HR job title
- Instructional Associate Professor
- Contact Info
- 1 979 845 7206
Maxwell, Steven Associate Professor
Positions
- Associate Professor, Cell Biology and Genetics, School of Medicine
My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL). One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.
- Overview
- Publications
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Maxwell, S. A., Fuchs-Young, R., Wells, G. B., Kapler, G. M., Conover, G. M., Green, S., ... Huston, D. P.
(2022).
Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors. Academic Medicine.
97(5), 684-688.
-
Dave, J. M., Kang, H., Abbey, C. A., Maxwell, S. A., & Bayless, K. J.
(2013).
Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). Journal of Biological Chemistry.
288(42), 30720-30733.
-
Maxwell, S. A., & Mousavi-Fard, S.
(2013).
Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance. Experimental Biology and Medicine.
238(9), 971-990.
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Kwak, H., Kang, H., Dave, J. M., Mendoza, E. A., Su, S., Maxwell, S. A., & Bayless, K. J.
(2012).
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. ANGIOGENESIS.
15(2), 287-303.
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Maxwell, S. A., Cherry, E. M., & Bayless, K. J.
(2011).
Akt, 14-3-3, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma. 52(5), 849-864.
-
Su, S., Maxwell, S. A., & Bayless, K. J.
(2010).
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. Journal of Biological Chemistry.
285(52), 40624-40634.
-
Maxwell, S. A., Li, Z., Jaye, D., Ballard, S., Ferrell, J., & Fu, H.
(2010).
14-3-3 mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen. Journal of Biological Chemistry.
285(49), 38740-38740.
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Maxwell, S. A., Li, Z., Jaya, D., Ballard, S., Ferrell, J., & Fu, H.
(2009).
14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen. 284(33), 22379-22389.
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Maxwell, S. A., & Kochevar, G. J.
(2008).
Identification of a p53-response element in the promoter of the proline oxidase gene. Biochemical and Biophysical Research Communications.
369(2), 308-313.
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Rivera, A., Mavila, A., Bayless, K. J., Davis, G. E., & Maxwell, S. A.
(2006).
Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. Cellular and Molecular Life Sciences.
63(12), 1425-1439.
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Rivera, A., & Maxwell, S. A.
(2005).
The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. Journal of Biological Chemistry.
280(32), 29346-29354.
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Maxwell, S. A., & Davis, G. E.
(2004).
Gene expression profiling of p53-sensitive and -resistant tumor cells using DNA microarray. Apoptosis: an international journal on programmed cell death.
9(2), 171-179.
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Maxwell, S. A., & Rivera, A.
(2003).
Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas. Journal of Biological Chemistry.
278(11), 9784-9789.
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Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., & Davis, G. E.
(2001).
Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. Journal of Cell Science.
114(Pt 15), 2755-2773.
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Davis, G. E., Pintar Allen, K. A., Salazar, R., & Maxwell, S. A.
(2001).
Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices. Journal of Cell Science.
114(Pt 5), 917-930.
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Nelson, V., Davis, G. E., & Maxwell, S. A.
(2001).
A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. 6(3), 221-234.
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Maxwell, S. A., & Davis, G. E.
(2000).
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Proceedings of the National Academy of Sciences of the United States of America.
97(24), 13009-13014.
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Maxwell, S. A., & Davis, G. E.
(2000).
Biological and molecular characterization of an ECV-304-derived cell line resistant to p53-mediated apoptosis. Apoptosis: an international journal on programmed cell death.
5(3), 277-290.
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Maxwell, S. A., Acosta, S. A., & Davis, G. E.
(1999).
Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line. Apoptosis: an international journal on programmed cell death.
4(2), 109-114.
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Gibson, A., Futter, C. E., Maxwell, S., Allchin, E. H., Shipman, M., Kraehenbuhl, J. P., ... Hopkins, C. R.
(1998).
Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells. The Journal of Cell Biology.
143(1), 81-94.
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Futter, C. E., Gibson, A., Allchin, E. H., Maxwell, S., Ruddock, L. J., Odorizzi, G., ... Hopkins, C. R.
(1998).
In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules. The Journal of Cell Biology.
141(3), 611-623.
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Maxwell, S. A., & Acosta, S.
