Li, Qinglei Professor

My long-term research goal is to identify the cellular and molecular basis of pregnancy failure and uterine dysfunction, thereby contributing to a framework for developing novel diagnostic and therapeutic strategies to improve reproductive potential. To benefit human and animal health, research in my lab focuses on defining the mechanism underlying uterine development and the pathogenesis of gynecologic cancers. My laboratory has created mouse models that harbor genetic modifications of critical transforming growth factor ? (TGF?) signaling components using conditional loss-of-function and gain-of-function approaches in the uterus. These models have yielded new insights into the fundamental roles of TGF? signaling in reproductive tract development and function. We have also developed pre-clinical mouse models for ovarian granulosa cell tumor and endometrial cancer. These disease models may be harnessed to uncover new opportunities for cancer treatment.