HR job title
- Professor
- Contact Info
- ORCiD
- 0000-0002-9936-7149
Wei, Yinan Professor
Positions
We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.
Research Areas
- Overview
- Publications
- Teaching
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academic article
-
Pandeya, A., Zhang, Y., Cui, J., Yang, L., Li, J., Zhang, G., ... Wei, Y.
(2023).
Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection. 275, 127460-127460.
-
Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., ... Glazer, E. C.
(2023).
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin. RSC Chemical Biology.
4(5), 344-353.
-
Yang, L., Shi, H., Zhang, L., Lin, X., Wei, Y., Jiang, H., & Zeng, Z.
(2023).
Emergence of two AcrB substitutions conferring multidrug resistance to Salmonella spp. Antimicrobial Agents and Chemotherapy.
65(5), AAC.01589-AAC.01520.
-
Zhang, Y., Wu, C., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2022).
Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death. International Journal of Molecular Sciences.
23(12), 6800-6800.
-
Wu, C., Zhang, Y., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2022).
Abstract 487: Extracellularhistonestrigger Disseminated Intravascular Coagulation By Lytic Cell Death. 42(Suppl_1), a487-a487.
-
Wei, Y., Yang, L., Pandeya, A., Cui, J., Zhang, Y., & Li, Z.
(2022).
Pyroptosis-Induced Inflammation and Tissue Damage. Journal of Molecular Biology.
434(4), 167301-167301.
-
Mills, R., Vogler, R. J., Bernard, M., Concolino, J., Hersh, L. B., Wei, Y., ... Bhattacharyya, D.
(2022).
Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes. Communications Materials.
3(1), 34.
-
Yang, L., Pandeya, A., Li, L., Ojo, I., Li, Z., & Wei, Y.
(2022).
Transport Across Two Membrane Bilayers in E. coli by Efflux Pumps of Different Dimensions. Journal of Molecular Biology.
434(2), 167376-167376.
-
Rajapaksha, P., Ojo, I., Yang, L., Pandeya, A., Abeywansha, T., & Wei, Y.
(2021).
Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies. Antibiotics.
10(7), 830-830.
-
Alegun, O., Pandeya, A., Cui, J., Ojo, I., & Wei, Y.
(2021).
Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics. Antibiotics.
10(6), 701-701.
-
Zhang, Y., Cui, J., Zhang, G., Wu, C., Abdel-Latif, A., Smyth, S. S., ... Li, Z.
(2021).
Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Advances.
5(12), 2619-2623.
-
Pandeya, A., Yang, L., Alegun, O., & Wei, Y.
(2021).
Biotinylation as a Tool to Enhance Uptake of Compounds in Gramnegative Bacteria. The FASEB Journal.
35(S1),
-
Pandeya, A., Yang, L., Alegun, O., Karunasena, C., Risko, C., Li, Z., & Wei, Y.
(2021).
Biotinylation as a tool to enhance the uptake of small molecules in Gram-negative bacteria. PLoS ONE.
16(11), e0260023-e0260023.
-
Li, Y., Lin, X., Hu, J., Shuai, J., Wei, Y., & He, D.
(2021).
Synthesis and biological evaluation of stilbene-based peptoid mimics against the phytopathogenic bacterium Xanthomonas citri pv. citri. 77(1), 343-353.
-
Pandeya, A., Alegun, O., Cai, Y., & Wei, Y.
(2020).
Distribution of fluoroquinolones in the two aqueous compartments of Escherichia coli. Biochemistry and Biophysics Reports.
24, 100849-100849.
-
Pandeya, A., Ojo, I., Alegun, O., & Wei, Y.
(2020).
Periplasmic Targets for the Development of Effective Antimicrobials against Gram-Negative Bacteria. ACS Infectious Diseases.
6(9), 2337-2354.
-
Rajapaksha, P., Pandeya, A., & Wei, Y.
(2020).
Probing the Dynamics of AcrB Through Disulfide Bond Formation. ACS Omega.
5(34), 21844-21852.
-
Ramsahoye, M., Pandeya, A., Cai, Y., & Wei, Y.
(2020).
