HR job title
- Professor
- Contact Info
- 214-828-8277
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Lu, Yongbo Associate Professor
Positions
- Associate Professor, Biomedical Sciences, School of Dentistry
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
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Overview
Publications
selected publications
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academic article
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Liang, T., Hu, Y., Zhang, H., Xu, Q., Smith, C. E., Zhang, C., ... Simmer, J. P.
(2021).
Mouse Dspp frameshift model of human dentinogenesis imperfecta. Scientific Reports.
11(1), 20653.
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Zhang, H., Xu, Q., Lu, Y., & Qin, C.
(2021).
Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice. European Journal Of Oral Sciences.
129(3), e12795.
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Xu, Q., Zhang, H., Wang, S., Qin, C., & Lu, Y.
(2021).
Constitutive expression of spliced XBP1 causes perinatal lethality in mice. Genesis: The Journal of Genetics and Development.
59(5-6), e23420.
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Liang, T., Xu, Q., Zhang, H., Wang, S., Diekwisch, T., Qin, C., & Lu, Y.
(2021).
Enamel Defects Associated With Dentin Sialophosphoprotein Mutation in Mice. Frontiers in Physiology.
12, 724098.
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Li, L., Saiyin, W., Zhang, H., Wang, S., Xu, Q., Qin, C., & Lu, Y.
(2019).
FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis. 50(6), 581-591.
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Liang, T., Zhang, H., Xu, Q., Wang, S., Qin, C., & Lu, Y.
(2019).
Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. Journal of Dental Research.
98(8), 912-919.
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Zhang, H., Li, L., Kesterke, M. J., Lu, Y., & Qin, C.
(2019).
High-Phosphate Diet Improved the Skeletal Development of Fam20c-Deficient Mice. Cells, Tissues, Organs: in vivo, in vitro.
208(1-2), 25-36.
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Saiyin, W., Li, L., Zhang, H., Lu, Y., & Qin, C.
(2019).
Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF- and MAPK signaling pathways. BBA: Molecular Basis of Disease.
1865(12), 165555-165555.
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Shiflett, L. A., Tiede-Lewis, L. M., Xie, Y., Lu, Y., Ray, E. C., & Dallas, S. L.
(2019).
Collagen Dynamics During the Process of Osteocyte Embedding and Mineralization. Frontiers in Cell and Developmental Biology.
7, 178.
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Liu, X., Li, N., Zhang, H., Liu, J., Zhou, N., Ran, C., ... Liu, C.
(2018).
Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. European Journal Of Oral Sciences.
126(5), 433-436.
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Liu, C., Zhang, H., Jani, P., Wang, X., Lu, Y., Li, N., Xiao, J., & Qin, C.
(2018).
FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. Journal of Cellular Physiology.
233(4), 3476-3486.
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Liu, C., Zhou, N., Wang, Y. u., Zhang, H., Jani, P., Wang, X., ... Qin, C.
(2018).
Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Experimental Cell Research.
363(2), 188-195.
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Lu, Y., Kamel-El Sayed, S. A., Wang, K., Tiede-Lewis, L. M., Grillo, M. A., Veno, P. A., ... Dallas, S. L.
(2018).
Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs. Journal of Bone and Mineral Research.
33(6), 1166-1182.
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Morris, J. L., Cross, S. J., Lu, Y., Kadler, K. E., Lu, Y., Dallas, S. L., & Martin, P.
(2018).
Live imaging of collagen deposition during skin development and repair in a collagen I - GFP fusion transgenic zebrafish line. Developmental Biology.
441(1), 4-11.
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Zhang, H., Xie, X., Liu, P., Liang, T., Lu, Y., & Qin, C.
(2018).
Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One.
13(4), e0195854-e0195854.
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Zhang, H., Jani, P., Liang, T., Lu, Y., & Qin, C.
(2017).
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of Molecular Histology.
48(2), 83-98.
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Liu, P., Ma, S. u., Zhang, H., Liu, C., Lu, Y., Chen, L. i., & Qin, C.
(2017).
Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Scientific Reports.
7(1), 3590.
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Liang, T., Meng, T., Wang, S., Qin, C., & Lu, Y.
(2016).
The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum. Journal of Cellular Physiology.
231(7), 1468-1475.
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Xie, X., Liu, C., Zhang, H., Jani, P. H., Lu, Y., Wang, X., Zhang, B., & Qin, C.
