physiology.
91(6), 2602-2610.
-
Ding, A. Q., & Stallone, J. N
(2001).
Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation. Journal of applied physiology.
91(6), 2742-2750.
-
Deenadayalu, V. P., White, R. E., Stallone, J. N., Gao, X., & Garcia, A. J.
(2001).
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. 281(4), H1720-H1727.
-
Eatman, D., Stallone, J. N., Rutecki, G. W., & Whittier, F. C.
(1998).
Sex differences in extracellular and intracellular calcium-mediated vascular reactivity to vasopressin in rat aorta. European Journal of Pharmacology.
361(2-3), 207-216.
-
Deenadayalu, V., Gao, X., White, R. E., & Stallone, J. N.
(1998).
Testosterone-induced vasorelaxation of porcine coronary artery involves K+ channel activation. The FASEB Journal.
12(5),
-
Chao, J., Stallone, J. N., Liang, Y. M., Chen, L. M., Wang, D. Z., & Chao, L.
(1997).
Kallistatin is a potent new vasodilator. 100(1), 11-17.
-
Ding, A. O., & Stallone, J. N.
(1997).
Testosterone-induced relaxation of rat thoracic aorta: Structural specificity of androgen analog effects on vascular smooth muscle (VSM) and endothelium (ENDO). The FASEB Journal.
11(3),
-
Costarella, C. E., Stallone, J. N., Rutecki, G. W., & Whittier, F. C.
(1996).
Testosterone causes direct relaxation of rat thoracic aorta. Journal of Pharmacology and Experimental Therapeutics.
277(1), 34-39.
-
Burton, R. D., & Stallone, J. N.
(1996).
Sexual dimorphism in renal vascular reactivity to ang1otensin in spontaneously hypertensive rats: Effects of gonadectomy and estrogen replacement. The FASEB Journal.
10(3),
-
Ding, A. O., & Stallone, J. N.
(1996).
Testosterone-induced relaxation of rat thoracic aorta involves vascular smooth muscle (VSM) K+ channel activation. The FASEB Journal.
10(3),
-
Stallone, J. N.
(1995).
Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats. 268(1 Pt 2), R40-R49.
-
Stallone, J. N.
(1994).
Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy. European Journal of Pharmacology.
259(3), 273-283.
-
Stallone, J. N.
(1993).
Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta. AMERICAN JOURNAL OF PHYSIOLOGY.
265(6 Pt 2), H2073-H2080.
-
Richardson, B. A., Studier, E. H., Stallone, J. N., & Kennedy, C. M.
(1992).
Effects of melatonin on water metabolism and renal function in male Syrian hamsters (Mesocricetus auratus). Journal of Pineal Research.
13(2), 49-59.
-
Howard, M. G., DiCarlo, S. E., & Stallone, J. N.
(1992).
Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings. Medicine & Science in Sports & Exercise.
24(10), 1102-1107.
-
Stallone, J. N., Crofton, J. T., & Share, L.
(1991).
Sexual dimorphism in vasopressin-induced contraction of rat aorta. AMERICAN JOURNAL OF PHYSIOLOGY.
260(2 Pt 2), H453-H458.
-
Stallone, J. N., Nishimura, H., & Nasjletti, A.
(1990).
Angiotensin II binding sites in aortic endothelium of domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
258(3 Pt 2), R777-R782.
-
Stallone, J. N., Nishimura, H., & Khosla, M. C.
(1989).
Angiotensin II vascular receptors in fowl aorta: binding specificity and modulation by divalent cations and guanine nucleotides. Journal of Pharmacology and Experimental Therapeutics.
251(3), 1076-1082.
-
Braun, E. J., & Stallone, J. N.
(1989).
The occurrence of nephrogenic diabetes insipidus in domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
256(4 Pt 2), F639-F645.
-
Takei, Y., Stallone, J. N., Nishimura, H., & Campanile, C. P.
(1988).
Angiotensin II receptors in the fowl aorta. General and Comparative Endocrinology.
69(2), 205-216.
-
Stallone, J. N., & Braun, E. J.
(1988).
Regulation of plasma antidiuretic hormone in the dehydrated kangaroo rat (Dipodomys spectabilis M.). General and Comparative Endocrinology.
69(1), 119-127.
-
Stallone, J. N., & Braun, E. J.
(1986).
Osmotic and volemic regulation of plasma arginine vasotocin in conscious domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
250(4 Pt 2), R644-R657.
-
Stallone, J. N., & Braun, E. J.
(1986).
Regulation of plasma arginine vasotocin in conscious water-deprived domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
250(4 Pt 2), R658-R664.
-
Stallone, J. N., & Braun, E. J.
(1986).
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl. American Journal of Physiology: Renal Physiology.
250(6), f1130-f1130.
-
Stallone, J. N., & Braun, E. J.
(1986).
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl. American Journal of Physiology: Renal Physiology.
250(4), f757-f757.
-
Stallone, J. N., & Braun, E. J.
(1986).
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
250(6), F842-F850.
-
Stallone, J. N., & Braun, E. J.
(1985).
