HR job title
- Associate Professor
- Contact Info
- 1 979 463 0330
Winzer-Serhan, Ursula Associate Professor
Positions
I am interested in studying how gene environmental interactions shape the brain during development. In particular, I am interested in how early life exposure to psychoactive drugs, like nicotine and alcohol, permanently shape the brain which could result in long-term cognitive impairments, anxiety, and anti-social behavior. My lab is currently focused on the effects of nicotine. Nicotine interacts with nicotinic acetylcholine receptors (nAChR) which are ligand-gated, pentameric cation channels.
- Overview
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- Works By Students
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Overview
Publications
selected publications
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academic article
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McCamy, K. M., Rees, K. A., & Winzer-Serhan, U. H.
(2022).
Peripheral immune challenges elicit differential up-regulation of hippocampal cytokine and chemokine mRNA expression in a mouse model of the 15q13.3 microdeletion syndrome. Cytokine.
159, 156005-156005.
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Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H.
(2020).
Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome. BRAIN RESEARCH.
1746, 147024-147024.
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Halawa, A. A., Rees, K. A., McCamy, K. M., & Winzer-Serhan, U. H.
(2020).
Central and peripheral immune responses to low-dose lipopolysaccharide in a mouse model of the 15q13.3 microdeletion. Cytokine.
126, 154879-154879.
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Broide, R. S., Winzer-Serhan, U. H., Chen, Y., & Leslie, F. M.
(2019).
Distribution of 7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. Frontiers in Neuroanatomy.
13, 76.
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Halawa, A. A., Damborsky, J. C., Slaton, G. S., & Winzer-Serhan, U. H.
(2018).
Activation of immediate early genes by nicotine after chronic neonatal nicotine exposure in brain areas involved in stress and anxiety responses. Brain Research.
1687, 32-40.
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Winzer-Serhan, U. H.
(2015).
Evaluation of Chronic Oral Nicotine Treatment in Food Consumption, Body Weight and [125I] Epibatidine Binding in Adult Mice. 1(1),
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Damborsky, J. C., Slaton, G. S., & Winzer-Serhan, U. H.
(2015).
Expression of Npas4 mRNA in Telencephalic Areas of Adult and Postnatal Mouse Brain. Frontiers in Neuroanatomy.
9(November), 145-10.
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Damborsky, J. C., Griffith, W. H., & Winzer-Serhan, U. H.
(2015).
Neonatal nicotine exposure increases excitatory synaptic transmission and attenuates nicotine-stimulated GABA release in the adult rat hippocampus. Neuropharmacology.
88, 187-198.
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Robin, M. P., Mabire, A. B., Damborsky, J. C., Thom, E. S., Winzer-Serhan, U. H., Raymond, J. E., & O'Reilly, R. K.
(2013).
New functional handle for use as a self-reporting contrast and delivery agent in nanomedicine. Journal of the American Chemical Society.
135(25), 9518-9524.
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Mendez, I. A., Damborsky, J. C., Winzer-Serhan, U. H., Bizon, J. L., & Setlow, B.
(2013).
42 and 7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision-making tasks. Neuroscience.
230, 121-131.
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DuBois, D. W., Damborsky, J. C., Fincher, A. S., Frye, G. D., & Winzer-Serhan, U. H.
(2013).
Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons. LIFE SCIENCES.
92(6-7), 337-344.
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Balaraman, S., Winzer-Serhan, U. H., & Miranda, R. C.
(2012).
Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcoholism: Clinical and Experimental Research.
36(10), 1669-1677.
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Andersson, R. H., Johnston, A., Herman, P. A., Winzer-Serhan, U. H., Karavanova, I., Vullhorst, D., Fisahn, A., & Buonanno, A.
(2012).
Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors. Proceedings of the National Academy of Sciences of the United States of America.
109(32), 13118-13123.
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Abbott, L. C., & Winzer-Serhan, U. H.
(2012).
Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models. Critical Reviews in Toxicology.
42(4), 279-303.
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Mitchell, M. R., Mendez, I. A., Vokes, C. M., Damborsky, J. C., Winzer-Serhan, U. H., & Setlow, B.
(2012).
Effects of developmental nicotine exposure in rats on decision-making in adulthood. BEHAVIOURAL PHARMACOLOGY.
23(1), 34-42.
