Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. Academic Article

abstract

• Recent studies have implicated a role for the p50 subunit of the NF-kappa B transcription factor complex in tumorigenesis. Therefore, we investigated the expression of the p50 subunit of the NF-kappa B transcription factor complex in paired normal and non-small cell lung carcinoma (NSCLC) tissues. Here we show that nine of 11 (81.8%) fresh NSCLC tissues expressed from two- to 20-fold higher levels of the p50 subunit than normal lung tissue. Thirteen NSCLC cell lines also exhibited high levels of p50. Alterations in the normal NF-kappa B/rel pathway of regulation may play a role in the genesis of NSCLC.

authors

• Maxwell, Steven

published proceedings

• Oncogene

author list (cited authors)

• Mukhopadhyay, T., Roth, J. A., & Maxwell, S. A.

citation count

• 99

complete list of authors

• Mukhopadhyay, T||Roth, JA||Maxwell, SA

publication date

• September 1995

published in

• Oncogene  Journal

keywords

• Carcinoma, Non-Small-Cell Lung
• Humans
• Lung Neoplasms
• NF-kappa B
• NF-kappa B P50 Subunit
• RNA, Messenger
• Tumor Cells, Cultured

PubMed Central ID

• 7675461

start page

• 999

end page

• 1003

volume

• 11

issue

• 5