Weed management systems were established near Lubbock, TX in 2013, 2014, and 2015 to assess the effectiveness of premixed 2,4-D choline+glyphosate alone and in combination with glufosinate and soil-residual herbicides for Palmer amaranth control. Systems consisted of trifluralin applied preplant incorporated followed by an early POST application followed by a mid-POST application. Palmer amaranth control 21 days after the early POST application ranged from 75 to 90% for all treatments that included 2,4-D choline+glyphosate alone or in a tank-mixture in 2013. Twenty-eight days after the mid-POST application, Palmer amaranth was controlled 86 to 99% for all herbicide systems with the exception of systems that included a mid-POST application of glufosinate alone. Combined across 2014 and 2015, Palmer amaranth control 21 days after the early POST application ranged from 96 to 98% for all systems that included 2,4-D choline+glyphosate, 2,4-D choline alone, or 2,4-D choline in a tank-mixture. Combined across 2014 and 2015, Palmer amaranth control 28 days after the mid-POST application ranged from 95 to 100% with the exception of the following: trifluralin preplant incorporated followed by glufosinate with or without acetochlor applied early POST followed by glufosinate mid-POST and trifluralin preplant incorporated followed by glyphosate early POST followed by glyphosate mid-POST. Overall, numerous effective systems were identified; however, systems containing 2,4-D choline+glyphosate or 2,4-D choline early POST and/or mid-POST were among the most effective. Glyphosate or glufosinate only systems or systems that relied on glufosinate alone at the mid-POST timing were inconsistent and often performed poorly.