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Damborsky, J. C., & Winzer-Serhan, U. H.
(2012).
EFFECTS OF SEX AND CHRONIC NEONATAL NICOTINE TREATMENT ON NA(2+)/K+/CL- CO-TRANSPORTER 1, K+/CL- CO-TRANSPORTER 2, BRAIN-DERIVED NEUROTROPHIC FACTOR, NMDA RECEPTOR SUBUNIT 2A AND NMDA RECEPTOR SUBUNIT 2B MRNA EXPRESSION IN THE POSTNATAL RAT HIPPOCAMPUS (vol 225, pg 105, 2012). Neuroscience.
227, 381-381.
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Damborsky, J. C., & Winzer-Serhan, U. H.
(2012).
Effects of sex and chronic neonatal nicotine treatment on Na/K/Cl co-transporter 1, K/Cl co-transporter 2, brain-derived neurotrophic factor, NMDA receptor subunit 2A and NMDA receptor subunit 2B mRNA expression in the postnatal rat hippocampus. Neuroscience.
225, 105-117.
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Damborsky, J. C., Griffith, W. H., & Winzer-Serhan, U. H.
(2012).
Chronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner. BRAIN RESEARCH.
1430, 8-17.
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Huang, P., Son, J., Abbott, L. C., & Winzer-Serhan, U. H.
(2011).
Regulated expression of neuronal SIRT1 and related genes by aging and neuronal 2-containing nicotinic cholinergic receptors. Neuroscience.
196, 189-202.
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Garza, A., Huang, L. Z., Son, J., & Winzer-Serhan, U. H.
(2009).
Expression of nicotinic acetylcholine receptors and subunit messenger RNAs in the enteric nervous system of the neonatal rat. Neuroscience.
158(4), 1521-1529.
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Son, J., & Winzer-Serhan, U. H.
(2009).
Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Research.
1278, 1-14.
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Son, J., & Winzer-Serhan, U. H.
(2009).
Signal intensities of radiolabeled cRNA probes used alone or in combination with non-isotopic in situ hybridization histochemistry. Journal of Neuroscience Methods.
179(2), 159-165.
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Schmitt, H. F., Huang, L. Z., Son, J., Pinzon-Guzman, C., Slaton, G. S., & Winzer-Serhan, U. H.
(2008).
Acute nicotine activates c-fos and activity-regulated cytoskeletal associated protein mRNA expression in limbic brain areas involved in the central stress-response in rat pups during a period of hypo-responsiveness to stress. Neuroscience.
157(2), 349-359.
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Son, J., & Winzer-Serhan, U. H.
(2008).
Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs in rat hippocampal GABAergic interneurons. The Journal of Comparative Neurology.
511(2), 286-299.
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Winzer-Serhan, U. H.
(2008).
Long-term consequences of maternal smoking and developmental chronic nicotine exposure. Frontiers in Bioscience.
13(13), 636-649.
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Huang, L. Z., Liu, X., Griffith, W. H., & Winzer-Serhan, U. H.
(2007).
Chronic neonatal nicotine increases anxiety but does not impair cognition in adult rats. BEHAVIORAL NEUROSCIENCE.
121(6), 1342-1352.
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Moser, N., Mechawar, N., Jones, I., Gochberg-Sarver, A., Orr-Urtreger, A., Plomann, M., ... Wevers, A.
(2007).
Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures. Journal of Neurochemistry.
102(2), 479-492.
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Huang, L. Z., Abbott, L. C., & Winzer-Serhan, U. H.
(2007).
Effects of chronic neonatal nicotine exposure on nicotinic acetylcholine receptor binding, cell death and morphology in hippocampus and cerebellum. Neuroscience.
146(4), 1854-1868.
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Huang, L. Z., & Winzer-Serhan, U. H.
(2007).
Nicotine regulates mRNA expression of feeding peptides in the arcuate nucleus in neonatal rat pups. 67(3), 363-377.
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Huang, L. Z., & Winzer-Serhan, U. H.
(2006).
Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression. BRAIN RESEARCH.
1113(1), 94-109.
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Huang, L. Z., Hsiao, S., Trzeciakowski, J., Frye, G. D., & Winzer-Serhan, U. H.
(2006).
Chronic nicotine induces growth retardation in neonatal rat pups. LIFE SCIENCES.