(1998).
Cell type-specific induction and alternative splicing of the Bax gene mediated by p53. The FASEB Journal.
12(5), A778-A778.
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Mukhopadhyay, T., Roth, J. A., Acosta, S. A., & Maxwell, S. A.
(1998).
Two-dimensional gel analysis of apoptosis-specific p53 isoforms induced by 2-methoxyestradiol in human lung cancer cells. Apoptosis: an international journal on programmed cell death.
3(6), 421-430.
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Maxwell, S. A., Acosta, S. A., Tombusch, K., & Davis, G. E.
(1997).
Expression of Bax, Bcl-2, Waf-1, and PCNA gene products in an immortalized human endothelial cell line undergoing p53-mediated apoptosis. Apoptosis: an international journal on programmed cell death.
2(5), 442-454.
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Maxwell, S. A., Capp, D., & Acosta, S. A.
(1997).
Telomerase activity in immortalized endothelial cells undergoing p53-mediated apoptosis. Biochemical and Biophysical Research Communications.
241(3), 642-645.
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Maxwell, S. A., Roth, J. A., & Mukhopadhyay, T.
(1996).
Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis. Electrophoresis.
17(11), 1772-1775.
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Mukhopadhyay, T., Roth, J., & Maxwell, S.
(1996).
Induction of p53 DNA-binding activity by tumor necrosis factor-alpha. International Journal of Oncology.
9(4), 715-720.
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Srinivasan, R., & Maxwell, S. A.
(1996).
A cellular protein activates the sequence-specific DNA-binding of p53 by interacting with the central conserved region. Oncogene.
12(1), 193-200.
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Mukhopadhyay, T., Roth, J. A., & Maxwell, S. A.
(1995).
Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. Oncogene.
11(5), 999-1003.
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Mukhopadhyay, T., Fang, K., & Maxwell, S.
(1995).
Posttranscriptional regulation of epidermal growth-factor receptor expression by retinoic Acid in a human lung epithelial-cell line. Oncology Reports: an international journal devoted to fundamental and applied research in oncology.
2(3), 451-456.
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Maxwell, S. A., & Mukhopadhyay, T.
(1995).
A novel NF-kappa B p65 spliced transcript lacking exons 6 and 7 in a non-small cell lung carcinoma cell line. Gene.
166(2), 339-340.
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Maxwell, S. A.
(1995).
Identification of p53 Proteins and Targets. ImmunoMethods.
8(3), 182-197.
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Maxwell, S., & Zhang, W.
(1995).
Cell-type-specific regulation of p53 expression in nonsmall cell lung-carcinoma cells. Oncology Reports: an international journal devoted to fundamental and applied research in oncology.
2(1), 81-87.
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Maxwell, S. A.
(1994).
Selective compartmentalization of different mdm2 proteins within the nucleus. Anticancer Research: international journal of cancer research and treatment.
14(6 B), 2541-2547.
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Maxwell, S. A.
(1994).
Two-dimensional gel analysis of p53-mediated changes in protein expression. Anticancer Research: international journal of cancer research and treatment.
14(6 B), 2549-2556.
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Maxwell, S. A.
(1994).
Selective compartmentalization of different mdm2 proteins within the nucleus. 14(6B), 2541-2547.
-
Maxwell, S. A.
(1994).
Two-dimensional gel analysis of p53-mediated changes in protein expression. Anticancer Research: international journal of cancer research and treatment.
14(6B), 2549-2556.
-
Maxwell, S. A.
(1994).
Retinoblastoma protein in non-small cell lung carcinoma, cells arrested for growth by retinoic acid. Anticancer Research: international journal of cancer research and treatment.
14(4A), 1535-1540.
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MAXWELL, S. A.
(1994).
2-DIMENSIONAL GEL ANALYSIS OF P53-MEDIATED CHANGES IN PROTEIN EXPRESSION. Anticancer Research: international journal of cancer research and treatment.
14(6B), 2549-2556.
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Maxwell, S. A., & Mukhopadhyay, T.
(1994).
Transient stabilization of p53 in non-small cell lung carcinoma cultures arrested for growth by retinoic acid. Experimental Cell Research.
214(1), 67-74.
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Maxwell, S. A., & Roth, J. A.
