HR job title
- Associate Professor
- Contact Info
- 1 979 862 2009
- Websites
- ORCiD
- 0000-0002-4515-7963
Li, Qinglei Associate Professor
Positions
- Associate Professor, The Texas A&M University System
My lab is interested in understanding the genetic and epigenetic mechanisms that underpin the development and function of the female reproductive tract. We focus on key signaling pathways such as TGF-beta signaling and their interactions in regulating critical events in female reproductive organs during pregnancy. My lab has also created new mouse models to study ovarian and uterine cancer development.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Ni, N., Fang, X., & Li, Q.
(2021).
Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract. SCIENTIFIC REPORTS.
11(1), 9294.
-
Fang, X., & Li, Q.
(2020).
New insights into testicular granulosa cell tumors. Oncology Letters.
20(6), 293-1.
-
Fang, X., Ni, N., Gao, Y., Lydon, J. P., Ivanov, I., Rijnkels, M., Bayless, K. J., & Li, Q.
(2020).
Transforming growth factor beta signaling and decidual integrity in mice. BIOLOGY OF REPRODUCTION.
103(6), 1186-1198.
-
Fang, X., Ni, N., Lydon, J. P., Ivanov, I., Bayless, K. J., Rijnkels, M., & Li, Q.
(2019).
Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity. AMERICAN JOURNAL OF PATHOLOGY.
189(6), 1212-1225.
-
Li, Q.
(2019).
Tumor-suppressive signaling in the uterus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
116(9), 201821606-3369.
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Ni, N., Gao, Y., Fang, X., Melgar, M., Vincent, D. F., Lydon, J. P., Bartholin, L., & Li, Q.
(2018).
Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment. PLOS ONE.
13(12), e0209417-e0209417.
-
Fang, X., Ni, N., Gao, Y., Vincent, D. F., Bartholin, L., & Li, Q.
(2018).
A novel mouse model of testicular granulosa cell tumors. Molecular Human Reproduction.
24(7), 343-356.
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Gao, Y., Fang, X., Vincent, D. F., Threadgill, D. W., Bartholin, L., & Li, Q.
(2017).
Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reproductive Biology and Endocrinology.
15(1), 94.
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Ni, N., & Li, Q.
(2017).
TGFβ superfamily signaling and uterine decidualization. Reproductive Biology and Endocrinology.
15(1), 84.
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Gao, Y., Lin, P., Lydon, J. P., & Li, Q.
(2017).
Conditional abrogation of transforming growth factor‐β receptor 1 in PTEN‐inactivated endometrium promotes endometrial cancer progression in mice. The Journal of Pathology.
243(1), 89-99.
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Gao, Y., Vincent, D. F., Davis, A. J., Sansom, O. J., Bartholin, L., & Li, Q.
(2016).
Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget.
7(27), 40904-40918.
-
Fang, X., Gao, Y., & Li, Q.
(2016).
SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?1. BIOLOGY OF REPRODUCTION.
95(5), 105-105.
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Gao, Y., Duran, S., Lydon, J. P., DeMayo, F. J., Burghardt, R. C., Bayless, K. J., Bartholin, L., & Li, Q.
(2014).
Constitutive Activation of Transforming Growth Factor Beta Receptor 1 in the Mouse Uterus Impairs Uterine Morphology and Function1. BIOLOGY OF REPRODUCTION.
92(2), article-13.
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Li, Q.
(2014).
Inhibitory SMADs: Potential Regulators of Ovarian Function1. BIOLOGY OF REPRODUCTION.
92(2), article-6.
-
Li, Q.
(2014).
Transforming growth factor β signaling in uterine development and function. J Anim Sci Biotechnol.
5(1), 52.
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Gao, Y., Li, S., & Li, Q.
(2014).
Uterine epithelial cell proliferation and endometrial hyperplasia: evidence from a mouse model. Molecular Human Reproduction.
20(8), 776-786.
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Gao, Y., Bayless, K. J., & Li, Q.
(2014).
TGFBR1 is required for mouse myometrial development. Endocrinology.
28(3), 380-394.
-
Gao, Y., Wen, H., Wang, C., & Li, Q.
(2013).
SMAD7 antagonizes key TGFβ superfamily signaling in mouse granulosa cells in vitro. REPRODUCTION.
146(1), 1-11.
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Nagashima, T., Li, Q., Clementi, C., Lydon, J. P., DeMayo, F. J., & Matzuk, M. M.
(2013).
BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest.
123(6), 2539-2550.
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Peng, J., Li, Q., Wigglesworth, K., Rangarajan, A., Kattamuri, C., Peterson, R. T., ... Matzuk, M. M.
(2013).
Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
110(25), e2258-e2258.