78(13), 1483-1493.
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Huang, L. Z., & Winzer-Serhan, U. H.
(2006).
Effects of paraformaldehyde fixation on nicotinic acetylcholine receptor binding in adult and developing rat brain sections. Journal of Neuroscience Methods.
153(2), 312-317.
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Son, J., & Winzer-Serhan, U. H.
(2006).
Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus. Journal of Chemical Neuroanatomy.
32(2-4), 179-190.
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Winzer-Serhan, U. H., & Leslie, F. M.
(2005).
Expression of alpha5 nicotinic acetylcholine receptor subunit mRNA during hippocampal and cortical development. Journal of Comparative Neurology.
481(1), 19-30.
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Azam, L., Winzer-Serhan, U., & Leslie, F. M.
(2003).
Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons. Neuroscience.
119(4), 965-977.
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Winzer-Serhan, U. H., Chen, Y., & Leslie, F. M.
(2003).
Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development. Journal of Chemical Neuroanatomy.
26(1), 17-36.
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Azam, L., Winzer-Serhan, U. H., Chen, Y., & Leslie, F. M.
(2002).
Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. Journal of Comparative Neurology.
444(3), 260-274.
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Adams, C. E., Broide, R. S., Chen, Y., Winzer-Serhan, U. H., Henderson, T. A., Leslie, F. M., & Freedman, R.
(2002).
Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. Brain research. Developmental brain research.
139(2), 175-187.
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Shi, T. S., Winzer-Serhan, U., Leslie, F., & Hkfelt, T.
(2000).
Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. Pain.
84(2-3), 319-330.
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Winzer-Serhan, U. H., & Leslie, F. M.
(1999).
Expression of alpha2A adrenoceptors during rat neocortical development. Developmental Neurobiology.
38(2), 259-269.
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Shi, T. J., Winzer-Serhan, U., Leslie, F., & Hkfelt, T.
(1999).
Distribution of alpha2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats. NeuroReport.
10(13), 2835-2839.
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Winzer-Serhan, U. H., Broide, R. S., Chen, Y., & Leslie, F. M.
(1999).
Highly sensitive radioactive in situ hybridization using full length hydrolyzed riboprobes to detect alpha 2 adrenoceptor subtype mRNAs in adult and developing rat brain. Brain Research.
3(3), 229-241.
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Leslie, F. M., Chen, Y., & Winzer-Serhan, U. H.
(1998).
Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
76(3), 284-293.
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Winzer-Serhan, U. H., & Leslie, F. M.
(1997).
Codistribution of nicotinic acetylcholine receptor subunit alpha3 and beta4 mRNAs during rat brain development. 386(4), 540-554.
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Winzer-Serhan, U. H., & Leslie, F. M.
(1997).
Alpha2B adrenoceptor mRNA expression during rat brain development. Brain research. Developmental brain research.
100(1), 90-100.
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Winzer-Serhan, U. H., Raymon, H. K., Broide, R. S., Chen, Y., & Leslie, F. M.
(1997).
Expression of alpha 2 adrenoceptors during rat brain development--I. Alpha 2A messenger RNA expression. Neuroscience.
76(1), 241-260.
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Winzer-Serhan, U. H., Raymon, H. K., Broide, R. S., Chen, Y., & Leslie, F. M.
(1997).
Expression of alpha 2 adrenoceptors during rat brain development--II. Alpha 2C messenger RNA expression and [3H]rauwolscine binding. Neuroscience.
76(1), 261-272.
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Jensen, J. J., Winzer-Serhan, U. H., & Leslie, F. M.
(1997).
Glial regulation of alpha 7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons. Journal of Neurochemistry.
68(1), 112-120.
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Winzer-Serhan, U. H., & Leslie, F. M.
(1996).
117 Alpha2A adrenoceptor expression during neocortical development. International Journal of Developmental Neuroscience.
14, 78-78.
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Winzer-Serhan, U. H., Schfer, H., & Friedl, P.
(1993).
Isolation and characterization of mouse monoclonal antibodies against a human vascular endothelial cell-specific antigen. EUROPEAN JOURNAL OF CELL BIOLOGY.
60(1), 42-47.
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McCamy, K. M., Rees, K. A., & Winzer-Serhan, U. H.
(2022).