Observations of Compound Penetration in Escherichia coli using Ethidium Bromide as a Model Compound. Biophysical Journal.
118(3), 230a-231a.
-
Rajapaksha, P., & Wei, Y.
(2020).
Probing the Dynamic Aspects of AcrB Function through Disulfide Bond Formation. Biophysical Journal.
118(3), 528a-529a.
-
Ojo, I., & Wei, Y.
(2020).
Probing the Functional Relevance of the Tip-to-Tip Acrab-Tolc Structural Model. Biophysical Journal.
118(3), 57a-58a.
-
Pandeya, A., Alegun, O., & Wei, Y.
(2020).
Subcellular Accumulation of Fluoroquinolones in E. coli. Biophysical Journal.
118(3), 232a-232a.
-
Zhang, Y., Zhang, G., Jian, C., Wu, C., Mackman, N., Smyth, S., Wei, Y., & Li, Z.
(2019).
Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis. Blood.
134(Supplement_1), 3644-3644.
-
Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., ... Li, Z.
(2019).
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity.
50(6), 1401-1411.e4.
-
Pandeya, A., Li, L., Li, Z., & Wei, Y.
(2019).
Gasdermin D (GSDMD) as a new target for the treatment of infection. MedChemComm.
10(5), 660-667.
-
Ojo, I., & Wei, Y.
(2019).
Functional Relevance of Unstructured Regions of AcrA, the Periplasmic Adaptor of the Major Multidrug Efflux System in E. coli. The FASEB Journal.
33(S1), 483.12-483.12.
-
Rajapaksha, P. I., & Wei, Y.
(2019).
Study of Multidrug Efflux System Protein Degradation in E. coli Using Transposons Library. The FASEB Journal.
33(S1), 463.9-463.9.
-
Wagh, P., Zhang, X., Blood, R., Kekenes-Huskey, P. M., Rajapaksha, P., Wei, Y., & Escobar, I. C.
(2019).
Increasing Salt Rejection of Polybenzimidazole Nanofiltration Membranes via the Addition of Immobilized and Aligned Aquaporins. Processes.
7(2), 76-76.
-
Thokkadam, A. M., Rajapaksha, P., Tu, Y., Kumar, M., & Wei, Y.
(2019).
Purification of an Engineered Membrane Protein FhuA for Size-Dependent Separation. Biophysical Journal.
116(3), 346a-346a.
-
Wang, Z., Lu, W., Rajapaksha, P., Wilkop, T., Cai, Y., & Wei, Y.
(2018).
Comparison of in vitro and in vivo oligomeric states of a wild type and mutant trimeric inner membrane multidrug transporter. Biochemistry and Biophysics Reports.
16, 122-129.
-
Cai, Y., Wilkop, T., & Wei, Y.
(2018).
Data on spectrum-based fluorescence resonance energy transfer measurement of E. coli multidrug transporter AcrB. Data in Brief.
21, 1649-1653.
-
Sun, X., Li, D., Wang, Z., Liu, Q., Wei, Y., & Liu, T.
(2018).
A dimorphism shift of hepatitis B virus capsids in response to ionic conditions. Nanoscale.
10(36), 16984-16989.
-
Abeywansha, T., Chai, Q., Zhang, X., Wang, Z., & Wei, Y.
(2018).
Accessibility from the Cytoplasm Is Critical for ssrA Tag-Mediated Degradation of Integral Membrane Proteins by ClpXP Protease. Biochemistry.
57(38), 5602-5608.
-
Wu, C., Wei, Y., & Li, Z.
(2018).
Abstract 038: Inflammasome Activation Triggers Blood Coagulation Through Pyroptosis. Arteriosclerosis, Thrombosis and Vascular Biology.
38(Suppl_1),
-
Sun, X., Li, D., Wang, Z., Yin, P., Hu, R., Li, H., ... Liu, T.
(2018).
Role of Protein Charge Density on Hepatitis B Virus Capsid Formation. ACS Omega.
3(4), 4384-4391.
-
Zhang, X., Lu, W., Kwan, K., Bhattacharyya, D., & Wei, Y.
(2017).
