Field studies were conducted in various peanut production regions of Texas and Oklahoma during the 2013 and 2014 growing seasons to determine peanut response to single and sequential postemergence applications of pyraflufen-ethyl at the labelled use rate (3.6 g ai ha1). Pyraflufen-ethyl injured peanut in all single and two-application treatments. Injury consisted of white spots on leaves up to 14 d after treatment and became small necrotic spots on older leaf tissue. No injury was apparent on any new growth. Injury did not translate into yield loss in three of five locations; however, yield reductions (approximately 26%) were observed in two of five locations. Peanut grade was not affected by pyraflufen-ethyl applications.