selected publications academic article Liang, T., Hu, Y., Zhang, H., Xu, Q., Smith, C. E., Zhang, C., ... Simmer, J. P. (2021). Mouse Dspp frameshift model of human dentinogenesis imperfecta. Scientific Reports. 11(1), 20653. Liang, T., Xu, Q., Zhang, H., Wang, S., Diekwisch, T., Qin, C., & Lu, Y. (2021). Enamel Defects Associated With Dentin Sialophosphoprotein Mutation in Mice. Frontiers in Physiology. 12, 724098. Zhang, H., Xu, Q., Lu, Y., & Qin, C. (2021). Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice. European Journal Of Oral Sciences. 129(3), e12795. Xu, Q., Zhang, H., Wang, S., Qin, C., & Lu, Y. (2021). Constitutive expression of spliced XBP1 causes perinatal lethality in mice. Genesis: The Journal of Genetics and Development. 59(5-6), e23420. Li, L., Saiyin, W., Zhang, H., Wang, S., Xu, Q., Qin, C., & Lu, Y. (2019). FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis. 50(6), 581-591. Liang, T., Zhang, H., Xu, Q., Wang, S., Qin, C., & Lu, Y. (2019). Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. Journal of Dental Research. 98(8), 912-919. Shiflett, L. A., Tiede-Lewis, L. M., Xie, Y., Lu, Y., Ray, E. C., & Dallas, S. L. (2019). Collagen Dynamics During the Process of Osteocyte Embedding and Mineralization. Frontiers in Cell and Developmental Biology. 7, 178. Zhang, H., Li, L., Kesterke, M. J., Lu, Y., & Qin, C. (2019). High-Phosphate Diet Improved the Skeletal Development of Fam20c-Deficient Mice. Cells, Tissues, Organs: in vivo, in vitro. 208(1-2), 25-36. Saiyin, W., Li, L., Zhang, H., Lu, Y., & Qin, C. (2019). Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF- and MAPK signaling pathways. BBA: Molecular Basis of Disease. 1865(12), 165555-165555. Liu, X., Li, N., Zhang, H., Liu, J., Zhou, N., Ran, C., ... Liu, C. (2018). Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. European Journal Of Oral Sciences. 126(5), 433-436. Liu, C., Zhang, H., Jani, P., Wang, X., Lu, Y., Li, N., Xiao, J., & Qin, C. (2018). FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. Journal of Cellular Physiology. 233(4), 3476-3486. Liu, C., Zhou, N., Wang, Y. u., Zhang, H., Jani, P., Wang, X., ... Qin, C. (2018). Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Experimental Cell Research. 363(2), 188-195. Lu, Y., Kamel-El Sayed, S. A., Wang, K., Tiede-Lewis, L. M., Grillo, M. A., Veno, P. A., ... Dallas, S. L. (2018). Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs. Journal of Bone and Mineral Research. 33(6), 1166-1182. Morris, J. L., Cross, S. J., Lu, Y., Kadler, K. E., Lu, Y., Dallas, S. L., & Martin, P. (2018). Live imaging of collagen deposition during skin development and repair in a collagen I - GFP fusion transgenic zebrafish line. Developmental Biology. 441(1), 4-11. Zhang, H., Xie, X., Liu, P., Liang, T., Lu, Y., & Qin, C. (2018). Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One. 13(4), e0195854-e0195854. Zhang, H., Jani, P., Liang, T., Lu, Y., & Qin, C. (2017). Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of Molecular Histology. 48(2), 83-98. Liu, P., Ma, S. u., Zhang, H., Liu, C., Lu, Y., Chen, L. i., & Qin, C. (2017). Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Scientific Reports. 7(1), 3590. Jani, P. H., Gibson, M. P., Liu, C., Zhang, H., Wang, X., Lu, Y., & Qin, C. (2016). Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol. 52-54, 95-112. Liang, T., Meng, T., Wang, S., Qin, C., & Lu, Y. (2016). The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum. Journal of Cellular Physiology. 231(7), 1468-1475. Xie, X., Liu, C., Zhang, H., Jani, P. H., Lu, Y., Wang, X., Zhang, B., & Qin, C. (2016). Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Scientific Reports. 