HR job title
- Associate Professor
- Contact Info
- Websites
- ORCiD
- 0000-0002-2894-3487
Lele, Pushkar Assistant Professor
Positions
- Assistant Professor, Chemical Engineering, College of Engineering
We combine sensitive biophysical techniques such as single-molecule fluorescence and force-spectroscopy with mechanistic modeling and molecular genetics to study bacterial motility, adaptability and antibiotic resistance.
- Overview
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Overview
Publications
selected publications
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academic article
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Antani, J. D., Shaji, A., Gupta, R., & Lele, P. P.
(2023).
Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in Helicobacter pylori. Annual Review of Chemical and Biomolecular Engineering.
15(1),
-
Vidwans, N. A., Rhee, K. Y., Lele, P. P., & Vaddiraju, S.
(2023).
Real-Time Deduction of Mechanisms and Kinetics Underlying Photocatalytic Water Disinfection: Cell Motility and Particle Tracking. ACS ES&T Water.
3(9), 2938-2947.
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Lee, A. H., Gupta, R., Nguyen, H. N., Schmitz, I. R., Siegele, D. A., & Lele, P. P.
(2023).
Heterogeneous Distribution of Proton Motive Force in Nonheritable Antibiotic Resistance. mBio.
14(1), e0238422-e02322.
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Katiyar, A., Zhang, J., Antani, J. D., Yu, Y., Scott, K. L., Lele, P. P., ... Lele, T. P.
(2022).
The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C. Advanced Science.
9(23), e2201248-2201248.
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Gupta, R., Rhee, K. Y., Beagle, S. D., Chawla, R., Perdomo, N., Lockless, S. W., & Lele, P. P.
(2022).
Indole modulates cooperative protein-protein interactions in the flagellar motor. 1(2), pgac035-.
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Antani, J. D., Gupta, R., Lee, A. H., Rhee, K. Y., Manson, M. D., & Lele, P. P.
(2021).
Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor. Nature Communications.
12(1), 5442.
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Wong, G., Antani, J. D., Lele, P. P., Chen, J., Nan, B., Kühn, M. J., ... Dunkel, J.
(2021).
Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Physical Biology.
18(5), 10.1088/1478-13975/abdc0e.
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Katiyar, A., Antani, J. D., McKee, B. P., Gupta, R., Lele, P. P., & Lele, T. P.
(2021).
A method for direct imaging of x-z cross-sections of fluorescent samples. Journal of Microscopy.
281(3), 224-230.
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Antani, J. D., Sumali, A. X., Lele, T. P., & Lele, P. P.
(2021).
Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori. eLife.
10, e63936.
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Yang, J., Chawla, R., Rhee, K. Y., Gupta, R., Manson, M. D., Jayaraman, A., & Lele, P. P.
(2020).
Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole. Proceedings of the National Academy of Sciences of the United States of America.
117(11), 6114-6120.
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Orr, A. A., Yang, J., Sule, N., Chawla, R., Hull, K. G., Zhu, M., ... Tamamis, P.
(2020).
Molecular Mechanism for Attractant Signaling to DHMA by E.coli Tsr. Biophysical Journal.
118(2), 492-504.
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Chawla, R., Gupta, R., Lele, T. P., & Lele, P. P.
(2020).
A Skeptic's Guide to Bacterial Mechanosensing. Journal of Molecular Biology.
432(2), 523-533.
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Rhee, K. Y., Chawla, R., & Lele, P. P.
(2020).
Protein expression-independent response of intensity-based pH-sensitive fluorophores in Escherichia coli. PLoS ONE.
15(6), e0234849-e0234849.
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Ford, K. M., Antani, J. D., Nagarajan, A., Johnson, M. M., & Lele, P. P.
(2018).
Switching and Torque Generation in Swarming E. coli. Frontiers in Microbiology.
9(SEP), 2197.
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Lele, P. P.
(2018).
Quantitative Modeling of Flagellar Motor-Mediated Adaptation. 1729, 347-352.