(2016).
Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Scientific Reports.
6(1), 25364.
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Jani, P. H., Gibson, M. P., Liu, C., Zhang, H., Wang, X., Lu, Y., & Qin, C.
(2016).
Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol.
52-54, 95-112.
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Zhang, H., Liu, P., Wang, S., Liu, C., Jani, P., Lu, Y., & Qin, C.
(2016).
Transgenic expression of dentin phosphoprotein inhibits skeletal development. European Journal of Histochemistry.
60(1), 2587-54.
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Kamel-ElSayed, S. A., Tiede-Lewis, L. M., Lu, Y., Veno, P. A., & Dallas, S. L.
(2016).
Corrigendum to novel approaches for two and three dimensional multiplexed imaging of osteocytes Bone 76 (2015) [129-140]. BONE.
83, 93-93.
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Meng, T., Huang, Y., Wang, S., Zhang, H., Dechow, P. C., Wang, X., ... Lu, Y.
(2015).
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. Journal of Biological Chemistry.
290(49), 29593-29602.
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Liu, C., Wang, X., Zhang, H., Xie, X., Liu, P., Liu, Y., ... Qin, C.
(2015).
Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics. Journal of Cellular Physiology.
230(11), 2581-2587.
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Kamel-ElSayed, S. A., Tiede-Lewis, L. M., Lu, Y., Veno, P. A., & Dallas, S. L.
(2015).
Novel approaches for two and three dimensional multiplexed imaging of osteocytes. BONE.
76, 129-140.
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Gibson, M. P., Jani, P., Wang, X., Lu, Y., & Qin, C.
(2014).
Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of Oral Biosciences.
56(4), 143-148.
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Lin, S., Zhang, Q. i., Cao, Z., Lu, Y., Zhang, H., Yan, K., ... Feng, J. Q.
(2014).
Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. Journal of Biological Chemistry.
289(31), 21533-21543.
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Wang, X., Wang, J., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C.
(2014).
Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connective Tissue Research.
55(4), 299-303.
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Huang, Y., Meng, T., Wang, S., Zhang, H., Mues, G., Qin, C., ... Lu, Y.
(2014).
Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One.
9(6), e99331-e99331.
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Lin, S., Zhang, Q. i., Zhang, H., Yan, K., Ward, L., Lu, Y., & Feng, J.
(2014).
Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice. International Journal of Oral Science.
6(3), 133-141.
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Gibson, M. P., Jani, P., Liu, Y., Wang, X., Lu, Y., Feng, J. Q., & Qin, C.
(2013).
Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice. European Journal Of Oral Sciences.
121(6), 545-550.
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Wang, X., Jung, J., Liu, Y., Yuan, B., Lu, Y., Feng, J. Q., & Qin, C.
(2013).
The specific role of FAM20C in amelogenesis. Journal of Dental Research.
92(11), 995-999.
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Huang, Y., Lu, Y., Mues, G., Wang, S., Bonds, J., & D'Souza, R.
(2013).
Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation. European Journal Of Oral Sciences.
121(4), 313-318.
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Gibson, M. P., Liu, Q., Zhu, Q., Lu, Y., Jani, P., Wang, X., ... Qin, C.
(2013).
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. European Journal Of Oral Sciences.
121(2), 76-85.
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Gibson, M. P., Zhu, Q., Wang, S., Liu, Q., Liu, Y., Wang, X., ... Lu, Y.
(2013).
The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Journal of Biological Chemistry.
288(10), 7204-7214.
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Mammoto, T., Jiang, E., Jiang, A., Lu, Y., Juan, A. M., Chen, J., & Mammoto, A.
(2013).
Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One.
8(9), e73407-e73407.
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Lu, Y., Li, Y., Cavender, A. C., Wang, S., Mansukhani, A., & D'Souza, R. N
(2012).
Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Developmental Dynamics.
241(11), 1708-1715.
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Wang, X., Wang, S., Lu, Y., Gibson, M. P., Liu, Y., Yuan, B., Feng, J. Q., & Qin, C.
(2012).
FAM20C plays an essential role in the formation of murine teeth. Journal of Biological Chemistry.
287(43), 35934-35942.
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Zhu, Q., Gibson, M. P., Liu, Q., Liu, Y., Lu, Y., Wang, X., Feng, J. Q., & Qin, C.
(2012).
Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. Journal of Biological Chemistry.
