Glucose responsive hydrogel networks based on protein recognition. uri icon

abstract

  • Stimuli-responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose-responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative "accordion"-like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.

published proceedings

  • Macromol Biosci

altmetric score

  • 3

author list (cited authors)

  • Ehrick, J. D., Luckett, M. R., Khatwani, S., Wei, Y., Deo, S. K., Bachas, L. G., & Daunert, S.

citation count

  • 62

complete list of authors

  • Ehrick, Jason D||Luckett, Matthew R||Khatwani, Santoshkumar||Wei, Yinan||Deo, Sapna K||Bachas, Leonidas G||Daunert, Sylvia

publication date

  • September 2009

publisher