6(1), 25364. Zhang, H., Liu, P., Wang, S., Liu, C., Jani, P., Lu, Y., & Qin, C. (2016). Transgenic expression of dentin phosphoprotein inhibits skeletal development. European Journal of Histochemistry. 60(1), 2587-54. Kamel-ElSayed, S. A., Tiede-Lewis, L. M., Lu, Y., Veno, P. A., & Dallas, S. L. (2016). Corrigendum to novel approaches for two and three dimensional multiplexed imaging of osteocytes Bone 76 (2015) [129-140]. BONE. 83, 93-93. Meng, T., Huang, Y., Wang, S., Zhang, H., Dechow, P. C., Wang, X., ... Lu, Y. (2015). Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. Journal of Biological Chemistry. 290(49), 29593-29602. Liu, C., Wang, X., Zhang, H., Xie, X., Liu, P., Liu, Y., ... Qin, C. (2015). Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics. Journal of Cellular Physiology. 230(11), 2581-2587. Kamel-ElSayed, S. A., Tiede-Lewis, L. M., Lu, Y., Veno, P. A., & Dallas, S. L. (2015). Novel approaches for two and three dimensional multiplexed imaging of osteocytes. BONE. 76, 129-140. Gibson, M. P., Jani, P., Wang, X., Lu, Y., & Qin, C. (2014). Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of Oral Biosciences. 56(4), 143-148. Wang, X., Wang, J., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C. (2014). Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connective Tissue Research. 55(4), 299-303. Huang, Y., Meng, T., Wang, S., Zhang, H., Mues, G., Qin, C., ... Lu, Y. (2014). Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One. 9(6), e99331-e99331. Lin, S., Zhang, Q. i., Cao, Z., Lu, Y., Zhang, H., Yan, K., ... Feng, J. Q. (2014). Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. Journal of Biological Chemistry. 289(31), 21533-21543. Lin, S., Zhang, Q. i., Zhang, H., Yan, K., Ward, L., Lu, Y., & Feng, J. (2014). Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice. International Journal of Oral Science. 6(3), 133-141. Gibson, M. P., Jani, P., Liu, Y., Wang, X., Lu, Y., Feng, J. Q., & Qin, C. (2013). Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice. European Journal Of Oral Sciences. 121(6), 545-550. Wang, X., Jung, J., Liu, Y., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C. (2013). The specific role of FAM20C in amelogenesis. Journal of Dental Research. 92(11), 995-999. Mammoto, T., Jiang, E., Jiang, A., Lu, Y., Juan, A. M., Chen, J., & Mammoto, A. (2013). Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One. 8(9), e73407-e73407. Huang, Y., Lu, Y., Mues, G., Wang, S., Bonds, J., & D'Souza, R. (2013). Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation. European Journal Of Oral Sciences. 121(4), 313-318. Gibson, M. P., Liu, Q., Zhu, Q., Lu, Y., Jani, P., Wang, X., ... Qin, C. (2013). Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. European Journal Of Oral Sciences. 121(2), 76-85. Gibson, M. P., Zhu, Q., Wang, S., Liu, Q., Liu, Y., Wang, X., ... Lu, Y. (2013). The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Journal of Biological Chemistry. 288(10), 7204-7214. Zhu, Q., Prasad, M., Kong, H., Lu, Y., Sun, Y., Wang, X., ... Qin, C. (2012). Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s). Connective Tissue Research. 53(4), 307-312. Lu, Y., Li, Y., Cavender, A. C., Wang, S., Mansukhani, A., & D'Souza, R. N (2012). Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Developmental Dynamics. 241(11), 1708-1715. Wang, X., Wang, S., Lu, Y., Gibson, M. P., Liu, Y., Yuan, B., Feng, J. Q., & Qin, C. (2012). FAM20C plays an essential role in the formation of murine teeth. Journal of Biological Chemistry. 287(43), 35934-35942. Zhu, Q., Gibson, M. P., Liu, Q., Liu, Y., Lu, Y., Wang, X., Feng, J. Q., & Qin, C. (2012). Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. Journal of Biological Chemistry. 