HR job title
- Associate Professor
- Contact Info
- 1 979 436 0272
Shapiro, Lee Associate Professor
Positions
- Overview
- Publications
- Research
- Teaching
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academicarticle
-
Iannucci, J., Dominy, R., Bandopadhyay, S., Arthur, E. M., Noarbe, B., Jullienne, A., ... Shapiro, L. A.
(2024).
Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP+B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice. Journal of Neuroinflammation.
21(1), 165.
-
Wang, F., Wang, W., Gu, S., Qi, D., Smith, N. A., Peng, W., ... Huang, J. H.
(2023).
Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice. Nature Communications.
14(1), 2186.
-
Iannucci, J., Beevers, S., Tobin, R., NewellRogers, M. K., & Shapiro, L. A.
(2022).
Altered Affect and Increased CLIP+ B cells in the Meningeal Lymphatics of 5xFAD mice are mitigated by antagonizing MHCIIassociated invariant chain (CLIP). Alzheimer's and Dementia.
18(S3),
-
Iannucci, J., Nizamutdinov, D., & Shapiro, L. A.
(2022).
Neurogenesis and chronic neurobehavioral outcomes are partially improved by vagus nerve stimulation in a mouse model of Gulf War illness. 90, 205-215.
-
Newell-Rogers, M. K., Duong, A., Nazarali, R., Tobin, R. P., Rogers, S. K., & Shapiro, L. A.
(2022).
Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to a Traumatic Brain Injury. International Journal of Molecular Sciences.
23(17), 9851-9851.
-
Venkatasamy, L., Nizamutdinov, D., Jenkins, J., & Shapiro, L. A.
(2021).
Vagus Nerve Stimulation Ameliorates Cognitive Impairment and Increased Hippocampal Astrocytes in a Mouse Model of Gulf War Illness. Neuroscience Insights.
16, 26331055211018456-263310552110184.
-
Newell-Rogers, M. K., Rogers, S. K., Tobin, R. P., Mukherjee, S., & Shapiro, L. A.
(2020).
Antagonism of Macrophage Migration Inhibitory Factory (MIF) after Traumatic Brain Injury Ameliorates Astrocytosis and Peripheral Lymphocyte Activation and Expansion. International Journal of Molecular Sciences.
21(20), 7448-7448.
-
Mukherjee, S., Arisi, G. M., Mims, K., Hollingsworth, G., O'Neil, K., & Shapiro, L. A.
(2020).
Neuroinflammatory mechanisms of post-traumatic epilepsy. Journal of Neuroinflammation.
17(1), 193.
-
Sulhan, S., Lyon, K. A., Shapiro, L. A., & Huang, J. H.
(2020).
Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets. Journal of Neuroscience Research.
98(1), 19-28.
-
Bancroft, E., Srinivasan, R., & Shapiro, L. A.
(2019).
Macrophage Migration Inhibitory Factor Alters Functional Properties of CA1 Hippocampal Neurons in Mouse Brain Slices. International Journal of Molecular Sciences.
21(1), 276-276.
-
Wang, F., Pan, F., Shapiro, L. A., & Huang, J. H.
(2018).
Stress Induced Neuroplasticity and Mental Disorders 2018. Neural Plasticity.
2018, 5382537-3.
-
Nizamutdinov, D., Mukherjee, S., Deng, C., Stauss, H. M., & Shapiro, L. A.
(2018).
Gulf War agents pyridostigmine bromide and permethrin cause hypersensitive nociception that is restored after vagus nerve stimulation. 69, 93-96.
-
Shapiro, L. A.
(2017).
Altered Hippocampal Neurogenesis during the First 7 Days after a Fluid Percussion Traumatic Brain Injury. Cell Transplantation.
26(7), 1314-1318.
-
Nizamutdinov, D., DeMorrow, S., McMillin, M., Kain, J., Mukherjee, S., Zeitouni, S., ... Shapiro, L. A.
(2017).
Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury. Scientific Reports.
7(1), 40112.
-
Wang, F., Wang, X., Shapiro, L. A., Cotrina, M. L., Liu, W., Wang, E. W., ... Huang, J. H.
(2017).
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. 222(3), 1543-1556.
-
Nizamutdinov, D., & Shapiro, L. A.
(2017).
Overview of Traumatic Brain Injury: An Immunological Context. Brain Sciences.
7(1), 11-11.
-
Wang, F., Pan, F., Shapiro, L. A., & Huang, J. H.
(2017).
Stress Induced Neuroplasticity and Mental Disorders. Neural Plasticity.
2017, 9634501-3.