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Peng, J., Li, Q., Wigglesworth, K., Rangarajan, A., Kattamuri, C., Peterson, R. T., ... Matzuk, M. M.
(2013).
Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
110(8), e776-e785.
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Matzuk, M. M., McKeown, M. R., Filippakopoulos, P., Li, Q., Ma, L., Agno, J. E., ... Bradner, J. E.
(2012).
Small-Molecule Inhibition of BRDT for Male Contraception. CELL.
150(4), 673-684.
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Li, Q., Agno, J. E., Edson, M. A., Nagaraja, A. K., Nagashima, T., & Matzuk, M. M.
(2011).
Transforming Growth Factor β Receptor Type 1 Is Essential for Female Reproductive Tract Integrity and Function. PLOS Genetics.
7(10), e1002320-e1002320.
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Nagashima, T., Kim, J., Li, Q., Lydon, J. P., DeMayo, F. J., Lyons, K. M., & Matzuk, M. M.
(2011).
Connective tissue growth factor is required for normal follicle development and ovulation. Endocrinology.
25(10), 1740-1759.
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Sugiura, K., Su, Y., Li, Q., Wigglesworth, K., Matzuk, M. M., & Eppig, J. J.
(2010).
Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15. Endocrinology.
24(12), 2303-2314.
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Rajanahally, S., Agno, J. E., Nalam, R. L., Weinstein, M. B., Loveland, K. L., Matzuk, M. M., & Li, Q.
(2010).
Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice. Reproductive Biology and Endocrinology.
8(1), 69-69.
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Nagaraja, A. K., Middlebrook, B. S., Rajanahally, S., Myers, M., Li, Q., Matzuk, M. M., & Pangas, S. A.
(2010).
Defective Gonadotropin-Dependent Ovarian Folliculogenesis and Granulosa Cell Gene Expression in Inhibin-Deficient Mice. Endocrinology.
151(10), 4994-5006.
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Su, Y., Sugiura, K., Li, Q., Wigglesworth, K., Matzuk, M. M., & Eppig, J. J.
(2010).
Mouse Oocytes Enable LH-Induced Maturation of the Cumulus-Oocyte Complex via Promoting EGF Receptor-Dependent Signaling. Endocrinology.
24(6), 1230-1239.
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Li, Q., Rajanahally, S., Edson, M. A., & Matzuk, M. M.
(2009).
Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15. Molecular Human Reproduction.
15(12), 779-788.
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Sugiura, K., Su, Y., Li, Q., Wigglesworth, K., Matzuk, M. M., & Eppig, J. J.
(2009).
Fibroblast Growth Factors and Epidermal Growth Factor Cooperate with Oocyte-Derived Members of the TGFbeta Superfamily to Regulate Spry2 mRNA Levels in Mouse Cumulus Cells1. BIOLOGY OF REPRODUCTION.
81(5), 833-841.
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Li, Q., Jimenez-Krassel, F., Ireland, J. J., & Smith, G. W.
(2009).
Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process. REPRODUCTION.
137(2), 297-307.
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Li, Q., Pangas, S. A., Jorgez, C. J., Graff, J. M., Weinstein, M., & Matzuk, M. M.
(2008).
Redundant Roles of SMAD2 and SMAD3 in Ovarian Granulosa Cells In Vivo ▿. Molecular and Cellular Biology.
28(23), 7001-7011.
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Li, Q., McKenzie, L. J., & Matzuk, M. M.
(2008).
Revisiting oocyte–somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence. Molecular Human Reproduction.
14(12), 673-678.
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Bettegowda, A., Yao, J., Sen, A., Li, Q., Lee, K., Kobayashi, Y., ... Smith, G. W.
(2007).
JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
104(45), 17602-17607.
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Li, Q., Graff, J. M., O’Connor, A. E., Loveland, K. L., & Matzuk, M. M.
(2007).
SMAD3 Regulates Gonadal Tumorigenesis. Endocrinology.
21(10), 2472-2486.
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Li, Q., Kumar, R., Underwood, K., O'Connor, A. E., Loveland, K. L., Seehra, J. S., & Matzuk, M. M.
(2007).
Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein. Molecular Human Reproduction.
13(9), 675-683.
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Li, Q., Jimenez-Krassel, F., Bettegowda, A., Ireland, J. J., & Smith, G. W.
(2007).
Evidence that the preovulatory rise in intrafollicular progesterone may not be required for ovulation in cattle. Journal of Endocrinology.
192(3), 473-483.
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Li, Q., Jimenez-Krassel, F., Kobayashi, Y., Ireland, J. J., & Smith, G. W.
(2006).
Effect of intrafollicular indomethacin injection on gonadotropin surge-induced expression of select extracellular matrix degrading enzymes and their inhibitors in bovine preovulatory follicles. REPRODUCTION.