(1994).
Posttranslational regulation of p53 tumor suppressor protein function. Critical Reviews in Oncogenesis.
5(1), 23-57.
-
Maxwell, S. A.
(1994).
Retinoblastoma protein in non-small cell lung carcinoma, cells arrested for growth by retinoic acid. Anticancer Research: international journal of cancer research and treatment.
14(4 A), 1535-1540.
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Maxwell, S. A., & Roth, J. A.
(1993).
Binding of cellular proteins to a conformational domain of tumor suppressor protein p53. Oncogene.
8(12), 3421-3426.
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Srinivasan, R., Roth, J. A., & Maxwell, S. A.
(1993).
Sequence-specific interaction of a conformational domain of p53 with DNA. Cancer Research.
53(22), 5361-5364.
-
Maxwell, S. A.
(1991).
Epithelial cancers of the aerodigestive tract: biology, prevention, and therapy. Cancer cells (Cold Spring Harbor, N.Y. : 1989).
3(7), 282-286.
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Maxwell, S. A., Ames, S. K., Sawai, E. T., Decker, G. L., Cook, R. G., & Butel, J. S.
(1991).
Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells. Molecular Cancer Research.
2(2), 115-127.
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Maxwell, S. A., Sacks, P. G., Gutterman, J. U., & Gallick, G. E.
(1989).
Epidermal growth factor receptor protein-tyrosine kinase activity in human cell lines established from squamous carcinomas of the head and neck. Cancer Research.
49(5), 1130-1137.
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BUTEL, J. S., JARVIS, D. L., & MAXWELL, S. A.
(1989).
SV40 T-ANTIGEN AS A DUAL ONCOGENE - STRUCTURE AND FUNCTION OF THE PLASMA MEMBRANE-ASSOCIATED POPULATION. Annals of the New York Academy of Sciences.
567, 104-121.
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Butel, J. S., Jarvis, D. L., & Maxwell, S. A.
(1989).
SV40 T-antigen as a dual oncogene: structure and function of the plasma membrane-associated population. Annals of the New York Academy of Sciences.
567(1), 104-121.
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Maxwell, S. A., Santos, M., Wong, C., Rasmussen, G., & Butel, J. S.
(1989).
Solubilization of SV40 plasma-membrane-associated large tumor antigen using single-phase concentrations of 1-butanol. Molecular Carcinogenesis.
2(6), 322-335.
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Lai, C. N., Gallick, G. E., Maxwell, S. A., Brinkley, B. R., & Becker, F. F.
(1988).
Potassium inhibition of transforming protein P85gag-mos and reversal of the transformed phenotype in 6m2 cells. Journal of Cellular Physiology.
134(3), 445-452.
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Maxwell, S. A., Kurzrock, R., Parsons, S. J., Talpaz, M., Gallick, G. E., Kloetzer, W. S., ... Gutterman, J. U.
(1987).
Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients. Cancer Research.
47(6), 1731-1739.
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Steck, P. A., Gallick, G. E., Maxwell, S. A., Kloetzer, W. S., Arlinghaus, R. B., Moser, R. P., Gutterman, J. U., & Yung, W. K.
(1986).
Expression of epidermal growth factor receptor and associated glycoprotein on cultured human brain tumor cells. Journal of Cellular Biochemistry.
32(1), 1-10.
-
Gallick, G. E., Sacks, P. G., Maxwell, S. A., Steck, P. A., & Gutterman, J. U.
(1986).
Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis. Progress in clinical and biological research.
212, 97-111.
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Maxwell, S. A., & Arlinghaus, R. B.
(1985).
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos. JOURNAL OF GENERAL VIROLOGY.
66 ( Pt 10)(10), 2135-2146.
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Massaro, D., Teich, N., Maxwell, S., Massaro, G. D., & Whitney, P.
(1985).
Postnatal development of alveoli. Regulation and evidence for a critical period in rats. Journal of Clinical Investigation.
76(4), 1297-1305.
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Maxwell, S. A., & Arlinghaus, R. B.
(1985).
Use of site-specific antipeptide antibodies to perturb the serine kinase catalytic activity of p37mos. Journal of Virology.
55(3), 874-876.