-
Robinson, C., Apgar, C., & Shapiro, L. A.
(2016).
Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury. 2016, 1347987-10.
-
Arisi, G. M., Foresti, M. L., Katki, K., & Shapiro, L. A.
(2015).
Increased CCL2, CCL3, CCL5, and IL-1 cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures. Journal of Neuroinflammation.
12(1), 129.
-
Rogers, S. K., Shapiro, L. A., Tobin, R. P., Tow, B., Zuzek, A., Mukherjee, S., & Newell-Rogers, M. K.
(2014).
Levetiracetam Differentially Alters CD95 Expression of Neuronal Cells and the Mitochondrial Membrane Potential of Immune and Neuronal Cells in vitro. Frontiers in Neurology.
5, 17.
-
Tobin, R. P., Mukherjee, S., Kain, J. M., Rogers, S. K., Henderson, S. K., Motal, H. L., Newell Rogers, M. K., & Shapiro, L. A.
(2014).
Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathologica Communications.
2(1), 143.
-
Niesman, I. R., Schilling, J. M., Shapiro, L. A., Kellerhals, S. E., Bonds, J. A., Kleschevnikov, A. M., ... Head, B. P.
(2014).
Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. Journal of Neuroinflammation.
11(1), 39.
-
Mukherjee, S., Zeitouni, S., Cavarsan, C. F., & Shapiro, L. A.
(2013).
Increased seizure susceptibility in mice 30days after fluid percussion injury. Frontiers in Neurology.
4, 28.
-
Sanchez, R. M., Ribak, C. E., & Shapiro, L. A.
(2012).
Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy. EPILEPSIA.
53 Suppl 1(SUPPL. 1), 98-108.
-
Arisi, G. M., Foresti, M. L., Mukherjee, S., & Shapiro, L. A.
(2012).
The role of olfactory stimulus in adult mammalian neurogenesis. Behavioural Brain Research.
227(2), 356-362.
-
Arisi, G. M., Ruch, M., Foresti, M. L., Mukherjee, S., Ribak, C. E., & Shapiro, L. A.
(2011).
Astrocyte Alterations in the Hippocampus Following Pilocarpine-induced Seizures in Aged Rats. Aging and Disease.
2(4), 294-300.
-
Shapiro, L. A.
(2011).
From bench to bedside: unique challenges of treating epilepsy in the aging brain. Aging and Disease.
2(4), 275-277.
-
Shapiro, L. A., Wang, L., Upadhyaya, P., & Ribak, C. E.
(2011).
Seizure-induced Increased Neurogenesis Occurs in the Dentate Gyrus of Aged Sprague-Dawley Rats. Aging and Disease.
2(4), 286-293.
-
Mukherjee, S., Katki, K., Arisi, G. M., Foresti, M. L., & Shapiro, L. A.
(2011).
Early TBI-Induced Cytokine Alterations are Similarly Detected by Two Distinct Methods of Multiplex Assay. Frontiers in Molecular Neuroscience.
4, 21.
-
Foresti, M. L., Arisi, G. M., & Shapiro, L. A.
(2011).
Role of glia in epilepsy-associated neuropathology, neuroinflammation and neurogenesis. Brain Research Reviews.
66(1-2), 115-122.
-
Shapiro, L. A., Bialowas-McGoey, L. A., & Whitaker-Azmitia, P. M.
(2010).
Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease: Studies in an S100B Overexpressing Mouse Model. Cardiovascular Psychiatry and Neurology.
2010, 153657-13.
-
Ribak, C. E., Shapiro, L. A., Yan, X., Dashtipour, K., Nadler, J. V., Obenaus, A., Spigelman, I., & Buckmaster, P. S.
(2010).
Seizure-induced basal dendrites on granule cells. EPILEPSIA.
51, 43-43.
-
Foresti, M. L., Arisi, G. M., Katki, K., Montaez, A., Sanchez, R. M., & Shapiro, L. A.
(2009).
Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. Journal of Neuroinflammation.
6(1), 40.
-
Ribak, C. E., Shapiro, L. A., Perez, Z. D., & Spigelman, I.
(2009).
Microglia-associated granule cell death in the normal adult dentate gyrus. 214(1), 25-35.
-
Shapiro, L. A., Perez, Z. D., Foresti, M. L., Arisi, G. M., & Ribak, C. E.
(2009).
Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus. BRAIN RESEARCH.
1266, 29-36.
-
Shapiro, L. A., Ng, K., Zhou, Q., & Ribak, C. E.
(2009).
Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. Epilepsy and Behavior.
