Distribution of alpha2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats.

abstract

• Using riboprobe in situ hybridization we have studied the distribution of alpha2A-, alpha2B- and alpha2c-adrenoceptor (AR) mRNAs in the lumbar spinal cord in normal rats and after peripheral axotomy. A strong alpha2A- and alpha2C AR mRNA labelling was found in motoneurons and other cells in the ventral horns. In the dorsal horns strong alpha2A-AR mRNA labelling was found in all layers and in the lateral spinal nucleus, whereas alpha2C-AR mRNA was found in lower numbers of cells in various layers. The alpha2B-AR mRNA signal was only detected in some small cells superficially in the dorsal horn. With regard to axotomy only a marginal effect was observed for alpha2C-AR mRNA in the ventral horn. The results suggest that alpha2-ARs are involved both in sensory and motor processing.

authors

• Winzer-Serhan, Ursula

published proceedings

• Neuroreport

altmetric score

• 3

author list (cited authors)

• Shi, T. J., Winzer-Serhan, U., Leslie, F., & Hkfelt, T.

citation count

• 52

complete list of authors

• Shi, TJ||Winzer-Serhan, U||Leslie, F||Hökfelt, T

publication date

• January 1999

publisher

• Wolters Kluwer  Publisher

published in

• NeuroReport  Journal

keywords

• Animals
• Axotomy
• In Situ Hybridization
• Lumbosacral Region
• Male
• Neurons
• Protein Isoforms
• RNA, Messenger
• Rats
• Rats, Sprague-Dawley
• Receptors, Adrenergic, Alpha
• Reference Values
• Spinal Cord
• Tissue Distribution

Digital Object Identifier (DOI)

• 10.1097/00001756-199909090-00025

start page

• 2835

end page

• 2839

volume

• 10

issue

• 13

URL

• http://dx.doi.org/10.1097/00001756-199909090-00025