-
Whitney, P., Maxwell, S., Ryan, U., & Massaro, D.
(1985).
Synthesis and binding of lactose-specific lectin by isolated lung cells. AMERICAN JOURNAL OF PHYSIOLOGY.
248(3 Pt 1), C258-C264.
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Gallick, G. E., Sparrow, J. T., Singh, B., Maxwell, S. A., Stanker, L. H., & Arlinghaus, R. B.
(1985).
Recognition of mos-related proteins with an antiserum to a peptide of the v-mos gene product. JOURNAL OF GENERAL VIROLOGY.
66+%28+Pt+5%29(MAY), 945-955.
-
Maxwell, S. A., & Arlinghaus, R. B.
(1985).
Serine kinase activity associated with Maloney murine sarcoma virus-124-encoded p37mos. Virology.
143(1), 321-333.
-
Maxwell, S. A., & Arlinghaus, R. B.
(1985).
Further characterization of the in vitro products generated by proteolytic cleavage of Gazdar murine sarcoma virus p65gag. JOURNAL OF GENERAL VIROLOGY.
66 ( Pt 1)(1), 97-107.
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Gallick, G. E., Sparrow, J. T., Singh, B., Maxwell, S. A., Stanker, L. H., & Arlinghaus, R. B.
(1985).
Recognition of mos-related proteins with an antiserum to a peptide of the v-mos gene product. JOURNAL OF GENERAL VIROLOGY.
66(5), 945-955.
-
Whitney, P., Maxwell, S., Ryan, U., & Massaro, D.
(1985).
Synthesis and binding of lactose-specific lectin by isolated lung cells. American Journal of Physiology: Cell Physiology.
17(2),
-
Kloetzer, W. S., Maxwell, S. A., & Arlinghaus, R. B.
(1984).
Further characterization of the P85gag-mos -associated protein kinase activity. Virology.
138(1), 143-155.
-
Gallick, G. E., Hamelin, R., Maxwell, S., Duyka, D., & Arlinghaus, R. B.
(1984).
The gag-mos hybrid protein of ts110 Moloney murine sarcoma virus: variation of gene expression with temperature. Virology.
139(2), 366-374.
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KLOETZER, W. S., MAXWELL, S. A., & ARLINGHAUS, R. B.
(1983).
P85GAG-MOS ENCODED BY TS110 MOLONEY MURINE SARCOMA-VIRUS HAS AN ASSOCIATED PROTEIN-KINASE ACTIVITY. Proceedings of the National Academy of Sciences of the United States of America.
80(2), 412-416.
-
Kloetzer, W. S., Maxwell, S. A., & Arlinghaus, R. B.
(1983).
P85gag-mos encoded by ts110 Moloney murine sarcoma virus has an associated protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America.
80(2), 412-416.
-
Maxwell, S., & Arlinghaus, R. B.
(1981).
In vitro proteolytic cleavage of Gazdar murine sarcoma virus p65gag. Journal of Virology.
39(3), 963-967.
-
Maxwell, S. A., Fuchs-Young, R., Wells, G. B., Kapler, G. M., Conover, G. M., Green, S., ... Huston, D. P.
(2022).
Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors. Academic Medicine.
97(5), 684-688.
-
book
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Mukhopadhyay, T., Maxwell, S. A., & Roth, J. A.
(1995).
p53 Suppressor Gene. Springer Nature.
-
Mukhopadhyay, T., Maxwell, S. A., & Roth, J. A.
(1995).
p53 Suppressor Gene. Springer Nature.
-
chapter
-
Maxwell, S. A.
(2013).
Tumor suppressor activities of proline oxidase. Proline: Biosynthesis, Regulation and Health Benefits.
(pp. 135-159).
-
Maxwell, S. A.
(2013).
Tumor suppressor activities of proline oxidase. Proline: Biosynthesis, Regulation and Health Benefits.
(pp. 135-159).
-
conference paper
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Maxwell, S. A., Wallis, D., Zhou, N., Baker, D., Mousavi-Fard, S. H., Loesch, K., ... Sacchettini, J. C.
(2022).
Development of novel, non-toxic rifamycins that reverse drug resistance. Cancer Research.