14 Suppl 1(Suppl 1), 74-80.
-
Jacquin, M. F., Arends, J., Xiang, C., Shapiro, L. A., Ribak, C. E., & Chen, Z.
(2008).
In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. Journal of Neuroscience.
28(14), 3577-3585.
-
Shapiro, L. A., Wang, L., & Ribak, C. E.
(2008).
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. EPILEPSIA.
49+Suppl+2, 33-41.
-
Shapiro, L. A., Ribak, C. E., & Jessberger, S.
(2008).
Structural changes for adult-born dentate granule cells after status epilepticus. EPILEPSIA.
49 Suppl 5(s5), 13-18.
-
Shapiro, L. A., Ng, K. L., Zhou, Q., & Ribak, C. E.
(2007).
Olfactory enrichment enhances the survival of newly born cortical neurons in adult mice. NeuroReport.
18(10), 981-985.
-
Ribak, C. E., & Shapiro, L. A.
(2007).
Dendritic development of newly generated neurons in the adult brain. Brain Research Reviews.
55(2), 390-394.
-
Shapiro, L. A., Figueroa-Aragon, S., & Ribak, C. E.
(2007).
Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizures. European Journal of Neuroscience.
26(3), 583-592.
-
Shapiro, L. A., Ng, K. L., Kinyamu, R., Whitaker-Azmitia, P., Geisert, E. E., Blurton-Jones, M., Zhou, Q., & Ribak, C. E.
(2007).
Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. 212(2), 133-148.
-
Shapiro, L. A., Upadhyaya, P., & Ribak, C. E.
(2007).
Spatiotemporal profile of dendritic outgrowth from newly born granule cells in the adult rat dentate gyrus. BRAIN RESEARCH.
1149, 30-37.
-
Shapiro, L. A., & Ribak, C. E.
(2006).
Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses. Epilepsy Research.
69(1), 53-66.
-
Shapiro, L. A., Korn, M. J., Shan, Z., & Ribak, C. E.
(2005).
GFAP-expressing radial glia-like cell bodies are involved in a one-to-one relationship with doublecortin-immunolabeled newborn neurons in the adult dentate gyrus. BRAIN RESEARCH.
1040(1-2), 81-91.
-
Shapiro, L. A., & Ribak, C. E.
(2005).
Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents. Brain Research Reviews.
48(1), 43-56.
-
Shapiro, L. A., Korn, M. J., & Ribak, C. E.
(2005).
Newly generated dentate granule cells from epileptic rats exhibit elongated hilar basal dendrites that align along GFAP-immunolabeled processes. Neuroscience.
136(3), 823-831.
-
Shapiro, L. A., & Whitaker-Azmitia, P. M.
(2004).
Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43. BRAIN RESEARCH.
1019(1-2), 39-46.
-
Shapiro, L. A., Marks, A., & Whitaker-Azmitia, P. M.
(2004).
Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome. BRAIN RESEARCH.
1010(1-2), 17-21.
-
Kahne, D., Tudorica, A., Borella, A., Shapiro, L., Johnstone, F., Huang, W., & Whitaker-Azmitia, P. M.
(2002).
Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism. Physiology and Behavior.
75(3), 403-410.
-
Kirmani, B. F., Shetty, A. K., & Shapiro, L. A.
Editorial: New Directions in the Management of Status Epilepticus. Frontiers in Neurology.
9(NOV), 994.
-
Brakel, K., Aceves, M., Garza, A., Yoo, C., Escobedo, G., Panchani, N., Shapiro, L., & Hook, M.
Inflammation increases the development of depression behaviors in male rats after spinal cord injury. Brain, Behavior, and Immunity - Health.
14, 100258-100258.
-
Kirmani, B. F., Shapiro, L. A., & Shetty, A. K.
Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment. Aging and Disease.
12(4), 950-953.
-
Iannucci, J., Dominy, R., Bandopadhyay, S., Arthur, E. M., Noarbe, B., Jullienne, A., ... Shapiro, L. A.
(2024).
Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP+B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice. Journal of Neuroinflammation.
21(1), 165.
-
chapter
-
Ribak, C. E., Shapiro, L. A., Yan, X., Dashtipour, K., Nadler, J. V., Obenaus, A., Spigelman, I., & Buckmaster, P. S.
(2012).
Seizure-Induced Formation of Basal Dendrites on Granule Cells of the Rodent Dentate Gyrus. Jasper's Basic Mechanisms of the Epilepsies.
(pp. 484-493).
Oxford University Press (OUP).
-
Ribak, C. E., Perez, Z. D., & Shapiro, L. A.
(2008).