131(3), 533-543.
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Zhang, X., Lin, H. Y., Liu, G. Y., Wang, H. M., Li, Q. L., & Zhu, C.
(2005).
Expressions and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy. Frontiers in Bioscience.
10(1-3), 3172-3182.
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Li, Q., Bakke, L. J., Pursley, J. R., & Smith, G. W.
(2004).
Erratum: Localization and temporal regulation of tissue inhibitors of metalloproteinases 3 and 4 in bovine preovulatory follicles. REPRODUCTION.
128(6), 863-863.
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Kobayashi, Y., Jimenez-Krassel, F., Li, Q., Yao, J., Huang, R., Ireland, J. J., Coussens, P. M., & Smith, G. W.
(2004).
Evidence that cocaine- and amphetamine-regulated transcript is a novel intraovarian regulator of follicular atresia. Endocrinology.
145(11), 5373-5383.
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Li, Q., Bakke, L. J., Pursley, J. R., & Smith, G. W.
(2004).
Localization and temporal regulation of tissue inhibitors of metalloproteinases 3 and 4 in bovine preovulatory follicles. REPRODUCTION.
128(5), 555-564.
-
Wang, H., Wang, H., Li, Q., Lin, H., Qian, D., & Zhu, C.
(2004).
Expression of Proteasome Subunits Low Molecular Mass Polypeptide (LMP) 2 and LMP7 in the Endometrium and Placenta of Rhesus Monkey (Macaca mulatta) During Early Pregnancy1. BIOLOGY OF REPRODUCTION.
71(4), 1317-1324.
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Bakke, L. J., Li, Q., Cassar, C. A., Dow, M., Pursley, J. R., & Smith, G. W.
(2004).
Gonadotropin Surge-Induced Differential Upregulation of Collagenase-1 (MMP-1) and Collagenase-3 (MMP-13) mRNA and Protein in Bovine Preovulatory Follicles1. BIOLOGY OF REPRODUCTION.
71(2), 605-612.
-
Qian, D., Lin, H., Wang, H., Zhang, X., Liu, D., Li, Q., & Zhu, C.
(2004).
Involvement of ERK1/2 pathway in TGF‐β1‐induced VEGF secretion in normal human cytotrophoblast cells. Molecular Reproduction and Development.
68(2), 198-204.
-
Qian, D., Lin, H., Wang, H., Zhang, X., Liu, D., Li, Q., & Zhu, C.
(2004).
Normoxic Induction of the Hypoxic-Inducible Factor-1 by Interleukin-1 Involves the Extracellular Signal-Regulated Kinase 1/2 Pathway in Normal Human Cytotrophoblast Cells1. BIOLOGY OF REPRODUCTION.
70(6), 1822-1827.
-
Zhang, X., Wang, H. M., Lin, H. Y., Liu, G. Y., Li, Q. L., & Zhu, C.
(2004).
Regulation of Matrix Metalloproteinases (MMPs) and their Inhibitors (TIMPs) during Mouse Peri-implantation: Role of Nitric Oxide. PLACENTA.
25(4), 243-252.
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Wang, H. M., Zhang, X., Qian, D., Lin, H. Y., Li, Q. L., Liu, D. L., ... Zhu, C.
(2004).
Effect of Ubiquitin-Proteasome Pathway on Mouse Blastocyst Implantation and Expression of Matrix Metalloproteinases-2 and -91. BIOLOGY OF REPRODUCTION.
70(2), 481-487.
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Lin, H., Wang, H., Li, Q., Liu, D., Zhang, X., Liu, G., Qian, D., & Zhu, C.
(2004).
Expression of Smad2 and Smad4, transforming growth factor-β signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci.
80(3-4), 303-316.
-
Liu, D. L., Liu, W. Z., Li, Q. L., Wang, H. M., Qian, D., Treuter, E., & Zhu, C.
(2003).
Expression and Functional Analysis of Liver Receptor Homologue 1 as a Potential Steroidogenic Factor in Rat Ovary1. BIOLOGY OF REPRODUCTION.
69(2), 508-517.
-
Wang, H., Li, Q., Lin, H., Yu, X., Qian, D., Dai, J., Duan, E., & Zhu, C.
(2003).
Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Molecular Reproduction and Development.
65(2), 123-131.
-
Li, Q., Illman, S. A., Wang, H., Liu, D., Lohi, J., & Zhu, C.
(2003).
Matrix metalloproteinase‐28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy. Molecular Human Reproduction.
9(4), 205-211.
-
QIAN, D.
(2003).
Effect of UPP on the expression of VEGF and its receptors in mouse uterus during peri-implantation. SCIENCE BULLETIN.
48(4), 338-342.
-
LIN, H.
(2003).