287(36), 30426-30435. Rangiani, A., Cao, Z., Sun, Y., Lu, Y., Gao, T., Yuan, B., ... Feng, J. Q. (2012). Protective roles of DMP1 in high phosphate homeostasis. PLoS One. 7(8), e42329-e42329. Wang, X., Wang, S., Li, C., Gao, T., Liu, Y., Rangiani, A., ... Qin, C. (2012). Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. 8(5), e1002708-e1002708. Siyam, A., Wang, S., Qin, C., Mues, G., Stevens, R., D'Souza, R. N., & Lu, Y. (2012). Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochemical and Biophysical Research Communications. 424(3), 641-646. Li, Y., Lu, Y., Maciejewska, I., Galler, K. M., Cavender, A., & D'Souza, R. N. (2011). TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Advances in Dental Research. 23(3), 280-284. Sun, Y., Lu, Y., Chen, L., Gao, T., D'Souza, R., Feng, J. Q., & Qin, C. (2011). DMP1 processing is essential to dentin and jaw formation. Journal of Dental Research. 90(5), 619-624. Zhang, R., Lu, Y., Ye, L., Yuan, B., Yu, S., Qin, C., ... Feng, J. Q. (2011). Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. Journal of Bone and Mineral Research. 26(5), 1047-1056. Lu, Y., Yuan, B., Qin, C., Cao, Z., Xie, Y., Dallas, S. L., ... Feng, J. Q. (2011). The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. Journal of Bone and Mineral Research. 26(2), 331-340. Lu, Y., & Feng, J. Q. (2011). FGF23 in skeletal modeling and remodeling. Current Osteoporosis Reports. 9(2), 103-108. Jiang, B., Cao, Z., Lu, Y., Janik, C., Lauziere, S., Xie, Y., ... Feng, J. Q. (2010). DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. Journal of Bone and Mineral Research. 25(10), 2155-2164. Lv, K., Huang, H., Lu, Y., Qin, C., Li, Z., & Feng, J. Q. (2010). Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. International Journal of Biological Sciences. 6(6), 537-545. Sun, Y., Lu, Y., Chen, S., Prasad, M., Wang, X., Zhu, Q., ... Qin, C. (2010). Key proteolytic cleavage site and full-length form of DSPP. Journal of Dental Research. 89(5), 498-503. Ma, D., Barragan-Adjemian, C., Xie, Y., Lu, Y., Bonewald, L. F., & Feng, J. Q. (2008). Pre-odontoblasts, odontoblasts, or "odontocytes" - Reply. Journal of Dental Research. 87(3), 199-199. Huang, B., Maciejewska, I., Sun, Y., Peng, T., Qin, D., Lu, Y., ... Qin, C. (2008). Identification of full-length dentin matrix protein 1 in dentin and bone. Calcified Tissue International. 82(5), 401-410. Kula, K., Trimmell, J., Lu, Y., Briscoe, P., & Feng, J. Q. (2008). Tooth agenesis in a family and homozygous PAX9 mutation in exon 3: a case report. World Journal of Orthodontics. 9(4), e55-e61. Lu, Y., Xie, Y., Zhang, S., Dusevich, V., Bonewald, L. F., & Feng, J. Q. (2007). DMP1-targeted Cre expression in odontoblasts and osteocytes. Journal of Dental Research. 86(4), 320-325. Lu, Y., Ye, L., Yu, S., Zhang, S., Xie, Y., McKee, M. D., ... Feng, J. Q. (2007). Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Developmental Biology. 303(1), 191-201. Lu, Y., Liu, S., Xie, Y., Yu, S., Quarles, L., Bonewald, L. F., & Feng, J. Q. (2007). Use of the transgenic approach to determine the role of DMP1 in phosphate regulation. 7(4), 309. Zhang, K., Barragan-Adjemian, C., Ye, L., Kotha, S., Dallas, M., Lu, Y., ... Bonewald, L. F. (2006). E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. 26(12), 4539-4552. Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., ... White, K. E. (2006). Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature Genetics. 38(11), 1310-1315. Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005). DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Journal of Bone and Mineral Research. 20(12), 2169-2177. Yang, W., Lu, Y., Kalajzic, I., Guo, D., Harris, M. A., Gluhak-Heinrich, J., ... Harris, S. E. (2005). Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. Journal of Biological Chemistry. 280(21), 20680-20690. Yang, W., Kalajzic, I., Lu, Y., Guo, D., Harris, M. A., Gluhak-Heinrich, J., ... Harris, S. E. (2004). In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. 4(4), 386-387. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., ... Feng, J. Q. (2004). Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Journal of Biological Chemistry. 279(18), 19141-19148. Feng, J. Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., ... Mishina, Y. (2003). The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Journal of Dental Research. 82(10), 776-780. Fen, J. Q., Zhang, J., Dallas, S. L., Lu, Y., Chen, S., Tan, X., ... MacDougall, M. (2002). Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. Journal of Bone and Mineral Research. 17(10), 1822-1831. Zhang, J., Tan, X., Contag, C. H., Lu, Y., Guo, D., Harris, S. E., & Feng, J. Q. (2002). Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles. Biochemical and Biophysical Research Communications. 293(5), 1412-1419. Feng, J. Q., Zhang, J., Tan, X., Lu, Y., Guo, D., & Harris, S. E. (2002). Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo. Journal of Dental Research. 81(1), 6-10. conference paper Peng, T., Huang, B., Sun, Y., Lu, Y., Bonewald, L., Chen, S., ... Qin, C. (2009). Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells, Tissues, Organs: in vivo, in vitro. 192-197. Lu, Y., Qin, C., Xie, Y., Bonewald, L. F., & Feng, J. Q. (2009). Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells, Tissues, Organs: in vivo, in vitro. 175-185. Lu, Y., Liu, S., Yu, S., Xie, Y., Zhou, J., Quarles, L. D., Bonewald, L. F., & Feng, J. O. (2007). The 57 kDa C-terminal fragment of dentin matrix protein 1 (DMPI) retains all biological activity: Osteocytic regulation of Pi homeostasis through FGF23. Journal of Bone and Mineral Research. S82-S82. Lu, Y., Zhang, S., Xie, Y., Pi, Y., & Feng, J. Q. (2005). Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells, Tissues, Organs: in vivo, in vitro. 241-247. Feng, J. Q., Ye, L., Chen, D., Huang, H., Zhang, J., Lu, Y., ... Mishina, Y. (2002). Dmp1-deficient mice develop dwarfism, chondrodysplasia, and exhibit disorganized bone mineralization during postnatal development. Journal of Bone and Mineral Research. S127-S127.
principal investigator on Functions of Family with Sequence Similarity 20 - Member C (FAM20C) and Member A (FAM20A) in Amelogenesis and Dentinogenesis awarded by National Institute of Dental and Craniofacial Research - (Bethesda, Maryland, United States) 2020 - 2024 Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogensis Imperfecta (DGI) and Odontoblast Function awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023 Identification and Function of nuDMP1 in Odontoblast Differentiation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2019
chaired theses and dissertations Liang, Tian (2018-08). Molecular Pathogenesis of Dentinogenesis Imperfecta Associated with Dentin Sialophosphoprotein Mutations.
education and training M.S. in Medical Microbiology, Qingdao University - (Qingdao, China) 1997 M.D. in Medicine, Qingdao University - (Qingdao, China) 1994
awards and honors Basic Science Faculty Research Award, conferred by Texas A&M University - (College Station, Texas, United States), 2014 ASBMR John Haddad Young Investigator Award, conferred by American Society for Bone and Mineral Research - (Washington D.C., District of Columbia, United States), 2011
mailing address Texas A&M University College of Dentistry Biomedical Sciences 3302 Gaston Avenue Dallas, TX 75246 USA