287(36), 30426-30435.
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Zhu, Q., Prasad, M., Kong, H., Lu, Y., Sun, Y., Wang, X., ... Qin, C.
(2012).
Partial Blocking of Mouse DSPP Processing by Substitution of Gly451–Asp452 Bond Suggests the Presence of Secondary Cleavage Site(s). Connective Tissue Research.
53(4), 307-312.
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Rangiani, A., Cao, Z., Sun, Y., Lu, Y., Gao, T., Yuan, B., ... Feng, J. Q.
(2012).
Protective roles of DMP1 in high phosphate homeostasis. PLoS One.
7(8), e42329-e42329.
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Wang, X., Wang, S., Li, C., Gao, T., Liu, Y., Rangiani, A., ... Qin, C.
(2012).
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. 8(5), e1002708-e1002708.
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Siyam, A., Wang, S., Qin, C., Mues, G., Stevens, R., D'Souza, R. N., & Lu, Y.
(2012).
Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochemical and Biophysical Research Communications.
424(3), 641-646.
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Li, Y., Lu, Y., Maciejewska, I., Galler, K. M., Cavender, A., & D'Souza, R. N.
(2011).
TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Advances in Dental Research.
23(3), 280-284.
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Sun, Y., Lu, Y., Chen, L., Gao, T., D'Souza, R., Feng, J. Q., & Qin, C.
(2011).
DMP1 processing is essential to dentin and jaw formation. Journal of Dental Research.
90(5), 619-624.
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Zhang, R., Lu, Y., Ye, L., Yuan, B., Yu, S., Qin, C., ... Feng, J. Q.
(2011).
Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. Journal of Bone and Mineral Research.
26(5), 1047-1056.
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Lu, Y., Yuan, B., Qin, C., Cao, Z., Xie, Y., Dallas, S. L., ... Feng, J. Q.
(2011).
The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. Journal of Bone and Mineral Research.
26(2), 331-340.
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Lu, Y., & Feng, J. Q.
(2011).
FGF23 in skeletal modeling and remodeling. Current Osteoporosis Reports.
9(2), 103-108.
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Jiang, B., Cao, Z., Lu, Y., Janik, C., Lauziere, S., Xie, Y., ... Feng, J. Q.
(2010).
DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. Journal of Bone and Mineral Research.
25(10), 2155-2164.
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Lv, K., Huang, H., Lu, Y., Qin, C., Li, Z., & Feng, J. Q.
(2010).
Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. International Journal of Biological Sciences.
6(6), 537-545.
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Sun, Y., Lu, Y., Chen, S., Prasad, M., Wang, X., Zhu, Q., ... Qin, C.
(2010).
Key proteolytic cleavage site and full-length form of DSPP. Journal of Dental Research.
89(5), 498-503.
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Ma, D., Barragan-Adjemian, C., Xie, Y., Lu, Y., Bonewald, L. F., & Feng, J. Q.
(2008).
Pre-odontoblasts, odontoblasts, or "odontocytes" - Reply. Journal of Dental Research.
87(3), 199-199.
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Huang, B., Maciejewska, I., Sun, Y., Peng, T., Qin, D., Lu, Y., ... Qin, C.
(2008).
Identification of full-length dentin matrix protein 1 in dentin and bone. Calcified Tissue International.
82(5), 401-410.
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Kula, K., Trimmell, J., Lu, Y., Briscoe, P., & Feng, J. Q.
(2008).
Tooth agenesis in a family and homozygous PAX9 mutation in exon 3: a case report. World Journal of Orthodontics.
9(4), e55-e61.
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Lu, Y., Xie, Y., Zhang, S., Dusevich, V., Bonewald, L. F., & Feng, J. Q.
(2007).
DMP1-targeted Cre expression in odontoblasts and osteocytes. Journal of Dental Research.
86(4), 320-325.
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Lu, Y., Ye, L., Yu, S., Zhang, S., Xie, Y., McKee, M. D., ... Feng, J. Q.
(2007).
Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Developmental Biology.
303(1), 191-201.
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Lu, Y., Liu, S., Xie, Y., Yu, S., Quarles, L., Bonewald, L. F., & Feng, J. Q.
(2007).
Use of the transgenic approach to determine the role of DMP1 in phosphate regulation. 7(4), 309.
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Zhang, K., Barragan-Adjemian, C., Ye, L., Kotha, S., Dallas, M., Lu, Y., ... Bonewald, L. F.