Peripheral immune challenges elicit differential up-regulation of hippocampal cytokine and chemokine mRNA expression in a mouse model of the 15q13.3 microdeletion syndrome. Cytokine.
159, 156005-156005.
-
chapter
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Winzer-Serhan, U. H.
(2023).
Chapter 13 Nicotinic acetylcholine receptors in the autonomic nervous system. Primer on the Autonomic Nervous System.
(pp. 77-80).
Elsevier.
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Son, J., & Winzer-Serhan, U. H.
(2015).
Combined Radioactive and Nonradioactive Double In Situ Hybridization (DISH). Neuromethods.
In Situ Hybridization Methods.
(pp. 109-126).
Springer Nature.
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Winzer-Serhan, U. H., & Leslie, F. M.
(2000).
Quantitative Light Microscopic Autoradiography of 2-Adrenergic Radioligand Binding Sites. Methods in molecular biology (Clifton, N.J.).
Adrenergic Receptor Protocols.
(pp. 507-517).
Springer Nature.
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Winzer-Serhan, U. H., & Leslie, F. M.
(2000).
Quantitative light microscopic autoradiography of alpha 2-adrenergic radioligand binding sites. Methods in molecular biology (Clifton, N.J.).
Adrenergic Receptor Protocols.
(pp. 507-517).
Humana Press.
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Winzer-Serhan, U. H.
(2023).
Chapter 13 Nicotinic acetylcholine receptors in the autonomic nervous system. Primer on the Autonomic Nervous System.
(pp. 77-80).
Elsevier.
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conference paper
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Balaraman, S., Tsai, P., Pappalardo, D., Winzer-Serhan, U., & Miranda, R. C.
(2012).
ETHANOL-RESPONSIVE FETAL NEURAL STEM CELL MIRNAS ARE COMMON TARGETS FOR FETAL TERATOGENS. Alcoholism: Clinical and Experimental Research.
333A-333A.
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DuBois, D. W., Fincher, A. S., Winzer-Serhan, U. H., & Frye, G. D.
(2012).
VARENICLINE ENHANCES GABAERGIC SYNAPTIC TRANSMISSION AND AMELIORATES ETHANOL-INDUCED DEFICITS IN GABAERGIC SIGNALING IN BASAL FOREBRAIN NEURONS. Alcoholism: Clinical and Experimental Research.
393A-393A.
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DuBois, D. W., Fincher, A. S., Winzer-Serhan, U. H., & Frye, G. D.
(2012).
VARENICLINE MODULATES GABAERGIC SYNAPTIC TRANSMISSION AND MITIGATES ETHANOL-INDUCED DEFICITS IN GABAERGIC SIGNALING IN BASAL FOREBRAIN NEURONS. Alcoholism: Clinical and Experimental Research.
38A-38A.
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Balaraman, S., Tsai, P., Pappalardo, D., Winzer-Serhan, U., & Miranda, R. C.
(2012).
ETHANOL-RESPONSIVE FETAL NEURAL STEM CELL MIRNAS ARE COMMON TARGETS FOR FETAL TERATOGENS. Alcoholism: Clinical and Experimental Research.
333A-333A.
Research
investigator on
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- GENE491 Hnr-research Instructor
- MEID608 Neuroscience Block Co-Leader, Instructor
- MEID708 Integument/musculoskeletal Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NEXT603 Neuropsychopharmacology Instructor
- NEXT681 Seminar Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC633 Neuropsychopharmacology Instructor
- NRSC685 Directed Studies Instructor
Works By Students
chaired theses and dissertations
Background
education and training
- Ph.D. in Cell Biology, University of Bremen - (Bremen, Germany) 1989
- M.S. in Plant Physiology, University of Florida - (Gainesville, Florida, United States) 1986
- M.S. in Biology, University of Bremen - (Bremen, Germany) 1986
- Virginia Commonwealth University Medical Center - (Richmond, Virginia, United States) , Postdoctoral Training 1999
- University of California, Irvine - (Irvine, California, United States) , Postdoctoral Training 1997
Contact
first name
- Ursula
has last name
- Winzer-Serhan
mailing address
-
Texas A&M Health Science Center
Neuroscience & Experimental Therapeutics
1359 TAMUS
Bryan, TX 77807-3260
USA
Other
In the News
- winzer-serhan@tamu.edu