Determine effective, profitable, and sustainable weed management systems in cotton and crops grown in rotation with cotton on the Texas Southern High Plains. Best management practices are critical for effective and sustainable crop production in light of the development of herbicide resistant weeds. Rotational crops including corn, sorghum, peanut, and sesame help to break up crop/weed associations and allow the use of a diversity of mechanical, cultural, biological, and chemical practices. Weed biology and ecology is essential to better understand weeds in these production systems.