(2006).
E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Molecular and Cellular Biology.
26(12), 4539-4552.
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Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., ... White, K. E.
(2006).
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature Genetics.
38(11), 1310-1315.
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Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L.
(2005).
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. 20(12), 2169-2177.
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Yang, W., Lu, Y., Kalajzic, I., Guo, D., Harris, M. A., Gluhak-Heinrich, J., ... Harris, S. E.
(2005).
Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. Journal of Biological Chemistry.
280(21), 20680-20690.
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Yang, W., Kalajzic, I., Lu, Y., Guo, D., Harris, M. A., Gluhak-Heinrich, J., ... Harris, S. E.
(2004).
In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. 4(4), 386-387.
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Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., ... Feng, J. Q.
(2004).
Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. 279(18), 19141-19148.
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Feng, J. Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., ... Mishina, Y.
(2003).
The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Journal of Dental Research.
82(10), 776-780.
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Fen, J. Q., Zhang, J., Dallas, S. L., Lu, Y., Chen, S., Tan, X., ... MacDougall, M.
(2002).
Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. Journal of Bone and Mineral Research.
17(10), 1822-1831.
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Zhang, J., Tan, X., Contag, C. H., Lu, Y., Guo, D., Harris, S. E., & Feng, J. Q.
(2002).
Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles. Biochemical and Biophysical Research Communications.
293(5), 1412-1419.
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Feng, J. Q., Zhang, J., Tan, X., Lu, Y., Guo, D., & Harris, S. E.
(2002).
Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo. Journal of Dental Research.
81(1), 6-10.
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Liang, T., Hu, Y., Zhang, H., Xu, Q., Smith, C. E., Zhang, C., ... Simmer, J. P.
(2021).
Mouse Dspp frameshift model of human dentinogenesis imperfecta. Scientific Reports.
11(1), 20653.
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conference paper
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Peng, T., Huang, B., Sun, Y., Lu, Y., Bonewald, L., Chen, S., ... Qin, C.
(2009).
Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells, Tissues, Organs: in vivo, in vitro.
192-197.
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Lu, Y., Qin, C., Xie, Y., Bonewald, L. F., & Feng, J. Q.
(2009).
Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells, Tissues, Organs: in vivo, in vitro.
175-185.
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Lu, Y., Liu, S., Yu, S., Xie, Y., Zhou, J., Quarles, L. D., Bonewald, L. F., & Feng, J. O.
(2007).
The 57 kDa C-terminal fragment of dentin matrix protein 1 (DMPI) retains all biological activity: Osteocytic regulation of Pi homeostasis through FGF23. Journal of Bone and Mineral Research.
S82-S82.
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Lu, Y., Zhang, S., Xie, Y., Pi, Y., & Feng, J. Q.
(2005).
Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells, Tissues, Organs: in vivo, in vitro.
241-247.
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Feng, J. Q., Ye, L., Chen, D., Huang, H., Zhang, J., Lu, Y., ... Mishina, Y.
(2002).
Dmp1-deficient mice develop dwarfism, chondrodysplasia, and exhibit disorganized bone mineralization during postnatal development. Journal of Bone and Mineral Research.
S127-S127.
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Peng, T., Huang, B., Sun, Y., Lu, Y., Bonewald, L., Chen, S., ... Qin, C.
(2009).
Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells, Tissues, Organs: in vivo, in vitro.
192-197.
Research
principal investigator on
- Functions of Family with Sequence Similarity 20 - Member C (FAM20C) and Member A (FAM20A) in Amelogenesis and Dentinogenesis 2020 - 2024
- Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogensis Imperfecta (DGI) and Odontoblast Function awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Identification and Function of nuDMP1 in Odontoblast Differentiation awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2019
Teaching
teaching activities
- OBIO640 Cel Mol Bio Of Oral Cran Tis I Instructor
Works By Students
chaired theses and dissertations
Background
education and training
- M.S. in Medical Microbiology, Qingdao University - (Qingdao, China) 1997
- M.D. in Medicine, Qingdao University - (Qingdao, China) 1994
awards and honors
Contact
first name
- Yongbo
has last name
- Lu
mailing address
-
Texas A&M University College of Dentistry
Biomedical Sciences
3302 Gaston Avenue
Dallas, TX 75246
USA
Other
- ylu@tamu.edu