Contributions of glomerular and tubular mechanisms to antidiuresis in conscious domestic fowl. AMERICAN JOURNAL OF PHYSIOLOGY.
249(6 Pt 2), F842-F850.
-
Stallone, J. N., & Nishimura, H.
(1985).
Angiotensin II (AII)-induced natriuresis in anesthetized domestic fowl. FEDERATION PROCEEDINGS.
44(5),
-
Takei, Y., Stallone, J. N., & Nishimura, H.
(1985).
Angiotensin II vascular receptors in the domestic fowl. FEDERATION PROCEEDINGS.
44(3),
-
Stallone, J. N., & Braun, E. J.
(1984).
Effects of arginine vasotocin (AVT) infusion on glomerular filtration rate (GFR) in conscious domestic fowl. FEDERATION PROCEEDINGS.
43(3),
-
Braun, E. J., & Stallone, J. N.
(1984).
Immunoreactive plasma arginine vasotocin (P(AVT)) in the putative diabetes insipidus domestic fowl. FEDERATION PROCEEDINGS.
43(4),
-
Stallone, J. N., & Braun, E. J.
(1982).
Osmotic regulation of plasma arginine vasotocin (PAVT) in conscious domestic fowl. FEDERATION PROCEEDINGS.
41(4),
-
Stallone, J. N.
(1979).
Seasonal changes in the water metabolism of woodrats. Oecologia.
38(2), 203-216.
-
Nagy, K. A., & Stallone, J. N.
(1976).
Temperature maintenance and CO2 concentration in a swarm cluster of honey bees, Apis mellifera. Comparative Biochemistry and Physiology - A: Comparative Physiology.
55(2a), 169-171.
-
Stallone, J. N., & Oloyo, A. K.
(2023).
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?. 208, 115347-115347.
-
conference paper
-
Li, F., Wang, G., Zhou, B., White, R., Heaps, C., Stallone, J., & Han, G.
(2012).
Activation of G-protein-coupled estrogen receptor (GPER) inhibits coronary artery smooth muscle cell proliferation. The FASEB Journal.
663.9-663.9.
-
Stallone, J. N., & White, R. E
(2005).
Nongenomic androgen-induced vasorelaxation is structurally-specific and involves vascular smooth muscle K+ channel activation via nitric oxide-cyclic-gmp pathway. Steroids.
481-482.
-
Li, M., Kuo, L., & Stallone, J. N.
(2002).
Estrogen enhances contractile responses of rat aorta by upregulating expression of cyclooxygenase-2 and thromboxame synthase. Circulation.
211-211.
-
Fulton, C. T., Freeman, E. J., & Stallone, J. N
(1999).
Long-term tamoxifen (TMX)-treatment enhances endothelium-dependent nitric oxide (NO) and constrictor prostanoid (PG) function in female rat aorta. Circulation.
220-220.
-
Yu, X., Li, F., Sellers, M., Stallone, J., White, R., Prossnitz, E., & Han, G.
The mechanism of activation of G-protein coupled estrogen receptor induced coronary artery smooth muscle relaxation. The FASEB Journal.
1009.5-1009.5.
-
Li, F., Wang, G., Zhou, B., White, R., Heaps, C., Stallone, J., & Han, G.
(2012).
Activation of G-protein-coupled estrogen receptor (GPER) inhibits coronary artery smooth muscle cell proliferation. The FASEB Journal.
663.9-663.9.
Teaching
teaching activities
- VTPP285 Directed Studies Instructor
- VTPP485 Directed Studies Instructor
- VTPP605 Systemic Vet Phys I Instructor
- VTPP606 Systemic Vet Phys Ii Instructor
- VTPP681 Seminar: Cardio Instructor
- VTPP685 Directed Studies Instructor
- VTPP691 Research: In-ab Instructor
Works By Students
chaired theses and dissertations
-
Baltzer, Wendy Irene (2005-02). The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats.
-
Deer, Rachel Renee (2013-07). Physiological Factors that Modulate Vascular Function: States of Endothelial Dysfunction and Therapeutic Interventions.
-
Li, Min (2004-09). Constrictor prostanoid-potentiated vascular contraction: regulation of endothelial and vascular smooth muscle mechanism by estrogen.
-
Osborn, Pamela (2014-01). The Relative Contributions of COX-1 and COX-2 to Vascular Biosynthesis of Prostacyclin and Thromboxane.
-
Sellers, Minga Miown (2009-05). The role of estrogen receptors in the contribution of constrictor prostanoids to aortic coarctation-induced hypertension.
Background
education and training
- Ph.D. in Medical Physiology, University of Arizona - (Tucson, Arizona, United States) 1984
- M.S. in Comparative Physiology, San Diego State University - (San Diego, California, United States) 1974
- B.S. in Vertebrate Zoology, San Diego State University - (San Diego, California, United States) 1972
- University of Tennessee Health Science Center - (Memphis, Tennessee, United States) , Postdoctoral Training 1988
Contact
first name
- John
has last name
- Stallone
mailing address
-
Texas A&M University
Vet Med - Physiology & Pharmacology
4466 TAMU
College Station, TX 77843-4466
USA
Other
In the News
- john-n-stallone@tamu.edu