Expression of smad2 and smad4 in rhesus monkey endometrium during the menstrual cycle and early pregnancy. PROGRESS IN NATURAL SCIENCE.
13(8), 584-584.
-
Li, Q., Wang, H., Lin, H., Liu, D., Zhang, X., Liu, G., Qian, D., & Zhu, C.
(2002).
Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Molecular Reproduction and Development.
63(3), 273-281.
-
Zhang, X., Wang, H., Lin, H., Li, Q., Liu, D., Qian, D., Liu, G., & Zhu, C.
(2002).
Regulation of embryo implantation by nitric oxide in mouse. SCIENCE BULLETIN.
47(17), 1461-1465.
-
Li, Q., Wang, H., Lin, H., Shao, L., Ni, J., Duan, E., & Zhu, C.
(2002).
Expression of vascular endothelial growth factor in rat ovary during pregnancy and postpartum. Science China Life Sciences.
45(4), 379-387.
-
Liu, D., Li, Q., Lin, H., Liu, W., Wang, H., Zhang, X., & Zhu, C.
(2002).
Expression and localization of RAP250 mRNA in rat ovary. Endocrine.
18(2), 173-178.
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Yu, X., Li, Q., Wang, H., Luo, W., Shao, L., Ni, J., & Zhu, C.
(2002).
Expression and regulation of metalloproteinases-2, -9 and tissue inhibitors of metalloproteinases in rat corpus luteum. SCIENCE BULLETIN.
47(12), 1011-1014.
-
YU, X.
(2002).
Expression and regulation of metalloproteinases-2, -9 and tissue inhibitors of metalloproteinases in rat corpus luteum. SCIENCE BULLETIN.
47(12), 1011-1014.
-
Li, Q., Wang, H., Shao, L., Yu, X., Ni, J., & Zhu, C.
(2001).
Expression of gelatinases and tissue inhibitors of metalloproteinases in the rhesus monkey (Macaca mulatta) corpus luteum. SCIENCE BULLETIN.
46(15), 1292-1296.
-
Wang, H., Li, Q., Shao, L., & Zhu, C.
(2001).
Expression of Matrix Metalloproteinase-2, -9, -14, and Tissue Inhibitors of Metalloproteinase-1, -2, -3 in the Endometrium and Placenta of Rhesus Monkey (Macaca mulatta) During Early Pregnancy1. BIOLOGY OF REPRODUCTION.
65(1), 31-40.
-
Li, Q. L., Ni, J., Bian, S. L., Yao, L. C., Zhu, H., & Zhang, W.
(2001).
Inhibition of steroidogenesis and induction of apoptosis in rat luteal cells by cell-permeable ceramide in vitro. Acta Physiol Sinica.
53(2), 142-146.
-
Ni, N., Fang, X., & Li, Q.
(2021).
Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract. SCIENTIFIC REPORTS.
11(1), 9294.
-
chapter
-
Peng, J., Li, Q., & Matzuk, M. M.
(2013).
Mouse models to identify genes throughout oogenesis. Biology and Pathology of the Oocyte.
(pp. 73-80).
Cambridge University Press.
-
Matzuk, M. M., & Li, Q.
(2012).
How the Oocyte Influences Follicular Cell Function and Why. Oogenesis.
(pp. 75-92).
Springer London.
-
Peng, J., Li, Q., & Matzuk, M. M.
(2013).
Mouse models to identify genes throughout oogenesis. Biology and Pathology of the Oocyte.
(pp. 73-80).
Cambridge University Press.
Research
principal investigator on
- TGF-BETA Signaling in Endometrial Cell Function and Dysfunction awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2022
- A novel mouse model of testicular granulosa cell tumors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2021
- A New Paradigm for Ovarian Sex Cord-Stromal Tumor Development awarded by United States Army - (Washington D.C., District of Columbia, United States) 2015 - 2018
- Characterization of a novel mouse model with enhanced TGF-Beta signaling in the ovary awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2018
- Tgf-Beta Signaling In Myometrial Development and Function awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2015
awards and honors
Teaching
teaching activities
- VIBS285 Directed Studies Instructor
- VIBS485 Directed Studies Instructor
- VIBS609 Antmy Of Reprdctv Sytm Instructor
- VIBS617 Cell Biology Instructor
- VIBS685 Directed Studies Instructor
- VIBS691 Research Instructor
Works By Students
chaired theses and dissertations
Background
education and training
- Ph.D. in Physiology, Harbin Medical University - (Harbin, Heilongjiang, China) 2001
Contact
first name
- Qinglei
has last name
- Li
mailing address
-
Texas A&M University
Veterinary Integrative Biosciences
4458 TAMU
College Station, TX 77843-4458
USA
Other
In the News
- qingleili@tamu.edu