Dual-Functional-Tag-Facilitated Protein Labeling and Immobilization. ACS Omega.
2(2), 522-528.
-
Hernndez, S., Porter, C., Zhang, X., Wei, Y., & Bhattacharyya, D.
(2017).
Layer-by-layer Assembled Membranes with Immobilized Porins. RSC Advances.
7(88), 56123-56136.
-
Chai, Q., Webb, S. R., Wang, Z., Dutch, R. E., & Wei, Y.
(2016).
Study of the degradation of a multidrug transporter using a non-radioactive pulse chase method. Analytical and Bioanalytical Chemistry.
408(27), 7745-7751.
-
Chai, Q., Wang, Z., Webb, S. R., Dutch, R. E., & Wei, Y.
(2016).
The ssrA-Tag Facilitated Degradation of an Integral Membrane Protein. Biochemistry.
55(16), 2301-2304.
-
Wang, Z., Ye, C., Zhang, X., & Wei, Y.
(2015).
Cysteine residue is not essential for CPM protein thermal-stability assay. Analytical and Bioanalytical Chemistry.
407(13), 3683-3691.
-
Gajadeera, C. S., Zhang, X., Wei, Y., & Tsodikov, O. V.
(2015).
Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site. Journal of Structural Biology.
189(2), 81-86.
-
Wang, Z., Zhong, M., Lu, W., Chai, Q., & Wei, Y.
(2015).
Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB. Frontiers in Microbiology.
6, 4.
-
Ye, C., Wang, Z., Lu, W., & Wei, Y.
(2014).
Unfolding study of a trimeric membrane protein AcrB. Protein Science.
23(7), 897-905.
-
Ye, C., Wang, Z., Lu, W., Zhong, M., Chai, Q., & Wei, Y.
(2014).
Correlation between AcrB trimer association affinity and efflux activity. Biochemistry.
53(23), 3738-3746.
-
Chai, Q., Ferrell, B., Zhong, M., Zhang, X., Ye, C., & Wei, Y.
(2014).
Diverse sequences are functional at the C-terminus of the E. coli periplasmic chaperone SurA. Protein Engineering Design and Selection.
27(4), 111-116.
-
Lu, W., Zhong, M., Chai, Q., Wang, Z., Yu, L., & Wei, Y.
(2014).
Functional relevance of AcrB Trimerization in pump assembly and substrate binding. 9(2), e89143-e89143.
-
Nehru, N., Yu, L., Wei, Y., & Hastings, J. T.
(2014).
Using U-Shaped Localized Surface Plasmon Resonance Sensors to Compensate for Nonspecific Interactions. IEEE Transactions On Nanotechnology.
13(1), 55-61.
-
Yu, L., Lu, W., Ye, C., Wang, Z., Zhong, M., Chai, Q., Sheetz, M., & Wei, Y.
(2013).
Role of a conserved residue R780 in Escherichia coli multidrug transporter AcrB. Biochemistry.
52(39), 6790-6796.
-
Fang, J., Yu, L., Wu, M., & Wei, Y.
(2013).
Dissecting the function of a protruding loop in AcrB trimerization. Journal of Biomolecular Structure and Dynamics.
31(4), 385-392.
-
Lu, W., Chai, Q., Zhong, M., Yu, L., Fang, J., Wang, T., ... Wei, Y.
(2013).
Corrigendum to Assembling of AcrB Trimer in Cell Membrane [J. Mol. Biol. 423(1) (2012) 123134]. Journal of Molecular Biology.
425(5), 968-968.
-
Zhong, M., Ferrell, B., Lu, W., Chai, Q., & Wei, Y.
(2013).
Insights into the function and structural flexibility of the periplasmic molecular chaperone SurA. 195(5), 1061-1067.
-
Ye, C., Chai, Q., Zhong, M., & Wei, Y.
(2013).
Effect of crowding by Ficolls on OmpA and OmpT refolding and membrane insertion. Protein Science.
22(2), 239-245.
-
Baker, N. A., Karounos, M., English, V., Fang, J., Wei, Y., Stromberg, A., ... Cassis, L. A.
(2013).
Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environmental Health Perspectives.