Developmental Profile of Newly Generated Granule Cells in the Adult Rodent Dentate Gyrus. From Development to Degeneration and Regeneration of the Nervous System.
(pp. 225-242).
Oxford University Press (OUP).
-
Ribak, C. E., & Shapiro, L. A.
(2007).
Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrus. Progress in Brain Research.
The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications.
(pp. 155-166).
Elsevier.
-
RIBAK, C. E., SHAPIRO, L. A., SERESS, L., & BAKAY, R. A.
(2006).
CHAPTER 14 Alumina Gel Injection Models of Epilepsy in Monkeys. Models of Seizures and Epilepsy.
(pp. 179-187).
Elsevier.
-
Ribak, C. E., Shapiro, L. A., Yan, X., Dashtipour, K., Nadler, J. V., Obenaus, A., Spigelman, I., & Buckmaster, P. S.
(2012).
Seizure-Induced Formation of Basal Dendrites on Granule Cells of the Rodent Dentate Gyrus. Jasper's Basic Mechanisms of the Epilepsies.
(pp. 484-493).
Oxford University Press (OUP).
-
conference paper
-
Iannucci, J., Beevers, S., Newell-Rogers, M. K., & Shapiro, L. A.
(2022).
ADAPTIVE IMMUNE TARGETING AMELIORATES DEPRESSION AND COGNITIVE IMPAIRMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE FOLLOWING TBI. JOURNAL OF NEUROTRAUMA.
A118-A118.
-
Nazarali, R., Shapiro, L. A., & Mukherjee, S.
(2018).
Vagotomy decreases splenocytes and MHCII+/CD11B+cells in the spleen. Journal of Immunology.
-
Shapiro, L. A., & Huang, J. H.
(2014).
ALTERED NEUROGENESIS FOLLOWING A FLUID PERCUSSION INJURY IN MICE. JOURNAL OF NEUROTRAUMA.
A96-A97.
-
Shapiro, L. A., Obenaus, A., Mukherjee, S., Hurst, J., Kain, J., Tobin, R., & Newell-Rogers, K.
(2014).
HIPPOCAMPAL NEURON LOSS, WHITE MATTER DAMAGE AND BEHAVIORAL ALTERATIONS FOLLOWING A FLUID PERCUSSION INJURY IN MICE. JOURNAL OF NEUROTRAUMA.
A34-A34.
-
Foresti, M. L., Arisi, G. M., Montanez, A., & Shapiro, L. A.
(2009).
CCR2 EXPRESSION IS UP-REGULATED IN THE HIPPOCAMPUS AFTER PILOCARPINE-INDUCED SEIZURES. EPILEPSIA.
475-476.
-
Heida, J. G., Katki, K., Arisi, G. M., Zhang, K., Shapiro, L. A., & Sanchez, R. M.
(2009).
HIPPOCAMPAL CYTOKINE EXPRESSION AFTER NEONATAL HYPOXIA-INDUCED SEIZURES. EPILEPSIA.
368-369.
-
Arisi, G., Montanez, A., Foresti, M. L., Katki, K., Heida, J. G., Sanchez, R. M., & Shapiro, L. A.
(2009).
MINOCYCLINE RESCUES RATS FROM WEIGHT LOSS AND CEREBRAL LESIONS AFTER PILOCARPINE-INDUCED STATUS EPILEPTICUS. EPILEPSIA.
130-130.
-
Sanchez, R. M., Zhang, K., & Shapiro, L. A.
(2008).
ASTROCYTE HYPERTROPHY IN NEONATAL RAT DENTATE GYRUS AFTER HYPOXIA-INDUCED SEIZURES. EPILEPSIA.
352-353.
-
Iannucci, J., Beevers, S., Newell-Rogers, M. K., & Shapiro, L. A.
(2022).
ADAPTIVE IMMUNE TARGETING AMELIORATES DEPRESSION AND COGNITIVE IMPAIRMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE FOLLOWING TBI. JOURNAL OF NEUROTRAUMA.
A118-A118.
Research
principal investigator on
co-principal investigator on
- Mechanisms by which CD74 Contributes to Traumatic Brain Injury awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2023
- The Contributions of CD74 to Acquired Epilepsy awarded by Citizens United for Research in Epilepsy - (Chicago, Illinois, United States) 2015 - 2017
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- MSCI685 Directed Studies Instructor
- MSCI689 Sptp: Intro To Neuroimmunology Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
Contact
first name
- Lee
has last name
- Shapiro
mailing address
-
Texas A&M Health Science Center
Neuroscience & Experimental Therapeutics
Bryan, TX 77807
USA
Other
- lshapiro99@tamu.edu