-
Dave, J. M., Maxwell, S. A., & Bayless, K. J.
(2012).
RACK1 and vimentin complex to regulate FAK during endothelial invasion. Molecular Biology of the Cell.
-
Cherry, E. M., Bayless, K. J., & Maxwell, S. A.
(2011).
Drug resistance and invasion in diffuse large B-cell lymphoma are mediated by Akt, 14-3-3 zeta, and Vimentin. Cancer Research.
702-702.
-
Bayless, K. J., Kwak, H., Mendoza, E. A., & Maxwell, S. A.
(2007).
ADAM17 mediates endothelial invasion in three-dimensional collagen matrices. The FASEB Journal.
A194-A194.
-
Maxwell, S. A., & Davis, G. E.
(2000).
Comparative gene expression profiling in p53-mediated apoptosis-resistant and sensitive endothelial cell lines. The FASEB Journal.
A555-A555.
-
Davis, G. E., Bell, S. E., Bayless, K. J., Salazar, R., Pintar, K. A., Suhasini, K., & Maxwell, S. A.
(2000).
Molecular regulation of capillary morphogenesis and regression in three-dimensional extracellular matrix environments. The FASEB Journal.
A787-A787.
-
MAXWELL, S. A., SRINIVASAN, R., & ROTH, J. A.
(1994).
CELLULAR PROTEINS MODULATE NONSPECIFIC AND SEQUENCE-SPECIFIC DNA-BINDING OF A CONFORMATIONAL DOMAIN OF P53. Journal of Cellular Biochemistry.
179-179.
-
STECK, P. A., GALLICK, G. E., MAXWELL, S. A., & YUNG, W.
(1986).
ANALYSIS OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND ASSOCIATED GLYCOPROTEIN ON HUMAN GLIOMA-CELLS INVITRO. Journal of Neuro-Oncology.
98-98.
-
STECK, P. A., GALLICK, G. E., MAXWELL, S. A., & YUNG, W.
(1986).
EXPRESSION AND ACTIVITIES OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND ASSOCIATED GLYCOPROTEIN ON CULTURED HUMAN GLIOMA-CELLS. Journal of Cellular Biochemistry.
44-44.
-
GALLICK, G. E., SACKS, P. G., MAXWELL, S. A., STECK, P. A., & GUTTERMAN, J. U.
(1986).
EXPRESSION AND ACTIVITY OF EGF RECEPTOR IN HEAD AND NECK SQUAMOUS CARCINOMA CELL-LINES. Journal of Cellular Biochemistry.
19-19.
-
Maxwell, S. A., Wallis, D., Zhou, N., Baker, D., Mousavi-Fard, S. H., Loesch, K., ... Sacchettini, J. C.
(2022).
Development of novel, non-toxic rifamycins that reverse drug resistance. Cancer Research.
-
patent
-
Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D.
(2018).
Compositions and methods for drug-sensitization or inhibition of a cancer cell
-
Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D.
(2017).
Compositions and methods for drug-sensitization or inhibition of a cancer cell
-
Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D.
(2015).
Compositions and methods for drug-sensitization or inhibition of a cancer cell
-
Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D.
(2018).
Compositions and methods for drug-sensitization or inhibition of a cancer cell
Teaching
teaching activities
- MEID618 Medical Student Grand Rounds Block Co-Leader, Instructor
- MEID705 Seminar Day Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Molecular Virology, The University of Texas Health Science Center at Houston - (Houston, Texas, United States) 1985
- M.S. in Molecular Virology, The University of Texas Health Science Center at Houston - (Houston, Texas, United States) 1982
- B.A. in Chemistry, Abilene Christian University - (Abilene, Texas, United States) 1980
- B.S. in Biology and Chemistry, Abilene Christian University - (Abilene, Texas, United States) 1980
- Baylor College of Medicine - (Houston, Texas, United States) , Postdoctoral Training 1990
- The University of Texas MD Anderson Cancer Center - (Houston, Texas, United States) , Postdoctoral Training 1987
Contact
first name
- Steven
has last name
- Maxwell
mailing address
-
Texas A&M Health Science Center
Molecular And Cellular Medicine
1114 TAMUS
College Station, TX 77843-1114
USA
Other
- s-maxwell@tamu.edu