Optimal self-referenced sensing using long- and short- range surface plasmons. Academic Article

abstract

• Dual-mode surface-plasmon resonance (SPR) sensors use both long- and short- range surface plasmon waves to differentiate surface binding interactions from interfering bulk effects. We have optimized the design of these sensors for minimum surface limit of detection (LOD) using a Cramer-Rao lower bound for spectral shift estimation. Despite trade-offs between resonance width, minimum reflectivity, and sensitivity for the two modes, a range of reasonable design parameters provides nearly optimal performance. Experimental verification using biotin-streptavidin binding as a model system reveals that sensitivity and LOD for dual-mode sensors remains competitive with single-mode sensors while compensating for bulk effects.

authors

• Wei, Yinan

published proceedings

• Opt Express

altmetric score

• 6

author list (cited authors)

• Hastings, J. T., Guo, J., Keathley, P. D., Kumaresh, P. B., Wei, Y., Law, S., & Bachas, L. G.

citation count

• 62

complete list of authors

• Hastings, JT||Guo, J||Keathley, PD||Kumaresh, PB||Wei, Y||Law, S||Bachas, LG

publication date

• December 2007

publisher

• Optica Publishing Group  Publisher

published in

• Optics Express  Journal

keywords

• Computer-Aided Design
• Equipment Design
• Equipment Failure Analysis
• Reproducibility Of Results
• Sensitivity And Specificity
• Surface Plasmon Resonance
• Transducers

PubMed Central ID

• 19551062

Digital Object Identifier (DOI)

• 10.1364/oe.15.017661

start page

• 17661

end page

• 17672

volume

• 15

issue

• 26

URL

• http://dx.doi.org/10.1364/oe.15.017661