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Diethmaier, C., Chawla, R., Canzoneri, A., Kearns, D. B., Lele, P. P., & Dubnau, D.
(2017).
Viscous drag on the flagellum activates Bacillus subtilis entry into the K-state. Molecular Microbiology.
106(3), 367-380.
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Chawla, R., Ford, K. M., & Lele, P. P.
(2017).
Torque, but not FliL, regulates mechanosensitive flagellar motor-function. Scientific Reports.
7(1), 5565.
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Ford, K. M., Chawla, R., & Lele, P. P.
(2017).
Biophysical Characterization of Flagellar Motor Functions. Journal of Visualized Experiments.
2017(119),
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Lele, P. P., Roland, T., Shrivastava, A., Chen, Y., & Berg, H. C.
(2016).
The flagellar motor of Caulobacter crescentus generates more torque when a cell swims backward. Nature Physics.
12(2), 175-178.
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Lele, P. P., Shrivastava, A., Roland, T., & Berg, H. C.
(2015).
Response thresholds in bacterial chemotaxis. Science Advances.
1(9), e1500299.
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Lele, P. P., & Berg, H. C.
(2015).
Correction. Biophysical Journal.
108(7), 1840-1840.
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Lele, P. P., & Berg, H. C.
(2015).
Switching of bacterial flagellar motors [corrected] triggered by mutant FliG. Biophysical Journal.
108(5), 1275-1280.
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Shrivastava, A., Lele, P. P., & Berg, H. C.
(2015).
A rotary motor drives Flavobacterium gliding. Current Biology.
25(3), 338-341.
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Lele, P. P., Hosu, B. G., & Berg, H. C.
(2013).
Dynamics of mechanosensing in the bacterial flagellar motor. Proceedings of the National Academy of Sciences of the United States of America.
110(29), 11839-11844.
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Lele, P. P., Branch, R. W., Nathan, V., & Berg, H. C.
(2012).
Mechanism for adaptive remodeling of the bacterial flagellar switch. Proceedings of the National Academy of Sciences of the United States of America.
109(49), 20018-20022.
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Wu, J., Shekhar, N., Lele, P. P., & Lele, T. P.
(2012).
FRAP analysis: accounting for bleaching during image capture. PLoS ONE.
7(8), e42854-e42854.
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Lele, P. P., Swan, J. W., Brady, J. F., Wagner, N. J., & Furst, E. M.
(2011).
Colloidal diffusion and hydrodynamic screening near boundaries. SOFT MATTER.
7(15), 6844-6852.
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Aglave, B. A., Lele, P. P., Lokhande, M. O., & Pagare, R. S.
(2009).
Production and enzyme activity of an extracellular amylase from Aspergillus niger, Aspergillus oryzae and Bacillus subtilis. Asian journal of microbiology, biotechnology & environmental sciences : AJMBES.
11(3), 573-575.
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Lele, P. P., & Furst, E. M.
(2009).
Assemble-and-stretch method for creating two- and three-dimensional structures of anisotropic particles. Langmuir.
25(16), 8875-8878.
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Singh, J. P., Lele, P. P., Nettesheim, F., Wagner, N. J., & Furst, E. M.
(2009).
One- and two-dimensional assembly of colloidal ellipsoids in ac electric fields. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics.
79(5 Pt 1), 050401.
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Lele, P. P., Mittal, M., & Furst, E. M.
(2008).
Anomalous particle rotation and resulting microstructure of colloids in AC electric fields. Langmuir.
24(22), 12842-12848.
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Mittal, M., Lele, P. P., Kaler, E. W., & Furst, E. M.
(2008).
Polarization and interactions of colloidal particles in ac electric fields. Journal of Chemical Physics.
129(6), 064513-064513.
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Lele, P. P., & Siems, M. M.
(2007).
Diversity in shareholder protection in common law countries. CESifo DICE Report.
5(1), 3-9.