121(1), 105-110.
-
Lu, W., Chai, Q., Zhong, M., Yu, L., Fang, J., Wang, T., ... Wei, Y.
(2012).
Assembling of AcrB trimer in cell membrane. Journal of Molecular Biology.
423(1), 123-134.
-
Knecht, L. D., Ali, N., Wei, Y., Hilt, J. Z., & Daunert, S.
(2012).
Nanoparticle-mediated remote control of enzymatic activity. ACS Nano.
6(10), 9079-9086.
-
Geng, S., Fang, J., Turner, K. B., Daunert, S., & Wei, Y.
(2012).
Accumulation and efflux of polychlorinated biphenyls in Escherichia coli. Analytical and Bioanalytical Chemistry.
403(8), 2403-2409.
-
Yewle, J. N., Wei, Y., Puleo, D. A., Daunert, S., & Bachas, L. G.
(2012).
Oriented immobilization of proteins on hydroxyapatite surface using bifunctional bisphosphonates as linkers. Biomacromolecules.
13(6), 1742-1749.
-
Deo, S., Wei, Y., & Daunert, S.
(2012).
Probing a myth: does the younger generation of scientists have it easier?. Analytical and Bioanalytical Chemistry.
403(8), 2065-2067.
-
Nehru, N., Donev, E. U., Huda, G. M., Yu, L., Wei, Y., & Hastings, J. T.
(2012).
Differentiating surface and bulk interactions using localized surface plasmon resonances of gold nanorods. Optics Express.
20(7), 6905-6914.
-
Lu, W., Zhong, M., & Wei, Y.
(2011).
Folding of AcrB Subunit Precedes Trimerization. Journal of Molecular Biology.
411(1), 264-274.
-
Fang, J., Zhang, X., Cai, Y., & Wei, Y.
(2011).
Small globular protein motif forms particulate hydrogel under various pH conditions. Biomacromolecules.
12(5), 1578-1584.
-
Yu, L., Lu, W., Zhong, M., & Wei, Y.
(2011).
Insight into the MultidrugEfflux Pump AcrB Oligomerization Process. The FASEB Journal.
25(S1), 932.9-932.9.
-
Yu, L., Lu, W., & Wei, Y.
(2011).
AcrB trimer stability and efflux activity, insight from mutagenesis studies. 6(12), e28390-e28390.
-
Yu, L., Zhong, M., & Wei, Y.
(2010).
Direct fluorescence polarization assay for the detection of glycopeptide antibiotics. Analytical Chemistry.
82(16), 7044-7048.
-
Zhong, M., Fang, J., & Wei, Y.
(2010).
Site specific and reversible protein immobilization facilitated by a DNA binding fusion tag. Bioconjugate Chemistry.
21(7), 1177-1182.
-
Fang, J., Yu, L., Gao, P., Cai, Y., & Wei, Y.
(2010).
Detection of protein-DNA interaction and regulation using gold nanoparticles. Analytical Biochemistry.
399(2), 262-267.
-
Wei, Y., & Daunert, S.
(2010).
Enabling technologies in discovery: the 2009 Nobel Prize and its implications in antibiotic design. Analytical and Bioanalytical Chemistry.
396(5), 1623-1626.
-
Bachas-Daunert, P. G., Law, S. A., & Wei, Y.
(2009).
Characterization of a recombinant thermostable dehalogenase isolated from the hot spring thermophile Sulfolobus tokodaii. Applied Biochemistry and Biotechnology.
159(2), 382-393.
-
Bachas-Daunert, P. G., Sellers, Z. P., & Wei, Y.
(2009).
Detection of halogenated organic compounds using immobilized thermophilic dehalogenase. Analytical and Bioanalytical Chemistry.
395(4), 1173-1178.
-
Ehrick, J. D., Luckett, M. R., Khatwani, S., Wei, Y., Deo, S. K., Bachas, L. G., & Daunert, S.
(2009).
Macromol. Biosci. 9/2009. Macromolecular Bioscience.
9(9), na-na.
-
Ehrick, J. D., Luckett, M. R., Khatwani, S., Wei, Y., Deo, S. K., Bachas, L. G., & Daunert, S.
(2009).
Glucose responsive hydrogel networks based on protein recognition. Macromolecular Bioscience.
9(9), 864-868.
-
Seelbach, M. J., Chen, L., Choi, Y. J., Wei, Y., Layne, J. D., Hennig, B., & Toborek, M.
(2009).
Novel model of brain metastasis formation: the influence of polychlorinated biphenyls on bloodbrain barrier integrity and brain metastasis. The FASEB Journal.
23(S1), 1020.9-1020.9.
-
Yu, L., Fang, J., & Wei, Y.
(2009).
Characterization of the ligand and DNA binding properties of a putative archaeal regulator ST1710. Biochemistry.
48(10), 2099-2108.
-
Hamorsky, K. T., Ensor, C. M., Wei, Y., & Daunert, S.
(2008).
A Bioluminescent Molecular Switch For Glucose. Angewandte Chemie.
120(20), 3778-3781.
-
Teasley Hamorsky, K., Ensor, C. M., Wei, Y., & Daunert, S.
(2008).
A bioluminescent molecular switch for glucose. Angewandte Chemie International Edition.
47(20), 3718-3721.
-
Hastings, J. T., Guo, J., Keathley, P. D., Kumaresh, P. B., Wei, Y., Law, S., & Bachas, L. G.
(2007).
Optimal self-referenced sensing using long- and short- range surface plasmons. Optics Express.
15(26), 17661-17672.
-
Wei, Y., & Fu, D.
(2006).
Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP. 281(33), 23492-23502.
-
Wei, Y., & Fu, D.
(2005).
Selective metal binding to a membrane-embedded aspartate in the Escherichia coli metal transporter YiiP (FieF). 280(40), 33716-33724.
-
Wei, Y., Li, H., & Fu, D.
(2004).
Oligomeric state of the Escherichia coli metal transporter YiiP. 279(38), 39251-39259.
-
Pandeya, A., Zhang, Y., Cui, J., Yang, L., Li, J., Zhang, G., ... Wei, Y.
(2023).
Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection. 275, 127460-127460.
-
chapter
-
Wang, Z., Li, C., & Wei, Y.
(2019).
Application of Fluorescence in Studying Therapeutic Enzymes. Advances in Experimental Medicine and Biology.
Therapeutic Enzymes: Function and Clinical Implications.
(pp. 105-114).
Springer Nature.
-
Wang, Z., Li, C., & Wei, Y.
(2019).
Application of Fluorescence in Studying Therapeutic Enzymes. Advances in Experimental Medicine and Biology.
Therapeutic Enzymes: Function and Clinical Implications.
(pp. 105-114).
Springer Nature.
-
conference paper
-
Nehru, N., Yu, L., Wei, Y., & Hastings, J. T.
(2012).
Multi-mode Localized Surface Plasmon Resonance Sensors for Compensation of Interfering Effects. 1-4.
-
Nehru, N., Yu, L., Wei, Y., & Hastings, J. T.
(2012).
Multi-mode Localized Surface Plasmon Resonance Sensors for Compensation of Interfering Effects. 1-4.
-
institutional repository document
-
Wu, C., Zhang, Y., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2020).
Extracellular histones trigger disseminated intravascular coagulation by lytic cell death
-
Wu, C., Zhang, Y., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2020).
Extracellular histones trigger disseminated intravascular coagulation by lytic cell death
Teaching
teaching activities
- PHAR627 Biochemistry Instructor
- PHSC610 Into Biotech Drug Vacc Prod Instructor
- PHSC613 Laboratory Rotations Instructor
- PHSC685 Directed Studies Instructor
- PHSC689 Sptp: Research Techniques Instructor
- PHSC691 Research Instructor
Background
education and training
- Ph.D. in Biochemistry, Princeton University - (Princeton, New Jersey, United States) 2003
- B.S. in Chemistry, Peking University - (Beijing, Beijing, China) 1996
- Brookhaven National Laboratory - (Upton, New York, United States) , Postdoctoral Training 2006
Contact
first name
- Yinan
has last name
- Wei
Other
- yinan.wei@tamu.edu