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Wang, T., Abolghasemzade, S., McKee, B. P., Singh, I., Pendyala, K., Mohajeri, M., ... Lele, T. P.
Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization. Nature Communications.
15(1), 10151.
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Shanmughan, P., Subrahmaniyan, P., Bhatnagar, D., Ranganathan, S., & Lele, P. P.
Urea-Loaded PLGA Microspheres as Chemotaxis Stimulants for Helicobacter pylori. Biotechnology and Bioengineering.
-
Antani, J. D., Shaji, A., Gupta, R., & Lele, P. P.
(2023).
Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in Helicobacter pylori. Annual Review of Chemical and Biomolecular Engineering.
15(1),
-
chapter
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Lele, P. P., & Siems, M. M.
(2009).
Shareholder protection: a leximetric approach. Corporate Governance and Development: Reform, Financial Systems and Legal Frameworks.
(pp. 143-175).
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Lele, P. P., & Siems, M. M.
(2009).
Shareholder protection: a leximetric approach. Corporate Governance and Development: Reform, Financial Systems and Legal Frameworks.
(pp. 143-175).
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conference paper
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Antani, J. D., & Lele, P. P.
(2020).
Anisotropic Swimming Modes in Helicobacter pylori. Biophysical Journal.
127A-127A.
-
Lele, P.
(2013).
Bacterial mechanobiology: Rotary flagellar motors as mechanosensors. 13.
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Panczyk, M. M., Lele, P. P., Singh, J. P., Furst, E. M., & Wagner, N. J.
(2009).
COLL 298-Ordering of anisotropic particles in 2D with AC electric fields. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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Furst, E. M., Mittal, M., & Lele, P. P.
(2009).
COLL 30-Directed colloidal assembly in AC electric fields. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Antani, J. D., & Lele, P. P.
(2020).
Anisotropic Swimming Modes in Helicobacter pylori. Biophysical Journal.
127A-127A.
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institutional repository document
-
Antani, J., Gupta, R., Lee, A., Rhee, K., Manson, M., & Lele, P.
(2021).
Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor
-
Antani, J. D., Sumali, A. X., Lele, T. P., & Lele, P. P.
(2020).
Anisotropic random walks reveal chemotaxis signaling output in run-reversing bacteria
-
Antani, J., Gupta, R., Lee, A., Rhee, K., Manson, M., & Lele, P.
(2021).
Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor
Research
principal investigator on
- Mechanical Regulation of Ultra-Sensitivity in E. coli Flagellar Motors awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2021
- Mechanosensitive Self-Assembly of Flagellar Stator Proteins in Bacteria awarded by United States Army - (Washington D.C., District of Columbia, United States) 2018 - 2020
- Etiology and Prevention of Gastric Cancers by Mitigation of H pylori Mechanosensing awarded by Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States) 2017
investigator on
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS491 Hnr-research Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- BMEN691 Research Instructor
- CHEN205 Chem Engr Thermo I Instructor
- CHEN285 Hnr-directed Studies Instructor
- CHEN291 Hnr-research Instructor
- CHEN323 Chem Engr Heat Ops Instructor
- CHEN382 Bioprocess Engineering Instructor
- CHEN482 Bioprocess Engineering Instructor
- CHEN491 Hnr-research Instructor
- CHEN684 Professional Internship: In-ab Instructor
- CHEN685 Directed Studies Instructor
- CHEN689 Sptp:colloidal App & Biomolec Instructor
- CHEN691 Research Instructor
- CHEN695 Grad Mentoring Seminar I Instructor
- ENGR491 Hnr-research Instructor
Background
education and training
- Ph.D. in Chemical Engineering, University of Delaware - (Newark, Delaware, United States) 2010
Contact
first name
- Pushkar
has last name
- Lele
mailing address
-
Texas A&M University
Chemical Engineering
3122 TAMU
College Station, TX 77843-3122
USA
Other
In the News
- plele@tamu.edu